CN1342462A - Composite medicine for treating rheumatoid arthritis - Google Patents
Composite medicine for treating rheumatoid arthritis Download PDFInfo
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- CN1342462A CN1342462A CN00113920A CN00113920A CN1342462A CN 1342462 A CN1342462 A CN 1342462A CN 00113920 A CN00113920 A CN 00113920A CN 00113920 A CN00113920 A CN 00113920A CN 1342462 A CN1342462 A CN 1342462A
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Abstract
A composite medicine for treating rheumatoid arthritis is prepared from ant as primary component, auxiliary Chinese medicinal materials and carrier. Its advantages include high curative effect (total effective rate up to 94.8%), no toxic by-effect and low cost.
Description
The present invention relates to a kind of medicine of treatment of arthritis, especially a kind of pharmaceutical composition of rheumatoid arthritis.
Rheumatoid arthritis is a kind of general autoimmune disease based on arthropathy, is again a kind of commonly encountered diseases, apyetous, multiple arthrosis, and China's 1,100,000,000 populations have 1100 all creation rheumatic sufferers at least.Rheumatoid arthritis is mainly in person between twenty and fifty, the women is more than the male, onset is slow, early symptoms such as that patient has is weak, low grade fever, appetite are poor, trick cold, symmetry arthritis appears in after this most patients, the joint of getting involved is remarkable with the little joint of end, and then invades big joint to arthroncus, pain and stiff.In addition, also have rheumatoid nodules, laboratory examination shows as the anti-O positive, the rheumatoid factor positive, erythrocyte sedimentation rate raises, and immunoglobulin increases, and serum zinc and hematochrome are on the low side.The visible soft tissue swelling of X-ray, osteoporosis, the joint space narrows down etc. and can be diagnosed as early stage " rheumatoid arthritis ", is the very high disease of a kind of disability rate.
Because the cause of disease is not bright, so method of treatment is various, curative effect is not good enough, doctor trained in Western medicine anti-inflammatory analgesic commonly used and hormone therapy, then the drawback of " difficulty of getting down from horse easily starts " and significant side effects are arranged and the abandoning cure of having to.
U.S. Miami University can carry out experimentation by treating rheumatic arthritis specially to a kind of Bolivia Formica fusca, proves the venom energy treating rheumatic arthritis of this Formica fusca, and effect duration is two to three years.The long-term observation of insect pathology man found " Formica fusca has antiheumatic peculiar ability ", because of it lives in cold-resistant moisture resistance in the environment of relative humidity more than 80% for a long time.
Clinical practice proves, through the wild medical ant of selecting of breeding, the merit that multiple deficient property diseases such as rheumatoid arthritis, ankylosing spondylitis is had " strengthening vital QI to eliminate pathogenic factors ", the special curative effect that rheumatoid arthritis and different diseases such as carcinoma is had " treating different diseases with the same therapeutic principle ", it is not only nontoxic, harmless, can also bring into play therapeutical effect on constitutional basis.In recent years, China biologist has done deep research to the mechanism that Formica fusca is cured the disease, and has obtained bigger success from the immunology aspect.Ant preparation is very marvellous to Immune Effects, and it can promote the hypertrophy of immune organs such as thymus spleen and send out the region between the heart and the diaphragm that the blood leucocyte number is increased, and lysozyme activity and phagocytic activity strengthen, antibody horizontal during raising is replied antigen or the like.Ant preparation can also improve old people's immune function effectively, Formica fusca is again a kind of broad-spectrum immunosuppressant simultaneously, make rheumatoid factor transfer feminine gender to, reduce erythrocyte sedimentation rate, this characteristic of Formica fusca has important meaning in allergic diseases such as treatment rheumatoid arthritis.Formica fusca can make weak person strengthen to the two-ways regulation of immune function of human body, and the powerhouse is weakened, and is similar to " setting upright " and " eliminating evil " of the traditional Chinese medical science.According to clinical research, the composition of Formica fusca uniqueness has very high health care and is worth, and is promoting child growth to send out the region between the heart and the diaphragm, health invigorating, and defying age is adjusted immunologic function, and treatment heart disease, hepatopathy, tumor and rheumatoid etc. are exempted from
All there is wide application future epidemic disease dysfunctional disease aspect.
