CN101966239B - 一种用于预防和治疗心脑血管疾病的中药组合物及其制备方法 - Google Patents
一种用于预防和治疗心脑血管疾病的中药组合物及其制备方法 Download PDFInfo
- Publication number
- CN101966239B CN101966239B CN2010102971740A CN201010297174A CN101966239B CN 101966239 B CN101966239 B CN 101966239B CN 2010102971740 A CN2010102971740 A CN 2010102971740A CN 201010297174 A CN201010297174 A CN 201010297174A CN 101966239 B CN101966239 B CN 101966239B
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- preparing
- chinese medicine
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title abstract description 18
- 208000018152 Cerebral disease Diseases 0.000 title abstract 3
- 230000000747 cardiac effect Effects 0.000 title abstract 3
- 230000002490 cerebral effect Effects 0.000 title abstract 3
- 208000019553 vascular disease Diseases 0.000 title abstract 3
- 244000236655 Diospyros kaki Species 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 239000003814 drug Substances 0.000 claims description 42
- 238000000034 method Methods 0.000 claims description 38
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 238000010992 reflux Methods 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 18
- 238000000605 extraction Methods 0.000 claims description 17
- 239000003921 oil Substances 0.000 claims description 16
- 235000008597 Diospyros kaki Nutrition 0.000 claims description 14
- 239000000284 extract Substances 0.000 claims description 14
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 9
- 208000026106 cerebrovascular disease Diseases 0.000 claims description 9
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 9
- 238000001291 vacuum drying Methods 0.000 claims description 9
- 239000008187 granular material Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000011084 recovery Methods 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 241000219780 Pueraria Species 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 3
- 239000003643 water by type Substances 0.000 claims 3
- 238000011282 treatment Methods 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 9
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 208000029078 coronary artery disease Diseases 0.000 abstract description 6
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 5
- 208000011580 syndromic disease Diseases 0.000 abstract description 2
- 244000160089 Crataegus cuneata Species 0.000 abstract 1
- 235000008440 Crataegus cuneata Nutrition 0.000 abstract 1
- 235000011511 Diospyros Nutrition 0.000 abstract 1
- 241001632410 Eleutherococcus senticosus Species 0.000 abstract 1
- 241001013934 Erigeron breviscapus Species 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 244000153955 Reynoutria sachalinensis Species 0.000 abstract 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 231100000862 numbness Toxicity 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 238000012360 testing method Methods 0.000 description 5
- 238000009835 boiling Methods 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 239000000469 ethanolic extract Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 238000007602 hot air drying Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 210000000115 thoracic cavity Anatomy 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 208000002173 dizziness Diseases 0.000 description 3
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 description 2
- 206010008479 Chest Pain Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 241000633855 Litsea pungens Species 0.000 description 2
- AIGAZQPHXLWMOJ-UHFFFAOYSA-N Tanshinone I Chemical compound C1=CC2=C(C)C=CC=C2C(C(=O)C2=O)=C1C1=C2C(C)=CO1 AIGAZQPHXLWMOJ-UHFFFAOYSA-N 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 201000005577 familial hyperlipidemia Diseases 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 201000005851 intracranial arteriosclerosis Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- SNKFFCBZYFGCQN-UHFFFAOYSA-N 2-[3-[3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyloxy]-3-(3,4-dihydroxyphenyl)propanoic acid Chemical compound C=1C=C(O)C=2OC(C=3C=C(O)C(O)=CC=3)C(C(=O)OC(CC=3C=C(O)C(O)=CC=3)C(O)=O)C=2C=1C=CC(=O)OC(C(=O)O)CC1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-UHFFFAOYSA-N 0.000 description 1
