CN102885961B - Medicine for treating rheumatic arthritis and rheumatoid arthritis and method for preparing medicine - Google Patents
Medicine for treating rheumatic arthritis and rheumatoid arthritis and method for preparing medicine Download PDFInfo
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Abstract
The invention relates to a medicine for treating rheumatic arthritis and rheumatoid arthritis and a method for preparing the medicine. The medicine is mainly prepared from pharmaceuticals of polyrhachis vicina roger, zaocys dhumnades, radix aconiti preparata, radix rehmanniae, tripterygium wilfordii, radix clematidis, paniculate swallowwort root, suberect spatholobus stem, herba epimedii, anemarrhena asphodeloides, cornu cervi, buthus martensi karsch, centipede and earthworm, pseudo-ginseng, astragalus, pawpaw, herba taxilli, eucommia ulmoides, radix achyranthis bidentatae, ligusticum chuanxiong and the like. The medicine is used for treating the rheumatoid arthritis and the rheumatic arthritis of finger morning stiffness, muscle and join pain, inhibited bending and stretching, muscle emaciation and anchylosis and malformation, and has the functions of tonifying kidney and strengthening bones, activating blood and relieving wind, dispelling cold and clearing dampness, an exact curative effect and no toxic and side effects.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of rheumatic arthritis, rheumatoid arthritis, the invention still further relates to the preparation method of this medicine.
Background technology
Arthritis is one of common disease being detrimental to health, particularly rheumatoid arthritis, and home and overseas has a lot of people inquiring into its cause of disease, finds the situation that effectively prevention and Therapeutic Method change its prognosis mala.Rheumatoid arthritis is a kind of cause of disease arthritis of not yet sure chronic progressive external so far, it has been generally acknowledged that it is a kind of autoimmunity illness, be body defending system the caused result of killing each other, heredity, infection, cold wet etc. may be all pathogenic factors in addition.Arthritic is mainly synovial membrane inflammation in early days, slides cured hyperemia, swelling, has Fibrin exudation, forms hydrarthrosis, has typical inflammatory cell infiltration in synovial membrane, then involves articular cartilage and osseous tissue, finally causes ankylosis.That ill joint shows as is red, swollen, hot, bitterly and moving obstacle, joint deformity is more and more obvious, patient's rheumatoid factor is often positive, x-ray inspection has obvious Novel presentation.Doctor trained in Western medicine is mainly oral drug therapy to the treatment of rheumatoid arthritis, and salicylic acid formulation example, if aspirin is drug of first choice, is secondly indometacin, Phenylbutazone and prednisone etc., to the feasible operative treatment of end-stage patients.Rheumatoid arthritis belongs to " arthromyodynia " scope in motherland's medical science, and with dampness removing dredging collateral, dispelling cold by warming the meridian is main, and conventional prescription is Radix Angelicae Pubescentis et Herba Taxilli Decoction.Theory of Chinese medical science is thought, the rheumatoid origin cause of formation, mostly due to the wet outer ailment said due to cold or exposure of invading, feel again of water, or diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, hold concurrently wet to hold under the arm, so that rheumatism is rich and fall ill mutually, lingers on do not go as rheumatism, can there is arthralgia, articular instability, or grain contracture, or the disease such as apathetic, and often with the passing of time delay, forms chronic disease.In sum, the disease such as rheumatism, rheumatoid arthritis there is no specific short in treatment.
Summary of the invention
The object of this invention is to provide a kind of medicine for the treatment of the definite and pure Chinese medicinal preparation that has no side effect of rheumatic arthritis, Rheumatoid Arthritis; Another object of the present invention is to provide the preparation method of this medicine.
Solution of the present invention is to develop according to inventor's years of researches and clinical experience prescription, preparation process, quality standard, assay, stability, pharmacodynamics, curative effect contrast observing etc., grope to inquire in research, through Experiment and clinic presentations screening repeatedly, form.
