NZ510437A - Amiloride analogues for modulating Vpu ion channel functional activity - Google Patents
Amiloride analogues for modulating Vpu ion channel functional activityInfo
- Publication number
- NZ510437A NZ510437A NZ510437A NZ51043799A NZ510437A NZ 510437 A NZ510437 A NZ 510437A NZ 510437 A NZ510437 A NZ 510437A NZ 51043799 A NZ51043799 A NZ 51043799A NZ 510437 A NZ510437 A NZ 510437A
- Authority
- NZ
- New Zealand
- Prior art keywords
- use according
- vpu
- ion channel
- agent
- hiv
- Prior art date
Links
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- 230000004044 response Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000004347 surface barrier Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960003766 thrombin (human) Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000007486 viral budding Effects 0.000 description 1
- 108700026222 vpu Genes Proteins 0.000 description 1
- 101150090490 vpu gene Proteins 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP6464A AUPP646498A0 (en) | 1998-10-12 | 1998-10-12 | A method of modulating ion channel functional activity |
| PCT/AU1999/000872 WO2000021538A1 (en) | 1998-10-12 | 1999-10-12 | A method of modulating ion channel functional activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ510437A true NZ510437A (en) | 2005-01-28 |
Family
ID=3810686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ510437A NZ510437A (en) | 1998-10-12 | 1999-10-12 | Amiloride analogues for modulating Vpu ion channel functional activity |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7179803B1 (https=) |
| EP (1) | EP1121128B1 (https=) |
| JP (1) | JP4624562B2 (https=) |
| CN (1) | CN1245161C (https=) |
| AU (1) | AUPP646498A0 (https=) |
| CA (1) | CA2345896C (https=) |
| NZ (1) | NZ510437A (https=) |
| WO (1) | WO2000021538A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10210206A1 (de) * | 2002-03-01 | 2003-09-04 | Florian Lang | Fertilitätsreduzierung bei Vertebraten |
| AU2003903251A0 (en) * | 2003-06-26 | 2003-07-10 | Biotron Limited | Antiviral compounds and methods |
| JP5030587B2 (ja) | 2003-06-26 | 2012-09-19 | バイオトロン・リミテッド | 抗ウイルスアシルグアニジン化合物および方法 |
| US20060275812A1 (en) * | 2005-06-01 | 2006-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Assay for agonists and antagonists of ion channels and for regulators of genetic expression |
| CN112156753A (zh) * | 2020-09-23 | 2021-01-01 | 中国石油大学(华东) | 石墨烯气凝胶及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4085211A (en) * | 1975-12-15 | 1978-04-18 | Merck & Co., Inc. | Pyrazinecarboxamides and processes for preparing same |
| WO1990009792A1 (en) * | 1989-03-03 | 1990-09-07 | The General Hospital Corporation | Topical application of amiloride or analogues thereof for treatment of inflammation |
| US5506231A (en) * | 1989-03-31 | 1996-04-09 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy and blindness |
| US5215991A (en) * | 1990-01-26 | 1993-06-01 | Allergan, Inc. | Combination of selective alpha-adrenergic agonists and Na+ /H+ ex |
| JPH0725768A (ja) | 1993-07-09 | 1995-01-27 | Mitsubishi Chem Corp | 血管内膜肥厚抑制剤 |
| WO1995027510A1 (en) | 1994-04-12 | 1995-10-19 | Alza Corporation | Screening methods for integumental inflammation modulating agents |
| AUPO258196A0 (en) * | 1996-09-27 | 1996-10-17 | Australian National University, The | Method for determining ion channel activity of a substance |
-
1998
- 1998-10-12 AU AUPP6464A patent/AUPP646498A0/en not_active Abandoned
-
1999
- 1999-10-12 EP EP99970324.2A patent/EP1121128B1/en not_active Expired - Lifetime
- 1999-10-12 CA CA002345896A patent/CA2345896C/en not_active Expired - Fee Related
- 1999-10-12 WO PCT/AU1999/000872 patent/WO2000021538A1/en not_active Ceased
- 1999-10-12 JP JP2000575514A patent/JP4624562B2/ja not_active Expired - Fee Related
- 1999-10-12 CN CNB998120197A patent/CN1245161C/zh not_active Expired - Fee Related
- 1999-10-12 US US09/807,277 patent/US7179803B1/en not_active Expired - Lifetime
- 1999-10-12 NZ NZ510437A patent/NZ510437A/en not_active IP Right Cessation
-
2006
- 2006-12-14 US US11/638,416 patent/US20070112013A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000021538A1 (en) | 2000-04-20 |
| CA2345896C (en) | 2009-03-24 |
| AUPP646498A0 (en) | 1998-11-05 |
| EP1121128B1 (en) | 2013-04-17 |
| CN1323212A (zh) | 2001-11-21 |
| JP4624562B2 (ja) | 2011-02-02 |
| JP2002527397A (ja) | 2002-08-27 |
| CA2345896A1 (en) | 2000-04-20 |
| US7179803B1 (en) | 2007-02-20 |
| CN1245161C (zh) | 2006-03-15 |
| EP1121128A4 (en) | 2004-10-27 |
| EP1121128A1 (en) | 2001-08-08 |
| US20070112013A1 (en) | 2007-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AVOD | Application void | ||
| S37A | Application for proceedings under section 37 (restoration of application where complete specification not accepted) | ||
| S37R | Proceedings under section 37 (restoration of application where complete specification not accepted): application restored | ||
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired |