CN102805775B

CN102805775B - Medicine for treating rheumatic arthritis and preparation method thereof

Info

Publication number: CN102805775B
Application number: CN201210304731.6A
Authority: CN
Inventors: 兰恒志
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-25
Filing date: 2012-08-25
Publication date: 2014-05-07
Anticipated expiration: 2032-08-25
Also published as: CN102805775A

Abstract

The invention discloses a medicine for treating rheumatic arthritis and a preparation method thereof. The medicine is mainly prepared from broad leaf vetch, ground beetle, medicinal cyathula root, phellodendron, suberect spatholobus stem, Japanese honeysuckle stem, dried rehmannia and the like in a certain weight ratio. The medicine for treating rheumatic arthritis has effects of reinforcing qi and nourishing blood, dispelling wind and eliminating dampness, expelling wind, dredging collaterals and dissipating blood stasis, and is quick in response, short in treatment course and high in cure rate, and rheumatic arthritis does not relapse.

Description

A kind of medicine for the treatment of rheumatic arthritis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of rheumatic arthritis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Rheumatic arthritis is a kind of common acute or chronic ICT.Can repeatedly show effect and involve heart.Clinical take joint and muscle migration is miserable, heavily work, pain is feature.Belong to allergic disease.One of main manifestations of rheumatic fever, mainly with febris acuta and arthralgia onset.Typical case's performance of rheumatic arthritis is slight or moderate heating, migratory polyarthritis, the joint of getting involved mostly is the large joint such as knee joint, ankle, shoulder, elbow wrist, commonly by a joint, be transferred to another joint; pathological changes part presents redness, scorching hot, severe pain part patient also has several joints to fall ill simultaneously; atypical patient only has arthralgia and without other inflammation performances, acute inflammation generally disappears in 2-4 week and do not stay sequela, but Chang Fanfu outbreak.At present, because Western medicine cannot effectively be treated rheumatic arthritis, and have certain side effect, therefore, there is very large demand to the Chinese medicine of effective treatment rheumatic arthritis in people.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment rheumatic arthritis, thereby has completed the present invention.

Object of the present invention is just to provide a kind of composition of medicine that can treat rheumatic arthritis.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Herba Viciae Amoenae, Eupolyphaga Seu Steleophaga, Radix Achyranthis Bidentatae, RADIX ACONITILATERALIS PREPARATA, Radix Stephaniae Tetrandrae, Radix Glycyrrhizae Preparata, Cortex Phellodendri, Caulis Spatholobi, Lumbricus, Radix Gentianae Macrophyllae, Caulis Lonicerae, Semen Persicae, Semen Armeniacae Amarum, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of rheumatic arthritis.Wherein selecting Herba Viciae Amoenae, call bean seedling, mountain Semen sojae atricolor, Herba speranskiae tuberculatae, is that temperature, has wind-damp dispelling because of its nature and flavor sweetness and bitterness, invigorate blood circulation, and relaxing muscles and tendons, the function of pain relieving, dispelling the wind and dampness pathogens pain, sprain and contusion wound, innominate toxic swelling, eczema scrotum.It is salty because of its nature and flavor, cold, slightly poisonous selecting Eupolyphaga Seu Steleophaga.Return Liver Channel.Removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea ， mass in the abdomen mass in the abdomen.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury, ripe in invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, four fertile contractures, flaccidity syndrome and arthralgia syndrome.Selecting Radix Aconiti Lateralis Preparata is because of its property acrid-sweet flavor, and heat is poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Select Radix Stephaniae Tetrandrae to be because its nature and flavor are bitter, cold, enter wing thorax, spleen, kidney channel, there is row water, rush down the function of damp-heat in lower-JIAO, the swollen tympanites of harnessing the river, hygropyretic beriberi, brothers' spasm and pain, tinea scabies is swollen.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Cortex Phellodendri to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, there is nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Selecting Caulis Spatholobi is because its property bitter but sweet flavor, and temperature, enters the heart, spleen two warps, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Lumbricus to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, there is heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control height fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Radix Gentianae Macrophyllae to be because its nature and flavor toil is flat, enter liver, stomach, gallbladder meridian, have expelling wind and removing dampness, and blood relaxing muscles and tendons, the function of clearing away heat and promoting diuresis, dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.Select Caulis Lonicerae to be because its nature and flavor are sweet, cold, enter the heart, lung meridian, there is heat clearing away, removing toxic substances, the function of dredging collateral, controls epidemic febrile disease heating, toxic-heat and blood stasis, infectious hepatitis, carbuncle sore tumefacting virus, bones and muscles pain.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Semen Armeniacae Amarum to be because its nature and flavor are bitter, temperature, poisonous, enter lung, large intestine channel, there is expelling phlegm for arresting cough, to relieving asthma, the function of intestine moistening, controls exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.Select Radix Rehmanniae to be because its nature and flavor sweetness and bitterness is cool, enter the heart, liver, kidney channel, have YIN nourishing, the function nourishing blood, controls fever due to yin deficiency, quenches one's thirst, spit blood, and epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon is hindered constipation.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Selecting Ramulus Cinnamomi is that temperature, enters bladder, the heart, lung meridian, has diaphoresis expelling pathogenic factors from muscles because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.

