CN105343460A - External-use Chinese herbal medicine composition for treating traumatic injury, fracture dislocation and rheumatism bone disease - Google Patents

External-use Chinese herbal medicine composition for treating traumatic injury, fracture dislocation and rheumatism bone disease Download PDF

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CN105343460A
CN105343460A CN201510857003.1A CN201510857003A CN105343460A CN 105343460 A CN105343460 A CN 105343460A CN 201510857003 A CN201510857003 A CN 201510857003A CN 105343460 A CN105343460 A CN 105343460A
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chinese herbal
herbal medicine
traumatic injury
medicine composition
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张德东
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/32—Burseraceae (Frankincense family)
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Abstract

The invention relates to an external-use Chinese herbal medicine composition for treating traumatic injury, fracture dislocation and rheumatism bone disease. The external-use Chinese herbal medicine composition is prepared from angelica sinensis, pseudo-ginseng, sangusis draconis, frankincense, myrrh, leopard bone, ossa draconis, dog bone, musk, ground beeltle, radix angelicae, rhizoma atractylodis, eucommia ulmoides, colophony, radix dipsaci, angelica, Sichuan mountain armour, caulis sinomenii, rhizoma drynariae, elderberry and phryma leptostachya. The Chinese herbal medicine composition has the effects of invigorating the circulation of blood to remove stasis, relieving swelling and pain, setting a fracture and muscles, stimulating the menstrual flow and removing stasis and dispelling wind and eliminating dampness. The external-use Chinese herbal medicine composition mainly cures various pains caused by traumatic injury, dislocation, cervical spondylosis, scapulohumeral periarthritis, lumbar disc herniation, rheumatism rheumatoid, gout and osteoproliferation.

