CN104208587A - Medicine for treating osteoarthritis and preparation method thereof - Google Patents
Medicine for treating osteoarthritis and preparation method thereof Download PDFInfo
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- CN104208587A CN104208587A CN201410453154.6A CN201410453154A CN104208587A CN 104208587 A CN104208587 A CN 104208587A CN 201410453154 A CN201410453154 A CN 201410453154A CN 104208587 A CN104208587 A CN 104208587A
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Abstract
The invention discloses a medicine for treating osteoarthritis and a preparation method thereof. The medicine is mainly prepared from the following components in a certain weight ratio: fructus psoraleae, wallich pepper stem and leaf, radix aconiti sinensis, aconitum kusnezoffii, caulis sinomenii, semen cuscutae, frankincense, myrrh, rhizoma cibotii, gentiana macrophylla, earthworm, radix cyathulae, herba pyrolae, herba taxilli, fructus rosae laevigatae, berba aristolochiae mollissimae, eucommia ulmoides, rhizoma arisaematis, honeysuckle stem, vicia amoena, suberect spatholobus stem, radix stephaniae tetrandrae, turmeric, scutellaria baicalensis and lycopodium clavatum. The medicine has the functions of dispelling wind, relieving pain, relaxing tendons, dredging collaterals, regulating qi circulation and activating blood circulation, has the advantages of high effect taking speed, good curative effect and no toxic or side effect when being used for treating osteoarthritis.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of osteoarthritis and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Osteoarthritis is a kind of degeneration, be the articular cartilage degeneration damage because the factors such as increasing age, obesity, strain, wound, joint birth defect, joint deformity cause, joint margins and subchondral bone reactive hyperplasia, also known as osteoarthritis, degenerative osteoarthritis, senile arthritis, hypertrophiarthritis etc.Clinical manifestation is the arthralgia of slowly development, tenderness, stiff, arthroncus, limitation of activity and joint deformity etc.Because Western medicine effectively cannot treat osteoarthritis, and long-term taking Western medicine has side effect to human body.Therefore there is great demand in the Chinese medicine of people to rapid, effective treatment osteoarthritis, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, through research experiment repeatedly and clinical checking repeatedly, finally have found the medicine of effectively treatment osteoarthritis, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment osteoarthritis.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Fructus Psoraleae, Caulis et Folium piperis, Radix Aconiti, Radix Aconiti Kusnezoffii, Caulis Sinomenii, Semen Cuscutae, Olibanum, Myrrha, Rhizoma Cibotii, Radix Gentianae Macrophyllae, Lumbricus, Radix Cyathulae, Herba Pyrolae, Herba Taxilli, Fructus Rosae Laevigatae, Herba Aristolochiae Mollissimae, the Cortex Eucommiae, Rhizoma Arisaematis, Caulis Lonicerae, Herba Viciae Amoenae, Caulis Spatholobi, Radix Stephaniae Tetrandrae, Rhizoma Curcumae Longae, Radix Scutellariae, Herba Lycopodii medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat osteoarthritis.Fructus Psoraleae is selected to be that temperature, enter kidney channel, have the function of reinforcing the kidney and supporting YANG, control cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and coughed, external curing vitiligo because its nature and flavor are pungent.Caulis et Folium piperis is selected to be that temperature, enter liver, spleen, small intestinal three warp, have wind-damp dispelling, the meridian dredging, strong waist foot, the function of pain relieving, controls anemofrigid-damp arthralgia, bones and muscles pain, lumbago, postoperative pain because its nature and flavor are pungent.Select Radix Aconiti, different name Radix Aconiti, its nature and flavor are pungent, heat, poisonous, enter spleen, the gate of vitality two warp, have dispelling cold and dampness, loose ailment said due to cold or exposure, warming the meridian, and the function of pain relieving, controls anemofrigid-damp arthralgia, severe and migratory arthralgia pain, spasm of the limbs, and hemiplegia, wind syndrome of head is had a headache, trusted subordinate's cold type of pain, carbuncle of yin nature toxic swelling.Select Radix Aconiti Kusnezoffii, different name Radix Aconiti Kusnezoffii, its nature and flavor are pungent, heat, poisonous, enter liver, spleen, lung meridian, search wind prevailing over dampness, dispersing cold for relieving pain, open expectorant, the function of detumescence, controls anemofrigid-damp arthralgia, paralysis due to windstroke, tetanus, wind syndrome of head, coldness and pain in the epigastrium, accumulation of phlegm in the hypochondrium, air parcel, cold-dysentery, sore throat, carbuncle, furuncle, scrofula.Select Caulis Sinomenii to be because its nature and flavor hardship is flat, have wind-damp dispelling, the function of profit inconvenience, dispelling the wind and dampness pathogens arthralgia pain, the arthroncus of knee, edema, beriberi.Select Semen Cuscutae to be because its property acrid-sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quench one's thirst, dripping urination, order is dark.Select Olibanum to be that temperature, enters the heart, liver, spleen channel, have regulating qi and activating blood, analgesic therapy because its nature and flavor are worked hard, chase after the function of poison, control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Myrrha is selected to be that flat, enter Liver Channel, have loose blood blood stasis removing, the function of subduing swelling and relieving pain, controls and fall damage, incised wound, muscles and bones, trusted subordinate all Tong ， mass in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye because its nature and flavor are bitter.Select Rhizoma Cibotii to be because its property bitter but sweet flavor, temperature, enters liver, kidney channel, has invigorating the liver and kidney, and except rheumatism, strong waist foot, the function in sharp joint, controls back ache, gonalgia flaccidity of the lower limbs, cold-damp general arthralgia, loses and drowns, frequent micturition, seminal emission, leucorrhea.Radix Gentianae Macrophyllae is selected to be because its nature and flavor toil, flat, enter liver, stomach, gallbladder meridian, have expelling wind and removing dampness, and blood relaxing muscles and tendons, the function of clearing away heat and promoting diuresis, dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.Lumbricus is selected to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, have heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control high fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Radix Cyathulae is selected to be that the micro-hardship of bitter in the mouth, nontoxic, enter liver, kidney two warp, dispel the wind, dampness removing, stimulates the menstrual flow, the function of invigorating blood circulation, dispelling the wind and dampness pathogens lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea ， mass in the abdomen because its nature and flavor are put down.Select Herba Pyrolae to be because its nature and flavor sweetness and bitterness, temperature, enters liver, kidney two warp, has tonify deficiency, kidney tonifying, expelling wind and removing dampness, the function of promoting blood flow to regulate menstruation, controls weak cough, over-strained hemoptysis, rheumatic arthritis, metrorrhagia, leucorrhea, traumatic hemorrhage.Select Herba Taxilli to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive function, controls soreness of waist and knee joint, and muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Fructus Rosae Laevigatae is selected to be that flat, have reinforcing the kidney and controlling nocturnal emission, the function of reducing urination and antidiarrheal, controls spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen dysentery because its nature and flavor are sour and astringent.Herba Aristolochiae Mollissimae is selected to be because its nature and flavor are bitter, flat, dispelling the wind and dampness pathogens arthralgia, stomachache, malaria, carbuncle.Select the Cortex Eucommiae be because its nature and flavor sweet micro-pungent, temperature, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, antiabortive function, control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, hypertension.Selection of rhizoma arisaematis because of their bitter taste, temperature, toxic, into the lung, liver, spleen, with dry wet phlegm, wind to calm the frightened, the function of detumescence fights, cure phlegm indicates a stroke, facial hemiparalysis, hemiparalysis, epilepsy, present concern.charlotte, tetanus, wind phlegm vertigo, throat bi, scrofula, carbuncle swollen, down injured, snake insect bites.Caulis Lonicerae is selected to be because its nature and flavor are sweet, cold, enter the heart, lung meridian, have heat clearing away, removing toxic substances, the function of dredging collateral, control epidemic febrile disease heating, toxic-heat and blood stasis, infectious hepatitis, carbuncle sore tumefacting virus, bones and muscles pain.Select Herba Viciae Amoenae, call bean seedling, mountain Semen sojae atricolor, Herba speranskiae tuberculatae, be because its nature and flavor sweetness and bitterness, temperature, has wind-damp dispelling, invigorates blood circulation, relaxing muscles and tendons, the function of pain relieving, and dispelling the wind and dampness pathogens pain, sprain and contusion are hindered, innominate toxic swelling, eczema scrotum.Select Caulis Spatholobi to be because its property bitter but sweet flavor, temperature, enters the heart, spleen two warp, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Radix Stephaniae Tetrandrae to be because its nature and flavor are bitter, cold, enter wing thorax, spleen, kidney channel, have row water, rush down the function of damp-heat in lower-JIAO, swollen tympanites of harnessing the river, hygropyretic beriberi, brothers' spasm and pain, tinea scabies swells.Select Rhizoma Curcumae Longae to be that temperature, enters spleen, Liver Channel, have removing blood stasis, circulation of qi promoting, stimulate the menstrual flow, the function of pain relieving, control trusted subordinate's feeling of fullness distending pain, brachialgia ， mass in the abdomen, women's blood stasis amenorrhea because its nature and flavor are worked hard, puerperal, the stasis of blood stopped stomachache, injury from falling down, carbuncle.Select Radix Scutellariae to be because its nature and flavor bitter cold, enter cardiopulmonary, gallbladder, large intestine channel, have removing the relative excess fire, except damp and hot, the function of arresting bleeding and miscarriage prevention, controls high fever excessive thirst, cough due to lung-heat.Select Herba Lycopodii to be because its nature and flavor toil, temperature, enters liver, stomach, kidney three warp, has expelling wind and cold, and dehumidifying detumescence, the function of relaxing muscles and tendons to promote blood circulation, controls anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis, edema, traumatic injury.
detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:
Fructus Psoraleae 6-9 gram of Caulis et Folium piperis 9-15 gram of Radix Aconiti 5-8 gram
Radix Aconiti Kusnezoffii 5-8 gram of Caulis Sinomenii 20-25 gram of Semen Cuscutae 9-15 gram
Olibanum 6-9 gram of Myrrha 12-20 gram of Rhizoma Cibotii 9-15 gram
Radix Gentianae Macrophyllae 9-15 gram of Lumbricus 8-15 gram of Radix Cyathulae 8-15 gram
Herba Pyrolae 25-30 gram of Herba Taxilli 20-30 gram of Fructus Rosae Laevigatae 9-15 gram
Herba Aristolochiae Mollissimae 15-25 gram Cortex Eucommiae 15-25 gram Rhizoma Arisaematis 3-5 gram
Caulis Lonicerae 25-35 Keshan vetch 15-25 gram of Caulis Spatholobi 25-30 gram
Radix Stephaniae Tetrandrae 9-15 gram of Rhizoma Curcumae Longae 3-9 gram of Radix Scutellariae 9-15 gram
Herba Lycopodii 9-15 gram
Be preferably
Fructus Psoraleae 6 grams of Caulis et Folium piperis 12 grams of Radix Aconitis 6 grams
Radix Aconiti Kusnezoffii 6 grams of Caulis Sinomeniis 22 grams of Semen Cuscutae 10 grams
Olibanum 8 grams of Myrrhas 15 grams of Rhizoma Cibotii 12 grams
Radix Gentianae Macrophyllae 12 grams of Lumbricuss 9 grams of Radix Cyathulaes 9 grams
Herba Pyrolae 25 grams of Herba Taxillis 25 grams of Fructus Rosae Laevigatae 12 grams
Herba Aristolochiae Mollissimae 22 grams of Cortexs Eucommiae 20 grams of Rhizoma Arisaematiss 4 grams
Caulis Lonicerae 30 Keshan vetch 20 grams of Caulis Spatholobis 25 grams
Radix Stephaniae Tetrandrae 12 grams of Rhizoma Curcumae Longaes 6 grams of Radix Scutellariaes 12 grams
Herba Lycopodii 12 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Fructus Psoraleae: clean impurity of winnowing with a dustpan, cleans, dries;
2, Caulis et Folium piperis: wash, soaks, runs through, cutting, dry;
3, Radix Aconiti: pick decontamination, cleans ash bits, dries;
4, Radix Aconiti Kusnezoffii: get crude drug, removing impurity, cleaning, drying, the used time smashs to pieces;
5, Caulis Sinomenii: the autumn and winter adopt old rattan, cutting is dried;
6, Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;
7, Olibanum: pick the sub-impurity of shakeout;
8, Myrrha: pick decontamination, breaks into fragment;
9, Rhizoma Cibotii: get sand and put the interior stir-fry of pot to easily, add and pick clean Rhizoma Cibotii, fry to heaving and showing buff with high heat, take out, screen out sand, after wind dries in the air, hits or scraping Huang floss hair;
10, Radix Gentianae Macrophyllae: pick decontamination, except removing LU, slightly soaks, runs through section, dry;
11, Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
12, Radix Cyathulae: pick decontamination, dries;
13, Herba Pyrolae: pick decontamination, sieve removes silt, cleans, slightly moistens, chop up, dry;
14, Herba Taxilli: wash, runs through, and cutting is dried;
15, Fructus Rosae Laevigatae: pick decontamination, cuts two lobes, slightly soaks with water, pull out, and after moistening, the residual burr of removing, digs clean hair, core, dry;
16, Herba Aristolochiae Mollissimae: gather before blooming May, dry;
17, the Cortex Eucommiae: removing rough bark, clean, run through, dice or strand, dry;
18, Rhizoma Arisaematis: pick decontamination, cleans ash bits, dries;
19, Caulis Lonicerae: pick decontamination, is soaked in water, and runs through, and section, dries;
20, Herba Viciae Amoenae: pick decontamination, dries;
21, Caulis Spatholobi: run through with water, section, or steam soft after cut into slices while hot, dry;
22, Radix Stephaniae Tetrandrae: former medicine washes, and pulls out and runs through, section, dries;
23, Rhizoma Curcumae Longae: pick decontamination, is soaked in water, and picks up, and runs through rear section, dries;
24, Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;
25, Herba Lycopodii: sieve dedust bits, pick clean impurity, be cut into segment.
Two, prepare
(1) preparation of oral liquid
1, by the Fructus Psoraleae of described weight, Caulis et Folium piperis, Radix Aconiti, Radix Aconiti Kusnezoffii, Caulis Sinomenii, Semen Cuscutae, Olibanum, Myrrha, Rhizoma Cibotii, Radix Gentianae Macrophyllae, Lumbricus, Radix Cyathulae, Herba Pyrolae, Herba Taxilli, Fructus Rosae Laevigatae, Herba Aristolochiae Mollissimae, the Cortex Eucommiae, Rhizoma Arisaematis, Caulis Lonicerae, Herba Viciae Amoenae, Caulis Spatholobi, Radix Stephaniae Tetrandrae, Rhizoma Curcumae Longae, Radix Scutellariae, Herba Lycopodii decocts with water twice, first time adds water 6 times amount, and intense fire decocts boiling 10 minutes, then uses slow fire boiling 25 minutes, filter first time decoction liquor.
2, add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor.
3, merge twice decoction liquor, intense fire boils, then within 10 minutes, namely obtains medicinal liquid with slow fire boiling, is divided into two doses to take.
(2) preparation of pill
1, by the Fructus Psoraleae of described weight, Caulis et Folium piperis, Radix Aconiti, Radix Aconiti Kusnezoffii, Caulis Sinomenii, Semen Cuscutae, Olibanum, Myrrha, Rhizoma Cibotii, Radix Gentianae Macrophyllae, Lumbricus, Radix Cyathulae, Herba Pyrolae, Herba Taxilli, Fructus Rosae Laevigatae, Herba Aristolochiae Mollissimae, the Cortex Eucommiae, Rhizoma Arisaematis, Caulis Lonicerae, Herba Viciae Amoenae, Caulis Spatholobi, Radix Stephaniae Tetrandrae, Rhizoma Curcumae Longae, Radix Scutellariae, Herba Lycopodii decocts with water twice, add water 8 times amount for the first time, decoct 1.5 hours, add water 6 times amount for the second time, decoct 1 hour, merge twice decoction liquor, be condensed into the extractum that proportion is 1.35, extractum is added the ethanol of 90%-95%, stir, precipitation reclaims ethanol and concentrates, dry at 45 DEG C-50 DEG C, obtained dry extract.
2, dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, make pill.
Medicine of the present invention has wind-expelling pain-stopping, channels sootheing and network vessel quickening, regulating qi and activating blood, invigorating the liver and kidney, bone and muscle strengthening, and analgesic therapy chases after the function of poison, is used for the treatment of osteoarthritis instant effect, good effect, has no side effect.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 38 examples for medical treatment.
2, diagnostic criteria
Cardinal symptom is arthralgia, often betides daystart, and after movable, pain alleviates on the contrary, but as hyperactivity, pain can increase the weight of again.Another symptom is ankylosis, often appears at WA or after daytime, joint kept certain position for a long time in morning.Check the swelling of affected joints visible joint, tenderness, have friction sense or " click clatter " sound time movable, the person of being in a bad way can have amyotrophy and joint deformity.
3, Therapeutic Method
Selecting above-mentioned medicinal liquid, take to patient, every twice-daily, each potion, or take pill, every twice-daily, each 0.8 gram, 20 days is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: osteoarthritis pathological changes symptom is controlled, physical efficiency recovery is normal, recovery from illness;
Take a turn for the better: osteoarthritis pathological changes symptom alleviates, and patient sign improves, and the state of an illness progressively takes a turn for the better;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy Human Osteoarthritis 38 example of the present invention, effective 31 examples of result, obvious effective rate is 81.58%, and take a turn for the better 5 examples, and improvement rate is 13.16%, and invalid 2 examples, total effective rate is 94.74%.
Claims (3)
1. treat a medicine for osteoarthritis, it is characterized in that: it is made up of the crude drug in following weight range:
Fructus Psoraleae 6-9 gram of Caulis et Folium piperis 9-15 gram of Radix Aconiti 5-8 gram
Radix Aconiti Kusnezoffii 5-8 gram of Caulis Sinomenii 20-25 gram of Semen Cuscutae 9-15 gram
Olibanum 6-9 gram of Myrrha 12-20 gram of Rhizoma Cibotii 9-15 gram
Radix Gentianae Macrophyllae 9-15 gram of Lumbricus 8-15 gram of Radix Cyathulae 8-15 gram
Herba Pyrolae 25-30 gram of Herba Taxilli 20-30 gram of Fructus Rosae Laevigatae 9-15 gram
Herba Aristolochiae Mollissimae 15-25 gram Cortex Eucommiae 15-25 gram Rhizoma Arisaematis 3-5 gram
Caulis Lonicerae 25-35 Keshan vetch 15-25 gram of Caulis Spatholobi 25-30 gram
Radix Stephaniae Tetrandrae 9-15 gram of Rhizoma Curcumae Longae 3-9 gram of Radix Scutellariae 9-15 gram
Herba Lycopodii 9-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Fructus Psoraleae 6 grams of Caulis et Folium piperis 12 grams of Radix Aconitis 6 grams
Radix Aconiti Kusnezoffii 6 grams of Caulis Sinomeniis 22 grams of Semen Cuscutae 10 grams
Olibanum 8 grams of Myrrhas 15 grams of Rhizoma Cibotii 12 grams
Radix Gentianae Macrophyllae 12 grams of Lumbricuss 9 grams of Radix Cyathulaes 9 grams
Herba Pyrolae 25 grams of Herba Taxillis 25 grams of Fructus Rosae Laevigatae 12 grams
Herba Aristolochiae Mollissimae 22 grams of Cortexs Eucommiae 20 grams of Rhizoma Arisaematiss 4 grams
Caulis Lonicerae 30 Keshan vetch 20 grams of Caulis Spatholobis 25 grams
Radix Stephaniae Tetrandrae 12 grams of Rhizoma Curcumae Longaes 6 grams of Radix Scutellariaes 12 grams
Herba Lycopodii 12 grams.
3. the preparation method of medicine according to right 1 or 2, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Fructus Psoraleae: clean impurity of winnowing with a dustpan, cleans, dries;
(2) Caulis et Folium piperis: wash, soaks, runs through, cutting, dry;
(3) Radix Aconiti: pick decontamination, cleans ash bits, dries;
(4) Radix Aconiti Kusnezoffii: get crude drug, removing impurity, cleaning, drying, the used time smashs to pieces;
(5) Caulis Sinomenii: the autumn and winter adopt old rattan, cutting is dried;
(6) Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;
(7) Olibanum: pick the sub-impurity of shakeout;
(8) Myrrha: pick decontamination, breaks into fragment;
(9) Rhizoma Cibotii: get sand and put the interior stir-fry of pot to easily, add and pick clean Rhizoma Cibotii, fry to heaving and showing buff with high heat, take out, screen out sand, after wind dries in the air, hits or scraping Huang floss hair;
(10) Radix Gentianae Macrophyllae: pick decontamination, except removing LU, slightly soaks, runs through section, dry;
(11) Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;
(12) Radix Cyathulae: pick decontamination, dries;
(13) Herba Pyrolae: pick decontamination, sieve removes silt, cleans, slightly moistens, chop up, dry;
(14) Herba Taxilli: wash, runs through, and cutting is dried;
(15) Fructus Rosae Laevigatae: pick decontamination, cuts two lobes, slightly soaks with water, pull out, and after moistening, the residual burr of removing, digs clean hair, core, dry;
(16) Herba Aristolochiae Mollissimae: gather before blooming May, dry;
(17) Cortex Eucommiae: removing rough bark, clean, run through, dice or strand, dry;
(18) Rhizoma Arisaematis: pick decontamination, cleans ash bits, dries;
(19) Caulis Lonicerae: pick decontamination, is soaked in water, and runs through, and section, dries;
(20) Herba Viciae Amoenae: pick decontamination, dries;
(21) Caulis Spatholobi: run through with water, section, or steam soft after cut into slices while hot, dry;
(22) Radix Stephaniae Tetrandrae: former medicine washes, and pulls out and runs through, section, dries;
(23) Rhizoma Curcumae Longae: pick decontamination, is soaked in water, and picks up, and runs through rear section, dries;
(24) Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;
(25) Herba Lycopodii: sieve dedust bits, pick clean impurity, be cut into segment;
(2) prepare
(1) preparation of oral liquid
1. by the Fructus Psoraleae of described weight, Caulis et Folium piperis, Radix Aconiti, Radix Aconiti Kusnezoffii, Caulis Sinomenii, Semen Cuscutae, Olibanum, Myrrha, Rhizoma Cibotii, Radix Gentianae Macrophyllae, Lumbricus, Radix Cyathulae, Herba Pyrolae, Herba Taxilli, Fructus Rosae Laevigatae, Herba Aristolochiae Mollissimae, the Cortex Eucommiae, Rhizoma Arisaematis, Caulis Lonicerae, Herba Viciae Amoenae, Caulis Spatholobi, Radix Stephaniae Tetrandrae, Rhizoma Curcumae Longae, Radix Scutellariae, Herba Lycopodii decocts with water twice, first time adds water 6 times amount, and intense fire decocts boiling 10 minutes, then uses slow fire boiling 25 minutes, filter first time decoction liquor;
2. add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor;
3. merge twice decoction liquor, intense fire boils, then within 10 minutes, namely obtains medicinal liquid with slow fire boiling, is divided into two doses to take;
(2) preparation of pill
1. by the Fructus Psoraleae of described weight, Caulis et Folium piperis, Radix Aconiti, Radix Aconiti Kusnezoffii, Caulis Sinomenii, Semen Cuscutae, Olibanum, Myrrha, Rhizoma Cibotii, Radix Gentianae Macrophyllae, Lumbricus, Radix Cyathulae, Herba Pyrolae, Herba Taxilli, Fructus Rosae Laevigatae, Herba Aristolochiae Mollissimae, the Cortex Eucommiae, Rhizoma Arisaematis, Caulis Lonicerae, Herba Viciae Amoenae, Caulis Spatholobi, Radix Stephaniae Tetrandrae, Rhizoma Curcumae Longae, Radix Scutellariae, Herba Lycopodii decocts with water twice, add water 8 times amount for the first time, decoct 1.5 hours, add water 6 times amount for the second time, decoct 1 hour, merge twice decoction liquor, be condensed into the extractum that proportion is 1.35, extractum is added the ethanol of 90%-95%, stir, precipitation reclaims ethanol and concentrates, dry at 45 DEG C-50 DEG C, obtained dry extract,
2. dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, make pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410453154.6A CN104208587A (en) | 2014-09-09 | 2014-09-09 | Medicine for treating osteoarthritis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410453154.6A CN104208587A (en) | 2014-09-09 | 2014-09-09 | Medicine for treating osteoarthritis and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036386A (en) * | 2016-05-27 | 2016-10-26 | 黄莉娟 | Instant powder for treating rheumatic heart disease and preparation method thereof |
| CN113144145A (en) * | 2021-04-29 | 2021-07-23 | 广州周氏古法医药科技有限公司 | Spray for tendon and bone |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1676143A (en) * | 2004-04-02 | 2005-10-05 | 四川倍达尔新技术开发有限公司 | Chinese medicine compound formulation for treating rheumatism |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1676143A (en) * | 2004-04-02 | 2005-10-05 | 四川倍达尔新技术开发有限公司 | Chinese medicine compound formulation for treating rheumatism |
Non-Patent Citations (1)
| Title |
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| 王定等: "膝骨性关节炎中医药治疗的研究进展", 《中国中医骨伤科杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036386A (en) * | 2016-05-27 | 2016-10-26 | 黄莉娟 | Instant powder for treating rheumatic heart disease and preparation method thereof |
| CN113144145A (en) * | 2021-04-29 | 2021-07-23 | 广州周氏古法医药科技有限公司 | Spray for tendon and bone |
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Application publication date: 20141217 |