CN1228313A - Tonifying Yang anticancer powder for alimentary canal - Google Patents
Tonifying Yang anticancer powder for alimentary canal Download PDFInfo
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- CN1228313A CN1228313A CN98106551A CN98106551A CN1228313A CN 1228313 A CN1228313 A CN 1228313A CN 98106551 A CN98106551 A CN 98106551A CN 98106551 A CN98106551 A CN 98106551A CN 1228313 A CN1228313 A CN 1228313A
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Abstract
The yang-strengthening anti-cancer powder for curing gastrointestinal carcinoma with obvious advantages of good therapeutic effect, small toxic side reaction and low cost is made up by using the following prescription: (by weight portion) main medicinal material, house lizard 7-10 and notoginseng 17-20; and auxiliary medicinal material, centiped 12-15, leech 12-15, scorpion 12-15, dragon's blood 7-10, white mustard seed 7-10, toad venom 1.5-2 and agkistrodon acutus 1.5-2.
Description
The invention belongs to medical technical field, is a kind of tonifying Yang anticancer powder for alimentary canal.
Esophageal carcinoma is a multiple cancer.Patient Duo Yin physical factor, chemical factor, wherein certain factor of virus inherited genetic factors and feelings will carcinogenic factor exists down, smoking is arranged, drink, like bad life habits such as scalding food and sauerkraut, epithelium of esophagus hamartoplasia, or the caused cell transformations of pessimal stimulation such as esophagitis, white macula, polyp, cicatricial stricture or ceasma hernia are converted into the malignant tumor cell by benign cell, be the esophageal carcinoma, traditional Chinese medical science viewpoint thinks that the cloudy blood stasis of local network under the influence of mucous membrane of esophagus physics feelings will is due to healthy energy is damaged.Thereby in treatment the prescriptions that adopt blood circulation promoting and blood stasis dispelling, collateral dredging, softening the hard mass more, add controlling of setting upright, obtained certain curative effect.
The pathogeny of gastric cancer: the sickness rate of gastric cancer is in China tool first place.Patient Duo Yin dietary factor, by containing nitroso compound in the food, mycotoxin and fire-cure, the fried polycyclic aromatic hydrocarbon that produces.Carcinogen is with food, enter the approach of the carcinogen such as N-nitroso compound of the nitrate, nitrite of human body, strong carcinogenesis, cause the incidence gastric cancer condition, the tradition traditional Chinese medical science thinks that gastric cancer belongs to gastral cavity pain, regurgitation more, chokes every, fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times, the long-pending scope of disease belongs to the stagnation of QI, blood stasis, food stagnation accumulation of heat, Deficiency and coldness of spleen and stomach, phlegm-damp coagulates the moon etc.So many with heat clearing away cold expelling, detoxifcation blood stasis removing in treatment, promoting blood circulation and stopping pain, change the pain eliminating stagnation ruling by law it.
At present treatment esophageal carcinoma, gastric cancer adopt the cmp scheme more, but after the medication, patient occurs that the nausea and vomiting gastrointestinal reaction is more to be seen, leukopenia is particularly outstanding.It is good more that dosage increases curative effect, but the dosage increase, toxicity is outstanding more.Leukocyte descends, and bone marrow hematogenesis suppresses, immunologic function degression, and this is the most formidable problem of present chemotherapy work.The curative effect of cmp scheme is not obvious to most humans simultaneously.
The purpose of this invention is to provide a kind of evident in efficacy, the Chinese medicine that cures mainly esophageal carcinoma and gastric cancer that toxicity is little, with low cost.
Tonifying YANG of the present invention digests the prescription that anticancer powder adopts following formulation ratio and makes (proportioning employing weight portion):
Principal agent: Gekko Swinhonis 7-10 Radix Notoginseng 17-20
Accessory drugs: Scolopendra 12-15 Hirudo 12-15 Scorpio 12-15
Sanguis Draxonis 7-10 Semen Sinapis Albae 7-10 Venenum Bufonis 1.5-2
Agkistrodon 1.5-2
Below above prescription is likened to following compatibility analysis:
Anticancer powder is to be principal agent by Gekko Swinhonis, Radix Notoginseng, and Scolopendra, Hirudo, Scorpio, Sanguis Draxonis, Semen Sinapis Albae, Venenum Bufonis, Agkistrodon are accessory drugs.Conform to drug matching monarch, minister, help, make, prescription.In the side Radix Notoginseng, Sanguis Draxonis, Semen Sinapis Albae have invigorate blood circulation, the effect of disperse blood stasis and dredge collateral, mass dissipating and swelling eliminating.Gekko Swinhonis, Scolopendra, Scorpio, Venenum Bufonis, Hirudo have the effect of hard masses softening and resolving, the merit that Agkistrodon has collateral dredging, calms the frightened, dispels the wind.On theory of Chinese medical science, the cancerous protuberance that disappears, the transitional cell that kills and wounds around cancerous cell and the cancerous protuberance are had certain effect for this reason.And Radix Notoginseng has the effect of hemostasis, clots absorbing, tonification.Compatibility is wonderful in square for this reason.
