CN108310272A - A kind of Chinese medicine composition and preparation method thereof for treating gout - Google Patents

A kind of Chinese medicine composition and preparation method thereof for treating gout Download PDF

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CN108310272A
CN108310272A CN201810416894.0A CN201810416894A CN108310272A CN 108310272 A CN108310272 A CN 108310272A CN 201810416894 A CN201810416894 A CN 201810416894A CN 108310272 A CN108310272 A CN 108310272A
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parts
root
chinese medicine
chinese
medicine composition
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聂淑惠
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract

The invention discloses a kind of Chinese medicine compositions and preparation method thereof for treating gout, belong to technical field of traditional Chinese medicines, which is made of the raw material of following parts by weight：4 15 parts of Poria cocos, 14 15 parts of Radix Angelicae Pubescentis, 14 15 parts of giant knotweed, 14 15 parts of the root of Chinese clematis, 14 15 parts of Ramulus Taxilli, 14 15 parts of Chinese yam, 15 17 parts of radix scrophulariae, 14 15 parts of plantain seed, 4 15 parts of dark plum, 14 15 parts of dogwood fruit, 14 15 parts of the root of bidentate achyranthes, 14 15 parts of dandelion, 14 15 parts of Cortex Eucommiae, 14 15 parts of motherwort, 14 15 parts of plantain seed, 16 17 parts of matrimony vine, 14 15 parts of Schisandra chinensis, 16 17 parts of Semen Coicis, 14 15 parts of reed root, windproof 15 16 parts, 13 15 parts of oriental wormwood, 16 17 parts of pawpaw, 15 16 parts of Radix Rehmanniae.The Chinese medicine composition have nourishing the liver and kidney, enhance kidney function of detoxification, be conducive to the harmful substances such as purine it is dilute go out, reach clearing heat and detoxicating function.

Description

A kind of Chinese medicine composition and preparation method thereof for treating gout
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and preparation method thereof for treating gout.
Background technology
Gout is a kind of disease caused by purine metabolic disturbance, clinically with redness and swelling of joints heat pain recurrent exerbation, Dumb joint motion is main clinical manifestation.With hyperuricemia, acute arthritis recurrent exerbation, tophaceous deposition is chronic With the characteristics of arthritis and joint deformity, kidney essence lesion and uric-acid calculus are formed.It is often accompanied by hyperlipidemia, fat, diabetes, high blood Pressure, artery sclerosis, coronary heart disease etc. belong to genetic disease, mostly related with bad life habits.Past China's incidence is relatively low, with The improvement of people's living standards, in recent years gout oneself become common disease and frequently-occurring disease.However, treat at present it is most common still Based on Western medicine, it is often physical function degeneration and drug resistance that Western medicine, which has side effect, long-term administration, the result brought, can be made Body generates adverse reaction, moreover it is possible to form dependence to drug.
Invention content
The present invention provides a kind of Chinese medicine composition and preparation method thereof for treating gout, which, which has, nourishes liver Kidney, enhance kidney function of detoxification, be conducive to the harmful substances such as purine it is dilute go out, reach clearing heat and detoxicating function.
The present invention uses following technical scheme：
A kind of Chinese medicine composition for treating gout, is made of the raw material of following parts by weight：4-15 parts of Poria cocos, Radix Angelicae Pubescentis 14-15 Part, 14-15 parts of giant knotweed, 14-15 parts of the root of Chinese clematis, 14-15 parts of Ramulus Taxilli, 14-15 parts of Chinese yam, 15-17 parts of radix scrophulariae, plantain seed 14- 15 parts, 4-15 parts of dark plum, 14-15 parts of dogwood fruit, 14-15 parts of the root of bidentate achyranthes, 14-15 parts of dandelion, 14-15 parts of Cortex Eucommiae, motherwort 14- 15 parts, 14-15 parts of plantain seed, 16-17 parts of matrimony vine, 14-15 parts of Schisandra chinensis, 16-17 parts of Semen Coicis, 14-15 parts of reed root, windproof 15- 16 parts, 13-15 parts of oriental wormwood, 16-17 parts of pawpaw, 15-16 parts of Radix Rehmanniae.
As a kind of selection, it is made of the raw material of following parts by weight：10 parts of Poria cocos, 14 parts of Radix Angelicae Pubescentis, 15 parts of giant knotweed, the root of Chinese clematis 15 parts, 14 parts of Ramulus Taxilli, 14 parts of Chinese yam, 16 parts of radix scrophulariae, 15 parts of plantain seed, 11 parts of dark plum, 14 parts of dogwood fruit, 15 parts of the root of bidentate achyranthes, Pu 14 parts of public English, 14 parts of Cortex Eucommiae, 14 parts of motherwort, 15 parts of plantain seed, 16 parts of matrimony vine, 14 parts of Schisandra chinensis, 17 parts of Semen Coicis, reed root 15 Part, 16 parts windproof, 13 parts of oriental wormwood, 17 parts of pawpaw, 16 parts of Radix Rehmanniae.
The present invention also provides the preparation methods of the Chinese medicine composition, include the following steps：It is weighed respectively according to weight part ratio Kind raw medicinal material, mixing are ground into powder, and sieve of looking over so as to check obtains raw material fine powder, and granularity is 20-200 mesh；It is reconstituted with boiling water or directly Boiling is added to begin to drink use.
Application of the above-mentioned Chinese medicine composition in the drug for preparing treatment goat is also protection scope of the present invention.
In the Chinese medicine composition of the present invention, the effect of each taste bulk pharmaceutical chemicals, is as follows：
The root of Chinese clematis：Dispelling wind and eliminating dampness is removed obstruction in channels to relieve pain, dissolving phlegm water, dissipate the hypochondriac lump；
Radix Angelicae Pubescentis：Dispelling wind and eliminating dampness, numbness relieving and pain relieving；
It is windproof：It expels pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, spasmolysis is antipruritic；
Pawpaw：Soothing the liver relaxing muscles and tendons, stomach dampness elimination, expelling wind and removing dampness；
Ramulus Taxilli：Wind-damp dispelling, liver and kidney benefiting, strengthening the bones and muscles；
Semen Coicis：Clearing heat and promoting diuresis, curing rheumatism, diuresis, beneficial lung apocenosis, strengthening the spleen and stomach, strengthening the bones and muscles；
Giant knotweed：Clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness dissipates addiction analgesic therapy, relieving cough and reducing sputum；
Schisandra chinensis：Restrain astringent method, supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves；
Dogwood fruit：It tonifies the liver and kidney, puckery essence hidroschesis；
Matrimony vine：Nourishing the liver, nourshing kidney, moistening lung；
Dark plum：It astringes the lung, puckery intestines promote the production of body fluid, claming ascaris；
Poria cocos：Clearing damp and promoting diuresis, invigorating the spleen, calming heart；
Cortex Eucommiae：Filling liver kidney, strengthening the bones and muscles；
Chinese yam：Nourish it is strong, it is aid digestion, hold back abnormal sweating, antidiarrheal；
Oriental wormwood：Clearing heat and promoting diuresis protects liver, antipyretic, anti-inflammatory；
The root of bidentate achyranthes：Invigorate blood circulation, inducing diuresis for treating strangurtia are clearing heat and detoxicating；
Dandelion：It is clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia；
Motherwort：Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema；
Radix Rehmanniae：Cardiac stimulant, diuresis contribute to antipyretic；
Plantain seed：Reducing fever and causing diuresis, excreting dampness antidiarrheal, improving eyesight eliminating the phlegm, removing pattogenic heat from the blood and toxic material from the body；
Reed root：Clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis；
Radix scrophulariae：Clearing heat and cooling blood, nourishing yin and lessening fire, detoxicating and resolving a mass.
Each ingredient of the present invention is commercial product.
The present invention advantageous effects be：
Root of Chinese clematis compatibility giant knotweed, Radix Angelicae Pubescentis, Ramulus Taxilli, windproof, pawpaw, have effects that dispelling wind and eliminating dampness, remove obstruction in channels to relieve pain, and be Monarch drug in a prescription.Schisandra chinensis restrains astringent method, nourishing generate fluid, and dogwood fruit, matrimony vine, dark plum, Poria cocos have the work(of nourishing the liver, nourshing kidney, moistening lung, invigorating the spleen Effect, is all ministerial drug.In Cortex Eucommiae active ingredient other than the medicinal ingredient containing a large amount of known activities, also containing there are many nutrients Matter is all adjutant with Chinese yam, Semen Coicis, oriental wormwood, nourishes strong, strengthening the bones and muscles.The root of bidentate achyranthes is to make, and priming downlink has invigorate blood circulation, profit The effect for the treatment of stranguria, clearing heat and detoxicating is urinated, is to make medicine with dandelion, motherwort, Radix Rehmanniae, plantain seed, reed root, radix scrophulariae coordinating the drug actions of a prescription. Reasonable compatibility between above all drugs, nourishing the liver and kidney enhance kidney function of detoxification, be conducive to the harmful substances such as purine it is dilute go out, reach To clearing heat and detoxicating function.
