CN102764393B - A kind of medicine for the treatment of ankylosing spondylitis - Google Patents
A kind of medicine for the treatment of ankylosing spondylitis Download PDFInfo
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- CN102764393B CN102764393B CN201110117260.3A CN201110117260A CN102764393B CN 102764393 B CN102764393 B CN 102764393B CN 201110117260 A CN201110117260 A CN 201110117260A CN 102764393 B CN102764393 B CN 102764393B
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Abstract
The invention discloses the medicine that one treats ankylosing spondylitis (AS), pastern bone section, flank pain class OTC medicine.The Chinese medicine nontoxic by 33 tastes such as Rhizoma Cibotii forms.Manufacture capsule, tablet or pill, for oral.Its mild in medicine property and, orally have no side effect, male fertility is without impact.The evil silt friendship of AS patient hinders in spinal column and deeply through then, this medicine activating blood circulation to dissipate blood stasis, eleminating phlegm and freeing channels, and the efficacy of a drug is gone directly disease institute.Can course advancement be controlled, immediate pain alleviating, prevent destruction of joint, reduce disability rate.Patient consumes's two weeks curative effects are obvious, and the patients with terminal of bone destruction also can rehabilitation, and solving treatment AS does not at present have the problem of specific drug.
Description
Technical field the present invention relates to a kind of oral medicine for the treatment of flank pain, particularly relates to pure Chinese medicine as one that raw material is made treats the medicine of ankylosing spondylitis (AS).
Background technology ankylosing spondylitis is one group of chronic, Progressive symmetric erythrokeratodermia, disabling condition.Diseased region is mainly at sacro-iliac joints, spinal column, the other soft tissue of spinal column and extremities joint.Pathological change is ossified, the intervertebral movable joint of connective tissue near annulus fibrosus disci intervertebralis and fibrous ring and the inflammation of extremities joint synovial membrane and hypertrophy.Late period there is Bony union in each joint, and ligamentous ossification, spinal column is spasticity.
Also can there is the pathological changes such as skin, mucosa, eye, heart, lung and nervous system in the ankylosing spondylitis of Juvenile onset, also with some nonspecific General Symptomies, as the heating of low, moderate, hyperhidrosis, weak and become thin.
Ankylosing spondylitis belongs to the traditional Chinese medical science " rheumatism involving the bone " category, and the cause of disease may be that the comprehensive function of genetic factors and environmental factors causes.Pathogenesis feature: deficiency of both QI and blood, deficiency in both YIN and YANG.Phlegm accumulating with stagnant blood, cohesion joint." not Rong Ze pain ", " stagnation of QI and blood may bring about pain ".
Primary disease if obtain early treatment and can cure, but does not also have the specific drug that can effect a radical cure primary disease at present.Western medical treatment is based on wind-damp dispelling pain relieving, and common drug is as indomethacin, and aspirin etc., only can antiinflammatory, antipyretic, and analgesia, to the state of an illness without control action.Heavy dose of use corticosteroids medicine, as dexamethasone, has many side effect, disables or bring life danger.Change the medicine of the course of disease as sulfasalazine, likely control the progress of juvenile ankylosing spondylitis, but onset is slow, onset in 2 to 3 months of taking medicine of being everlasting, this class medicine, to there is the middle and advanced stage pathological changes of bone destruction with or without reverse effect, is still doubted at present.The subject matter of new Chinese medicine how can be cured in early days, controls and improve symptom in late period, and timely pain relieving and suppression hyperosteogeny are very important keys.
Summary of the invention the object of this invention is to provide a kind of medicine for the treatment of ankylosing spondylitis, and have qi and blood tonifying, negative and positive are taken into account, and the function of activating collaterals to relieve pain is oral rapid-action, and short treating period, has no side effect, and can cure ankylosing spondylitis, juvenile ankylosing spondylitis.Especially suitable sclerotin is damaged, the patient of flank pain stubbornness.
Technical scheme of the present invention realizes in the following manner:
A kind of medicine for the treatment of ankylosing spondylitis, the oral medicine that it is a first Chinese medicinal formulae processing or makes after refining, its prescription is: Radix Ginseng 15 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, 15 grams, Poria, Radix Glycyrrhizae Preparata 25 grams, Rhizoma Cibotii (remove floss) 105 grams, Cortex Eucommiae (parched) 15 grams, Radix Dipsaci 30 grams, Semen Cuscutae 15 grams, Radix Polygoni Multiflori Preparata 180 grams, the Radix Paeoniae Alba 90 grams, Radix Angelicae Sinensis 30 grams, Fructus Lycii 30 grams, Radix Salviae Miltiorrhizae 175 grams, Radix Cyathulae 60 grams, 15 grams, Flos Carthami, Radix Notoginseng 15 grams, Pericarpium Citri Reticulatae 50 grams, Rhizoma Cyperi (processed) 30 grams, Herba Taxilli 175 grams, Caulis Trachelospermi 30 grams, Radix Clematidis 15 grams, Rhizoma Smilacis Chinensis 90 grams, Semen Coicis 120 grams, Radix Saposhnikoviae 30 grams, Fructus Chaenomelis 30 grams, 30 grams, Rhizoma Gastrodiae, Eupolyphaga Seu Steleophaga 15 grams, Squama Manis (processed) 15 grams, Radix Rehmanniae 60 grams, Herba Patriniae 90 grams, Cortex Phellodendri 60 grams, the Rhizoma Anemarrhenae 60 grams, Radix Scutellariae 30 grams.
This prescription 33 taste Chinese medicine forms in proportion, weighs 1775 grams, takes orally and does not produce toxic and side effects.Do not affect male fertility.
According to the proportional component between this prescription medicine and medicine, i.e. relative dosage, make capsule, tablet or pill after processing or refinement, for oral.
This prescription is the agent for the treatment of both the principal and the secondary aspects of a disease at the same time.Ankylosing spondylitis pathological process is the good and evil growth and decline process that " healthy energy " of virulence factor " pathogen " and human disease resistance disaccords.Thus " eliminating evil with logical ", " righting is with flourish " during clinical treatment primary disease.Therefore strengthening vital QI to eliminate pathogenic factors is the rule for the treatment of of primary disease: qi and blood tonifying, negative and positive are taken into account, and activating collaterals to relieve pain is concrete method for the treatment of.In side, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Rhizoma Cibotii, the Cortex Eucommiae, Radix Dipsaci, Semen Cuscutae QI invigorating are held concurrently supporing yang.Radix Angelicae Sinensis, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Fructus Lycii are enriched blood and are taken into account the moon.Above medicine QI and blood two is mended, and negative and positive are taken into account, main caused by liver and kidney deficiency, lumbago back rigidity, for treating the key agents of ankylosing spondylitis.Radix Salviae Miltiorrhizae, Flos Carthami, Radix Cyathulae, Radix Notoginseng promoting blood circulation, promote blood, interior internal organs and change stasis, outer profit joint and network of promoting blood circulation, and merit is in lumbar and back pain.Pericarpium Citri Reticulatae, logical three Jiao of Rhizoma Cyperi, separate six kinds of stagnation-syndromes; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm." the capable then blood of gas, the stagnation of QI then blood clotting ".QI and blood tonneau, then pain is from stopping.Herba Taxilli, Caulis Trachelospermi, Radix Clematidis, Rhizoma Smilacis Chinensis, Semen Coicis, Radix Saposhnikoviae, Fructus Chaenomelis, Rhizoma Gastrodiae can remove muscle, and the wind and cold between meridians, muscles and bones wets.Main limbs pain, articular instability, spasm of muscles and vessels, lower limb flaccidity is weak, and be particularly good at stiffback lumbago, and effect is distinguished.The evil silt friendship of ankylosing spondylitis hinders in spinal column and deeply through then, non-general blood circulation promoting medicine can be controlled, therefore with Eupolyphaga Seu Steleophaga, Squama Manis activating blood circulation to dissipate blood stasis, eleminating phlegm and freeing channels, and the efficacy of a drug is gone directly disease institute.Radix Rehmanniae, Herba Patriniae, the Rhizoma Anemarrhenae, Cortex Phellodendri, Radix Scutellariae pathogenic fire purging are with consolidating YIN, and YIN nourishing, with heat clearing away, is rushed down middle residence and mended, and invigorating middle warmer residence rushes down, and hot drug combination, and cold and heat are made mutually, and dredging is executed clearly thoroughly altogether, the arthralgia pain of the mutual knot of interior cold of inducing sweat heat.
