CN1245161C - 调制离子通道机能活动的方法 - Google Patents

调制离子通道机能活动的方法 Download PDF

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Publication number
CN1245161C
CN1245161C CNB998120197A CN99812019A CN1245161C CN 1245161 C CN1245161 C CN 1245161C CN B998120197 A CNB998120197 A CN B998120197A CN 99812019 A CN99812019 A CN 99812019A CN 1245161 C CN1245161 C CN 1245161C
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CN
China
Prior art keywords
vpu
amiloride
hiv
functional activity
purposes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB998120197A
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English (en)
Chinese (zh)
Other versions
CN1323212A (zh
Inventor
G·考克斯
G·艾瓦特
P·盖格
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Australian National University
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Publication date
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Publication of CN1323212A publication Critical patent/CN1323212A/zh
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Publication of CN1245161C publication Critical patent/CN1245161C/zh
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Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB998120197A 1998-10-12 1999-10-12 调制离子通道机能活动的方法 Expired - Fee Related CN1245161C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPP6464A AUPP646498A0 (en) 1998-10-12 1998-10-12 A method of modulating ion channel functional activity
AUPP6464 1998-10-12

Publications (2)

Publication Number Publication Date
CN1323212A CN1323212A (zh) 2001-11-21
CN1245161C true CN1245161C (zh) 2006-03-15

Family

ID=3810686

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998120197A Expired - Fee Related CN1245161C (zh) 1998-10-12 1999-10-12 调制离子通道机能活动的方法

Country Status (8)

Country Link
US (2) US7179803B1 (https=)
EP (1) EP1121128B1 (https=)
JP (1) JP4624562B2 (https=)
CN (1) CN1245161C (https=)
AU (1) AUPP646498A0 (https=)
CA (1) CA2345896C (https=)
NZ (1) NZ510437A (https=)
WO (1) WO2000021538A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10210206A1 (de) * 2002-03-01 2003-09-04 Florian Lang Fertilitätsreduzierung bei Vertebraten
AU2003903251A0 (en) * 2003-06-26 2003-07-10 Biotron Limited Antiviral compounds and methods
JP5030587B2 (ja) 2003-06-26 2012-09-19 バイオトロン・リミテッド 抗ウイルスアシルグアニジン化合物および方法
US20060275812A1 (en) * 2005-06-01 2006-12-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Assay for agonists and antagonists of ion channels and for regulators of genetic expression
CN112156753A (zh) * 2020-09-23 2021-01-01 中国石油大学(华东) 石墨烯气凝胶及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4085211A (en) * 1975-12-15 1978-04-18 Merck & Co., Inc. Pyrazinecarboxamides and processes for preparing same
WO1990009792A1 (en) * 1989-03-03 1990-09-07 The General Hospital Corporation Topical application of amiloride or analogues thereof for treatment of inflammation
US5506231A (en) * 1989-03-31 1996-04-09 The Children's Medical Center Corporation Treatment of aids dementia, myelopathy and blindness
US5215991A (en) * 1990-01-26 1993-06-01 Allergan, Inc. Combination of selective alpha-adrenergic agonists and Na+ /H+ ex
JPH0725768A (ja) 1993-07-09 1995-01-27 Mitsubishi Chem Corp 血管内膜肥厚抑制剤
WO1995027510A1 (en) 1994-04-12 1995-10-19 Alza Corporation Screening methods for integumental inflammation modulating agents
AUPO258196A0 (en) * 1996-09-27 1996-10-17 Australian National University, The Method for determining ion channel activity of a substance

Also Published As

Publication number Publication date
WO2000021538A1 (en) 2000-04-20
CA2345896C (en) 2009-03-24
AUPP646498A0 (en) 1998-11-05
EP1121128B1 (en) 2013-04-17
CN1323212A (zh) 2001-11-21
JP4624562B2 (ja) 2011-02-02
JP2002527397A (ja) 2002-08-27
CA2345896A1 (en) 2000-04-20
US7179803B1 (en) 2007-02-20
EP1121128A4 (en) 2004-10-27
EP1121128A1 (en) 2001-08-08
NZ510437A (en) 2005-01-28
US20070112013A1 (en) 2007-05-17

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Effective date of registration: 20090313

Address after: Australian Capital Territory

Patentee after: Bioclimatic room Ltd

Address before: Australian Capital Territory

Patentee before: Convention Patent Application

ASS Succession or assignment of patent right

Owner name: BIOLOGY CLIMATE LAB CO., LTD.

Free format text: FORMER OWNER: AUSTRALIAN NATL UNIV AUSTRALIA

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060315

Termination date: 20171012

CF01 Termination of patent right due to non-payment of annual fee