Suck the active ingredient of strong glycoside in the Venenum Bufonis medicine, thereby after being used for patient, the heart tonifying diuretic actions is arranged.Hirudo has been sucked effective hirudin.Removing blood stasis with potent drugs is arranged, the effect of the detumescence of stimulating the menstrual flow, thereby in the treatment cancerous protuberance, play a role.
Aspect dosage: Scolopendra, Scorpio, Venenum Bufonis, Agkistrodon are poisonous, thereby strict aspect consumption.Unlikely poisoning is advisable to reach therapeutic purposes.
Optimization formula proportioning of the present invention is as follows:
Principal agent: Gekko Swinhonis 7-8g Radix Notoginseng 17-18g
Accessory drugs: Scolopendra 12-13g Hirudo 12-13g Scorpio 12-13g
Sanguis Draxonis 7-8g Caulis et Folium Sinapis albee 7-8g Venenum Bufonis 1.5-2g
BAIYAO Serpentis 1.5-2g
Another optimization formula proportioning of the present invention is as follows:
Principal agent: Gekko Swinhonis 9-10g Radix Notoginseng 19-20g
Accessory drugs: Scolopendra 14-15g Hirudo 14-15g Scorpio 14-15g
Sanguis Draxonis 9-10g Semen Sinapis Albae 9-10g Venenum Bufonis 1.5-2g
Agkistrodon 1.5-2g
Fixed square proportioning of the present invention is as follows:
Gekko Swinhonis 8.5g Radix Notoginseng 8.5g Scolopendra 13.5g water little molehill 13.5g
Scorpio 13.5g Sanguis Draxonis 8.5g Semen Sinapis Albae 8.5g Venenum Bufonis 1.7g
Agkistrodon 1.7g
The dosage form of anticancer powder and forming method
Dosage form: be powder
Formulation method: 9 kinds in the total Chinese medicine of full prescription, all the first-class medical material of dry product after 9 kinds of medicines grind respectively, lumps together altogether, is ground into powder.Crossing 100 mesh sieves, to get its fine powder be anticancer powder, adorns and seal standby.
Usage: every day 2 times, each oral 2 grams, 30 minutes after meal, boiled water was taken after mixing it with water.Use the anticancer powder of Chinese medicine tonifying YANG to be main treatment esophageal carcinoma, gastric cancer 25 routine controlled observations, curative effect all is better than the cmp scheme with toxicity, now provides as follows:
Data and method
One, case is selected: this group case is in February, 1991--in October, 1997,25 routine patients of " the anticancer powder of tonifying YANG " treatment were accepted in the operation back.Esophageal carcinoma 16 examples wherein, gastric cancer 9 examples.Dosage is every day 2 times, each 2 grams, and boiled water is taken after mixing it with water, and 30 days is a course of treatment.Wherein male 18 examples, women 7 examples.Age 28-65 year.
Two, matched group patient 22 examples adopt the treatment of cmp scheme.Dosage is:
CTX 600mg ivg
TTd
1My god
MMC 10mg " iv " d
1My god
PDD 80mg ivg
TTd
1My god
Add in the time of medication with emesis, hydration treatment, 14 days one-periods, two cycles are a course of treatment.
All do routine blood test, liver, renal function, the every inspection of electrocardiogram before the treatment of two groups of cases all in normal range, body condition score＜press Kaynofsky standards of grading〉the 60-70 branch.Two groups of timing statisticses were all followed up a case by regular visits to the statistics contrast in 30 days after medication.
Three, observation index: hemogram variation, toxic reaction, alopecia and Ke Shi translate branch.
Four, criterion of therapeutical effect and judgement: the standard that curative effect is formulated by national tumor meeting in 78 years is divided into: alleviate CR fully; Part is alleviated PR; Effective NR; Invalid PD.
