CN102631594B - Medicament for treating rheumatoid arthritis - Google Patents
Medicament for treating rheumatoid arthritis Download PDFInfo
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- CN102631594B CN102631594B CN2012101428455A CN201210142845A CN102631594B CN 102631594 B CN102631594 B CN 102631594B CN 2012101428455 A CN2012101428455 A CN 2012101428455A CN 201210142845 A CN201210142845 A CN 201210142845A CN 102631594 B CN102631594 B CN 102631594B
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- 206010039073 rheumatoid arthritis Diseases 0.000 title claims abstract description 17
- 239000003814 drug Substances 0.000 title claims abstract description 16
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- 241000903946 Clematidis Species 0.000 claims description 4
- 241000751897 Paederus Species 0.000 claims description 4
- 241000237636 Pheretima Species 0.000 claims description 4
- 241000522620 Scorpio Species 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 241000545442 Radix Species 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 10
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- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 241001061264 Astragalus Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 240000006432 Carica papaya Species 0.000 abstract 1
- 235000009467 Carica papaya Nutrition 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
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- 244000077995 Coix lacryma jobi Species 0.000 abstract 1
- 241000218671 Ephedra Species 0.000 abstract 1
- 241001420794 Formica rufa Species 0.000 abstract 1
- 241000305491 Gastrodia elata Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
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- 241000244365 Ligusticum sinense Species 0.000 abstract 1
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- 241000830536 Tripterygium wilfordii Species 0.000 abstract 1
- 241000157373 Uncaria rhynchophylla Species 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a medicament for treating rheumatoid arthritis. The medicament is prepared from the following crude medicaments in parts by weight: 20 to 50 parts of astragalus, 10 to 30 parts of largehead atractylodes rhizome, 10 to 40 parts of angelica, 10 to 20 parts of tripterygium wilfordii, 10 to 30 parts of herba siegesbeckiae, 10 to 20 parts of ovientvine, 10 to 30 parts of uncaria rhynchophylla, 10 to 20 parts of papaya, 10 to 30 parts of divaricate saposhnikovia root, 10 to 20 parts of radix paeoniae alba, 10 to 30 parts of cassia twig, 10 to 20 parts of ligusticum chuanxiong, 20 to 50 parts of coix seed, 10 to 20 parts of clematis root, 10 to 20 parts of common clubmoss herb, 5 to 20 parts of ephedra, 10 to 30 parts of gastrodia elata, 10 to 20 parts of earthworm, 10 to 30 parts of scorpion, 10 to 20 parts of red ant, 10 to 30 parts of eucommia ulmoides oliv and 5 to 20 parts of licorice. The medicament for treating the rheumatoid arthritis has good curative effects on rheumatism and the rheumatoid diseases, has the effect of repairing injured joints, and has the advantages of readily available raw materials, low cost, no side effect, short course of treatment and fast effect.
Description
Technical field
The present invention relates to tcm field, relate in particular to a kind of medicament for the treatment of rheumatoid arthritis.
Background technology
Rheumatoid arthritis (rheumatoid arthritis) is that a kind of chronic general self take articular synovitis as feature is exempted from rheumatoid symptom (Ying Fulixi capsule for treating) epidemic disease disease.Synovitis is outbreak repeatedly lastingly, the destruction that can cause intraarticular cartilage and bone, and joint function disturbance, even maimed.The vasculitis pathological changes is involved each organ of whole body, therefore primary disease is called again rheumatoid disease.
Rheumatoid arthritis claims again rheumatoid (RA), is the chronic systemic inflammatory disease that a kind of cause of disease not yet understands, pathological changes as main clinical manifestation, belongs to the autoimmune inflammatory diseases outside chronic, symmetry, many synovial jointss inflammation and the joint.This disease is apt to occur in the little joints such as hands, wrist, foot, and outbreak, be symmetric repeatedly.Joint red and swollen heat pain and dysfunction are arranged in early days, and late period, stiff deformity in various degree can appear in the joint, and with the atrophy of bone and bones flesh, very easily disabled.Angle from pathological change, rheumatoid arthritis is a kind of synovium of joint (can feed through to later on articular cartilage, osseous tissue, articular ligament and flesh key) that mainly involves, and is secondly the popularity diseases associated with inflammation of the connective tissues such as serous coat, the heart, lung and eye.The general performance of rheumatoid arthritis also has heating, fatigue and weak, pericarditis, subcutaneous nodule, pleuritis, arteritis, peripheral neuropathy etc. except arthropathy.The rheumatoid arthritis of broad sense also comprises the popularity pathological changes of whole body except the inflammatory disorders of joint part.