Each raw material components ratio range of medicine of the present invention is:
Formica fusca 10-70 part Zaocys 2-10 part Radix Aconiti Preparata 2-10 part Radix Rehmanniae 2-10 part
Tripterygium hypoglaucum 2-10 part Radix Clematidis 2-10 part Radix Cynanchi Paniculati 2-10 part Caulis Spatholobi 2-10 part
Herba Epimedii 2-10 part Rhizoma Anemarrhenae 2-8 part Cornu Cervi 0.5-5 part Scorpio 2-10 part
Scolopendra 0.5-5 part Pheretima 2-8 part Radix Notoginseng 1-5 part Radix Astragali 2-10 part
Each crude drug weight optimum ratio scope of the present invention is:
Formica fusca 20-60 part Zaocys 3-8 part Radix Aconiti Preparata 3-8 part Radix Rehmanniae 3-8 part
Tripterygium hypoglaucum 3-8 part Radix Clematidis 3-8 part Radix Cynanchi Paniculati 3-8 part Caulis Spatholobi 3-8 part
Herba Epimedii 3-8 part Rhizoma Anemarrhenae 3-7 part Cornu Cervi 0.5-5 part Scorpio 3-8 part
Scolopendra 0.5-5 part Pheretima 3-7 part Radix Notoginseng 1-4 part Radix Astragali 3-8 part
The best proportioning of each crude drug weight of medicine of the present invention is:
Formica fusca 50g Zaocys 6g Radix Aconiti Preparata 4g Radix Rehmanniae 6g
Tripterygium hypoglaucum 6g Radix Clematidis 6g Radix Cynanchi Paniculati 6g Caulis Spatholobi 6g
Herba Epimedii 6g Rhizoma Anemarrhenae 4g Cornu Cervi 1g Scorpio 6g
Scolopendra 1g Pheretima 5g Radix Notoginseng 2g Radix Astragali 6g
Each crude drug weight proportion also comprises:
Fructus Chaenomelis 2-10 part Herba Taxilli 2-10 part Cortex Eucommiae 2-10 part Radix Achyranthis Bidentatae 2-10 part
Rhizoma Chuanxiong 2-10 part
Wherein each crude drug weight optimum ratio is:
Fructus Chaenomelis 3-8 part Herba Taxilli 3-8 part Cortex Eucommiae 3-8 part Radix Achyranthis Bidentatae 3-8 part
Rhizoma Chuanxiong 3-8 part
The best proportioning of each crude drug weight is:
Medicine of the present invention is soft extract or granule or tablet or capsule or pill.
The preparation method of medicine of the present invention: A, animal drugs are ground into coarse powder, soak 1 hour, and the 6-10 times of decocting that adds medical material amount boils 4 times, each 1 hour; B, plant amedica are ground into coarse powder, soak 1 hour, and the 6-10 times of decocting that adds medical material amount boils 3 times, each 1 hour; C, merge decoction liquor, be concentrated into the clear paste of relative density 1.08, cooling, add ethanol to containing alcohol amount 55%--75%, stir, places 24 hours, filter, recovery ethanol obtains thick paste; D, thick paste are made mixture or soft extract or granule or tablet or capsule with sucrose, dextrin, soluble starch.
Another preparation method of medicine of the present invention: A, pulverizing medicinal materials is become to fine powder; B, fine powder add refined honey and make honeyed pill or water-honeyed pill, or add water and make the watered pill, or the encapsulated capsule of making of fine powder.
Clinical data
A kind of clinical trial data for the treatment of medicine (being called for short: rheumatism is precious) the treatment numbness sick (rheumatic arthralgia, class are closed scorching) of rheumatic arthritis, rheumatoid arthritis.Research adopts random packet, take YISHEN JUANBI WAN as matched group, observes two courses for the treatment of (one month per course for the treatment of).Guideline of clinical investigations according to new Chinese medicine treatment numbness disease carries out clinical trial, collects altogether the precious group of rheumatism 100 examples, and result is as follows:
The effective enabledisable total effective rate of name of disease number of cases clinic control
Rheumatic arthralgia 70 15 (21.4%) 20 (28.6%) 34 (48.6%) 1 (1.4%) 98.6%
Class closes scorching 30 9 (30.0%) 9 (30.0%) 11 (36.7%) 1 (3.3%) 96.7%
Add up to 100 24 (24%) 29 (28%) 45 (45%) 2 (2%) 98%
The aggregate efficiency of the precious treatment of rheumatism numbness disease is 98%, and clinic control rate is 24%, and obvious effective rate is 29%, and effective percentage is 45%, with matched group comparison, through Ridit, analyzes and has significant difference, and treatment group curative effect is better than matched group.