The objective of the invention is for provide a kind of with the Formica fusca be principal agent help again with invigorate blood circulation, the accessory drugs of expelling wind and removing dampness and invigorating the liver and kidney, strengthening the spleen and stomach forms the pure Chinese medicine preparation of broad spectrum activity at the various clinical symptoms of rheumatoid arthritis; Through clinical verification can cure in early days, mid-term may command, late period can alleviate, and be safe and reliable, has no side effect, totall effective rate in clinical treatment reaches 94.8%, and the medicine source is abundant, cost is low.
Purpose of the present invention can realize by following measure:
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis is to be principal agent with the Formica fusca, be aided with other accessory drugss and pharmaceutically useful carrier and/adjuvant; It is by contain following raw materials in percentage by weight routinely preparation process make medicament: Formica fusca 20-90%, accessory drugs 5-70%, pharmaceutically useful carrier and/or adjuvant 5-10%.
The present invention is all effective in cure to the various clinical symptoms of rheumatoid arthritis correspondence, as rheumatoid arthritis and the damp and hot stasis of blood of wind and cold pain concomitant disease, stiff numbness are arranged, that Liver and kidney is insufficiency of the spleen is weak, blood stasis symptom person, sick patient for a long time etc., the present invention is a kind of broad spectrum activity pure Chinese medicinal preparation at rheumatoid arthritis, all be that Formica fusca is a principal agent, be aided with the accessory drugs of suiting the medicine to the illness at different symptoms again; As in the treatment rheumatoid arthritis and when wind, cold, wet, heat, stasis of blood pain concomitant disease are arranged, described accessory drugs includes Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis at least respectively, Radix Aconiti Preparata, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, Herba Asari, Rhizoma Atractylodis, living Semen Coicis, Chinese Radix Stephaniae Tetrandrae, Rhizoma Smilacis , Cornu Bubali, Cornu Naemorhedi, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Rhizoma Arisaematis, Rhizoma Pinelliae, Bombyx Batryticatus, Pheretima, eupolyphaga worm, Squama Manis.When the rheumatoid arthritis of treatment limbs pain, stiff numbness, described accessory drugs is Bao Hanyou Herba Siegesbeckiae, Herba Lycopodii, Herba Erodii, Herba speranskiae tuberculatae, Caulis Sinomenii, Caulis Spatholobi, Caulis Lonicerae, Radix Tripterygii Wilfordii at least.When the rheumatoid arthritis of treatment Liver and kidney weakness, textured bone, described accessory drugs includes Radix Morindae Officinalis, Herba Epimedii, system Rhizoma Cibotii, Radix Dipsaci, Cortex Acanthopancis, Herba Taxilli, Radix Achyranthis Bidentatae, the Cortex Eucommiae, Rhizoma Drynariae, Herba Pyrolae at least.When treatment spleen-deficient rheumatoid arthritis, described accessory drugs includes the Radix Astragali, Rhizoma Atractylodis, Semen Coicis, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae at least.When treatment blood qi-deficiency type rheumatoid arthritis, described accessory drugs includes Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Chuanxiong at least.
The present invention has following advantage compared to existing technology:
1, the present invention makes full use of the characteristics of the anti-high and cold high humidity of Formica fusca, be aided with again at the different clinical symptoms of rheumatoid arthritis dispel the wind, dehumidifying, activating blood circulation and supplementing qi, the liver and the kidney tonifying and insects search the accessory drugs that picks and make the broad-spectrum compound preparation, it is evident in efficacy, through clinical verification, can cure in early days, mid-term can disease controlling development, late period can relief of symptoms, total effective rate reaches 94.8%.