Summary of the invention
The purpose of this invention is to provide a kind of medicament for the treatment of rheumatoid arthritis.
in order to realize purpose of the present invention, the invention provides a kind of medicament for the treatment of rheumatoid arthritis, it is to be made by weight by following bulk drugs: Radix Astragali 20-50 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Radix Angelicae Sinensis 10-40 part, Radix Tripterygii Wilfordii 10-20 part, Herba Siegesbeckiae 10-30 part, Caulis Sinomenii 10-20 part, Ramulus Uncariae Cum Uncis 10-30 part, Fructus Chaenomelis 10-20 part, Radix Saposhnikoviae 10-30 part, Radix Paeoniae Alba 10-20 part, Ramulus Cinnamomi 10-30 part, Rhizoma Chuanxiong 10-20 part, Semen Coicis 20-50 part, Radix Clematidis 10-20 part, Herba Lycopodii 10-20 part, Herba Ephedrae 5-20 part, Rhizoma Gastrodiae 10-30 part, Pheretima 10-20 part, Scorpio 10-30 part, Paederus densipennis Bernh. 10-20 part, Cortex Eucommiae 10-30 part and Radix Glycyrrhizae 5-20 part.
Preferably, the medicament for the treatment of rheumatoid arthritis of the present invention is to be made by weight by following bulk drugs: 10 parts, 40 parts of the Radixs Astragali, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Angelicae Sinensis, Radix Tripterygii Wilfordii 12 20 parts of Fen, Herba Siegesbeckiae, 15 parts of Caulis Sinomeniis, 15 parts of Ramulus Uncariae Cum Uncis, 15 parts of Fructus Chaenomeliss, 15 parts of Radix Saposhnikoviaes, 15 parts of the Radix Paeoniae Albas, 15 parts of Ramulus Cinnamomi, 12 parts of Rhizoma Chuanxiongs, 30 parts of Semen Coiciss, 15 parts of Radix Clematidis, 20 parts of Herba Lycopodiis, 9 parts, Herba Ephedrae, 15 parts, Rhizoma Gastrodiae, 15 parts of Pheretimas, 10 parts of Scorpios, 12 parts of Paederus densipennis Bernh., 20 parts of the Cortexs Eucommiae and Radix Glycyrrhizae.
Preferably, the medicament for the treatment of rheumatoid arthritis of the present invention is tablet, dispersible tablet, disintegrating tablet or decoction.
The medicament for the treatment of rheumatoid arthritis of the present invention has curative effect preferably to rheumatism, rheumatoid disease, and can play and repair the effect of impaired joint, and raw material is easy to get, cost is low, have no side effect, short treating period, instant effect.
The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not to be limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within the scope of the present invention.
The preparation of embodiment 1 decoction of the present invention
Get the Radix Astragali 40 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Angelicae Sinensis 20 grams, Radix Tripterygii Wilfordii 12 Ke, Herba Siegesbeckiae 20 grams, Caulis Sinomenii 15 grams, Ramulus Uncariae Cum Uncis 15 grams, Fructus Chaenomelis 15 grams, Radix Saposhnikoviae 15 grams, the Radix Paeoniae Alba 15 grams, Ramulus Cinnamomi 15 grams, Rhizoma Chuanxiong 12 grams, Semen Coicis 30 grams, Radix Clematidis 15 grams, Herba Lycopodii 20 grams, Herba Ephedrae 9 grams, Rhizoma Gastrodiae 15 grams, Pheretima 15 grams, Scorpio 10 grams, Paederus densipennis Bernh. 12 grams, the Cortex Eucommiae 20 grams and Radix Glycyrrhizae 10 grams, add entry 500 grams, be placed in the flask of sealing, heating is 3 hours under the water-bath of 90 ℃, filter, collect filtrate and get final product.