- VWDXGKUTGQJJHJ-UHFFFAOYSA-N Catenarin Natural products C1=C(O)C=C2C(=O)C3=C(O)C(C)=CC(O)=C3C(=O)C2=C1O VWDXGKUTGQJJHJ-UHFFFAOYSA-N 0.000 description 1
- 239000010282 Emodin Substances 0.000 description 1
- RBLJKYCRSCQLRP-UHFFFAOYSA-N Emodin-dianthron Natural products O=C1C2=CC(C)=CC(O)=C2C(=O)C2=C1CC(=O)C=C2O RBLJKYCRSCQLRP-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- YOOXNSPYGCZLAX-UHFFFAOYSA-N Helminthosporin Natural products C1=CC(O)=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O YOOXNSPYGCZLAX-UHFFFAOYSA-N 0.000 description 1
- SNKFFCBZYFGCQN-VWUOOIFGSA-N Lithospermic acid B Natural products C([C@H](C(=O)O)OC(=O)\C=C\C=1C=2[C@H](C(=O)O[C@H](CC=3C=C(O)C(O)=CC=3)C(O)=O)[C@H](OC=2C(O)=CC=1)C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-VWUOOIFGSA-N 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- NTGIIKCGBNGQAR-UHFFFAOYSA-N Rheoemodin Natural products C1=C(O)C=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1O NTGIIKCGBNGQAR-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 description 1
- VASFLQKDXBAWEL-UHFFFAOYSA-N emodin Natural products OC1=C(OC2=C(C=CC(=C2C1=O)O)O)C1=CC=C(C=C1)O VASFLQKDXBAWEL-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- PKUBGLYEOAJPEG-UHFFFAOYSA-N physcion Natural products C1=C(C)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O PKUBGLYEOAJPEG-UHFFFAOYSA-N 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- STCJJTBMWHMRCD-UHFFFAOYSA-N salvianolic acid B Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=O)C=Cc2cc(O)c(O)c3OC(C(C(=O)OC(Cc4ccc(O)c(O)c4)C(=O)O)c23)c5ccc(O)c(O)c5 STCJJTBMWHMRCD-UHFFFAOYSA-N 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (14)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102971740A CN101966239B (zh) | 2010-09-30 | 2010-09-30 | 一种用于预防和治疗心脑血管疾病的中药组合物及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102971740A CN101966239B (zh) | 2010-09-30 | 2010-09-30 | 一种用于预防和治疗心脑血管疾病的中药组合物及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101966239A CN101966239A (zh) | 2011-02-09 |
| CN101966239B true CN101966239B (zh) | 2012-07-18 |
Family
ID=43545501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102971740A Active CN101966239B (zh) | 2010-09-30 | 2010-09-30 | 一种用于预防和治疗心脑血管疾病的中药组合物及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101966239B (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552725A (zh) * | 2012-02-08 | 2012-07-11 | 宋斯文 | 具有降压作用的中药贴及其制备方法 |
| CN115364149A (zh) * | 2022-08-30 | 2022-11-22 | 朗致集团有限公司 | 心脑联通胶囊的制备方法及应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1490028A (zh) * | 2003-04-01 | 2004-04-21 | 贵州太和制药有限公司 | 治疗心脑血管疾病的中药制剂及其制备方法 |
| CN1973858A (zh) * | 2006-12-20 | 2007-06-06 | 贵阳中医学院 | 大果木姜子油乳剂及其制备方法 |
-
2010
- 2010-09-30 CN CN2010102971740A patent/CN101966239B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1490028A (zh) * | 2003-04-01 | 2004-04-21 | 贵州太和制药有限公司 | 治疗心脑血管疾病的中药制剂及其制备方法 |
| CN1973858A (zh) * | 2006-12-20 | 2007-06-06 | 贵阳中医学院 | 大果木姜子油乳剂及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101966239A (zh) | 2011-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2006060951A1 (fr) | Composition pharmaceutique pour le traitement et/ou la prevention de l’hyperlipidemie, procedes de production et utilisation de cette composition | |
| CN100335088C (zh) | 治疗骨坏死病的中药制剂及其制备方法 | |
| CN103623341A (zh) | 治疗高血压病以及由此引起心脑血管疾病的药物 | |
| CN102475830B (zh) | 一种治疗冠心病心绞痛的药物组合物与其制备方法及制剂 | |
| CN102319357B (zh) | 一种降脂灵分散片及其制备工艺 | |
| CN109276591A (zh) | 刺五加当归黄芪组合物辅助降血糖新用途 | |
| CN101966239B (zh) | 一种用于预防和治疗心脑血管疾病的中药组合物及其制备方法 | |
| CN111110735A (zh) | 一种降脂的药物组合物、制备方法及应用 | |
| CN101244122B (zh) | 药物组合物 | |