2, the present invention is directed to rheumatoid arthritis and have that wind and cold is wet to be mingled with the type patient, adopting with the Formica fusca is that principal agent is aided with accessory drugs again, strengthening the body resistance, kidney invigorating and YANG supporting is arranged, the effect of nourish blood flourish muscle, expelling wind and removing dampness, dispersing cold for relieving pain.
3, the present invention is directed to rheumatoid arthritis and the patient of Liver and kidney weakness, textured bone is arranged, adopt existing invigorating the kidney and strengthening the bones, the strong muscle accessory drugs of double effect such as dispel the wind is arranged again, there is the Formica fusca of " eliminating evil " effect to cooperate again with existing " setting upright ", immune function of human body is carried out two-phase regulate, can play the liver and the kidney tonifying, bone and muscle strengthening, chase after the deep effect of wind.
4, the present invention is directed to rheumatoid arthritis and blood stasis symptom, sick pain for a long time patient are very arranged, employing with the Formica fusca be main search pick dispel through in ailment said due to cold or exposure, remove cold-damp in the bone, allow pertinacious phlegm melts in the venation, reach the blood sector-style from going out, expectorant looses stiff from the effect that disappears, and can play the effect of dredge the meridian passage, blood stasis dispelling, pain relieving.
5, above-mentioned three kinds of compatibilities of the present invention both can use separately, and the utilization of can working in coordination again uses then merit to concentrate one's efforts grand separately; Cooperate and to use then treating both the principal and secondary aspects of a disease, complement each other, hold concurrently in nourishing blood invigorating blood circulation, residence is set upright and eliminating evil to dispel the wind in the kidney invigorating, the kidney invigorating and exempt from numbness.
6, the present invention is in addition at rheumatoid arthritis and limbs pain, numb patient are arranged, employing is principal agent with the Formica fusca, be aided with accessory drugs again, but the liver and the kidney tonifying, bone and muscle strengthening, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, and disease such as scapulohumeral periarthritis, ankylosing spondylitis, sciatica, senile osteoarthritis, hyperosteogeny, cervical spondylosis, peripheral nerve inflammation, apoplectic hemiplegia, new and old soft tissue injury, intractable talalgia.
7, preparation safety of the present invention is reliable, and nontoxic pair is appointed, and the medicine source is abundant, and cost is lower, and is economical and practical, can reach treating both the principal and secondary aspects of a disease, through clinical 320 example checkings; Total effective rate reaches 94.8%, obvious effective rate 40%, effective percentage 37%, cure rate reach 17.8%.
The present invention also will be described in further detail in conjunction with the embodiments:
Embodiment one:
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis when treatment wind pain type rheumatoid arthritis, it be by contain following raw materials in percentage by weight routinely preparation process make medicament: Formica fusca 55%, Radix Gentianae Macrophyllae 12%, Radix Saposhnikoviae 8%, Rhizoma Et Radix Notopterygii 8%, Radix Angelicae Pubescentis 6%, Mel 6%, wine 5%.
Its preparation method is that Formica fusca is done with the soaking in Chinese liquor system of taking out after 10-60 minute; With all the other accessory drugss pulverize the back mix add Mel and wine routinely formulation method make pill.
Embodiment two:
A kind of pharmaceutical composition of rheumatoid arthritis for the treatment of is when the cold pain of treatment type rheumatoid arthritis, it be by following raw materials in percentage by weight routinely formulation method make medicament: Formica fusca 40%, Radix Aconiti Preparata 8%, Radix Aconiti Lateralis Preparata 8%, Ramulus Cinnamomi 8%, Herba Asari 8%, its surplus are Chinese liquor.
Its preparation method is that Formica fusca is done with the soaking in Chinese liquor system of taking out after 10-60 minute; With all the other accessory drugss pulverize the back mix add wine routinely formulation method make medicated wine.
Embodiment three:
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis when the wet pain of treatment type rheumatoid arthritis, it be by following raw materials in percentage by weight routinely formulation method make medicament: Formica fusca 60%, Rhizoma Atractylodis 9%, give birth to Semen Coicis 7%, Radix Stephaniae Tetrandrae 8%, Rhizoma Smilacis 7%, starch 8%, sweeting agent 1%.
Its preparation method and example together are made into tablet.
Embodiment four:
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis when treatment burning pain type rheumatoid arthritis, it be by following raw materials in percentage by weight routinely formulation method make medicament: Formica fusca 70%, Cornu Bubali 6%, Cornu Naemorhedi 7%, Gypsum Fibrosum 6%, the Rhizoma Anemarrhenae 6%, starch 4%, sweeting agent 1%.
Its preparation method and example together are made into tablet.
Embodiment five:
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis when treatment stasis of blood pain type rheumatoid arthritis, it be by following raw materials in percentage by weight routinely formulation method make medicament: Formica fusca 25%, Rhizoma Arisaematis 15%, Rhizoma Pinelliae 10%, Bombyx Batryticatus 12%, Pheretima 10%, Squama Manis 10%, eupolyphaga worm 10%, Mel 2%, starch 6%.
Its preparation method and example together are made into tablet.
Embodiment six:
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis when the rheumatoid arthritis of treatment in treatment limbs pain, stiff numbness, it be by following raw materials in percentage by weight routinely formulation method make medicament: Formica fusca 50%, Herba Siegesbeckiae 6%, Herba Lycopodii 5%, Herba Erodii 5%, Herba speranskiae tuberculatae 5%, Caulis Sinomenii 4%, Caulis Spatholobi 4%, Caulis Lonicerae 4%, Radix Tripterygii Wilfordii 4%, wine 13%.
Its preparation method and example together can be made into medicated wine.
Embodiment seven:
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis when the rheumatoid arthritis of treatment Liver and kidney weakness, textured bone, it be by contain following raw materials in percentage by weight routinely preparation process make medicament: Formica fusca 82%, Radix Morindae Officinalis 2%, Herba Epimedii 2%, system Rhizoma Cibotii 1%, Radix Dipsaci 1%, Cortex Acanthopancis 2%, Herba Taxilli 2%, Radix Achyranthis Bidentatae 2%, the Cortex Eucommiae 2%, Rhizoma Drynariae 1%, Herba Pyrolae 1%, starch 2%.
Its preparation method and example together just are made into capsule.
Embodiment eight:
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis when treatment spleen-deficient rheumatoid arthritis, it be by following raw materials in percentage by weight routinely preparation process make medicament: Formica fusca 88%, the Radix Astragali 3%, Rhizoma Atractylodis 3%, Semen Coicis 2%, the Rhizoma Pinelliae 2%, Pericarpium Citri Reticulatae 2%.
Its preparation method and example together just are made into dissolved granule.
Embodiment nine:
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis when treatment blood qi-deficiency type rheumatoid arthritis, it be by following raw materials in percentage by weight routinely preparation process make medicament: Formica fusca 70%, Radix Ginseng 3%, the Rhizoma Atractylodis Macrocephalae 3%, Poria 3%, Radix Glycyrrhizae 3%, Radix Rehmanniae Preparata 3%, the Radix Paeoniae Alba 3%, Radix Angelicae Sinensis 3%, Rhizoma Chuanxiong 3%, Mel 6%.
Its preparation method and example together just are made into pill.
Clinical observation on the therapeutic effect of the present invention is as follows:
Clinical observation 388 examples, wherein male 104 people, women 284 people are divided into three groups at random; Therapeutic Method:
1, the control group A group adopts ZHENGQINGFENGTONGNING respectively, and every day 2-3 time, each 4, be a course of treatment January; Contrast B group adopts Thunder God Teng sheet, every day 2-3 time, each 2-4 sheet; 2, of the present invention group is adopted the present invention to treat the wet type rheumatoid arthritis, treatment Liver and kidney weakness, textured bone rheumatoid arthritis, treatment blood stasis disease, sick patient's rheumatoid arthritis for a long time of being mingled with of wind and cold to carry out Comprehensive Treatment, be a course of treatment January, sum up the course of treatment after three months, through clinical statistics, the total effective rate that wherein contrasts the A group is 83%, the total effective rate of contrast B group is 70%, total effective rate 98.6% of the present invention.
