CN1539448A - Drug for curing reheumatoid arthritis and atrophic artjritis - Google Patents
Drug for curing reheumatoid arthritis and atrophic artjritis Download PDFInfo
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- CN1539448A CN1539448A CNA031261310A CN03126131A CN1539448A CN 1539448 A CN1539448 A CN 1539448A CN A031261310 A CNA031261310 A CN A031261310A CN 03126131 A CN03126131 A CN 03126131A CN 1539448 A CN1539448 A CN 1539448A
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Abstract
A Chinese medicine for treating rheumatic arthritis and rheumatoid arthritis is prepared from 7 Chinese-medicinal materials including scorpion, chaenomeles fruit, safflower, Chinese angelica root, etc. Its advantage is high curative effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of rheumatism, rheumatoid arthritis, specifically is the medicine that raw material is made with the Chinese herbal medicine.
Background technology
Rheumatism, rheumatoid arthritis is a kind of obstinate commonly encountered diseases, the people who suffers from this disease can be difficult to stand because of arthralgia, this type of disease of treatment generally is to take or inject the different cultivars Western medicine according to patient's patient's condition at present, as hormone medicine or anti-inflammatory type medicine, but these medicines all have very big side effect, can damage other organs of patient, many for this reason medical personnels have studied some and have used Chinese herbal treatment rheumatism, the medicine of rheumatoid arthritis, in being the application documents of 00128564.X, number of patent application discloses a kind of treatment rheumatism, rheumatoid analgesic, this medicine is by Scorpio, Pheretima, eupolyphaga, Squama Manis, Hirudo, Formica fusca, nearly 30 flavor medicines such as Scolopendra are formed, this medicine makes rheumatism, patient with rheumatoid arthritis has reduced pain, but, therefore cost an arm and a leg because this drug component is more.
Summary of the invention
The objective of the invention is to: provide a kind of flavour of a drug few, side effect is little, taking convenience, the treatment rheumatism made from Chinese herbal medicine, the medicine of rheumatoid arthritis.
The present invention seeks to be achieved through the following technical solutions: promptly select for use have the treating blood disorders of dispeling the wind in China's Chinese medicine treasure-house, medicine that activating collaterals and eliminating stagnation, detumescence relieve the pain, and make the medicine of treatment rheumatism, rheumatoid arthritis by appropriate compatibility.In this medicine each component by weight, that is: Fructus Chaenomelis 50～70, Scorpio 50～100, Radix Saposhnikoviae 30～50, Flos Carthami 70～90, Radix Angelicae Sinensis 70～90, Radix Aconiti Preparata head 50～70, Semen Strychni (processed) 400～500.
Said medicine method is routinely made watered pill, and the weight of every pill is 2～3mg.
The flavour of a drug that comprise in the medicine of the present invention are less, so low price, in component of the present invention: Fructus Chaenomelis, Radix Angelicae Sinensis and Flos Carthami have promoting blood circulation, sharp joint, go the numbness carbuncle, the characteristic of restoring and treating injured soft tissues bone, function, the Radix Aconiti that Radix Saposhnikoviae has a treating blood disorders of delivering, dispel the wind to wet middle cold expelling, removing obstruction in the collateral to relieve pain, expelling wind and removing dampness, Scorpio energy dispersing pathogen accumulation, endogenous wind stopping spasmolytic, Semen Strychni can be eliminated and tie swollen, removing obstruction in the collateral to relieve pain, and the Scorpio use that matches with Semen Strychni, can restrict the eclamptogenic effect of Semen Strychni, in addition, adopted appropriate compatibility among the present invention, so make it have better curative effect.
