CN1227025C - 改进的加工活化c蛋白的方法 - Google Patents

改进的加工活化c蛋白的方法 Download PDF

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Publication number
CN1227025C
CN1227025C CNB988063824A CN98806382A CN1227025C CN 1227025 C CN1227025 C CN 1227025C CN B988063824 A CNB988063824 A CN B988063824A CN 98806382 A CN98806382 A CN 98806382A CN 1227025 C CN1227025 C CN 1227025C
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CN
China
Prior art keywords
protein
activated protein
apc
des
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB988063824A
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English (en)
Chinese (zh)
Other versions
CN1261280A (zh
Inventor
J·C·贝克
A·D·卡尔森
黄立华
T·A·舍利加
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
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Eli Lilly and Co
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Publication date
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Publication of CN1261280A publication Critical patent/CN1261280A/zh
Application granted granted Critical
Publication of CN1227025C publication Critical patent/CN1227025C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNB988063824A 1997-04-28 1998-04-24 改进的加工活化c蛋白的方法 Expired - Fee Related CN1227025C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4525597P 1997-04-28 1997-04-28
US60/045255 1997-04-28

Publications (2)

Publication Number Publication Date
CN1261280A CN1261280A (zh) 2000-07-26
CN1227025C true CN1227025C (zh) 2005-11-16

Family

ID=21936854

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB988063824A Expired - Fee Related CN1227025C (zh) 1997-04-28 1998-04-24 改进的加工活化c蛋白的方法
CNB988045672A Expired - Fee Related CN1235638C (zh) 1997-04-28 1998-04-24 活性蛋白c制剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB988045672A Expired - Fee Related CN1235638C (zh) 1997-04-28 1998-04-24 活性蛋白c制剂

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US (4) US6162629A (enExample)
EP (2) EP0875252B1 (enExample)
JP (2) JP4383546B2 (enExample)
KR (2) KR100564189B1 (enExample)
CN (2) CN1227025C (enExample)
AR (2) AR015598A1 (enExample)
AT (1) ATE285788T1 (enExample)
AU (2) AU743531B2 (enExample)
BR (2) BR9809304B1 (enExample)
CA (2) CA2287267C (enExample)
CO (2) CO4940438A1 (enExample)
CZ (1) CZ298429B6 (enExample)
DE (1) DE69828330T2 (enExample)
DK (1) DK0875252T3 (enExample)
EA (2) EA002149B1 (enExample)
EG (1) EG23685A (enExample)
ES (1) ES2234072T3 (enExample)
HU (2) HU224826B1 (enExample)
ID (2) ID22933A (enExample)
IL (2) IL132325A (enExample)
IN (2) IN187157B (enExample)
MY (2) MY120984A (enExample)
NO (2) NO995134L (enExample)
NZ (2) NZ337828A (enExample)
PE (2) PE84799A1 (enExample)
PL (2) PL195642B1 (enExample)
PT (1) PT875252E (enExample)
SI (1) SI0875252T1 (enExample)
SV (2) SV1998000050A (enExample)
TR (2) TR199902631T2 (enExample)
TW (2) TWI242443B (enExample)
UA (2) UA73071C2 (enExample)
WO (2) WO1998048822A1 (enExample)
ZA (2) ZA983497B (enExample)

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WO1998048822A1 (en) 1998-11-05
AU740753B2 (en) 2001-11-15
CN1235638C (zh) 2006-01-11
CA2287267A1 (en) 1998-11-05
BR9809304B1 (pt) 2011-02-08
JP4383546B2 (ja) 2009-12-16
HK1016472A1 (en) 1999-11-05
CZ298429B6 (cs) 2007-10-03
AU743531B2 (en) 2002-01-31
EA002149B1 (ru) 2001-12-24
JP2001524111A (ja) 2001-11-27
HUP0100284A2 (hu) 2001-06-28
AU740753C (en) 2002-10-10
IL132325A0 (en) 2001-03-19
BR9809292A (pt) 2000-07-04
EP0875252A3 (en) 2000-07-26
PL336889A1 (en) 2000-07-17
AU7161898A (en) 1998-11-24
CN1254284A (zh) 2000-05-24
EA199900979A1 (ru) 2000-06-26
EP0875563A2 (en) 1998-11-04
TR199902631T2 (xx) 2000-01-21
US6162629A (en) 2000-12-19
DE69828330T2 (de) 2005-10-13
HUP0003401A2 (hu) 2001-02-28
JP2001527543A (ja) 2001-12-25
EA004881B1 (ru) 2004-08-26
ZA983496B (en) 1999-10-25
TR199902529T2 (xx) 2000-02-21
DK0875252T3 (da) 2005-04-25
NZ500346A (en) 2001-08-31
HUP0003401A3 (en) 2003-01-28
EP0875563A3 (en) 2000-08-02
ID22933A (id) 1999-12-16
EA199900980A1 (ru) 2000-04-24
MY118591A (en) 2004-12-31
US6436397B1 (en) 2002-08-20
HU224826B1 (en) 2006-02-28
US6159468A (en) 2000-12-12
SV1998000050A (es) 1999-01-13
CN1261280A (zh) 2000-07-26
ID23172A (id) 2000-03-23
US6395270B1 (en) 2002-05-28
EG23685A (en) 2007-05-09
TW585871B (en) 2004-05-01
NO995134L (no) 1999-12-21
AU7258998A (en) 1998-11-24
PL195642B1 (pl) 2007-10-31
PL195090B1 (pl) 2007-08-31
KR20010020242A (ko) 2001-03-15
KR100564189B1 (ko) 2006-03-27
PT875252E (pt) 2005-03-31
AR012010A1 (es) 2000-09-13
UA55448C2 (uk) 2003-04-15
IL132502A0 (en) 2001-03-19
NO995198D0 (no) 1999-10-25
PE86299A1 (es) 1999-09-17
PE84799A1 (es) 1999-09-16
NZ337828A (en) 2001-06-29
MY120984A (en) 2005-12-30
CO4950523A1 (es) 2000-09-01
WO1998048818A1 (en) 1998-11-05
BR9809304A (pt) 2000-10-17
CA2287267C (en) 2006-08-15
CA2288143C (en) 2012-08-21
IL132325A (en) 2005-07-25
EP0875252B1 (en) 2004-12-29
NO995134D0 (no) 1999-10-21
UA73071C2 (en) 2005-06-15
CO4940438A1 (es) 2000-07-24
DE69828330D1 (de) 2005-02-03
PL336420A1 (en) 2000-06-19
IN183798B (enExample) 2000-04-15
KR100450856B1 (ko) 2004-10-02
TWI242443B (en) 2005-11-01
HUP0100284A3 (en) 2003-08-28
ES2234072T3 (es) 2005-06-16
IN187157B (enExample) 2002-02-16
KR20010020325A (ko) 2001-03-15
AR015598A1 (es) 2001-05-16
EP0875252A2 (en) 1998-11-04
ATE285788T1 (de) 2005-01-15
JP4383547B2 (ja) 2009-12-16
NO995198L (no) 1999-10-25
CA2288143A1 (en) 1998-11-05
ZA983497B (en) 1999-10-25
SV1998000051A (es) 1998-12-11
SI0875252T1 (en) 2005-06-30
CZ381099A3 (cs) 2000-03-15

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