Impact on rheumatic arthralgia: treatment group 70 examples, matched group 33 examples, analyze through Ridit for two groups, have significant difference (p < 0.05), and treatment group curative effect is better than matched group.
Class is closed to scorching impact: each 30 examples for the treatment of group and matched group, through Ridit, analyze for two groups, there is significant difference (p < 0.05), treatment group curative effect is better than matched group.
Impact on anemofrigid-damp arthralgia and paralysis: analyze through Ridit, compare there was no significant difference (p < 0.05) between treatment group anemofrigid-damp arthralgia and paralysis, the therapeutic equivalence of this medicine to anemofrigid-damp arthralgia and paralysis is described.The treatment group of anemofrigid-damp arthralgia and matched group comparison, there is significant difference (p < 0.01), the treatment group of paralysis and matched group comparison, have significant difference (p < 0.05), and two pattern of syndrome are treatment group curative effect and are better than matched group.
Impact on erythrocyte sedimentation rate: two groups more all have significant difference (p < 0.01) before and after self, illustrate that two medicines all can obviously reduce erythrocyte sedimentation rate.The comparison there was no significant difference (p > 0.05) of difference before and after between two groups of rheumatic arthralgia, class is closed the significant difference (p < 0.05) that relatively has of difference before and after scorching two groups and is illustrated reducing rheumatic arthralgia patient's erythrocyte sedimentation rate, two medicines are without obvious difference, the erythrocyte sedimentation rate that closes scorching patient to reducing class, curative is obviously better than contrasting medicine.
Class is closed to the impact of scorching patient RF, through X
2check, treatment group and matched group RF negative conversion rate have significant difference (p < 0.01), and treatment group RF negative conversion rate is apparently higher than matched group.
Impact on clinical symptoms integration: self more all have significant difference (p < 0.01) before and after two groups of treatments, illustrate that two medicines all can obviously improve numbness patient's clinical symptoms.Between two groups, before treatment, compare there was no significant difference (p > 0.05), between two groups, after treatment, compare, rheumatic arthralgia group no significant difference (P > 0.05), class is closed scorching group significant difference (p < 0.05), illustrates that rheumatism treasured more can improve the clinical symptoms that class is closed scorching patient compared with YISHEN JUANBI WAN.
The precious treatment of rheumatism class is closed scorching, by functional classification, I, II level patient's curative effect is better than to III, IV level patient's curative effect.By by stages, the curative effect of early stage patient is better than to middle and advanced stage patient's curative effect, to mid-term, patient's curative effect is better than the curative effect of patients with terminal.
In 100 routine treatment groups, only have 1 example to occur the discomfort of having sore throat, there is dizzy phenomenon in 1 example, adheres to that symptom after taking medicine disappears, by analysis, for the probability of drug-induced very little.All the other cases are showed no discomfort.Hematochrome, numeration of leukocyte, be improvement after the testing data treatments such as routine urinalysis or front and back are normally, also do not occur hepatic injury.Visible, it is safe using rheumatism treasured.
Model case:
Example 1: Xiong Jicheng, male, 41 years old, married, peasant, medical hospital: No. 1 Hospital Affiliated to Hunan Traditional Chinese Medical College, first visit time 1994.10.22
Both hands finger and palm joint, interphalangeal joint swell and ache more than 4 years repeatedly, often because suffer from cold (groundwater reservoir) brings out or increase the weight of, once take the medicines such as dipyrone, piroxicam, indometacin, numbness electuary, and period in a medicine symptom can be controlled, and drug withdrawal is easily recurrence.Now still feel both hands finger and palm joint and swell and ache, both hands foods, in, the class fusiformis swelling of nameless joint, moving obstacle, companion's soreness of the waist and knees is tired, pale tongue, white and thin fur, thready and weak pulse.Lab testing: Hb105g/L, WBC6.5 * 10
9/ L N0.28UR: normal, liver function is normal, ESR39mm/h, RF is positive, and the right hand is slapped positive oblique film: right hand articulations digitorum manus gap turn narrow, osteoporosis, soft tissue is slightly swollen.Suggestion: right hand metacarpophalangeal joints is rheumatoid sample and changes.