For curative effect of the present invention is described, the inventor once chose 109 routine patients and did clinical observation, and these patients have muscle or arthrodynia respectively, sore place or fixing not moving or twinge and sore spot tenderness, and the patient feels affected part heating or fear of cold; Or patient's local swelling has scleroma or symptoms such as ankylosis deformity, activities adverse, amyotrophy is arranged.These patients are divided into two groups, and wherein treatment group is 79 examples, and matched group is 30 examples; In the treatment group: the age is 20-62 year, and the mean age is 37.2 years old, male's 32 examples, women's 47 examples, the course of disease are 1 month～11 years, and average course of disease is 3.6 years, among them: rheumatic arthritis patient's 49 examples, rheumatoid arthritis people 30 examples are among the patient: erythrocyte sedimentation rate 28-40mm/h person 19 examples, above person's 17 examples of 41mm/h, anti-" O "＞1: 400 35 example, rheumatoid factor positive person 22 examples, person's 21 examples that have the abnormal change mutually through the X-ray examination joint, bone density is lower than normal person's 48 examples; In the matched group: the age is 19～63 years old, and the mean age is 36.9 years old, male's 12 examples, women's 18 examples, the course of disease are 3 week～12 year, and average course of disease is 3.5 years, wherein: rheumatic arthritis patient's 17 examples, rheumatoid arthritis people 13 examples are among the patient: erythrocyte sedimentation rate 30～40mm/h person 6 examples, above person's 5 examples of 41mm/h, anti-" O "＞1: 400 11 example, rheumatoid factor positive person 8 examples, person's 7 examples that have the abnormal change mutually through the X-ray examination joint, bone density is lower than normal person's 20 examples; More than all patients' diagnosis, meet the RA diagnostic criteria of revising in 51 international ARA meetings passing through in June, 1987.
When treatment, the treatment group is taken the pill among the present invention, and instructions of taking is to take once after the supper every day, each 20～25, send down with eliminating cold for resuscitation water.Matched group is obeyed three times with feprazone sheet (production of Jinan, Shandong Jin Tai pharmaceutical factory) every day, obeys 100～200mg at every turn.Be two months two groups of courses of treatment, then evaluates curative effect.
Criterion of therapeutical effect: clinical cure: symptom all disappears, and it is normal that functional activity recovers, and main physico-chemical examination index anti-" O ", rheumatoid factor, erythrocyte sedimentation rate recover normal person for curing; Transference cure, function of joint is recovered substantially, arthralgia, swelling is clearly better or disappears, the physico-chemical examination index resists " O ", rheumatoid factor, erythrocyte sedimentation rate to recover normal, but arthralgia as yet not disappearance person be produce effects; Cardinal symptom disappears substantially, main joint function recovery or have made marked progress, can't take care of oneself to transfer to can take care of oneself, the joint is red, swollen, bitterly, remission such as expand, mainly the physical and chemical index person of making moderate progress is effective; With the treatment before compare the sings and symptoms no change, it is invalid that the physico-chemical examination index resists " O ", rheumatoid factor, erythrocyte sedimentation rate no change.
Two groups of curative effects compare [example (%)]
| Group | The example number | Cure | Produce effects | Effectively | Invalid | Effectively total |
| The treatment group | ????79 | ?25(31.6) | 39(49.4) | 9(11.4) | 6(7.6) | 73(92.4) |
| Matched group | ????30 | ?6(20.0) | 10(33.3) | 6(20.0) | 8(26.7) | 22(73.3) |
Untoward reaction after taking medicine:
| Group | Mucocutaneous symptom (xerostomia or erythra) | Gastrointestinal symptoms (stomach discomfort, constipation) | Hematuria routine, electrocardiogram, hepatic and renal function |
| The treatment group | 1 example is inferior | Do not have | No abnormal change |
| Matched group | 2 examples are inferior | 2 examples are inferior | No abnormal change |
Concrete case is put to the proof:
Case one
Chen Yuhong, woman, 30 years old, the peasant, suffered from rheumatoid arthritis 16 years, four skin joint migration pain 7 years, upper limb joint distortion, swell and ache the aggravation limitation of activity more than 5 years, go to see a doctor in November, 2000, during prescription on individual diagnosis, take prednisone for a long time, indometacin, ibuprofen and treatment by Chinese herbs, heavy when light during symptom, control repeatly and do not heal, check and find: both hands near-end articulations digitorum manus is that fusiformis changes, the metacarpophalangeal joints distortion, finger is the ulnar side deflection, the atrophy of elbow joint bending, serious obstruction activity, the metatarsophalangeal joints tenderness is obvious, and functional activity is limited.Through chemically examining: erythrocyte sedimentation rate 76mm/h, anti-" O "＞1: 500, the rheumatoid factor strong positive, X-ray film shows: two palms refer to and proximal interphalangeal joint has osteoporosis to change, and articular surface is coarse, gap turn narrow; Be diagnosed as rheumatoid arthritis; Medicine through obeying the present invention is after one month, and all arthralgias obviously alleviate, and arthroncus is obviously disappeared, dysfunction is significantly improved, result of laboratory test is: erythrocyte sedimentation rate 36mm/h, and rheumatoid factor is weak positive, and it is many February to continue this medicine of clothes, its result is on inspection again: arthralgia disappears, erythrocyte sedimentation rate 17mm/h, anti-" O "＜1: 250, rheumatoid factor is negative, X-ray film shows: osteoporosis also has improvement, and following up a case by regular visits to did not have recurrence in 1 year.
Case two
The English of prunus mume (sieb.) sieb.et zucc., the woman, 60 years old, the peasant, on January 13rd, 2002 with the prescription on individual diagnosis in more than 10 year of swelling and ache of extremities joint repeatedly, hospitalization once over 10 years is taken Radix Tripterygii Wilfordii, prednisone, indometacin and piroxicam, multiple medicine after the remission.Still obey prednisone before the prescription on individual diagnosis, anti-inflammatory pain medicine is kept, patient is still very violent because of arthralgia, palm or phalanx, elbow and the enlargement of knee joint symmetry, and be deformity, and for fusiformis changes, periarticular soft tissues swelling, and joint deadlock in morning was greater than 2 hours, and the patients function state is the IV level.Check and find: erythrocyte sedimentation rate 42mm/h, anti-" O "＞1: 500, the rheumatoid factor positive, pale tongue, white and thin fur, stringy pulse delay, and are diagnosed as rheumatoid arthritis; Medicine through obeying the present invention is after one month, and all arthralgias obviously alleviate, and arthroncus is obviously disappeared, continued to take medicine two months, through chemical examination: erythrocyte sedimentation rate, anti-" O " are normal, rheumatoid factor is turned out cloudy, and arthralgia, morning, deadlock was alleviated fully, adhered to taking medicine recurrence not yet so far after the drug withdrawal 5 months.
Case three
Ancient Chinese prose is good, man, 65 years old, the teacher, because of extremities joint swelled and ache 4 years, arthroncus, limitation of activity, in calendar year 2001 December 14 days go to a doctor, successively all be diagnosed as rheumatoid arthritis at a few family large hospital inside the province, successively take the An Jiadie cry of certain animals, ibuprofen, medicines such as Radix Tripterygii Wilfordii produce stronger gastrointestinal reaction drug withdrawal because of these medicines make the patient, and then this patient is unable to leave the bed because of pain causes, on inspection: erythrocyte sedimentation rate 54mm/h, anti-" O "＞1: 500, the rheumatoid factor positive, after take medicine of the present invention, once a day, each 20, took for 4 weeks continuously, extremities joint pain swelling deadlock in morning obviously alleviates, and the energy out-of-bed activity is taken 6 weeks of this medicine again, again on inspection: erythrocyte sedimentation rate 12mm/h, anti-" O "＜1: 250, rheumatoid factor negative is taken medicine of the present invention, do not find any untoward reaction during this time, after the healing, follow the tracks of investigation so far, do not see recurrence.
Learn that from the above fact medicine the present invention has curative effect preferably to treatment rheumatism, rheumatoid arthritis, and essentially no side effect.
The specific embodiment
Embodiment 1: take by weighing the standard compliant medicine of respectively distinguishing the flavor of by following weight portion proportioning:
Semen Strychni (processed) 400, Fructus Chaenomelis 50, Scorpio 50, Radix Saposhnikoviae 30, Flos Carthami 70, Radix Angelicae Sinensis 70, Radix Aconiti Preparata head 50.
The medicine of said ratio is made watered pill by known preparation process after crushed, and every weight is the pill of 2～3mg.The weight difference of per 100 pills is no more than 5mg.
Embodiment 2: take by weighing the standard compliant medicine of respectively distinguishing the flavor of by following weight portion proportioning:
Semen Strychni (processed) 500, Fructus Chaenomelis 70, Scorpio 100, Radix Saposhnikoviae 50, Flos Carthami 90, Radix Angelicae Sinensis 90, Radix Aconiti Preparata head 70.
Adopt the method identical with embodiment 1, making every weight also is the pill of 2～3mg.
Embodiment 3: take by weighing the standard compliant medicine of respectively distinguishing the flavor of by following weight portion proportioning:
Semen Strychni (processed) 450, Fructus Chaenomelis 60, Scorpio 80, Radix Saposhnikoviae 40, Flos Carthami 80, Radix Angelicae Sinensis 80, Radix Aconiti Preparata head 60.
Adopt the method identical with embodiment 1, making every weight also is the pill of 2～3mg.
Embodiment 4: take by weighing the standard compliant medicine of respectively distinguishing the flavor of by following weight portion proportioning:
Semen Strychni (processed) 420, Fructus Chaenomelis 65, Scorpio 70, Radix Saposhnikoviae 45, Flos Carthami 85, Radix Angelicae Sinensis 75, Radix Aconiti Preparata head 65.
Adopt the method identical with embodiment 1, making every weight also is the pill of 2～3mg.
Embodiment 5: take by weighing the standard compliant medicine of respectively distinguishing the flavor of by following weight portion proportioning:
Semen Strychni (processed) 480, Fructus Chaenomelis 50, Scorpio 90, Radix Saposhnikoviae 50, Flos Carthami 75, Radix Angelicae Sinensis 85, Radix Aconiti Preparata head 55.
Adopt the method identical with embodiment 1, making every weight also is the pill of 2～3mg.
Also the medicine among above each embodiment can be decocted with water, make water preparation by known preparation process.
Claims (4)
1, a kind of medicine for the treatment of rheumatism, rheumatoid arthritis is characterized in that: it is made by following medicine and weight portion proportioning:
Fructus Chaenomelis 50～70, Scorpio 50～100, Radix Saposhnikoviae 30～50, Flos Carthami 70～90, Radix Angelicae Sinensis 70～90, Radix Aconiti Preparata head 50～70, Semen Strychni (processed) 400～500.
2, medicine according to claim 1 is characterized in that: it is made by following medicine and weight portion proportioning:
Fructus Chaenomelis 60～70, Scorpio 70～90, Radix Saposhnikoviae 40～50, Flos Carthami 70～85, Radix Angelicae Sinensis 75～85, Radix Aconiti Preparata head 60～70, Semen Strychni (processed) 450～500.
3, medicine according to claim 1 is characterized in that: it is made by following medicine and weight portion proportioning:
Fructus Chaenomelis 50～65, Scorpio 70～80, Radix Saposhnikoviae 40～45, Flos Carthami 75～80, Radix Angelicae Sinensis 75～80, Radix Aconiti Preparata head 60～75, Semen Strychni (processed) 420～480.
4, the medicine described in claim 1 or 2 or 3 is the watered pill pill, it is characterized in that: the weight of every pill is 2～3mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031261310A CN1539448A (en) | 2003-04-23 | 2003-04-23 | Drug for curing reheumatoid arthritis and atrophic artjritis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031261310A CN1539448A (en) | 2003-04-23 | 2003-04-23 | Drug for curing reheumatoid arthritis and atrophic artjritis |
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| Publication Number | Publication Date |
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| CN1539448A true CN1539448A (en) | 2004-10-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031261310A Pending CN1539448A (en) | 2003-04-23 | 2003-04-23 | Drug for curing reheumatoid arthritis and atrophic artjritis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716210A (en) * | 2012-06-05 | 2012-10-10 | 彭丽娟 | Traditional Chinese medicine for treating rheumatism and production method thereof |
| CN105878959A (en) * | 2014-12-15 | 2016-08-24 | 谢海雄 | Knee protection medicine bag for treating wandering arthritis and preparation method |
| CN107582775A (en) * | 2017-10-30 | 2018-01-16 | 李世辉 | It is a kind of to be used to treat Chinese medicine rheumatism ball of rheumatoid disease and preparation method thereof |
| CN110522819A (en) * | 2019-10-14 | 2019-12-03 | 王学习 | A kind of plaster and preparation method thereof for treating cervical spondylosis, scapulohumeral periarthritis, protrusion of lumber intervertebral disc, rheumatic arthritis |
-
2003
- 2003-04-23 CN CNA031261310A patent/CN1539448A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716210A (en) * | 2012-06-05 | 2012-10-10 | 彭丽娟 | Traditional Chinese medicine for treating rheumatism and production method thereof |
| CN102716210B (en) * | 2012-06-05 | 2014-08-20 | 彭丽娟 | Traditional Chinese medicine for treating rheumatism and production method thereof |
| CN105878959A (en) * | 2014-12-15 | 2016-08-24 | 谢海雄 | Knee protection medicine bag for treating wandering arthritis and preparation method |
| CN107582775A (en) * | 2017-10-30 | 2018-01-16 | 李世辉 | It is a kind of to be used to treat Chinese medicine rheumatism ball of rheumatoid disease and preparation method thereof |
| CN110522819A (en) * | 2019-10-14 | 2019-12-03 | 王学习 | A kind of plaster and preparation method thereof for treating cervical spondylosis, scapulohumeral periarthritis, protrusion of lumber intervertebral disc, rheumatic arthritis |
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