Description

A kind of Chinese herbal medicine for external use compositions for the treatment of traumatic injury, fracture dislocation, rheumatic osteopathia
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of Chinese herbal medicine for external use compositions for the treatment of traumatic injury, fracture dislocation, rheumatic osteopathia.
Background technology
Rheumatism is one group of disease of the musculoskeletal system based on Drug therapy, and it comprises: the disease of the joint that Diffuse Connective Tissue Disease and the various cause of disease cause and periarticular soft tissues, muscle, tendon, ligament etc., and based on the large arthralgia of extremity.Rheumatoid arthritis is one, and to involve periarticular be the struvite autoimmune disease of main multisystem, its distinctive symptom is symmetry, around multiple joints chronic inflammation pathological changes, clinical manifestation is affected joints pain, swelling, function reduction, and pathological changes becomes to continue, recurrent exerbation process.Its pathology is chronic synovitis, invades and the cartilage of lower floor and bone, causes destruction of joint.Clinical manifestation: 80% was fallen ill in 35-50 year, and women is male 3 times.Feature is slowly to hide mode onset.Joint manifestations has 3 features: 1. morning is stiff: night and morning ankylosis as gluing.2. secondly arthralgia: the most common is wrist, metacarpal joint is toe, knee joint, ankle, elbow, shoulder joint.Having a cold swells and ache increases the weight of.3. joint deformity: be more common in patients with terminal.The flexion joint deformities such as finger, wrist, foot, toe.Periarticular muscles atrophy, spasm then make deformity even more serious.The traditional Chinese medical science thinks rheumatism, rheumatoid disease all because of under the condition of the many factors such as human righteousness's deficiency, disharmony of nutrient QI with defensive QI, deficiency of both QI and blood, internal organs are weak or a certain factor, wind-cold damp pathogen is taken advantage of a weak point, invade the places such as collaterals of human, joint, muscle, skeleton, cause above-mentioned clinical manifestation.Primary disease also climate cold affects and recurrent exerbation, and obstinate disease person has caused QI and blood heavy losses, causes the stiff deformity of extremities joint, limitation of activity, hurt like hell, even disability, brings great misery to patient.Not yet clear and definite about rheumatism and rheumatoid etiology and pathogenesis, think relevant with autoimmune at present.Most of medical institutions take control pain to be main, and take a large amount of ibuprofen, diclofenac, indometacin etc., some Patients with Acutes are taken hormones to control, mitigation symptoms, finally fail to break away from the misery that this disease is brought.
Summary of the invention
The object of this invention is to provide a kind of Chinese herbal medicine for external use compositions for the treatment of traumatic injury, fracture dislocation, rheumatic osteopathia.
In order to realize object of the present invention, the invention provides one and treat traumatic injury, fracture dislocation, the Chinese herbal medicine for external use compositions of rheumatic osteopathia, it comprises the material of following weight portion: Radix Angelicae Sinensis 500-600 part, Radix Notoginseng 600-800 part, Sanguis Draxonis 500-600 part, Olibanum 400-500 part, Myrrha 400-500 part, Os pardi 500-700 part, Os Draconis 400-500 part, Os Canitis 600-800 part, Moschus 30-60 part, Eupolyphaga Seu Steleophaga 300-400 part, Radix Angelicae Dahuricae 300-400 part, Rhizoma Atractylodis 300-400 part, Cortex Eucommiae 300-400 part, Colophonium 300-500 part, Radix Dipsaci 300-500 part, angelica 300-500 part, river Squama Manis 500-600 part, Caulis Sinomenii 500-600 part, Rhizoma Drynariae 400-500 part, Ramulus Sambuci Williamsii 400-500 part and Herba speranskiae tuberculatae 400-500 part.
Preferably, the Chinese herbal medicine for external use compositions for the treatment of traumatic injury of the present invention, fracture dislocation, rheumatic osteopathia comprises the material of following weight portion: Radix Angelicae Sinensis 550 parts, Radix Notoginseng 700 parts, Sanguis Draxonis 550 parts, Olibanum 450 parts, Myrrha 450 parts, Os pardi 600 parts, Os Draconis 450 parts, Os Canitis 700 parts, 50 parts, Moschus, Eupolyphaga Seu Steleophaga 350 parts, the Radix Angelicae Dahuricae 350 parts, Rhizoma Atractylodis 350 parts, the Cortex Eucommiae 350 parts, Colophonium 400 parts, Radix Dipsaci 400 parts, angelica 400 parts, river Squama Manis 550 parts, Caulis Sinomenii 550 parts, Rhizoma Drynariae 450 parts, Ramulus Sambuci Williamsii 450 parts and Herba speranskiae tuberculatae 450 parts.
More preferably, the Chinese herbal medicine for external use compositions for the treatment of traumatic injury of the present invention, fracture dislocation, rheumatic osteopathia also comprises the material of following weight portion: cis-3-O-[4-(S)-(4-iodophenyl)-2-oxo-1 of 3 parts, 3,2-dioxy phosphorus heterocycle cyclohexyl]-18 β-enoxolone.
Most preferably, described herbal composite can be tablet, dispersible tablet, capsule, pill or decoction.
The present invention also provides cis-3-O-[4-(S)-(4-iodophenyl)-2-oxo-1,3,2-dioxy phosphorus heterocycle cyclohexyl] purposes of-18 β-enoxolone in the medicine of preparation treatment traumatic injury, fracture dislocation, rheumatic osteopathia, rheumatic arthritis.
Chinese medicine composition effect of the present invention: blood circulation promoting and blood stasis dispelling reducing swelling and alleviating pain reunion of bone stimulates the menstrual flow eliminating stagnation expelling wind and removing dampness.Cure mainly: traumatic injury, fracture dislocation, cervical spondylosis, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, rheumatic and rheumatoid, gout, the various pain that hyperosteogeny etc. cause.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment
Take Radix Angelicae Sinensis 550 grams, Radix Notoginseng 700 grams, Sanguis Draxonis 550 grams, Olibanum 450 grams, Myrrha 450 grams, Os pardi 600 grams, Os Draconis 450 grams, Os Canitis 700 grams, 50 grams, Moschus, Eupolyphaga Seu Steleophaga 350 grams, the Radix Angelicae Dahuricae 350 grams, Rhizoma Atractylodis 350 grams, the Cortex Eucommiae 350 grams, Colophonium 400 grams, Radix Dipsaci 400 grams, angelica 400 grams, river Squama Manis 550 grams, Caulis Sinomenii 550 grams, Rhizoma Drynariae 450 grams, Ramulus Sambuci Williamsii 450 grams and Herba speranskiae tuberculatae 450 grams, pulverize, cross 100 mesh sieves, mix homogeneously obtains powder.
Experimental example
To the effect of rat carrageenan foot swelling
Get 120-15g male and healthy Wistar rat 50, be divided into 5 groups at random: matched group, positive drug group, administration group 1, administration group 2, administration group 3.Often organize 10.Matched group gives normal saline gavage 1mL/100g body weight; Positive drug group gives dexamethasone 0.5g and adds 1000mL normal saline and become suspension, gives gavage 1mL/100g body weight; Administration group 1, the powder 10g of embodiment adds 1000mL normal saline and becomes suspension, gives gavage 1mL/100g body weight; Cis-3-O-[4-(S)-(4-iodophenyl)-2-oxo-1,3,2-dioxy phosphorus heterocycle cyclohexyl]-18 β-enoxolone of administration group 2,0.02g adds 1000mL normal saline and becomes suspension, gives gavage 1mL/100g body weight; Administration group 3, cis-3-O-[4-(S)-(4-iodophenyl)-2-oxo-1 of powder 5g and 0.01g of embodiment, 3,2-dioxy phosphorus heterocycle cyclohexyl]-18 β-enoxolone adds 1000mL normal saline and becomes suspension, gives gavage 1mL/100g body weight.1 times/day, successive administration 7 days.30min after last gavage, only causes inflammation at the right sufficient plantar subcutaneous injection l % by weight carrageenin aqueous solution 0.05m1/ of rat hindlimb, measures and causes scorching front and back rat paw perimeter change, calculates and compare to cause scorching rear each group swelling percentage rate.The results are shown in and see the following form.(n＝10 )
Group 2h foot swelling rate (%) 4h foot swelling rate (%)
Matched group 21.6±10.3 45.2±11.3
Positive drug group 19.7±9.6 26.5±8.7*
Administration group 1 21.1±9.2 32.3±10.5*
Administration group 2 19.9±10.2 27.2±9.3*
Administration group 3 20.6±11.5 30.1±10.1*
Note: compare * P<0.05 with matched group
Result shows, gives carrageenin after 4 hours, compares with matched group, and medicine of the present invention has remarkable inhibitory action (p<0.05) to its foot swelling, and good antiinflammatory action has been described.