Experimental example
Select 50 routine rheumatoid disease patients, male 25 examples, female's 25 examples, the mean age is 48 years old.Diagnostic criteria: with reference to the standard of " U.S. rheumatoid disease association " formulation, that is: according to medical history, physical diagnosis and radiological examination result: knee-joint pain, namely determine clinical diagnosises for 3 that possess simultaneously in following 6 conditions, 1. radiology shows hyperosteogeny formation; 2. rise morning and stiffly be less than 30 minutes; 3. the bone sound is arranged during joint motion; 4. the knee joint bone increases; 5. the bone tenderness is arranged; 6. without significantly synovial membrane intensification.
Treat with the decoction that makes in embodiment 1, wherein one day 3 times, each oral 50 milliliters, treating March is a course for the treatment of, treats continuously 2 courses for the treatment of.
Efficacy determination: 1. produce effects: gonalgia transference cure, morning stiff time shorten or without morning stiff, physico-chemical examination is normal.1. take a turn for the better: gonalgia sx↓, physico-chemical examination makes moderate progress.Invalid: the gonalgia is without alleviating, and physico-chemical examination is without change.
Through the observation of 2 courses for the treatment of is arranged, finding has 50 patient treatment effects to be produce effects, and does not observe obvious untoward reaction during whole treatment.
All the patient is followed up a case by regular visits to weekly after treating a course for the treatment of, continue half a year, find the sign of recurrence.
Claims (1)
1. medicament for the treatment of rheumatoid arthritis, it is characterized in that, it is to be made by weight by following bulk drugs: 10 parts, 40 parts of the Radixs Astragali, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Angelicae Sinensis, Radix Tripterygii Wilfordii 12 20 parts of Fen, Herba Siegesbeckiae, 15 parts of Caulis Sinomeniis, 15 parts of Ramulus Uncariae Cum Uncis, 15 parts of Fructus Chaenomeliss, 15 parts of Radix Saposhnikoviaes, 15 parts of the Radix Paeoniae Albas, 15 parts of Ramulus Cinnamomi, 12 parts of Rhizoma Chuanxiongs, 30 parts of Semen Coiciss, 15 parts of Radix Clematidis, 20 parts of Herba Lycopodiis, 9 parts, Herba Ephedrae, 15 parts, Rhizoma Gastrodiae, 15 parts of Pheretimas, 10 parts of Scorpios, 12 parts of Paederus densipennis Bernh., 20 parts of the Cortexs Eucommiae and Radix Glycyrrhizae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101428455A CN102631594B (en) | 2012-05-10 | 2012-05-10 | Medicament for treating rheumatoid arthritis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101428455A CN102631594B (en) | 2012-05-10 | 2012-05-10 | Medicament for treating rheumatoid arthritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102631594A CN102631594A (en) | 2012-08-15 |
| CN102631594B true CN102631594B (en) | 2013-06-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101428455A Expired - Fee Related CN102631594B (en) | 2012-05-10 | 2012-05-10 | Medicament for treating rheumatoid arthritis |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341080B (en) * | 2013-07-02 | 2014-12-31 | 上海市长宁区光华中西医结合医院 | Chinese medicine composite for treating rheumatoid arthritis and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1342462A (en) * | 2000-09-08 | 2002-04-03 | 何兴峰 | Composite medicine for treating rheumatoid arthritis |
| CN1375298A (en) * | 2001-01-04 | 2002-10-23 | 黄兆元 | Pain-relieving notoginseng mixture |
-
2012
- 2012-05-10 CN CN2012101428455A patent/CN102631594B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1342462A (en) * | 2000-09-08 | 2002-04-03 | 何兴峰 | Composite medicine for treating rheumatoid arthritis |
| CN1375298A (en) * | 2001-01-04 | 2002-10-23 | 黄兆元 | Pain-relieving notoginseng mixture |
Non-Patent Citations (4)
| Title |
|---|
| 中药治疗类风湿关节炎作用机理探讨;马晓文等;《甘肃中医》;20070630;第20卷(第06期);88-89 * |
| 任丽等.蚂蚁治疗类风湿性关节炎100例观察.《中医函授通讯》.1999,第18卷(第02期), |
| 蚂蚁治疗类风湿性关节炎100例观察;任丽等;《中医函授通讯》;19990228;第18卷(第02期);第36也第2栏倒数第1-3段 * |
| 马晓文等.中药治疗类风湿关节炎作用机理探讨.《甘肃中医》.2007,第20卷(第06期), |
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| CN102631594A (en) | 2012-08-15 |
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Granted publication date: 20130605 |
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