The specific embodiment

The consumption of medicine of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Herba Viciae Amoenae 15-25 gram of Eupolyphaga Seu Steleophaga 10-20 gram of Radix Achyranthis Bidentatae 3-7 gram

RADIX ACONITILATERALIS PREPARATA 5-15 gram of Radix Stephaniae Tetrandrae 10-20 gram of Radix Glycyrrhizae Preparata 5-15 gram

Cortex Phellodendri 5-15 gram of Caulis Spatholobi 5-15 gram of Lumbricus 15-25 gram

Radix Gentianae Macrophyllae 25-35 gram of Caulis Lonicerae 25-35 gram of Semen Persicae 5-5 gram

Semen Armeniacae Amarum 10-20 gram of Radix Rehmanniae 10-20 gram of Rhizoma Atractylodis Macrocephalae 3-7 gram

Ramulus Cinnamomi 5-15 gram

Wherein, be preferably

5 grams of 15 grams of Radix Achyranthis Bidentataes of 20 grams of Eupolyphaga Seu Steleophagas of Herba Viciae Amoenae

10 grams of 15 grams of Radix Glycyrrhizae Preparatas of 10 grams of Radixs Stephaniae Tetrandrae of RADIX ACONITILATERALIS PREPARATA

20 grams of 10 grams of Lumbricuss of 10 grams of Caulis Spatholobis of Cortex Phellodendri

10 grams, 30 grams of Semen Persicaes of 30 grams of Caulis Loniceraes of Radix Gentianae Macrophyllae

5 grams of 15 grams of Rhizoma Atractylodis Macrocephalaes of 15 grams of Radix Rehmanniaes of Semen Armeniacae Amarum

10 grams of Ramulus Cinnamomi

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Herba Viciae Amoenae: choose decontamination, dry;

2, Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

3, Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;

4, RADIX ACONITILATERALIS PREPARATA: salty Radix Aconiti Lateralis Preparata is cleaned, floated 2～3 days, change water every day 2～3 times, go most saline taste, taking-up, puts in pot, adds water and bean curd with boiling, and to chewing, without picotement, takes out, and removes bean curd, and airing, to outer dry interior profit, is cut wafer thin, dries sieve dedust bits;

5, Radix Stephaniae Tetrandrae: former medicine washes, pulls out and runs through, and section, dries;

6, Radix Glycyrrhizae Preparata: extracting liquorice sheet add cooked Mel and boiled water a little, mix thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, tack-free is degree, taking-up cools, 100 jin, every Radix Glycyrrhizae, with the close 25-30 jin of refining;

7, Cortex Phellodendri: remove impurity, spray clear water, runs through, and shredding is dry;

8, Caulis Spatholobi: water runs through, section, or steam after soft and take advantage of fervent sheet, dry;

9, Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;

10, Radix Gentianae Macrophyllae: choose decontamination, except removing LU, slightly soak, run through section, dry;

11, Caulis Lonicerae: choose decontamination, be soaked in water, run through, section, dries;

12, Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;

13, Semen Armeniacae Amarum: choose clean impurity, put in boiling water and slightly boil, pull out when Pi Wei wrinkles, soak in cold water, slough kind of a skin, dry, winnow with a dustpan clean;

14, Radix Rehmanniae: water slightly steeps, cleans sediment contamination, pulls stewing profit out, and section is dried or dried;

15, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

16, Ramulus Cinnamomi: water slightly soaks, pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff.

Two, preparation

1, the Herba Viciae Amoenae of described weight, Eupolyphaga Seu Steleophaga, Radix Achyranthis Bidentatae, RADIX ACONITILATERALIS PREPARATA, Radix Stephaniae Tetrandrae, Radix Glycyrrhizae Preparata, Cortex Phellodendri, Caulis Spatholobi, Lumbricus, Radix Gentianae Macrophyllae, Caulis Lonicerae, Semen Persicae, Semen Armeniacae Amarum, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi are decocted with water, add for the first time 6 times of amounts of water, soak 60 minutes, decoct with high heat boiling 30 minutes, use again slow fire boiling 20 minutes, obtain decoction liquor for the first time.

2, will filter for the first time rear medicinal residues and add 3 times of amounts of water, and decoct boiling, then within 15 minutes, obtain decoction liquor for the second time with slow fire boiling.

3, twice decoction liquor mixed, then use slow fire boiling 20 minutes, medicinal liquid is divided into 2 doses and takes.

Medicine of the present invention has the effect of benefiting QI and nourishing blood, expelling wind and removing dampness, expel wind to dredge collateral blood stasis dispelling, and treatment rheumatic arthritis instant effect, short treating period, do not recur.

By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day twice, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 260 examples for medical treatment, male patient's 160 examples wherein, female patient 100 examples.

2, diagnostic criteria

Rheumatic arthritis: patient joint is red, swollen, hot, pain is obvious, and stiff, site of pathological change is usually the large joints of lower limb such as knee joint, hip, ankle, is secondly shoulder, elbow, carpal joint, and brothers' little joint is rare, and pain migration is indefinite, outbreak repeatedly, protracted course of disease.

3, Therapeutic Method

Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day early, respectively take 1 evening, within 30 days, is a course for the treatment of, takes continuously 2-3 the course for the treatment of.

4, efficacy assessment standard

Effective: clinical symptom disappearance after treatment, it is normal that recover in joint, observes half a year without recidivist;

Take a turn for the better: clinical symptoms is obviously improved, and progressively recover in joint;

Invalid: clinical partial symptoms disappears or without change, do not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, by Drug therapy rheumatic arthritis patient of the present invention 260 examples, effective 134 examples of result, obvious effective rate is 87.31%%, 30 examples that take a turn for the better, and improvement rate is 11.54%, invalid 3 examples, total effective rate is 98.85%.

Claims

1. a medicine for the treatment of rheumatic arthritis, is characterized in that: it is to be made by the crude drug within the scope of following weight:

5 grams, Radix Gentianae Macrophyllae 25-35 gram of Caulis Lonicerae 25-35 gram Semen Persicae

Ramulus Cinnamomi 5-15 gram.

2. a medicine for the treatment of rheumatic arthritis, is characterized in that: be to be made by the crude drug of following weight:

10 grams of Ramulus Cinnamomi.

3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Herba Viciae Amoenae: choose decontamination, dry;

(2) Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

(3) Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;

(4) RADIX ACONITILATERALIS PREPARATA: salty Radix Aconiti Lateralis Preparata is cleaned, floated 2～3 days, change water every day 2～3 times, go most saline taste, taking-up, puts in pot, adds water and bean curd with boiling, and to chewing, without picotement, takes out, and removes bean curd, and airing, to outer dry interior profit, is cut wafer thin, dries sieve dedust bits;

(5) Radix Stephaniae Tetrandrae: former medicine washes, pulls out and runs through, and section, dries;

(6) Radix Glycyrrhizae Preparata: extracting liquorice sheet add cooked Mel and boiled water a little, mix thoroughly, slightly vexed, put in pot and fry to becoming buff with slow fire, tack-free is degree, taking-up cools, 100 jin, every Radix Glycyrrhizae, with refined honey 25-30 jin;

(7) Cortex Phellodendri: remove impurity, spray clear water, runs through, and shredding is dry;

(8) Caulis Spatholobi: water runs through, section, or steam after soft and take advantage of fervent sheet, dry;

(9) Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;

(10) Radix Gentianae Macrophyllae: choose decontamination, except removing LU, slightly soak, run through section, dry;

(11) Caulis Lonicerae: choose decontamination, be soaked in water, run through, section, dries;

(12) Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;

(13) Semen Armeniacae Amarum: choose clean impurity, put in boiling water and slightly boil, treat that Pi Wei purses up to pull out, soak in cold water, slough kind of a skin, dry, winnow with a dustpan clean;

(14) Radix Rehmanniae: water slightly steeps, cleans sediment contamination, pulls stewing profit out, and section is dried or dried;

(15) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;

(16) Ramulus Cinnamomi: water slightly soaks, pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;

(2) preparation

(1) Herba Viciae Amoenae of described weight, Eupolyphaga Seu Steleophaga, Radix Achyranthis Bidentatae, RADIX ACONITILATERALIS PREPARATA, Radix Stephaniae Tetrandrae, Radix Glycyrrhizae Preparata, Cortex Phellodendri, Caulis Spatholobi, Lumbricus, Radix Gentianae Macrophyllae, Caulis Lonicerae, Semen Persicae, Semen Armeniacae Amarum, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi are decocted with water, add for the first time 6 times of amounts of water, soak 60 minutes, decoct with high heat boiling 30 minutes, use again slow fire boiling 20 minutes, obtain decoction liquor for the first time;

(2) will filter for the first time rear medicinal residues and add 3 times of amounts of water, and decoct boiling, then within 15 minutes, obtain decoction liquor for the second time with slow fire boiling;

(3) twice decoction liquor mixed, then use slow fire boiling 20 minutes, medicinal liquid is divided into 2 doses and takes.