Claims (5)

1. a treatment traumatic injury, fracture dislocation, rheumatic osteopathia, the Chinese herbal medicine for external use compositions of rheumatic arthritis, it is characterized in that, it comprises the material of following weight portion: Radix Angelicae Sinensis 500-600 part, Radix Notoginseng 600-800 part, Sanguis Draxonis 500-600 part, Olibanum 400-500 part, Myrrha 400-500 part, Os pardi 500-700 part, Os Draconis 400-500 part, Os Canitis 600-800 part, Moschus 30-60 part, Eupolyphaga Seu Steleophaga 300-400 part, Radix Angelicae Dahuricae 300-400 part, Rhizoma Atractylodis 300-400 part, Cortex Eucommiae 300-400 part, Colophonium 300-500 part, Radix Dipsaci 300-500 part, angelica 300-500 part, river Squama Manis 500-600 part, Caulis Sinomenii 500-600 part, Rhizoma Drynariae 400-500 part, Ramulus Sambuci Williamsii 400-500 part and Herba speranskiae tuberculatae 400-500 part.
2. treatment traumatic injury according to claim 1, fracture dislocation, rheumatic osteopathia, the Chinese herbal medicine for external use compositions of rheumatic arthritis, it is characterized in that, it comprises the material of following weight portion: Radix Angelicae Sinensis 550 parts, Radix Notoginseng 700 parts, Sanguis Draxonis 550 parts, Olibanum 450 parts, Myrrha 450 parts, Os pardi 600 parts, Os Draconis 450 parts, Os Canitis 700 parts, 50 parts, Moschus, Eupolyphaga Seu Steleophaga 350 parts, the Radix Angelicae Dahuricae 350 parts, Rhizoma Atractylodis 350 parts, the Cortex Eucommiae 350 parts, Colophonium 400 parts, Radix Dipsaci 400 parts, angelica 400 parts, river Squama Manis 550 parts, Caulis Sinomenii 550 parts, Rhizoma Drynariae 450 parts, Ramulus Sambuci Williamsii 450 parts and Herba speranskiae tuberculatae 450 parts.
3. the Chinese herbal medicine for external use compositions for the treatment of traumatic injury according to claim 1 and 2, fracture dislocation, rheumatic osteopathia, rheumatic arthritis, it is characterized in that, it also comprises the material of following weight portion: cis-3-O-[4-(S)-(4-iodophenyl)-2-oxo-1 of 3 parts, 3,2-dioxy phosphorus heterocycle cyclohexyl]-18 β-enoxolone.
4. the Chinese herbal medicine for external use compositions for the treatment of traumatic injury according to claim 1 and 2, fracture dislocation, rheumatic osteopathia, rheumatic arthritis, is characterized in that, described herbal composite can be tablet, dispersible tablet, capsule, pill or decoction.
5. cis-3-O-[4-(S)-(4-iodophenyl)-2-oxo-1,3,2-dioxy phosphorus heterocycle cyclohexyl] purposes of-18 β-enoxolone in the medicine of preparation treatment traumatic injury, fracture dislocation, rheumatic osteopathia, rheumatic arthritis.
CN201510857003.1A 2015-11-30 2015-11-30 External-use Chinese herbal medicine composition for treating traumatic injury, fracture dislocation and rheumatism bone disease Pending CN105343460A (en)

