CN1254259C - 治疗心脑血管疾病的中药制剂及其制备方法 - Google Patents
治疗心脑血管疾病的中药制剂及其制备方法 Download PDFInfo
- Publication number
- CN1254259C CN1254259C CN 03117612 CN03117612A CN1254259C CN 1254259 C CN1254259 C CN 1254259C CN 03117612 CN03117612 CN 03117612 CN 03117612 A CN03117612 A CN 03117612A CN 1254259 C CN1254259 C CN 1254259C
- Authority
- CN
- China
- Prior art keywords
- extractum
- radix
- chinese medicine
- medicine preparation
- salviae miltiorrhizae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 201000010099 disease Diseases 0.000 title description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 13
- 210000004204 blood vessel Anatomy 0.000 title description 2
- 230000000747 cardiac effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 29
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 208000026106 cerebrovascular disease Diseases 0.000 claims abstract description 13
- 239000008187 granular material Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 7
- 238000000605 extraction Methods 0.000 claims description 18
- 238000010438 heat treatment Methods 0.000 claims description 18
- 244000236655 Diospyros kaki Species 0.000 claims description 14
- 235000008597 Diospyros kaki Nutrition 0.000 claims description 14
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 12
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 28
- 210000004369 blood Anatomy 0.000 abstract description 28
- 230000001737 promoting effect Effects 0.000 abstract description 24
- 230000017531 blood circulation Effects 0.000 abstract description 13
- 208000002193 Pain Diseases 0.000 abstract description 9
- 206010008479 Chest Pain Diseases 0.000 abstract description 7
- 206010019233 Headaches Diseases 0.000 abstract description 7
- 208000009205 Tinnitus Diseases 0.000 abstract description 7
- 210000000038 chest Anatomy 0.000 abstract description 7
- 231100000869 headache Toxicity 0.000 abstract description 7
- 231100000886 tinnitus Toxicity 0.000 abstract description 7
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 6
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract description 6
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 abstract description 5
- 208000029078 coronary artery disease Diseases 0.000 abstract description 5
- 201000005851 intracranial arteriosclerosis Diseases 0.000 abstract description 5
- 210000000115 thoracic cavity Anatomy 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 abstract description 4
- 208000012886 Vertigo Diseases 0.000 abstract 2
- 231100000889 vertigo Toxicity 0.000 abstract 2
- 235000009917 Crataegus X brevipes Nutrition 0.000 abstract 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 abstract 1
- 235000009685 Crataegus X maligna Nutrition 0.000 abstract 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 abstract 1
- 235000009486 Crataegus bullatus Nutrition 0.000 abstract 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 abstract 1
- 235000009682 Crataegus limnophila Nutrition 0.000 abstract 1
- 235000004423 Crataegus monogyna Nutrition 0.000 abstract 1
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 235000002313 Crataegus paludosa Nutrition 0.000 abstract 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 abstract 1
- 241000132521 Erigeron Species 0.000 abstract 1
- 244000153955 Reynoutria sachalinensis Species 0.000 abstract 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 description 10
- 230000004087 circulation Effects 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 235000019636 bitter flavor Nutrition 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗心脑血管疾病的中药制剂及其制备方法，它将灯盏、细辛、虎杖、野山楂等用水加热提取浓缩成浸膏，再将刺五加、丹参用乙醇加热提取浓缩成浸膏，最后将两种浸膏混匀喷雾干燥制成颗粒剂等，本发明提供的药物具有活血化瘀，通络止痛功能，用于治疗瘀血闭阻引起的胸痹，眩晕，症见胸闷，胸痛，心悸，头晕，头痛耳鸣以及冠心病，心绞痛，脑动脉硬化及高脂血症见上述症候者。
Description
本发明涉及一种治疗心脑血管疾病的中药制剂及其制备方法，属于药品的
技术领域。
背景技术：心脑血管疾病是一种现代生活中的常见病、多发病，由于生活习惯的改善，许多人员患上了这类疾病，症状反映为：胸痹、眩晕、胸闷、胸痛、心悸、头晕、头痛、耳鸣以及冠心病，心绞痛，脑动脉硬化及高脂血症，这类病症影响患者的正常生活，治疗过程比较长且目前使用的药物没有特别有效的药品，常见的药物为丹参制品等；如果用西药进行治疗，有效但副作用又比较大且治疗费用高，所以一般不为患者接受。
本发明的目的是：提供一种治疗心脑血管疾病的中药制剂及其制备方法，这种药品具有活血化瘀，通络止痛功能，用于治疗瘀血闭阻引起的胸痹，眩晕，症见胸闷，胸痛，心悸，头晕，头痛耳鸣等，以及冠心病，心绞痛，脑动脉硬化及高脂血症等；本发明是这样构成的：治疗心脑血管疾病的中药制剂，是由灯盏细辛380-420、虎杖360-420、野山楂350-450、刺五加300-350、丹参310-350制作而成；为了增强疗效，可以加入柿叶、葛根，按照重量配比计算：它就由灯盏细辛380-420、虎杖360-420、野山楂350-450、柿叶360-420、刺五加300-350、葛根300-340、丹参310-350制作而成；比较具体配方、比例是灯盏细辛390、虎杖390、野山楂390、柿叶390、刺五加320、葛根320、丹参320；本发明所说的中药制剂是任何一种药剂学上所说的剂型。最好为颗粒剂、片剂或胶囊剂。治疗心脑血管疾病的中药制剂的制备方法，根据给定的比例，将灯盏细辛380-420、虎杖360-420、野山楂350-450用水加热提取浓缩成浸膏，将刺五加300-350、丹参310-350用乙醇加热提取浓缩成浸膏，将两种浸膏混匀喷雾干燥制成20-60目颗粒，制成颗粒剂，也可以将得到的两种浸膏混匀喷雾干燥制成20-40目颗粒，加入辅料后经压片制成片剂，还可以将两种浸膏分别干燥、粉碎后混合均匀，经胶囊充填制成胶囊剂；加入柿叶、葛根后将灯盏细辛380-420、虎杖360-420、野山楂350-450、柿叶360-420、葛根300-340用水
加热提取浓缩成浸膏；将刺五加300-350、丹参310-350用乙醇加热提取浓缩成浸膏，将两种浸膏混匀、干燥，然后按照常规工艺制作成需要的剂型。
由于采用了上述技术方案，本发明提供的药物具有活血化瘀，通络止痛功能，用于治疗瘀血闭阻引起的胸痹，眩晕，症见胸闷，胸痛，心悸，头晕，头痛耳鸣等，以及冠心病，心绞痛，脑动脉硬化及高脂血症见上述症候者的药物。苗医理论认为冠心病、心绞痛、高脂血症见胸闷、胸痛、心悸、头晕、头痛耳鸣等，其病因是饮食不节、油腻过多、心情不舒、外受寒毒等，损伤人体气血而成。伤气则气结，以致胸中气不通畅；伤血则血滞。气血病变相互影响，以致产生上述血脉冷、热病症。上述胸闷、胸痛、头痛耳鸣等属热症，气短、眩晕等属冷症。根据苗医理论，属冷热并病，当以冷热药并用；本发明的方解为：灯盏细辛，性微温，味微苦，活血化瘀、行气止痛；刺五加，性温，味辛、苦，补益肝肾，活血祛瘀、行气止痛；虎杖，味酸，微寒，具有活血祛瘀、清热利湿；野山楂，味酸，具有活血祛瘀、消食化积之功；丹参，味辛、微凉，活血散瘀、凉血消痛、养血安神；野山楂与丹参相伍增强化瘀生新、行气宽中之功，即瘀血去而新血生、瘀阻除而脉络通，方中各药相伍为用共奏，活血化瘀、消食化滞、行气止痛之效。加入柿叶、葛根后的方解为：方中灯盏细辛性微热，味微苦，入冷经，功用为活血化瘀，行气止痛；柿叶性冷，味苦酸涩，入热经、慢经，功用为祛风通络，活血化瘀，上述二味为主药；虎杖性冷，味苦，清热利湿；苦葛性冷，味苦辛，退热补虚；丹参性微冷，味苦，活血化瘀，通络止痛，本组三味均入热经；野山楂性热，味甘、酸，消食行气、散瘀健胃；刺五加性热，味麻，驱风除湿，本组二味均入冷经、慢经，以上冷热药并用共为辅药。诸药伍用，共奏活血化瘀，消食化滞，行气止痛之功。用于瘀血闭阻引起的胸痹，眩晕，症见胸闷，胸痛，心悸，头晕，头痛耳鸣等，以及冠心病心绞痛，脑动脉硬化及高脂血症见上述症候者。
