CN1224404C - 一种对心血管疾病有控制作用的洋葱浸膏 - Google Patents
一种对心血管疾病有控制作用的洋葱浸膏 Download PDFInfo
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Abstract
本发明涉及一种对心血疾病有控制作用的洋葱浸膏，以新鲜洋葱为原料，将其洗净、沥水、切片，将洋葱片进行水中蒸馏、油水分离、提取洋葱挥发油备用，将经过蒸馏的洋葱片压榨成洋葱汁，将洋葱汁加入乙醇稀释醇化，将稀释醇化液分离滤去榨渣，先回收乙醇，再进行浓缩，将浓缩液进行喷雾干燥，将收集的浸膏与洋葱挥发油混匀，即得洋葱浸膏；可将洋葱浸膏制成片剂、胶囊、口服液等药剂，用于控制心血管疾病。
Description
本发明涉及一种对心血管病症有控制作用的洋葱浸膏，其特征在于其以新鲜洋葱为原料制备的洋葱浸膏，以及用它制备成片剂、胶囊、口服液等剂型，用于控制心血管疾病。
公知的洋葱(Allium cepal)，是百合科葱属球茎草本植物，含挥发油，碳水化合物、矿物质、氨基酸、维生素、多糖及微量元素，经常食用新鲜洋葱对扩张血管、降血压、降血脂确有一定的效用，日食量需达到160-200克，才会有明显的效果，特别是治疗动脉硬化、静脉炎、高血压、冠心病、血栓症、糠尿病，需要的食用量就得增加，大的食用量给患者产生食用量的负担，因而产生厌食、少食、拒食现象。
本发明的目的是为了解决上述存在的缺陷，提供一种洋葱浸膏的制备方法。
本发明涉及的洋葱浸膏是采用如下制备方法制得的：
1.将新鲜洋葱水洗3-5分钟，洗净去泥沙，沥水10-15分钟，切片，厚度为0.5厘米，切片的洋葱不宜放置时间过长，防止有效成分流失。
2.将洋葱片放入多功能提取罐内，加入蒸馏水或去离子水，加入量按新鲜洋葱片重量的1∶1倍，加温至85-90℃，进行水中蒸馏150-180分钟，混合汽经冷却的流出液，进行油水分离，收集洋葱挥发油备用，待洋葱挥发油蒸馏完全，将罐内温度降至40℃以下，放出经过蒸馏的洋葱片。
3.将经过蒸馏的洋葱片放入榨汁机料斗内，榨成洋葱汁。
4.将洋葱汁放入反应罐内，加入98度以上的乙醇，加入量按新鲜洋葱重量的1∶1.5倍，搅拌5-10分钟，静置240分钟，进行稀释醇化。
5.将稀释醇化液输入过滤器内，进行过滤，去渣。
6.将滤液放入真空浓缩器内，加温至58℃，回收乙醇完全，再加温至85-90℃进行浓缩至新鲜洋葱重量的25％，将温度降至40℃以下，放出浓缩液。
7.将浓缩液放入喷雾干燥机内，进行喷雾干燥，浸膏的水分含量控制在3-5％以内，收集浸膏备用。
8.将洋葱挥发油与洋葱干浸膏混匀。
9.将浸膏粉碎成200目的细粉。
10.将浸膏细粉置于-60℃低温下进行灭菌。
11.用塑料薄膜材料，真空包装，即得洋葱浸膏。
12.用洋葱浸膏0.3克制备片剂或胶囊，用0.9克制备10ml瓶的口服液。
本发明涉及的洋葱浸膏，其特征为棕色、粉状，有特异香味和甜味，水溶性浸出物大于60％，水分小于5％，灰分大于3％。