Good effect of the present invention is:
Pure Chinese medicine, cost is low, and crude drug source is wide.Mild in medicine property and, have no side effect.Tonify without causing stagnation, profit and oiliness, treating both the principal and the secondary aspects of a disease at the same time, strengthening vital QI to eliminate pathogenic factors is double to be executed.Have qi and blood tonifying, negative and positive are taken into account, effect of activating collaterals to relieve pain.Oral rapid-action, short treating period, not easily recurs more.Regulating immunological function, enhancing body resistance.Antiinflammatory, analgesia.Endocrine has an impact and improves hemopoietic system function, improves microcirculation.Thus reinforcing body resistance, regulating YIN and YANG, remedying defects and rectifying errors.Wind-cold damp pathogen, stagnation of phlegm, the stagnation of QI, blood stasis are evicted from external, and eliminate spinal column, waist, breast, cervical region, extremity and amphiarthrodial pathological changes, pain, swelling send out the symptom such as deadlock or amyotrophy.While treatment osteopathia, again can taste soon, enter diet, move back low grade fever, stop sweating due to debility.Patients with ankylosing spondylitis can be cured by early metaphase, control and improve symptom in late period, be especially suitable for bone destruction occurring, the patient of lumbago and skelalgia stubbornness.Solve treatment primary disease at present and there is no the problem of specific drug.
The property of medicine and function etc. below with regard to this prescription 33 taste Chinese medicine are described further.
Ginseng sweet, micro-hardship, flat.Return lung, spleen, the heart, kidney channel.Strongly invigorating primordial QI, invigorating the spleen to benefit the lung, Fructus Alpiniae Oxyphyllae of calming the nerves.Attention: anti-Rhizoma et radix veratri (Radix Rhizoma Veratri).
The Rhizoma Atractylodis Macrocephalae is bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis.
Poria is sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating and in, mind tranquilizing and the heart calming.
Radix Glycyrrhizae is sweet, flat.Return spleen, stomach, lung, heart channel.QI invigorating invigorating middle warmer, nourishing the lung to arrest cough, eliminating fire and detoxication, relieving spasm to stop pain, the mediation property of medicine.Should use by processed with honey.
Rhizoma Cibotii is bitter, sweet, and temperature, returns liver, kidney channel.Strong waist knee joint, wind-damp dispelling, sharp joint.Can be used as treatment ankylosing spondylitis guiding drug.Suitable remove floss, makes ripe use.
The Cortex Eucommiae is sweet, temperature.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Use should be fried.
Radix Dipsaci is bitter, pungent, temperature.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, gets round by bribery and blood vessels, arresting bleeding and miscarriage prevention.
Semen Cuscutae is pungent, sweet, flat.Return liver, kidney spleen channel.YANG invigorating tonifying YIN, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight antidiarrheal, antiabortive.
Radix Polygoni Multiflori is sweet, puckery, tepor.Return liver, kidney channel.Enrich and benefit essence and blood, reinforce the kidney black palpus.Should use processed.
Radix Angelicae Sinensis is sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation.
The Radix Paeoniae Alba is bitter, sour, is slightly cold.Return liver, spleen channel.Nourish blood and seek, relieving spasm to stop pain, arresting sweating suppressing the hyperactive liver.
Fructus Lycii is sweet, flat.Return liver, kidney, lung meridian.Liver nourishing, the kidney invigorating, lung moistening.
Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Activating blood and removing stasis, menstruction regulating and pain relieving, nourishing blood to tranquillize the mind.Attention: anemia of pregnant woman is cautious use of.
Sweet, the micro-hardship of Radix Cyathulae, flat.Return liver, kidney channel.Activating blood and removing stasis, sharp joint, strong waist knee joint.Attention: be not taken by pregnant women.
Flos Carthami is pungent, micro-hardship, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, silt pain relieving of dispelling.Attention: be not taken by pregnant women.
Radix Notoginseng is sweet, bitter, temperature.Return liver, stomach warp.Change hemostasis of becoming silted up, analgesic therapy of invigorating blood circulation, note: anemia of pregnant woman is cautious use of.
Pericarpium Citri Reticulatae is pungent, bitter, temperature.Return spleen, lung meridian.Circulation of qi promoting spleen invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, drying dampness to eliminate phlegm.
Pungent, sweet, the micro-hardship of Rhizoma Cyperi, returns liver, tri-jiao channel.Promoting QI circulation for relieving depression, menstruction regulating and pain relieving, antiabortive.Should use processed.
Herba Taxilli is bitter, sweet, flat.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, beneficial blood is antiabortive.
Caulis Trachelospermi is bitter, is slightly cold.GUIXIN, Liver Channel.Dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling.
Radix Clematidis is pungent, salty, micro-hardship, temperature.Slightly poisonous.Return urinary bladder channel.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.Should use by processed with wine.
Rhizoma Smilacis Chinensis is sweet, sour, is slightly cold.Return spleen, liver, kidney channel.Expelling wind and removing dampness, invigorating spleen and reinforcing stomach, eliminating impediment relaxing muscles and tendons, removing toxic substances and promoting subsidence of swelling.
Semen Coicis is sweet, light, be slightly cold.Return liver, stomach, lung meridian.Promoting diuresis to eliminate damp pathogen, invigorating spleen and reinforcing stomach, eliminating impediment relaxing muscles and tendons, evacuation of pus is subsided a swelling.Attention: anemia of pregnant woman is cautious use of.
Radix Saposhnikoviae is pungent, sweet, warm.Return bladder, lung, spleen channel.Dispel the wind and deliver, removing dampness to relieve pain, relieving convulsion.
Cydonic acid, temperature.Return liver, spleen channel, relaxing muscles and tendons and activating QI and blood in the collateral, removing dampness to restore normal function of the stomach.
Rhizoma Gastrodiae is sweet, flat, returns Liver Channel.Relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion, suppressing the hyperactive liver and subsiding YANG.
Eupolyphaga Seu Steleophaga is salty, cold.Poisonous.Return Liver Channel.Removing blood stasis by silt, reunion of fractured tendons and bones.
Squama Manis is salty, is slightly cold.Return liver, stomach warp.Promoting blood circulation to restore menstrual flow, stimulating milk secretion, detumescence and apocenosis.Contraindication in pregnancy.Yellow with processed with vinegar.
Radix Rehmanniae is sweet, bitter, is slightly cold.GUIXIN, liver, kidney channel.Nourishing YIN and clearing away heat, removing heat from blood is enriched blood.
Herba Patriniae is pungent, bitter, is slightly cold.GUIXIN, liver, stomach warp.Heat-clearing and toxic substances removing, detumescence and apocenosis, silt pain relieving of dispelling.Attention: anemia of pregnant woman is cautious use of.
Cortex Phellodendri is bitter, cold.Return kidney, bladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.
The Rhizoma Anemarrhenae is bitter, cold.Return lung, stomach, kidney channel.Clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, relieving restlessness of quenching the thirst.Should unhairing section use.
Radix Scutellariae is bitter, cold.Return lung, stomach, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention.
Below with regard to function for the treatment of the medicine of ankylosing spondylitis a kind of time this, to cure mainly etc. and be described.
[function] qi and blood tonifying, negative and positive are taken into account, activating collaterals to relieve pain.
The deformity of spine that [curing mainly] causes for ankylosing spondylitis, waist, breast, cervical region, the amphiarthrodial pathological changes of extremity, pain, swelling, bone destruction, sends out stiff, amyotrophy etc.
33 tastes such as [medicine composition] Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Rhizoma Cibotii, the Cortex Eucommiae, Radix Dipsaci.
[prescription dosage form] capsule, tablet or pill.Pill should be honeyed pill.
[character] this product be brown, gas is fragrant, bitter in the mouth, micro-sweet.
[Action categories] this product is orthopaedics, lumbago and skelalgia class nonprescription drugs medicine.
The each 3-8 gram of [usage and dosage] oral (crude drug in whole), two to three times on the one or follow the doctor's advice, child is cut down according to the circumstance, and within two months, is a course for the treatment of.Take a course for the treatment of can according to circumstances continue to take.
[points for attention] child, anemia of pregnant woman, woman in menstrual period are too much and have bleeding tendency person to avoid clothes.Deficiency and coldness patient be cautious use of.Period in a medicine avoids sitting, excessive drinking and work and rest mistake degree.Patient recovers in latter 1 year and forbids that participating in ass work moves.
Detailed description of the invention the specific embodiment of the present invention is clinical practice, is described below:
[case one] Li Guoquan, man, 30 years old.Tower Bridge town, Shangcai County white jade mausoleum people from village, special secondary school culture, in Sha Jingzhen new bridge three industrial occupancy, Shenzhen, Jingmuo Electronic Scince-Technology (Shenzhen) Co., Ltd. does manual work.
Ankylosing spondylitis is suffered from private prosecution, and in March, 2010 is seriously ill, in the regular hospitalize of Shenzhen Duo Jia, has spent nearly 40,000 yuan, treats aobvious not obvious.Go back home in May, 2010 treatment, spent again more than 20,000 yuan, and aggravation, sacro-iliac joints bone destruction, and involve lumbar vertebra, thoracic vertebra and cervical vertebra, difficulty in walking.Patient gets level Four certificate of disability in November, 2010.
On February 16th, 2011, patient takes drug powder of the present invention, and crude drug source is Zhumadian City " the large pharmacy of Zhang Zhongjing ", nearly 0.10 yuan of medicine valency every gram.Each serving with 6 grams, take three day.During taking this product, except oral calcium tablet, forbid any medicine.Curative effect on the 8th of taking medicine is obvious, pain relief, and can practise morning running, take medicine 50 days, normal on foot, joint is pain no longer.On April 30th, 2011, Rehabilitation, went to original unit to do manual work.
Acomia what side effect incumbent during patient consumes.Feel to control lumbago the fastest.Intend to take a period of time again, prevent recurrence.
[case two] Liu Liang, man, 24 years old, Qi Hai township, Shangcai County queen bee people from village, high chinesization, AS patient.The large hospital such as Zhengzhou, Zhumadian was removed in private prosecution, had spent more than 50,000 yuan, unsatisfactory curative effect.The bone destruction of patient's hip joint, waist, cervical vertebra, both sides pain of buttock unbearably.In April, 2009 takes drug powder of the present invention, each 8 grams, takes three day, successful.(crude drug source is shop of Chinese medicines at county level).Adhere to taking 1 year, treat aobvious satisfied.
[case three] Pan Jiangtao, man, 24 years old, University Culture, Shangcai County telecommunications company line manager, AS patient, private prosecution once at Beijing large hospital hospitalization, DeGrain, hip joint bone destruction, hurt like hell, difficulty in walking.In November, 2007 takes bolus of drug of the present invention, and each serving with 6-8 gram, rehabilitation in 2 months, is interrupted and takes medicine more than 2 years.Period in a medicine, lover gives birth to a girl baby, clever and sensible, grows normal.Medicine of the present invention on male fertility without impact.
[case four] Dong, man, 28 years old, high chinesization, Shangcai County and shop village people, AS patient.Private prosecution waist, cervical vertebra ache, limitation of activity, in October, 2009 takes drug powder of the present invention, takes medicine according to quantity, Be very effective.
Claims (2)
1. treat the medicine of ankylosing spondylitis for one kind, it is characterized in that it is by Radix Ginseng 15 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, 15 grams, Poria, Radix Glycyrrhizae Preparata 25 grams, the Rhizoma Cibotii of remove floss 105 grams, Cortex Eucommiae (parched) 15 grams, Radix Dipsaci 30 grams, Semen Cuscutae 15 grams, Radix Polygoni Multiflori Preparata 180 grams, the Radix Paeoniae Alba 90 grams, Radix Angelicae Sinensis 30 grams, Fructus Lycii 30 grams, Radix Salviae Miltiorrhizae 175 grams, Radix Cyathulae 60 grams, 15 grams, Flos Carthami, Radix Notoginseng 15 grams, Pericarpium Citri Reticulatae 50 grams, Rhizoma Cyperi (processed) 30 grams, Herba Taxilli 175 grams, Caulis Trachelospermi 30 grams, Radix Clematidis 15 grams, Rhizoma Smilacis Chinensis 90 grams, Semen Coicis 120 grams, Radix Saposhnikoviae 30 grams, Fructus Chaenomelis 30 grams, 30 grams, Rhizoma Gastrodiae, Eupolyphaga Seu Steleophaga 15 grams, Squama Manis (processed) 15 grams, Radix Rehmanniae 60 grams, Herba Patriniae 90 grams, Cortex Phellodendri 60 grams, the Rhizoma Anemarrhenae 60 grams, Radix Scutellariae 30 grams composition.
2. medicine according to claim 1, is characterized in that it is capsule, tablet or pill.
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| CN103071060B (en) * | 2013-01-16 | 2014-04-23 | 万健 | Traditional Chinese medicine preparation for treating ankylosing spondylitis |
| CN103520662A (en) * | 2013-08-28 | 2014-01-22 | 李新民 | Traditional Chinese medicine formula for treating ankylosing spondylitis |
| CN104147162B (en) * | 2014-07-11 | 2016-05-04 | 李开庆 | Rheumatic pain killing liquid and using method thereof |
| CN105663662A (en) * | 2016-03-29 | 2016-06-15 | 广州三得医疗科技有限公司 | Traditional Chinese medicine composition containing folium artemisiae argyi and used for treating ankylosing spondylitis |
| CN110742979A (en) * | 2018-07-23 | 2020-02-04 | 闫举 | Medicine for treating ankylosing spondylitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1259369A (en) * | 1999-10-14 | 2000-07-12 | 周沛 | Medicine for treating rigid spine inflammation and prepn. method thereof |
| CN1419929A (en) * | 2001-11-19 | 2003-05-28 | 樊余富 | Method for preparing Chinese medicine composition for treating tetanic rachitis complicated necrosis of femoral head |
| CN1535704A (en) * | 2003-04-09 | 2004-10-13 | 吴荣华 | Fresh Chinese medicine preparation for external application for mainly curing ankylosing spondylitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1259369A (en) * | 1999-10-14 | 2000-07-12 | 周沛 | Medicine for treating rigid spine inflammation and prepn. method thereof |
| CN1419929A (en) * | 2001-11-19 | 2003-05-28 | 樊余富 | Method for preparing Chinese medicine composition for treating tetanic rachitis complicated necrosis of femoral head |
| CN1535704A (en) * | 2003-04-09 | 2004-10-13 | 吴荣华 | Fresh Chinese medicine preparation for external application for mainly curing ankylosing spondylitis |
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