本发明的实施例1：将灯盏细辛380克、虎杖360克、野山楂350克用水加热提取浓缩成浸膏，将刺五加300克、丹参310克用乙醇加热提取浓缩成浸膏，将两种浸膏混匀喷雾干燥制成20-60目颗粒，制成颗粒剂。
本发明的实施例2：将灯盏细辛420克、虎杖420克、野山楂450克用水加热提取浓缩成浸膏，将刺五加350克、丹参350克用乙醇加热提取浓缩成浸膏，将两种浸膏混匀喷雾干燥制成20-40目颗粒，加入辅料后经压片制成片剂。
本发明的实施例3：将灯盏细辛390克、虎杖390克、野山楂390克、柿叶390克、葛根320克用水加热提取浓缩成浸膏；将刺五加320克、丹参320克用乙醇加热提取浓缩成浸膏，将两种浸膏混匀、干燥，然后按照常规工艺制作成需要的胶囊剂。本药品口服，一次4-5粒，一日3次。
本发明的实施例4：将灯盏细辛380克、虎杖360克、野山楂350克、柿叶360克、葛根300克用水加热提取浓缩成浸膏；将刺五加300克、丹参310克用乙醇加热提取浓缩成浸膏，将两种浸膏混匀、干燥，然后按照常规工艺制作成丸剂。
本发明的实施例5：将灯盏细辛420克、虎杖420克、野山楂450克、柿叶420克、葛根340克用水加热提取浓缩成浸膏；将刺五加350克、丹参克350用乙醇加热提取浓缩成浸膏，将两种浸膏混匀、干燥，然后按照常规工艺制作成口服液。
Claims (6)
1、一种治疗心脑血管疾病的中药制剂，其特征在于：按照重量配比计算：它是由灯盏细辛380-420、虎杖360-420、野山楂350-450、刺五加300-350和丹参310-350制作而成。
2、根据权利要求1所述的治疗心脑血管疾病的中药制剂，其特征在于：原料中还加入柿叶和葛根；按照重量配比计算：它由灯盏细辛380-420、虎杖360-420、野山楂350-450、柿叶360-420、刺五加300-350、葛根300-340和丹参310-350制作而成。
3、根据权利要求1或2所述的治疗心脑血管疾病的中药制剂，其特征在于：它由灯盏细辛390、虎杖390、野山楂390、柿叶390、刺五加320、葛根320和丹参320制作而成。
4、根据权利要求1或2所述的治疗心脑血管疾病的中药制剂，其特征在于：所说的中药制剂是颗粒剂、片剂或胶囊剂。
5、根据权利要求1所述的治疗心脑血管疾病的中药制剂的制备方法，其特征在于：先将灯盏细辛380-420、虎杖360-420、野山楂350-450用水加热提取浓缩成浸膏，将刺五加300-350、丹参310-350用乙醇加热提取浓缩成浸膏，然后将两种浸膏混匀喷雾干燥制成20-60目颗粒，制成颗粒剂，或将得到的两种浸膏混匀喷雾干燥制成20-40目颗粒，加入辅料后经压片制成片剂，还可以将两种浸膏分别干燥、粉碎后混合均匀，经胶囊充填制成胶囊剂。
6、按照权利要求2所述的治疗心脑血管疾病的中药制剂的制备方法，其特征在于：将灯盏细辛380-420、虎杖360-420、野山楂350-450、柿叶360-420、葛根300-340用水加热提取浓缩成浸膏；将刺五加300-350、丹参310-350用乙醇加热提取浓缩成浸膏，将两种浸膏混匀、干燥，然后按照常规工艺制作成需要的剂型。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03117612 CN1254259C (zh) | 2003-04-01 | 2003-04-01 | 治疗心脑血管疾病的中药制剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03117612 CN1254259C (zh) | 2003-04-01 | 2003-04-01 | 治疗心脑血管疾病的中药制剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1490028A CN1490028A (zh) | 2004-04-21 |
| CN1254259C true CN1254259C (zh) | 2006-05-03 |
Family
ID=34152686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03117612 Expired - Lifetime CN1254259C (zh) | 2003-04-01 | 2003-04-01 | 治疗心脑血管疾病的中药制剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1254259C (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002843B (zh) * | 2005-12-19 | 2010-09-08 | 山东轩竹医药科技有限公司 | 一种用于治疗心脑血管疾病的药物组合物 |
| CN101966239B (zh) * | 2010-09-30 | 2012-07-18 | 贵州太和制药有限公司 | 一种用于预防和治疗心脑血管疾病的中药组合物及其制备方法 |
| CN110420254A (zh) * | 2019-07-26 | 2019-11-08 | 贵州太和制药有限公司 | 一种治疗心脑血管疾病的中药制剂的制备方法 |
| CN115364149A (zh) * | 2022-08-30 | 2022-11-22 | 朗致集团有限公司 | 心脑联通胶囊的制备方法及应用 |
-
2003
- 2003-04-01 CN CN 03117612 patent/CN1254259C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1490028A (zh) | 2004-04-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102488850B (zh) | 治疗酒精性脂肪肝的中药组合物及其制备方法 | |
