CN1258358C - 聚合胶束组合物 - Google Patents

聚合胶束组合物 Download PDF

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Publication number
CN1258358C
CN1258358C CNB018144446A CN01814444A CN1258358C CN 1258358 C CN1258358 C CN 1258358C CN B018144446 A CNB018144446 A CN B018144446A CN 01814444 A CN01814444 A CN 01814444A CN 1258358 C CN1258358 C CN 1258358C
Authority
CN
China
Prior art keywords
compositions
poly
micelles
hydrophobic
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018144446A
Other languages
English (en)
Chinese (zh)
Other versions
CN1447683A (zh
Inventor
J·－C·勒罗克斯
A·S·贝纳梅德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labopharm Inc
Original Assignee
Labopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Inc filed Critical Labopharm Inc
Publication of CN1447683A publication Critical patent/CN1447683A/zh
Application granted granted Critical
Publication of CN1258358C publication Critical patent/CN1258358C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CNB018144446A 2000-06-29 2001-06-28 聚合胶束组合物 Expired - Fee Related CN1258358C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/606,398 US6338859B1 (en) 2000-06-29 2000-06-29 Polymeric micelle compositions
US09/606398 2000-06-29

Publications (2)

Publication Number Publication Date
CN1447683A CN1447683A (zh) 2003-10-08
CN1258358C true CN1258358C (zh) 2006-06-07

Family

ID=24427804

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018144446A Expired - Fee Related CN1258358C (zh) 2000-06-29 2001-06-28 聚合胶束组合物

Country Status (22)

Country Link
US (1) US6338859B1 (enExample)
EP (1) EP1296647B1 (enExample)
JP (1) JP5134179B2 (enExample)
KR (1) KR20030039332A (enExample)
CN (1) CN1258358C (enExample)
AT (1) ATE336229T1 (enExample)
AU (2) AU2001270405B2 (enExample)
BR (1) BR0112054A (enExample)
CA (1) CA2414241C (enExample)
CZ (1) CZ302369B6 (enExample)
DE (1) DE60122335T2 (enExample)
DK (1) DK1296647T3 (enExample)
ES (1) ES2271039T3 (enExample)
HU (1) HUP0300963A2 (enExample)
IL (2) IL153655A0 (enExample)
MX (1) MXPA03000065A (enExample)
NO (1) NO20026255L (enExample)
NZ (1) NZ523645A (enExample)
PL (1) PL202475B1 (enExample)
PT (1) PT1296647E (enExample)
RU (1) RU2308943C2 (enExample)
WO (1) WO2002000194A2 (enExample)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ260408A (en) 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
WO2001085213A2 (en) * 2000-05-08 2001-11-15 The University Of British Columbia Supports for photosensitizer formulations
AU2002214649A1 (en) * 2000-10-16 2002-04-29 Neopharm, Inc. Liposomal formulation of mitoxantrone
DK1343530T3 (da) * 2000-11-09 2007-10-15 Astrazeneca Ab Oral farmaceutisk sammensætning, der indeholder en blokcopolymer
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
CA2451187C (en) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
KR100481540B1 (ko) * 2002-02-26 2005-04-07 한국전자통신연구원 치료 약물 함유된 스마트 나노 입자의 제조 방법
JP2005524657A (ja) * 2002-02-27 2005-08-18 ファーメイン， エルティーディー． 治療剤及び他の物質を送達するための組成物、及び、前記組成物を作製し使用する方法
US7635463B2 (en) * 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
US20050260259A1 (en) * 2004-04-23 2005-11-24 Bolotin Elijah M Compositions for treatment with glucagon-like peptide, and methods of making and using the same
US6780324B2 (en) * 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
US7018655B2 (en) * 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
WO2003082303A1 (en) * 2002-03-29 2003-10-09 Wisconsin Alumni Research Foundation Polymeric micelle formulations of hydrophobic compounds and methods
EP1393718A1 (en) * 2002-08-29 2004-03-03 OctoPlus Sciences B.V. Colloidal drug carrier system
JP5118302B2 (ja) * 2002-10-29 2013-01-16 トランセイブ， インク． 抗感染剤の徐放
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
KR100508518B1 (ko) * 2002-11-13 2005-08-17 한미약품 주식회사 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체
WO2004045641A2 (en) * 2002-11-20 2004-06-03 Crucell Holland B.V. Antigen-complexes
US7491395B2 (en) 2002-11-20 2009-02-17 Bestewil Holding B.V. Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination
WO2004098569A1 (en) * 2003-04-18 2004-11-18 Northeastern University Micelle delivery system loaded with a pharmaceutical agent
US7262253B2 (en) * 2003-12-02 2007-08-28 Labopharm, Inc. Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers
CN100386115C (zh) * 2004-10-14 2008-05-07 孔庆忠 一种抗癌药物组合物
JP2008519076A (ja) * 2004-11-02 2008-06-05 テルアビブ ユニバーシティ フューチャー テクノロジー デベロップメント エル．ピー． 脂質化グリコサミノグリカン粒子中の水不溶性又は水難溶性薬物の処方、並びに診断及び治療のためのこれらの使用
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
EP1909771A1 (en) * 2005-08-02 2008-04-16 Miv Therapeutics Inc. Microdevices comprising nanocapsules for controlled delivery of drugs and method of manufacturing same
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
EP3067046B1 (en) 2005-12-08 2020-03-25 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections
AU2006330610B2 (en) 2005-12-19 2012-08-16 Pharmain Corporation Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same
CA2634830A1 (en) * 2005-12-27 2007-07-05 Labopharm Inc. Degradable polymeric microsphere composition
CA2650422A1 (en) * 2006-04-24 2007-11-08 Nanocarrier Co., Ltd. Process for producing polymer micelles encapsulating low molecular weight drugs
CN100434120C (zh) * 2006-09-14 2008-11-19 同济大学 两亲性荧光靶向纳米胶束及其制备方法
EP2081548A2 (en) * 2006-09-22 2009-07-29 Labopharm Inc. Compositions and methods for ph targeted drug delivery
RU2492872C2 (ru) * 2006-10-05 2013-09-20 Дзе Джонс Хопкинс Юниверсити Вододиспергируемые пероральные, парентеральные и местные композиции для плохо растворимых в воде лекарственных препаратов, включающие улучшающие их свойства полимерные наночастицы
US7758635B2 (en) * 2007-02-13 2010-07-20 Boston Scientific Scimed, Inc. Medical device including cylindrical micelles
WO2008137717A1 (en) * 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US8563527B2 (en) * 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
US9090737B2 (en) * 2007-11-13 2015-07-28 Surmodics, Inc. Viscous terpolymers as drug delivery platform
US20090176892A1 (en) * 2008-01-09 2009-07-09 Pharmain Corporation Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US8524783B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
US8524784B2 (en) * 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
US8207290B2 (en) 2010-03-26 2012-06-26 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
WO2011130834A1 (en) * 2010-04-23 2011-10-27 Labopharm Inc. Non-intravenous dosage form comprising solid formulation of liquid biologically active agent and uses thereof
WO2012030821A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Terpolymer blends and their use as pressure-sensitive adhesives
CN101953804A (zh) * 2010-09-26 2011-01-26 苏州同科生物材料有限公司 基于两亲性嵌段共聚物的壳层可脱落式纳米药物载体制剂及其制备方法
WO2012103182A1 (en) 2011-01-28 2012-08-02 Cerulean Pharma Inc. Method for fabricating nanoparticles
CN102793678B (zh) * 2011-05-26 2017-06-30 邓世明 一种不含吐温的多烯紫杉醇注射剂的制备方法
EP2748204B1 (en) * 2011-10-03 2016-04-20 Nanyang Technological University Cationic peptidopolysaccharides with excellent broad- spectrum antimicrobial activities and high selectivity
RU2480479C1 (ru) * 2011-11-01 2013-04-27 Елена Викторовна Свирщевская Гетерологичный пептидный мини-антиген в составе полимерной частицы для создания противоаллергенной вакцины
CN104105729B (zh) * 2012-02-10 2016-10-26 纳幕尔杜邦公司 高-x两嵌段共聚物的制备、纯化和使用
RU2501570C1 (ru) * 2012-05-11 2013-12-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) федеральный университет" (ФГАОУВПО КФУ) Трехфункциональные блоксополимеры этиленоксида и пропиленоксида для доставки активных веществ в живые клетки
EP4331675A3 (en) 2012-05-21 2024-05-29 Insmed Incorporated Systems for treating pulmonary infections
US10124066B2 (en) 2012-11-29 2018-11-13 Insmed Incorporated Stabilized vancomycin formulations
CN104434876B (zh) * 2013-09-13 2018-04-27 布里吉·P·吉里 用于癌症疗法及成像的缺氧-标靶聚合微胞
CN106535877A (zh) 2014-05-15 2017-03-22 英斯梅德股份有限公司 用于治疗肺部非结核性分枝杆菌感染的方法
KR102088663B1 (ko) * 2018-03-20 2020-03-13 한국세라믹기술원 친수성 및 소수성 약물의 동시 전달을 위한 온도민감성 나노스펀지 플랫폼 및 이의 용도
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
CN111592663B (zh) * 2020-03-27 2022-09-16 青岛大学 一种冠醚修饰的嵌段共聚物胶束的制备方法及其应用
CN114246831B (zh) * 2020-09-22 2024-10-15 鲁南制药集团股份有限公司 一种注射用紫杉烷类抗肿瘤药物的聚合物胶束冻干制剂
CN120346164B (zh) * 2025-06-20 2025-09-26 湖州亚瑟制药有限公司 一种环磷酰胺三元纳米胶束及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
US5484778C1 (en) * 1990-07-17 2001-05-08 Univ Cleveland Hospitals Phthalocynine photosensitizers for photodynamic therapy and methods for their use
US5817321A (en) * 1992-10-08 1998-10-06 Supratek Pharma, Inc. Biological agent compositions
US5484612A (en) * 1993-09-22 1996-01-16 The Board Of Trustees Of The Leland Stanford Junior University Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin
KR0180334B1 (ko) * 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
WO1997012895A1 (fr) * 1995-09-29 1997-04-10 Japan Science And Technology Corporation Nouveaux derives de composes d'anthracycline, et preparations medicamenteuses les contenant
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
JP3523821B2 (ja) * 2000-02-09 2004-04-26 ナノキャリア株式会社 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物
WO2001087227A2 (en) * 2000-05-17 2001-11-22 Labopharm, Inc. Drug containing polymeric micelles