Specific implementation mode
The present invention is further explained in the light of specific embodiments.
Embodiment 1
A kind of Chinese medicine composition for treating gout, is made of the raw material of following parts by weight：4 parts of Poria cocos, 14 parts of Radix Angelicae Pubescentis, giant knotweed 14 parts, 14 parts of the root of Chinese clematis, 14 parts of Ramulus Taxilli, 14 parts of Chinese yam, 15 parts of radix scrophulariae, 14 parts of plantain seed, 4 parts of dark plum, 14 parts of dogwood fruit, ox 14 parts of knee, 14 parts of dandelion, 14 parts of Cortex Eucommiae, 14 parts of motherwort, 14 parts of plantain seed, 16 parts of matrimony vine, 14 parts of Schisandra chinensis, Semen Coicis 16 Part, 14 parts of reed root, 15 parts windproof, 13 parts of oriental wormwood, 16 parts of pawpaw, 15 parts of Radix Rehmanniae.Various raw medicinal materials are weighed according to weight part ratio, Mixing, is ground into powder, and sieve of looking over so as to check obtains raw material fine powder, and granularity is 20-200 mesh；It is reconstituted with boiling water or directly boiling is added to begin to drink With.
Embodiment 2
A kind of Chinese medicine composition for treating gout, is made of the raw material of following parts by weight：15 parts of Poria cocos, 15 parts of Radix Angelicae Pubescentis, tiger 15 parts of cane, 15 parts of the root of Chinese clematis, 15 parts of Ramulus Taxilli, 15 parts of Chinese yam, 17 parts of radix scrophulariae, 15 parts of plantain seed, 15 parts of dark plum, dogwood fruit 15 Part, 15 parts of the root of bidentate achyranthes, 15 parts of dandelion, 15 parts of Cortex Eucommiae, 15 parts of motherwort, 15 parts of plantain seed, 17 parts of matrimony vine, 15 parts of Schisandra chinensis, the heart of a lotus seed 17 parts of rice, 15 parts of reed root, 16 parts windproof, 15 parts of oriental wormwood, 17 parts of pawpaw, 16 parts of Radix Rehmanniae.Various raw materials are weighed according to weight part ratio Medicinal material, mixing, is ground into powder, and sieve of looking over so as to check obtains raw material fine powder, and granularity is 20-200 mesh；Boiling is reconstituted or directly added with boiling water It begins to drink use.
Embodiment 3
A kind of Chinese medicine composition for treating gout, is made of the raw material of following parts by weight：10 parts of Poria cocos, 14 parts of Radix Angelicae Pubescentis, tiger 15 parts of cane, 15 parts of the root of Chinese clematis, 14 parts of Ramulus Taxilli, 14 parts of Chinese yam, 16 parts of radix scrophulariae, 15 parts of plantain seed, 11 parts of dark plum, dogwood fruit 14 Part, 15 parts of the root of bidentate achyranthes, 14 parts of dandelion, 14 parts of Cortex Eucommiae, 14 parts of motherwort, 15 parts of plantain seed, 16 parts of matrimony vine, 14 parts of Schisandra chinensis, the heart of a lotus seed 17 parts of rice, 15 parts of reed root, 16 parts windproof, 13 parts of oriental wormwood, 17 parts of pawpaw, 16 parts of Radix Rehmanniae.Various raw materials are weighed according to weight part ratio Medicinal material, mixing, is ground into powder, and sieve of looking over so as to check obtains raw material fine powder, and granularity is 20-200 mesh；Boiling is reconstituted or directly added with boiling water It begins to drink use.
Parts by weight in above-described embodiment are calculated in gram.
The toxicity test of the Chinese medicine composition for the treatment of gout provided by the invention：
Test drug is the Chinese medicine composition in the embodiment of the present invention 1, with 1:15 ratio reconstitutes to obtain liquid with boiling water.Examination Test animal be ICR kind small white mouses, 18-22 grams of weight, half male and half female, totally 40.Test method is, after fasting 12 hours, by 20 G kg was to mice lavage 4 months, and long term toxicity test is the results show that small white mouse weight, liver function, renal function, blood picture etc. With control group no significant difference, shows that the safety of the medicine is big, belong to nontoxic rank.
The Chinese medicine composition of the treatment gout of 3 gained of above-described embodiment is taken to be used for following clinical treatment：
Treatment object：The patient for selecting the different state of an illness, case history, age, gender, from be hospitalized and it is interior examine outpatient service random selection suffer from The case 100 for having goat is divided into treatment group and each 50 of control group.
Therapy：The Chinese medicine composition of 3 gained of embodiment is taken by treatment group, with 1:15 ratio reconstitutes to obtain medicine with boiling water Liquid is taken twice for each person every day, continuously takes two weeks, and control group routinely takes other purine, even served two weeks.Pay attention to：In patient During treatment, withdraw the drug of other treatment gout, disables high purine diet, maror and drinks etc..
Criterion of therapeutical effect is as follows：
Clinic control:Clinical symptoms disappear, and uric acid content is normal in blood urine liquid, normal renal function；
It is effective:Clinical symptom remission, joint is red, swollen, hot, pain disappears, and part is without any reaction, and activity is as usual, blood uric acid Value is down to normal range (NR), and renal function improves；
Effectively:Arthroncus is declined, pain relief, and blood uric acid value declines, but does not reach normal range (NR)；
In vain:After treating 2 weeks, clinical symptoms are without change, and joint red, swollen, hot, pain symptoms unobvious, activity is still impacted, Blood uric acid value does not decline.
Therapeutic effect such as following table：
The result shows that the Chinese medicine composition for the treatment of gout provided by the invention is notable through patient's using effect, it is below selection Wherein example takes situation：
Case one：Liu 60 years old, suffers from gout for 2017, and right ankle-joint is red and swollen, on foot when pain, it is every to take the liquid It is one, divides 2 times and takes, and red and swollen after 1 month to disappear, inspection blood uric acid is 350 μm of ol/L, after continuing taking the two courses, inspection Uric acid of having a blood test is normal, and right ankle-joint restores normal.
Case two：Wu 40 years old, suffers from gout for 2017, and finger, toes painful swelling of joints are very, to take this with hypnalgia Liquid one dose per day, divides 2 times and takes, and swells and ache and weakens after 1 month, inspection blood uric acid is 340 μm of ol/L, is continued taking the two courses Afterwards, check that blood uric acid is normal, finger, toes joint restore normal.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all skills in the present invention On the basis of art scheme, the various modifications or variations that can be made by those skilled in the art with little creative work still exists In protection scope of the present invention.