| CN102293985B (zh) | 用于治疗冠心病的中药组合物及其制备方法 | |
| CN102133273A (zh) | 一种中药降脂通便胶囊及其制备方法 | |
| CN101480472B (zh) | 调血脂的药物及生产方法 | |
| CN107007702A (zh) | 一种治疗骨关节病的中药组合物及其制剂 | |
| CN106581236A (zh) | 一种促进胃动力的药物组合物及其制备方法和应用 | |
| CN102552520A (zh) | 一种治疗胸痹心痛的活血止痛药物及制备工艺和应用 | |
| CN101549140B (zh) | 治疗艾滋病的中药组合物及其制备方法 | |
| CN1087627C (zh) | 一种治疗糖尿病的药物及其制备方法 | |
| CN101912537A (zh) | 治疗脑血管神经疼痛症的中药制剂 | |
| CN104547910A (zh) | 黄莪胶囊的药物用途 | |
| CN104257839A (zh) | 一种具有降糖降脂保护血管内皮作用的中药组合物及其制备方法 | |
| CN102688254B (zh) | 一种治疗慢性腹泻的药物组合物及制备方法和用途 | |
| CN108635457A (zh) | 一种治疗便秘的中药组合物及其制备方法与应用 | |
| CN104547027B (zh) | 一种丹参叶三七叶提取物的制备方法及其应用 | |
| CN1311849C (zh) | 治疗肿痛的药物组合物 | |
| CN100339093C (zh) | 一种治疗冠心病、心绞痛的复方药物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Chinese medicinal composition for preventing and treating cardiac cerebral and vascular diseases and preparation method thereof Effective date of registration: 20140429 Granted publication date: 20120718 Pledgee: Agricultural Bank of China, Limited by Share Ltd, Xifeng county subbranch Pledgor: Taihe Pharmaceutical Co., Ltd., Guizhou Registration number: 2014990000309 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20150807 Granted publication date: 20120718 Pledgee: Agricultural Bank of China, Limited by Share Ltd, Xifeng county subbranch Pledgor: Taihe Pharmaceutical Co., Ltd., Guizhou Registration number: 2014990000309 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Chinese medicinal composition for preventing and treating cardiac cerebral and vascular diseases and preparation method thereof Effective date of registration: 20150813 Granted publication date: 20120718 Pledgee: Agricultural Bank of China, Limited by Share Ltd, Xifeng county subbranch Pledgor: Taihe Pharmaceutical Co., Ltd., Guizhou Registration number: 2015990000675 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20160812 Granted publication date: 20120718 Pledgee: Agricultural Bank of China, Limited by Share Ltd, Xifeng county subbranch Pledgor: Taihe Pharmaceutical Co., Ltd., Guizhou Registration number: 2015990000675 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Chinese medicinal composition for preventing and treating cardiac cerebral and vascular diseases and preparation method thereof Effective date of registration: 20160816 Granted publication date: 20120718 Pledgee: Agricultural Bank of China, Limited by Share Ltd, Xifeng county subbranch Pledgor: Taihe Pharmaceutical Co., Ltd., Guizhou Registration number: 2016520000009 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20160926 Granted publication date: 20120718 Pledgee: Agricultural Bank of China, Limited by Share Ltd, Xifeng county subbranch Pledgor: Taihe Pharmaceutical Co., Ltd., Guizhou Registration number: 2016520000009 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Chinese medicinal composition for preventing and treating cardiac cerebral and vascular diseases and preparation method thereof Effective date of registration: 20160927 Granted publication date: 20120718 Pledgee: Agricultural Bank of China, Limited by Share Ltd, Xifeng county subbranch Pledgor: Taihe Pharmaceutical Co., Ltd., Guizhou Registration number: 2016520000012 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20171114 Granted publication date: 20120718 Pledgee: Agricultural Bank of China, Limited by Share Ltd, Xifeng county subbranch Pledgor: Taihe Pharmaceutical Co., Ltd., Guizhou Registration number: 2016520000012 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Chinese medicinal composition for preventing and treating cardiac cerebral and vascular diseases and preparation method thereof Effective date of registration: 20171121 Granted publication date: 20120718 Pledgee: Agricultural Bank of China, Limited by Share Ltd, Xifeng county subbranch Pledgor: Taihe Pharmaceutical Co., Ltd., Guizhou Registration number: 2017520000013 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |