CN103735645B - A kind of medicine for the treatment of lumbago and skelalgia - Google Patents

Abstract

The invention discloses a kind of medicine for the treatment of lumbago and skelalgia and preparation method thereof, it is mainly prepared from according to a certain weight ratio by Squama Manis, Semen Momordicae, Semen Strychni, Alumen, Realgar, the first-class medicine of Radix Aconiti, medicine of the present invention has removing blood stasis and activating blood flow, dredge the meridian passage, the function of subduing swelling and relieving pain, be used for the treatment of lumbago and skelalgia instant effect, good effect, do not recur.

Description

A kind of medicine for the treatment of lumbago and skelalgia

Technical field

The present invention relates to a kind of medicine for the treatment of lumbago and skelalgia and preparation method thereof, belong to the field of Chinese medicines.

Background technology

The surgical disease that lumbago and skelalgia is is cardinal symptom with waist and leg pain.Lumbago and skelalgia is many to be dodged wound, chronic strain because turning round and is affected by the cold caused by damp.The lighter's lumbago, can alleviate, then meet slight wound or experience cold-damp and still can recur or increase the weight of after having a rest; Severe one lumbago, and on rear side of thigh and after shank, outside and outside of foot radiate pain, aggravating when rotation, cough, sneeze, there is lateral bending in psoas muscle spasm.Straight-leg raising test is positive, and there is feeling of numbness on the little leg outer side of Ipsilateral or instep, even can occur intermittent claudication.Lumbago and skelalgia is mainly by intervertebral disk hernia, and hyperosteogeny, osteoporosis, lumbar muscle strain, rheumatism atrophic arthritis or tumor, congenital dysplasia etc. bring out.Be multiple with 25 ~ 50 years old long-term physical work or long-term sitting crowd.At present, because Western medicine effectively cannot treat lumbago and skelalgia, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effectively treating lumbago and skelalgia.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment lumbago and skelalgia, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating lumbago and skelalgia.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Squama Manis, Semen Momordicae, Semen Strychni, Alumen, Realgar, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Angelicae Pubescentis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Epimedii, Radix Cyathulae, Radix Glycyrrhizae, Mel medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating lumbago and skelalgia.Wherein select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of stimulating milk secretion of stimulating the menstrual flow, control carbuncle skin ulcer and swell, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external is stopped blooding.Semen Momordicae is selected to be because its property bitter but slightly sweet taste, temperature, poisonous, enter liver, spleen, stomach warp, have dispersing swelling and dissipating binds, the function of toxic removing, control carbuncle, furuncle, scrofula, hemorrhoid, innominate toxic swelling, tinea skin ulcer, rheumatic arthralgia, the contracture of muscle arteries and veins.Select Semen Strychni to be because its nature and flavor are bitter, cold, poisonous, have loose heat in blood, detumescence, the function of pain relieving, controls throat arthralgia pain, swollen ulcer drug, migratory arthralgia pain, fracture, and controls facial paralysis, myasthenia gravis.Alumen is selected to be because its nature and flavor are sour and astringent, cold, poisonous, enter lung, spleen, stomach, large intestine channel, there is expectorant, dampness, antidiarrheal, removing toxic substances, the function of parasite killing, Zhi epilepsy, sore throat, sputum is stopped up very, hepatitis, jaundice, general edema with yellowish skin, taste-blindness rate, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, water, fire, insect bite.Realgar is selected to be that temperature, poisonous, have dampness, dispel the wind, parasite killing, the function of removing toxic substances, controls scabies, tinea alba, carbuncle, acute gangrenous stomatitis, herpes zoster, tetanus, snakeworm sting, bromhidrosis, ecthyma, asthma, sore throat ， Jing Epilepsy, hemorrhoid complicated by anal fistula because its nature and flavor are worked hard.Select Radix Aconiti, different name Radix Aconiti, its nature and flavor are pungent, heat, poisonous, enter spleen, the gate of vitality two warp, have dispelling cold and dampness, loose ailment said due to cold or exposure, warming the meridian, and the function of pain relieving, controls anemofrigid-damp arthralgia, severe and migratory arthralgia pain, spasm of the limbs, and hemiplegia, wind syndrome of head is had a headache, trusted subordinate's cold type of pain, carbuncle of yin nature toxic swelling.Select Radix Aconiti Kusnezoffii, different name Radix Aconiti Kusnezoffii, its nature and flavor are pungent, heat, poisonous, enter liver, spleen, lung meridian, search wind prevailing over dampness, dispersing cold for relieving pain, open expectorant, the function of detumescence, controls anemofrigid-damp arthralgia, paralysis due to windstroke, tetanus, wind syndrome of head, coldness and pain in the epigastrium, accumulation of phlegm in the hypochondrium, air parcel, cold-dysentery, sore throat, carbuncle, furuncle, scrofula.Select Radix Angelicae Pubescentis to be that temperature, enters kidney, urinary bladder channel, dispel the wind because its nature and flavor are worked hard, victory is wet, cold expelling, and the function of pain relieving, controls anemofrigid-damp arthralgia, waist urushic acid pain, trick spasm and pain, chronic tracheitis, headache, toothache.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Herba Epimedii to be because its property acrid-sweet flavor, temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting, the function of expelling wind and removing dampness, control sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, and hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Radix Cyathulae is selected to be that the micro-hardship of bitter in the mouth, nontoxic, enter liver, kidney two warp, dispel the wind, dampness removing, stimulates the menstrual flow, the function of invigorating blood circulation, dispelling the wind and dampness pathogens lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea ， mass in the abdomen because its nature and flavor are put down.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Mel to be that flat, enter lung, spleen, large intestine channel, have invigorating middle warmer, moisturize, pain relieving, the function of removing toxic substances, controls xeropulmonary cough, dryness of the intestine constipation, gastralgia, nasal sinusitis, aphtha, the burning hot wound of soup because its nature and flavor are sweet, separate Aconitum Carmichaeli.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Squama Manis 130-180 gram of Semen Momordicae 80-120 Rana nigromaculata Semen Strychni 8-12 gram