The result
Two groups of cases compare judgement after treating a course of treatment, and observation group and matched group toxic reaction have notable difference, and curative effect is then basic identical.See Table 1.2 tables 1 liang group case toxicity synopsis
Table 2 liang group case curative effect comparision table
| Group | Case | Toxic reaction | Leukocyte | Deviate from | The Ke Shi scoring |
| Observation group's matched group | ?25 ?22 | ????0 ????19 | ????0 ????10 | ???0 ???5 | 60-70 divides 50-60 branch |
| Group | Case | ???CR | ???PR | ???NR | ????PD | Total effective rate |
| Observation group's matched group | ?25 ?22 | ???0 ???0 | ???20 ???17 | ????2 ????2 | ????3 ????2 | ?88％ ?86％ |
Table 1 as seen, observation group does not have any toxicity, no nausea and vomiting; No leukocyte descends, no alopecia case generation, and overall health of patients takes a turn for the better before than medication.And matched group all has toxicity in various degree, and leukocyte descends, alopecia and nausea and vomiting.As seen observation group is better than curative effect statistics: observation group＜PR+NR in the matched group table 2〉portion's effective percentage 88%, matched group (PR+NR) portion effective percentage 86%, observation group and matched group contrast no significant difference.
Discuss
The medicinal Radix Notoginseng of the anticancer powder of tonifying YANG is a principal agent, the effect that nourishing YIN tonifying YANG, hemostasia and detumescence are arranged, and wall worry, Scolopendra, Venenum Bufonis, Scorpio is a drug toxicity, consumption has been controlled at unlikely toxic dose, have the merit of hard masses softening and resolving, set upright again, so blood circulation promoting and blood stasis dispelling compatibility curative effect after use does not obviously have toxicity.In case observation, use repeatly repeatly and imitate.After the medication of CMP scheme, patient occurs that the nausea and vomiting gastrointestinal reaction is more to be seen, leukopenia is particularly outstanding.It is good more that dosage increases curative effect, but that dosage increases toxicity is just outstanding more, and particularly leukocyte descends, bone marrow hematogenesis suppresses, immunologic function degression, the problem that this is in the present chemotherapy work to be difficult to overcome.Thereby use anticancer powder curative effect of tonifying YANG and chemotherapeutic efficacy difference little, and do not have toxicity, disease is better than chemotherapy group for overall health of patients.
Claims (1)
1, a kind of tonifying Yang anticancer powder for alimentary canal, its feature is made (proportioning employing weight portion) at the prescription that adopts following formulation ratio:
Principal agent: Gekko Swinhonis 7-10 Radix Notoginseng 17-20
Accessory drugs: Scolopendra 12-15 Hirudo 12-15 Scorpio 12-15
Sanguis Draxonis 7-10
Semen Sinapis Albae 7-10 Venenum Bufonis 1.5-2 Agkistrodon 1.5-2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98106551A CN1228313A (en) | 1998-03-10 | 1998-03-10 | Tonifying Yang anticancer powder for alimentary canal |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98106551A CN1228313A (en) | 1998-03-10 | 1998-03-10 | Tonifying Yang anticancer powder for alimentary canal |
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| CN1228313A true CN1228313A (en) | 1999-09-15 |
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| CN98106551A Pending CN1228313A (en) | 1998-03-10 | 1998-03-10 | Tonifying Yang anticancer powder for alimentary canal |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005007177A1 (en) * | 2003-07-15 | 2005-01-27 | Toximed Gmbh | Pharmaceutical agent against stomach ulcers |
| CN103550472A (en) * | 2013-10-17 | 2014-02-05 | 张洁 | Health-protection prescription for cancer patient |
| CN104189339A (en) * | 2014-07-29 | 2014-12-10 | 刘庆芳 | Health formula for patients with lung cancer |
| CN105535286A (en) * | 2016-01-17 | 2016-05-04 | 新乡医学院第一附属医院 | Traditional Chinese medicine composition for resisting tumors in internal medicine |
-
1998
- 1998-03-10 CN CN98106551A patent/CN1228313A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005007177A1 (en) * | 2003-07-15 | 2005-01-27 | Toximed Gmbh | Pharmaceutical agent against stomach ulcers |
| CN103550472A (en) * | 2013-10-17 | 2014-02-05 | 张洁 | Health-protection prescription for cancer patient |
| CN103550472B (en) * | 2013-10-17 | 2015-03-18 | 张洁 | Health-protection prescription for cancer patient |
| CN104189339A (en) * | 2014-07-29 | 2014-12-10 | 刘庆芳 | Health formula for patients with lung cancer |
| CN105535286A (en) * | 2016-01-17 | 2016-05-04 | 新乡医学院第一附属医院 | Traditional Chinese medicine composition for resisting tumors in internal medicine |
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