Also Published As

Publication number Publication date
WO2002000194A2 (en) 2002-01-03
CA2414241C (en) 2011-04-12
AU2001270405B2 (en) 2005-01-20
US6338859B1 (en) 2002-01-15
EP1296647B1 (en) 2006-08-16
DE60122335D1 (de) 2006-09-28
NO20026255D0 (no) 2002-12-27
JP2004501180A (ja) 2004-01-15
CZ20024268A3 (cs) 2003-05-14
JP5134179B2 (ja) 2013-01-30
EP1296647A2 (en) 2003-04-02
DK1296647T3 (da) 2006-12-27
WO2002000194A3 (en) 2002-08-08
HK1059395A1 (en) 2004-07-02
HUP0300963A2 (hu) 2003-09-29
PT1296647E (pt) 2006-12-29
CA2414241A1 (en) 2002-01-03
ES2271039T3 (es) 2007-04-16
RU2308943C2 (ru) 2007-10-27
NO20026255L (no) 2003-02-25
PL360262A1 (pl) 2004-09-06
AU7040501A (en) 2002-01-08
DE60122335T2 (de) 2007-08-30
MXPA03000065A (es) 2004-04-02
NZ523645A (en) 2004-09-24
ATE336229T1 (de) 2006-09-15
CZ302369B6 (cs) 2011-04-13
BR0112054A (pt) 2003-09-30
KR20030039332A (ko) 2003-05-17
PL202475B1 (pl) 2009-06-30
IL153655A0 (en) 2003-07-06
CN1447683A (zh) 2003-10-08
IL153655A (en) 2008-11-26

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