Western medicine diagnose: rheumatoid arthritis
Tcm diagnosis and dialectical: arthromyodynia (paralysis)
Treatment: precious 500ml * 7 bottle of rheumatism, usage and consumption: each 20ml, every day 3 times, be 1 course for the treatment of January, took continuously for 2 courses for the treatment of.
Curative effect: 4th week end after taking medicine, clinical symptoms is obviously improved, and to rarely seen of the 7th weekend, has soreness of the waist and knees, joint transference cure, body of the tongue is partially red, white and thin fur, small and stringy pulse.
Lab testing check: Hb115g/L, WBC4.5 * 10
9/ L, N0.68 N0.32UR: normal, liver function is normal, ESR18mm/h, RF is negative, X-ray film: be right hand metacarpophalangeal joints is the change of rheumatoid sample originally, check and photo comparison on October 24 after treatment; Soft tissue swelling disappears, and articulations digitorum manus is slightly clear, and osteoporosis is slightly recovered, and remaining and former roughly the same.
Efficacy evaluation: clinic control
Example 2: patient Liu Manmei, women, 39 years old, married, cadre, work unit: Shaoyang City township enterprise administration, medical hospital: Shaoyang Municipal Traditional Chinese Medical Hospital, first visit time: on JIUYUE 27th, 1994.
The multiple pain in whole body size joint more than 4 years, the postemphasis of often suffering from cold, once took Radix Tripterygii Wilfordii tablet effective, but often outbreak repeatedly, existing disease is seen: whole body many places size arthralgia, swelling, moving obstacle, numb limbs and tense tendons, tired, emaciated physique, body of the tongue is partially red, white and thin fur, stringy pulse.Look into: body weight 40kg, both hands refer to, toes joint swelling deformation.Lab testing: Hb90g/L, WBC5.0 * 10
9/ L N0.80 L0.20, urinates 8 normally, epithelial cell 0-2/HP, and ESR38mm/h, RF is positive, the positive bit slice of both hands fingers and palms bone; Both hands metacarpophalangeal joints face is more coarse, and has swelling, and density is lower.Have no obvious destruction sign suggestion, above change meets rheumatoid arthritis and changes.
Western medicine diagnose: rheumatoid arthritis
Tcm diagnosis and dialectical: arthromyodynia (anemofrigid-damp arthralgia)
Treatment: precious 500ml * 7 bottle of rheumatism, usage and consumption: each 20ml, every day 3 times, takes 2 months altogether.
The 3rd week posterior joint pain of taking medicine, tenderness, swelling, moving obstacle obviously alleviates, rarely seen the Chang Guanjie mild pain not to the 8th week, remaining disease disappears, and body of the tongue is light red, white and thin fur, stringy and thready pulse.
Body weight 48kg, lab testing review result: Hb110g/L, WBC6.0 * 10
9/ LN0.75 N0.25 UR is normal, ESR8mm/h, and RF is negative, X-ray film: change and be before clearly better with 94.9.28 sheet comparison both hands metacarpophalangeal joints.
The specific embodiment
Embodiment mono-
Take clean material as follows:
6 parts, 4 parts of Radix Rehmanniae of 6 parts of Radix Aconiti Preparatas of 50 parts of Zaocyss of Formica fusca
6 parts of 6 portions of Caulis Spatholobis of 6 parts of Radix Cynanchi Paniculatis of 6 parts of Radix Clematidis of Tripterygium hypoglaucum
6 parts of 1 portion of Scorpios of 4 parts of Cornu Cervis of 6 parts of Rhizoma Anemarrhenaes of Herba Epimedii
6 parts of 2 parts of Radixs Astragali of 5 portions of Radix Notoginseng of 1 part of Pheretima of Scolopendra
Preparation method is as follows:
A, animal drugs are ground into coarse powder, soak 1 hour, add 6-10 times of decocting of medical material amount and boil 4 times, each 1 hour;
B, plant amedica are ground into coarse powder, soak 1 hour, add 6-10 times of decocting of medical material amount and boil 3 times, each 1 hour;
C, merge decoction liquor, be concentrated into the clear paste of relative density 1.08, cooling, add ethanol to containing alcohol amount 55%--75%, stir, places 24 hours, filter, recovery ethanol obtains thick paste;
D, thick paste are made mixture or soft extract or granule or tablet or capsule with sucrose, dextrin, soluble starch.
