CN1269494C - Medicine for treating numbness and preparing method thereof - Google Patents
Medicine for treating numbness and preparing method thereof Download PDFInfo
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- CN1269494C CN1269494C CN 200310101847 CN200310101847A CN1269494C CN 1269494 C CN1269494 C CN 1269494C CN 200310101847 CN200310101847 CN 200310101847 CN 200310101847 A CN200310101847 A CN 200310101847A CN 1269494 C CN1269494 C CN 1269494C
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Abstract
The present invention relates to a medicine for treating rheumatism and a preparation method thereof. Two traditional Chinese medicines of milkvetch root and orientvine stem are prepared into injections according to the prescription in the specification and the preparation method. The present invention has the advantages of reasonable prescription, advanced preparation technology, stable product quality, high contents of medicine effect components and good treatment effect, and the healing rate is 96%. The product of the present invention is used for treating rheumatism of deficiency of both vital energy and yin, such as rheumarthritis, rheumatoid arthritis, etc.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, relate to a kind of medicine for the treatment of the numbness disease, and preparation method thereof.
Background technology
The numbness disease is exopathogen invasion and attack limbs meridians and cause a kind of commonly encountered diseases of arthrodynia of extremities, numbness, joint stuffiness, frequently-occurring disease, and cause of disease complexity, existing various medicines can not be according to Chinese medicine medicine typing verification treatment, DeGrain.
Summary of the invention
The objective of the invention is to remedy weak point of the prior art, but on a large amount of clinical prescription bases, develop, use the dialectical opinion of Chinese medicine and control principle, a kind of active drug (trade name: chase after the wind prevailing over dampness capsule) for the treatment of syndrome of deficiency of both qi and yin numbness disease is provided, and preparation method thereof.
The present invention seeks to realize by following technical proposal:
A kind of medicine for the treatment of the numbness disease is the injection of being made by the following weight proportion raw material:
Radix Astragali 590-610 part
Caulis Sinomenii 590-610 part.
Preparation method is to be undertaken by medicine material prescription and following step:
(a) Caulis Sinomenii adds 6 times of amount 95% alcohol reflux 2 times, is followed successively by 1,1 hour, filters, and after filtrate concentrated, eluting was collected eluent, is decompressed to driedly, and residue 2% dissolving with hydrochloric acid was placed 24 hours filtration, filtrate evaporate to dryness for 3-5 ℃;
(b) 10 times of water gagings of the Radix Astragali are fried in shallow oil 2 times, are followed successively by 1,1 hour, filter, and filtrate is concentrated into the relative density thick paste, adds ethanol, place 24 hours, and 3-5 ℃, water dissolution is used in decompression, and ethanol elution is collected 70% eluent, and decompression recycling ethanol is to doing;
(c) (a) (b) merged, mixing is made freeze-dried powder promptly.
The Chinese patent medicine of Chu Shouing in the market, prescription is emphasized expelling wind and removing dampness mostly simply, or temperature compensation, ignore the performance of patient's disease, so that clinical efficacy is undesirable.Composition of raw materials of the present invention is according to tcm syndrome differentiation and typing, in conjunction with clinical practice, adopts benefiting QI and nourishing blood, and expelling wind and removing dampness, collateral dredging are main, the medicine of developing through updating for many years that cures mainly the numbness disease.
The raw material Radix Astragali of the present invention, main component is triterpene saponins such as astragaloside, has certain antiinflammatory and immunocompetence effect, and can resist the effect of immune formulation, be the key medicine of QI invigorating; The Caulis Sinomenii master contains alkaloid, has antiinflammatory, analgesic activity and immunoregulation effect.Two medicines share not only QI invigorating but also invigorate blood circulation, and reach optimum therapeuticing effect.
The present invention compared with the prior art, have following advantage: the present invention has reasonable recipe, processing technology advanced person, end product quality is stable, performance content of drug effect components height has curative effect preferably to rheumatic arthritis and rheumatoid arthritis etc., and cure rate is 96%.
Specific implementation method
Enumerate 1 embodiment below, the present invention is further specified.But the present invention is not only limited to these embodiment.
Embodiment 1
Caulis Sinomenii 600 grams add 6 times of amount 95% ethanol, and reflux, extract, 2 times was followed successively by 1,1 hour, filter, filtrate concentrates back 95% ethanol elution, collects eluent, and decompression recycling ethanol is to doing, residue 2% dissolving with hydrochloric acid was placed 24 hours for 4 ℃, filtered the filtrate evaporate to dryness.The Radix Astragali 600 grams, 10 times of water gagings are fried in shallow oil 2 times, are followed successively by 1,1 hour, filter, filtrate is concentrated into relative density 1.10-1.15 (25 ℃) thick paste, adds ethanol and makes and contain the alcohol amount and reach 80%, place 24 hours (4 ℃), decompression recycling ethanol also is concentrated into the relative density thick paste, uses water dissolution, on handled the D101 macroporous resin well, water, 40% ethanol, 70% ethanol elution is collected 70% eluent, and decompression recycling ethanol is to doing.Caulis Sinomenii, the Radix Astragali are merged, and mixing is made freeze-dried powder promptly.
Medicine of the present invention carries out clinical observation, and its result is as follows:
One, physical data
Case 189 examples, male 65 examples, women 124 examples, age 10-20 year 13 examples, 21-30 year 31 examples, 31-40 year 67 examples, 41-50 year 51 examples, 27 examples more than 50 years old.