| CN103169903B (zh) | 一种治疗小儿支气管炎的中药制剂及其制备方法 | |
| CN101947304A (zh) | 一种治疗虚寒性胃肠病的中药组合物 | |
| CN102988870A (zh) | 一种治疗肝胆胃肠道疾病的口服液 | |
| CN105169212A (zh) | 一种用于治疗慢性胃炎的中药组合物 | |
| CN104873705A (zh) | 一种治疗冠心病心绞痛的药物组合物及其应用 | |
| CN1254259C (zh) | 治疗心脑血管疾病的中药制剂及其制备方法 | |
| CN102293964B (zh) | 一种治疗胃溃疡的药物及其制备方法 | |
| CN101249255A (zh) | 一种治疗小儿咳嗽的中成药及其制备方法 | |
| CN106421053A (zh) | 一种健脾暖胃的中药 | |
| CN106334065A (zh) | 一种治疗妇科疾病及具有美容作用的药食两用中药配方及生产工艺 | |
| CN104984237A (zh) | 一种中药组合物及其制备方法 | |
| CN104873911A (zh) | 一种辅助治疗脓毒症的内服中药 | |
| CN101391078B (zh) | 一种内服治疗脂肪肝的药物 | |
| CN104840773A (zh) | 治疗椎动脉型颈椎病的中药组合物及制法 | |
| CN103656459B (zh) | 一种治疗肺脾两虚证型咳嗽的中药 | |
| CN104825795A (zh) | 治疗心律不齐的中药胶囊 | |
| CN105687474A (zh) | 癌症患者化疗期间服用的制剂及制备方法 | |
| CN106692858A (zh) | 一种治疗胎动不安的药物及其制备方法 | |
| CN104645061A (zh) | 一种治疗瘀血停滞型慢性胃溃疡的药物及制备方法 | |
| CN104435176B (zh) | 肝热上冲型高血压疏肝泄热药剂及制法 | |
| CN1171621C (zh) | 血脉通及其制作方法 | |
| CN104225129A (zh) | 妇女经期头痛活血行瘀制剂及制备方法 | |
| CN104288637A (zh) | 一种具有清肺止咳作用的药物组合物 | |
| CN101618169A (zh) | 一种治疗食道癌的中药 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20080422 Pledge (preservation): Pledge registration |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Effective date of registration: 20080422 Pledge (preservation): Pledge |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20091029 Pledge (preservation): Pledge registration |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Effective date of registration: 20091029 Pledge (preservation): Pledge |
|
| DD01 | Delivery of document by public notice |
Addressee: Jin Guochun Document name: Notification of Termination of Procedure |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20111116 Granted publication date: 20060503 Pledgee: Qingzhen City Rural Credit Cooperatives Pledgor: Guizhou Taihe Pharmaceutical Co.,Ltd. Registration number: 2009520000634 |
|
| DD01 | Delivery of document by public notice |
Addressee: Gao Yanli Document name: Invalidation case notification |
|
| DD01 | Delivery of document by public notice |
Addressee: Liang Weimin Document name: Notice of termination |
|
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhao Weiguo Document name: Notification that Application Deemed not to be Proposed |
|
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: Liang Weimin Document name: Notification of Termination of Procedure |
|
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhao Weiguo Document name: Notice of termination |
|
| CX01 | Expiry of patent term |
Granted publication date: 20060503 |
|
| CX01 | Expiry of patent term |