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CN202110772530.8A CN113350435A (en) 2015-11-30 2015-11-30 Application of composition in preparing medicine for treating traumatic injury, fracture dislocation, rheumatic bone disease and rheumatic arthritis
CN201510857003.1A CN105343460A (en) 2015-11-30 2015-11-30 External-use Chinese herbal medicine composition for treating traumatic injury, fracture dislocation and rheumatism bone disease

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112057527A (en) * 2020-09-12 2020-12-11 上海一末生物科技有限公司 A Chinese medicinal hot topical plaster for treating pain and bone injury, and its preparation method
CN113633698A (en) * 2021-09-03 2021-11-12 河南佳普医药科技有限公司 Traditional Chinese medicine micro-needle transdermal drug delivery patch and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062217A (en) * 2007-05-24 2007-10-31 四川省宜宾五粮液集团有限公司 Medicine combination for treating traumatic injury and the preparing method and the function thereof
CN102274372A (en) * 2011-08-15 2011-12-14 陈芝文 Traditional Chinese medicine for treating traumatic fracture rheumatism and various types of hemorrhage
CN102309644A (en) * 2011-09-28 2012-01-11 柴艳峰 Traditional Chinese medical composition for treating bone fracture
CN103127345A (en) * 2013-03-14 2013-06-05 吴小斌 Plaster for treating rheumatism, arthralgia and myalgia and preparation method thereof
CN104667124A (en) * 2015-02-03 2015-06-03 张德东 Traditional Chinese medicine composition capable of treating traumatic injuries and promoting factures to heal quickly

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062217A (en) * 2007-05-24 2007-10-31 四川省宜宾五粮液集团有限公司 Medicine combination for treating traumatic injury and the preparing method and the function thereof
CN102274372A (en) * 2011-08-15 2011-12-14 陈芝文 Traditional Chinese medicine for treating traumatic fracture rheumatism and various types of hemorrhage
CN102309644A (en) * 2011-09-28 2012-01-11 柴艳峰 Traditional Chinese medical composition for treating bone fracture
CN103127345A (en) * 2013-03-14 2013-06-05 吴小斌 Plaster for treating rheumatism, arthralgia and myalgia and preparation method thereof
CN104667124A (en) * 2015-02-03 2015-06-03 张德东 Traditional Chinese medicine composition capable of treating traumatic injuries and promoting factures to heal quickly

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
马清钧等: "《常用中药现代研究与临床》", 31 July 1995, 天津科技翻译出版公司出版 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112057527A (en) * 2020-09-12 2020-12-11 上海一末生物科技有限公司 A Chinese medicinal hot topical plaster for treating pain and bone injury, and its preparation method
CN113633698A (en) * 2021-09-03 2021-11-12 河南佳普医药科技有限公司 Traditional Chinese medicine micro-needle transdermal drug delivery patch and preparation method thereof

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