Two, diagnostic criteria
(1) tcm diagnosis standard
Position pain such as joint, skin, muscles and bones, or swelling deadlock in morning, numbness is weighing, or joint stuffiness, and joint swelling deformation is not very then tetanicly stretched amyotrophy etc.
(2) differential diagnosis in tcm
Syndrome of deficiency of both qi and yin
(3) Western medicine diagnose standard
Rheumatic arthritis and rheumatoid arthritis.Increase anti-" 0 ", and erythrocyte sedimentation rate speeds, or the rheumatoid factor positive.
Three, test case standard
(1) meets the patient of sick diagnostic criteria of numbness and differential diagnosis in tcm.
Position pain such as joint, skin, muscles and bones, or swelling deadlock in morning, numbness is weighing, or joint stuffiness, and joint swelling deformation is not very then tetanicly stretched amyotrophy etc.
(2) meet the diagnostic criteria of syndrome of deficiency of both qi and yin
Muscle, joint aches are unable, and movable back pain increases the weight of, or contraction is anxious, and skin does not have the pool, the slight fever of touching, or joint swelling deformation, or the flesh bone that withering, breathe hard, sleepy, xerostomia is the desire drink not, low grade fever, afternoon for outstanding, body of the tongue is red partially or crackle is arranged, less fur or nothing, deep,thready and forceless pulse.
(3) the weight classification of rheumatoid arthritis:
I level: can do comings and goings.
The II level: moderate is limited: though one or more joints discomfort or limitation of activity are arranged, can be engaged in normal activity.
III level: obviously limited: can only take care of oneself, but can not be engaged in general activity.
The IV level: bed or seat crouch, and can't take care of oneself.
(4) effectiveness is observed
1, observation index
(a) safety observation: general health check-up project: blood, urine, just routine test; The heart, liver, kidney function test.
(b) health giving quality observation: the cause of disease, joint, muscle, local symptoms such as muscles and bones; Function of joint; The tongue arteries and veins changes; Rheumatoid factor detects; Erythrocyte sedimentation rate detects; Anti-" 0 ", antistreptokinase, antihyaluronidase, c reactive protein detect; Immunoglobulin, antinuclear antibody detect; Electrocardioscopy; X line sclerotin change.
2, curative effect determinate standard
Clinical recovery: symptom all disappears, and it is normal that functional activity recovers; Main doctor trained in Western medicine physico-chemical examination index is normal.
Produce effects: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered substantially, can participate in operate as normal and work; The physico-chemical examination index is normal substantially.
Effectively: cardinal symptom disappears substantially, and main function of joint is recovered substantially or had made marked progress, and can't take care of oneself to transfer to can take care of oneself, and perhaps pushes the work forward and work capacity transfers the work or physical labor ability to and recovers to some extent; Main physico-chemical examination index makes moderate progress.
Invalid: and compare before the treatment, each side does not all have progress.
Product of the present invention is used for the treatment of syndrome of deficiency of both qi and yin numbness disease, as rheumatic arthritis and rheumatoid arthritis etc.
Claims (2)
1, a kind of medicine for the treatment of the numbness disease is characterized in that, it is the injectable powder of making by by the following weight proportion raw material:
Radix Astragali 590-610 part
Caulis Sinomenii 590-610 part.
2, prepare the preparation method of medicine according to claim 1, it is characterized in that being undertaken by medicine material prescription and following step:
(a) Caulis Sinomenii adds 6 times of amount 95% alcohol reflux 2 times, is followed successively by 1,1 hour, filters, and after filtrate concentrated, eluting was collected eluent, and decompression recycling ethanol is to doing, and residue 2% dissolving with hydrochloric acid was placed 24 hours for 3-5 ℃, filtered the filtrate evaporate to dryness;
(b) 10 times of water gagings of the Radix Astragali are fried in shallow oil 2 times, are followed successively by 1,1 hour, filter, filtrate is concentrated into the thick paste of 25 ℃ of following relative density 1.10-1.15, add ethanol and make and contain alcohol amount and reach 80%, placed 24 hours decompression at 3-5 ℃ down, reclaim ethanol simmer down to thick paste, use water dissolution, on handled the D101 macroporous resin well, water, 40%, 70% ethanol elution, collect 70% eluent, decompression recycling ethanol is to doing;
(c) (a) (b) merged, mixing is made freeze-dried powder, promptly gets product of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310101847 CN1269494C (en) | 2003-10-21 | 2003-10-21 | Medicine for treating numbness and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310101847 CN1269494C (en) | 2003-10-21 | 2003-10-21 | Medicine for treating numbness and preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1528404A CN1528404A (en) | 2004-09-15 |
| CN1269494C true CN1269494C (en) | 2006-08-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310101847 Expired - Fee Related CN1269494C (en) | 2003-10-21 | 2003-10-21 | Medicine for treating numbness and preparing method thereof |
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| Country | Link |
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| CN (1) | CN1269494C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421291A (en) * | 2016-11-09 | 2017-02-22 | 佘鹏 | Traditional Chinese medicine for treating knee arthralgia |
-
2003
- 2003-10-21 CN CN 200310101847 patent/CN1269494C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421291A (en) * | 2016-11-09 | 2017-02-22 | 佘鹏 | Traditional Chinese medicine for treating knee arthralgia |
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| Publication number | Publication date |
|---|---|
| CN1528404A (en) | 2004-09-15 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060816 Termination date: 20191021 |