Claims (4)

1. a kind of Chinese medicine composition for treating gout, which is characterized in that be made of the raw material of following parts by weight：4-15 parts of Poria cocos, 14-15 parts of Radix Angelicae Pubescentis, 14-15 parts of giant knotweed, 14-15 parts of the root of Chinese clematis, 14-15 parts of Ramulus Taxilli, 14-15 parts of Chinese yam, 15-17 parts of radix scrophulariae, 14-15 parts of plantain seed, 4-15 parts of dark plum, 14-15 parts of dogwood fruit, 14-15 parts of the root of bidentate achyranthes, 14-15 parts of dandelion, 14-15 parts of Cortex Eucommiae, 14-15 parts of motherwort, 14-15 parts of plantain seed, 16-17 parts of matrimony vine, 14-15 parts of Schisandra chinensis, 16-17 parts of Semen Coicis, reed root 14-15 Part, 15-16 parts windproof, 13-15 parts of oriental wormwood, 16-17 parts of pawpaw, 15-16 parts of Radix Rehmanniae.
2. a kind of Chinese medicine composition for treating gout according to claim 1, which is characterized in that by the original of following parts by weight Material is made：10 parts of Poria cocos, 14 parts of Radix Angelicae Pubescentis, 15 parts of giant knotweed, 15 parts of the root of Chinese clematis, 14 parts of Ramulus Taxilli, 14 parts of Chinese yam, 16 parts of radix scrophulariae, vehicle First sub 15 parts, 11 parts of dark plum, 14 parts of dogwood fruit, 15 parts of the root of bidentate achyranthes, 14 parts of dandelion, 14 parts of Cortex Eucommiae, 14 parts of motherwort, plantain seed 15 Part, 16 parts of matrimony vine, 14 parts of Schisandra chinensis, 17 parts of Semen Coicis, 15 parts of reed root, 16 parts windproof, 13 parts of oriental wormwood, 17 parts of pawpaw, 16 parts of Radix Rehmanniae.
3. a kind of preparation method of Chinese medicine composition that treating gout of claim 1-2 any one of them, which is characterized in that packet Include following steps：Various raw medicinal materials are weighed according to weight part ratio, mixes, is ground into powder, sieve of looking over so as to check obtains raw material fine powder, grain Degree is 20-200 mesh；It is reconstituted with boiling water or directly plus boiling is begun to drink use.
4. a kind of Chinese medicine composition for treating gout of claim 1-2 any one of them is in the drug for preparing treatment goat Application.
CN201810416894.0A 2018-05-03 2018-05-03 A kind of Chinese medicine composition and preparation method thereof for treating gout Pending CN108310272A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104352901A (en) * 2014-10-09 2015-02-18 姜成玲 Traditional Chinese medicine for treating gout
CN107582985A (en) * 2017-10-25 2018-01-16 单宇鹏 A kind of Chinese medicine composition of freckle removing and whitening and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104352901A (en) * 2014-10-09 2015-02-18 姜成玲 Traditional Chinese medicine for treating gout
CN107582985A (en) * 2017-10-25 2018-01-16 单宇鹏 A kind of Chinese medicine composition of freckle removing and whitening and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
刘宣成等: "痛风性关节炎的中西医结合治疗", 《长春中医学院学报》 *
吴俊荣 等: "《中医方剂趣味歌诀》", 31 July 2007, 黑龙江科学技术出版社 *
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