Embodiment bis-
Take raw material with embodiment mono-, preparation method is as follows:
A, pulverizing medicinal materials is become to fine powder;
B, fine powder add refined honey and make honeyed pill or water-honeyed pill, or add water and make the watered pill, or the encapsulated capsule of making of fine powder.
Embodiment 3
Take clean material as follows:
Preparation method is with embodiment 1
Embodiment 4
Take raw material with embodiment 3, preparation method is with embodiment 2.
Claims (9)
1. treat a medicine for rheumatic arthritis, rheumatoid arthritis, it is characterized in that it is to be made by the crude drug of following weight proportioning:
Formica fusca 10-70 part Zaocys 2-10 part Radix Aconiti Preparata 2-10 part Radix Rehmanniae 2-10 part
Tripterygium hypoglaucum 2-10 part Radix Clematidis 2-10 part Radix Cynanchi Paniculati 2-10 part Caulis Spatholobi 2-10 part
Herba Epimedii 2-10 part Rhizoma Anemarrhenae 2-8 part Cornu Cervi 0.5-5 part Scorpio 2-10 part
Scolopendra 0.5-5 part Pheretima 2-8 part Radix Notoginseng 1-5 part Radix Astragali 2-10 part.
2. a kind of medicine for the treatment of rheumatic arthritis, rheumatoid arthritis according to claim 1, wherein each crude drug ratio range is:
Formica fusca 20-60 part Zaocys 3-8 part Radix Aconiti Preparata 3-8 part Radix Rehmanniae 3-8 part
Tripterygium hypoglaucum 3-8 part Radix Clematidis 3-8 part Radix Cynanchi Paniculati 3-8 part Caulis Spatholobi 3-8 part
Herba Epimedii 3-8 part Rhizoma Anemarrhenae 3-7 part Cornu Cervi 0.5-5 part Scorpio 3-8 part
Scolopendra 0.5-5 part Pheretima 3-7 part Radix Notoginseng 1-4 part Radix Astragali 3-8 part.
3. a kind of medicine for the treatment of rheumatic arthritis, rheumatoid arthritis according to claim 1, wherein each crude drug weight proportion is:
6 parts, 4 parts of Radix Rehmanniae of 6 parts of Radix Aconiti Preparatas of 50 parts of Zaocyss of Formica fusca
6 parts of 6 portions of Caulis Spatholobis of 6 parts of Radix Cynanchi Paniculatis of 6 parts of Radix Clematidis of Tripterygium hypoglaucum
6 parts of 1 portion of Scorpios of 4 parts of Cornu Cervis of 6 parts of Rhizoma Anemarrhenaes of Herba Epimedii
6 parts of 2 parts of Radixs Astragali of 5 portions of Radix Notoginseng of 1 part of Pheretima of Scolopendra.
4. treat a medicine for rheumatic arthritis, rheumatoid arthritis, it is characterized in that it is to be made by the crude drug of following weight proportioning:
Formica fusca 10-70 part Zaocys 2-10 part Radix Aconiti Preparata 2-10 part Radix Rehmanniae 2-10 part
Tripterygium hypoglaucum 2-10 part Radix Clematidis 2-10 part Radix Cynanchi Paniculati 2-10 part Caulis Spatholobi 2-10 part
Herba Epimedii 2-10 part Rhizoma Anemarrhenae 2-8 part Cornu Cervi 0.5-5 part Scorpio 2-10 part
Scolopendra 0.5-5 part Pheretima 2-8 part Radix Notoginseng 1-5 part Radix Astragali 2-10 part
Fructus Chaenomelis 2-10 part Herba Taxilli 2-10 part Cortex Eucommiae 2-10 part Radix Achyranthis Bidentatae 2-10 part
Rhizoma Chuanxiong 2-10 part.
5. treat a medicine for rheumatic arthritis, rheumatoid arthritis, wherein each crude drug weight proportion is:
Formica fusca 10-70 part Zaocys 2-10 part Radix Aconiti Preparata 2-10 part Radix Rehmanniae 2-10 part
Tripterygium hypoglaucum 2-10 part Radix Clematidis 2-10 part Radix Cynanchi Paniculati 2-10 part Caulis Spatholobi 2-10 part
Herba Epimedii 2-10 part Rhizoma Anemarrhenae 2-8 part Cornu Cervi 0.5-5 part Scorpio 2-10 part
Scolopendra 0.5-5 part Pheretima 2-8 part Radix Notoginseng 1-5 part Radix Astragali 2-10 part
Fructus Chaenomelis 3-8 part Herba Taxilli 3-8 part Cortex Eucommiae 3-8 part Radix Achyranthis Bidentatae 3-8 part
Rhizoma Chuanxiong 0-8 part.