Alumen 40-60 gram of Realgar 8-12 gram of Radix Aconiti 80-120 gram

Radix Aconiti Kusnezoffii 80-120 gram of Radix Angelicae Pubescentis 80-120 gram of Rhizoma Chuanxiong 100-150 gram

Radix Angelicae Sinensis 100-150 gram of Herba Epimedii 80-120 gram of Radix Cyathulae 100-150 gram

Radix Glycyrrhizae 80-120 gram of Mel 490-510 gram

Preferable amount is

Squama Manis 150 grams of Semen Momordicae 100 Rana nigromaculata Semen Strychni 10 grams

Alumen 40 grams of Realgars 10 grams of Radix Aconitis 100 grams

Radix Aconiti Kusnezoffii 100 grams of Radix Angelicae Pubescentiss 100 grams of Rhizoma Chuanxiongs 125 grams

Radix Angelicae Sinensis 125 grams of Herba Epimedii 100 grams of Radix Cyathulaes 125 grams

Radix Glycyrrhizae 100 grams of Mel 500 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, stir-baked SQUAMA MANITIS: get the Squama Manis sheet picking clean, separately size, separately puts sand in pot and makes popular, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;

2, Semen Momordicae: removing impurity, clean, dry, used time Fructus Forsythiae is smashed, or shells and get core;

3, Semen Strychni: get sand, puts in pot and makes popular, adds and picks clean Semen Strychni, fries to being buff and heaving taking-up, and sieve shakeout, scrapes unhairing, levigation;

4, calcined Alumen: get and pick clean Alumen, puts heating in marmite and dissolves and be calcined to dried-up, take out, chop block;

5, Realgar: be ground into impalpable powder, or water flies, and dries;

6, Radix Aconiti: pick decontamination, cleans ash bits, dries;

7, Radix Aconiti Kusnezoffii: get crude drug, removing impurity, cleaning, drying, the used time smashs to pieces;

8, Radix Angelicae Pubescentis: pick decontamination, separately size, clean, run through rear section, dry;

9, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;

10, Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;

11, Herba Epimedii: pick clean impurity, destemming, shredding, sieve removes chip;

12, Radix Cyathulae: pick decontamination, dries;

13, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;

14, Mel: get pure Mel, temper with slow fire, filters skimming.

Two, prepare

The Squama Manis of described weight, Semen Momordicae, Semen Strychni, Alumen, Realgar, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Angelicae Pubescentis, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Epimedii, Radix Cyathulae, Radix Glycyrrhizae medicine are put into container grind into powder, add the Mel of described weight, stir, make honeyed pill, 2.5 grams, every ball.

Medicine of the present invention has removing blood stasis and activating blood flow, dredge the meridian passage, effect of subduing swelling and relieving pain, and treatment lumbago and skelalgia instant effect, short treating period, do not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is each 1 ball, and normal amount is each 0.5 ball, and administering mode is the administration of dilution administration by gavage, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient 237 example for medical treatment.

2, diagnostic criteria

Lumbago and skelalgia is with waist and leg pain for cardinal symptom, and the lighter shows as lumbago, and severe one, except lumbago, also to leg radiation pain, and psoas muscle spasm, occurs lateral bending.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving using 2 balls, every day early, evening respectively takes 1 time, within 10 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: treating lumbocrural pain removes, without recurring after observing half a year;

Take a turn for the better: lumbago and skelalgia symptom is clearly better;

Invalid: symptom, without improvement, does not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, by Drug therapy lumbago and skelalgia patient 237 example of the present invention, effective 228 examples of result, obvious effective rate is 96.2%, and take a turn for the better 6 examples, and improvement rate is 2.53%, and invalid 3 examples, total effective rate is 98.73%.

Claims (2)

1. treat a medicine for lumbago and skelalgia, it is characterized in that: it is made up of the crude drug in following weight range:

Squama Manis 130-180 gram of Semen Momordicae 80-120 Rana nigromaculata Semen Strychni 8-12 gram

Alumen 40-60 gram of Realgar 8-12 gram of Radix Aconiti 80-120 gram

Radix Aconiti Kusnezoffii 80-120 gram of Radix Angelicae Pubescentis 80-120 gram of Rhizoma Chuanxiong 100-150 gram

Radix Angelicae Sinensis 100-150 gram of Herba Epimedii 80-120 gram of Radix Cyathulae 100-150 gram

Radix Glycyrrhizae 80-120 gram of Mel 490-510 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Squama Manis 150 grams of Semen Momordicae 100 Rana nigromaculata Semen Strychni 10 grams

Alumen 40 grams of Realgars 10 grams of Radix Aconitis 100 grams

Radix Aconiti Kusnezoffii 100 grams of Radix Angelicae Pubescentiss 100 grams of Rhizoma Chuanxiongs 125 grams

Radix Angelicae Sinensis 125 grams of Herba Epimedii 100 grams of Radix Cyathulaes 125 grams

Radix Glycyrrhizae 100 grams of Mel 500 grams.