Clinical data is as follows:
Patient Yu Haiying, woman, 20 years old, be that the warm township of Linze county duck duckling village school gives birth to, the patient fell down accidentally in October, 1996, caused right arm joint dislocation, then cause that both hands refer to swollen hard pain, doctor trained in Western medicine antiinflammatory symptomatic treatment, curative effect do not show, after whole body joint and extremity size redness and swelling of joints burning pain appear, and accompany stiff tetanic sense, through hospital diagnosis is " rheumatoid arthritis ", through looking into: and erythrocyte sedimentation rate 46mm/h, ASO (+), RF (+), skin rubefaction, swell and ache.Through adopting embodiments of the invention one and embodiment four partner treatments after 3 courses of treatment, General Symptoms is greatly improved, and continues to adopt one, two, four back 5 courses of treatment of embodiment, and check: erythrocyte sedimentation rate 18mm/h, ASO (-), RF (-) transference cure, the colour of skin is normal.
The patient stone forest, the man, 38 years old is Huocheng, Shandan County people from village, the patient in by the end of April, 1984, the little joint of extremity symmetry pain is through looking into the rheumatoid factor positive, anti-" O " feminine gender, erythrocyte sedimentation rate 64mm/h, patient's pale complexion, pulse condition moistens slow, and happiness heat is afraid of cold the diet poor appetite, the red tongue tongue is greasy in vain, blood stasis at the bottom of the tongue, bulbar conjunctiva hyperemia, be " subacute rheumatoid " after diagnosing, treat that the state of an illness takes a turn for the better through embodiments of the invention one, three.
Patient Hu Lixia, the woman, 20 years old is that Zhangye is sweet dredges Junichiro Koizumi village, township ten peasants of society, and 1996 because of surplus " both hands articulations digitorum manus and the stiff congestion and swelling pain of biped toe joint " ten day, through looking into: erythrocyte sedimentation rate 68mm/h, anti-" O " positive, the rheumatoid factor positive, morning is obviously stiff, symmetry red and swollen heat in the little joint of extremity is painful, and the moderate deformity appears, through adopting the embodiment of the invention one, every clothes 6 grams, every day three times, above-mentioned symptom is obviously alleviated, and continues to take 6 courses of treatment, check: erythrocyte sedimentation rate 16mm/h, anti-" O " negative (-), rheumatoid factor negative (-), transference cure.
Patient Yang Xiuzhen, the woman, 65 years old, be Xuanhua, Gaotai County township estrade temple village peasant, the patient the chill pain limitation of activity of knee joint occurs in 93 years unknown causes, adopt physical therapy and Western medicine to hold up not symptomatic treatment, effect does not show, after waist cold type of pain, chill, and gonalgia joint stuffiness appear, through looking into: erythrocyte sedimentation rate 48mm/h, anti-" O " positive (+) rheumatoid factor positive, show: the erosion of lumbar vertebra hyperosteogeny distortion knee joint sclerotin, be diagnosed as rheumatoid arthritis, after the present invention treated for 6 courses of treatment, symptom disappeared substantially.
Claims (10)
1, a kind of pharmaceutical composition for the treatment of rheumatoid arthritis is characterized in that said composition is is principal agent with the Formica fusca, be aided with other accessory drugss and pharmaceutically useful carrier and/adjuvant; It is by contain following raw materials in percentage by weight routinely preparation process make medicament:
Pharmaceutically useful carrier of Formica fusca 20-90% accessory drugs 5-70% and/or adjuvant 5-10%.