6. a kind of medicine for the treatment of rheumatic arthritis, rheumatoid arthritis according to claim 4, wherein each crude drug weight proportion is:
6 parts, 4 parts of Radix Rehmanniae of 6 parts of Radix Aconiti Preparatas of 50 parts of Zaocyss of Formica fusca
6 parts of 6 portions of Caulis Spatholobis of 6 parts of Radix Cynanchi Paniculatis of 6 parts of Radix Clematidis of Tripterygium hypoglaucum
6 parts of 1 portion of Scorpios of 4 parts of Cornu Cervis of 6 parts of Rhizoma Anemarrhenaes of Herba Epimedii
6 parts of 2 parts of Radixs Astragali of 5 portions of Radix Notoginseng of 1 part of Pheretima of Scolopendra
6 parts of 6 parts of Radix Achyranthis Bidentataes of 6 parts of Cortexs Eucommiae of 6 parts of Herba Taxillis of Fructus Chaenomelis
6 parts of Rhizoma Chuanxiongs
7. according to a kind of medicine for the treatment of rheumatic arthritis, rheumatoid arthritis described in claim 1,2,3,4,5 or 6, it is characterized in that said medicine is soft extract or granule or tablet or capsule or pill.
8. according to a kind of preparation method for the treatment of the medicine of rheumatic arthritis, rheumatoid arthritis described in claim 1,2,3,4,5,6 or 7, it is characterized in that: A, animal drugs are ground into coarse powder, soak 1 hour, add 6-10 times of decocting of medical material amount and boil 4 times, each 1 hour; B, plant amedica are ground into coarse powder, soak 1 hour, add 6-10 times of decocting of medical material amount and boil 3 times, each 1 hour; C, merge decoction liquor, be concentrated into the clear paste of relative density 1.08, cooling, add ethanol to containing alcohol amount 55%--75%, stir, places 24 hours, filter, recovery ethanol obtains thick paste; D, thick paste are made soft extract or granule or tablet or capsule with sucrose, dextrin, soluble starch.
9. according to a kind of preparation method for the treatment of the medicine of rheumatic arthritis, rheumatoid arthritis described in claim 1,2,3,4,5,6 or 7, it is characterized in that: A, pulverizing medicinal materials is become to fine powder; B, fine powder add refined honey and make honeyed pill, or add water and make the watered pill, or the encapsulated capsule of making of fine powder.
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| CN105194248A (en) * | 2015-07-17 | 2015-12-30 | 柳培健 | Traditional Chinese medicine for treating arthritis |
| CN112717082B (en) * | 2021-02-23 | 2022-03-04 | 成都医学院 | Pharmaceutical composition for treating rheumatoid arthritis and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101361923A (en) * | 2008-09-11 | 2009-02-11 | 周功庚 | Traditional Chinese medicine for treating rheumatism |
| CN101406646A (en) * | 2008-11-26 | 2009-04-15 | 路敦祥 | Chinese medicinal liquor for treating arthritis |
| CN101530566A (en) * | 2008-03-10 | 2009-09-16 | 王林祥 | Drug for treating rheumatism and rheumatoid disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530566A (en) * | 2008-03-10 | 2009-09-16 | 王林祥 | Drug for treating rheumatism and rheumatoid disease |
| CN101361923A (en) * | 2008-09-11 | 2009-02-11 | 周功庚 | Traditional Chinese medicine for treating rheumatism |
| CN101406646A (en) * | 2008-11-26 | 2009-04-15 | 路敦祥 | Chinese medicinal liquor for treating arthritis |
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Denomination of invention: A drug for treating rheumatoid arthritis and rheumatoid arthritis and its preparation method Effective date of registration: 20230828 Granted publication date: 20140326 Pledgee: Bank of China Limited Shaoyang Branch Pledgor: Hunan Province Xiangzhong Pharmaceutical Co.,Ltd. Registration number: Y2023980054088 |