2, the pharmaceutical composition of treatment rheumatoid arthritis as claimed in claim 1 is characterized in that: when treatment wind pain type rheumatoid arthritis, described accessory drugs includes Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis at least.
3, the pharmaceutical composition of treatment rheumatoid arthritis as claimed in claim 1 is characterized in that: when the cold pain of treatment type rheumatoid arthritis, described accessory drugs includes Radix Aconiti Preparata, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, Herba Asari at least.
4, the pharmaceutical composition of treatment rheumatoid arthritis as claimed in claim 1 is characterized in that: when the wet pain of treatment type rheumatoid arthritis, described accessory drugs includes Rhizoma Atractylodis at least, gives birth to Semen Coicis, Chinese Radix Stephaniae Tetrandrae, Sichuan Cordyceps .
5, the pharmaceutical composition of treatment rheumatoid arthritis as claimed in claim 1 is characterized in that: when treatment burning pain type rheumatoid arthritis, described accessory drugs includes Cornu Bubali, Cornu Naemorhedi, Gypsum Fibrosum, the Rhizoma Anemarrhenae at least.
6, the pharmaceutical composition of treatment rheumatoid arthritis as claimed in claim 1 is characterized in that: when treatment stasis of blood pain type rheumatoid arthritis, described accessory drugs includes Rhizoma Arisaematis, Rhizoma Pinelliae, Bombyx Batryticatus, Pheretima, eupolyphaga worm, Squama Manis at least.
7, the pharmaceutical composition of treatment rheumatoid arthritis as claimed in claim 1, it is characterized in that: when the rheumatoid arthritis of treatment limbs pain, stiff numbness, described accessory drugs is Bao Hanyou Herba Siegesbeckiae, Herba Lycopodii, Herba Erodii, Herba speranskiae tuberculatae, Caulis Sinomenii, Caulis Spatholobi, Caulis Lonicerae, Radix Tripterygii Wilfordii at least.
8, the pharmaceutical composition of treatment rheumatoid arthritis as claimed in claim 1, it is characterized in that: when the rheumatoid arthritis of treatment Liver and kidney weakness, textured bone, described accessory drugs includes Radix Morindae Officinalis, Herba Epimedii, system Rhizoma Cibotii, Radix Dipsaci, Cortex Acanthopancis, Herba Taxilli, Radix Achyranthis Bidentatae, the Cortex Eucommiae, Rhizoma Drynariae, Herba Pyrolae at least.
9, the pharmaceutical composition of treatment rheumatoid arthritis as claimed in claim 1 is characterized in that: when treatment spleen-deficient rheumatoid arthritis, described accessory drugs includes the Radix Astragali, Rhizoma Atractylodis, Semen Coicis, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae at least.
10, the pharmaceutical composition of treatment rheumatoid arthritis as claimed in claim 1, it is characterized in that: when treatment blood qi-deficiency type rheumatoid arthritis, described accessory drugs includes Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Chuanxiong at least.
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| CN00113920A CN1342462A (en) | 2000-09-08 | 2000-09-08 | Composite medicine for treating rheumatoid arthritis |
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| CN00113920A CN1342462A (en) | 2000-09-08 | 2000-09-08 | Composite medicine for treating rheumatoid arthritis |
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| CN1301129C (en) * | 2004-12-08 | 2007-02-21 | 天津同仁堂股份有限公司 | Medication for treating arthralgia due to wind-cold dampness and weary muscles and bones |
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| CN101181355B (en) * | 2007-11-09 | 2010-09-15 | 张庆 | Medicament for curing rheumatism and rheumatoid as well as preparation method thereof |
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| CN101099812B (en) * | 2006-07-03 | 2010-05-12 | 李承平 | Capsule for strengthening muscles and bones |
| CN101181355B (en) * | 2007-11-09 | 2010-09-15 | 张庆 | Medicament for curing rheumatism and rheumatoid as well as preparation method thereof |
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