药理实验表明：洋葱浸膏及其洋葱浸膏制备的片剂、胶囊、口服液对血液、心血管疾病有药效作用，能扩张血管、降血压、降血脂，每天服用洋葱浸膏1.8克，分2次服，每次服0.9克，服用120天，对动脉硬化、静脉炎、高血压、冠心病、血栓症、糖尿病有明显的控制效果。
急性毒性试验和残毒性试验表明：洋葱浸膏及其洋葱浸膏制备的片剂、胶囊、口服液均无任何毒副作用，使用安全可靠。
本发明的优点是采用新鲜洋葱为原料制备洋葱浸膏及其洋葱浸膏制备的片剂、胶囊、口服液，扩大了洋葱的药用原料资源，洋葱原料来源充足而且有保证。本发明的另一个优点是利用新鲜洋葱为原料，降低了原料成本，制备浸膏得率高，生产工艺先进，适合现代工业化生产。本发明最突出的优点是为抗血液、心血管系统疾病提供了一种治疗新药。
实施例：
取新鲜洋葱100kg，洗净、沥水、切片成0.5厘米厚，将洋葱片放入多功能提取罐内，加入蒸馏水或去离子水100kg，加温85-90℃，蒸馏150-180分钟，油水分离，蒸馏提取洋葱挥发油20克，收集备用；将多功提取罐内的料液降温至40℃以下，放出料液；将经过蒸馏的洋葱片料液放入榨汁机料斗内榨成洋葱汁，将洋葱汁放入反应罐内，加入98度以上的乙醇150kg，搅拌5-10分钟，静置240分钟，进行稀释醇化；将稀释醇化液输入过滤器内，进行过滤、去渣；将滤液放入真空浓缩器内，先加温至58℃回收乙醇完全后，再加温至85-90℃进行浓缩至新鲜洋葱重量的25％，约25kg浓缩液，将浓缩器内的浓缩液降温至40℃以下，放出浓缩液，将浓缩液放入喷雾干燥机内进行喷雾干燥，控制浸膏的水分在3-5％以内，收集1000-1200克浸膏备用；将洋葱油与洋葱浸膏混匀，放入粉碎机内制成200目的细粉，将细粉置入-60℃低温下灭菌；将洋葱浸膏制备成0.3克/片的片剂，0.3克/粒的胶囊，0.9克浸膏制备成10ml/瓶的口服液，每天2次，每次服用量为3片(粒)或1瓶口服液，早晚饭后各服1次，服用120天对心血管疾病有明显的控制效果。
本发明上述实施例仅仅是为清楚地说明本发明所作的举例，而并非对本发明的实施方式的限定。对于所属领域的制备工艺技术方案，在上述说明的基础上显然可以做出其它不同形式的变化，制备不同剂型的产品，这里无需也无法对所有实施方式予以穷举。而这些变化及其不同剂型的产品，仍处于本发明的保护范围之中。
Claims (1)
1.一种对心血管疾病有控制作用的洋葱浸膏，其特征在于它是通过下列方法制成的：(1)将新鲜洋葱水洗3-5分钟，洗净去泥沙，沥水10-15分钟，切片，厚度为0.5厘米；(2)将洋葱片放入多功能提取罐内，加入蒸馏水或去离子水，加入量按新鲜洋葱片重量的1∶1倍，加温至85-90℃，进行水中蒸馏150-180分钟，混合汽经冷却的流出液，进行油水分离，收集洋葱挥发油备用，待洋葱挥发油蒸馏完全，将罐内温度降至40℃以下，放出经过蒸馏的洋葱片；(3)将经过蒸馏的洋葱片放入榨汁机料斗内，榨成洋葱汁；(4)将洋葱汁放入反应罐内，加入98度以上的乙醇，加入量按新鲜洋葱重量的1∶1.5倍，搅拌5-10分钟，静置240分钟，进行稀释醇化；(5)将稀释醇化液输入过滤器内，进行过滤、去渣；(6)将滤液放入真空浓缩器内，加温至58℃，回收乙醇完全，再加温至85-90℃进行浓缩至新鲜洋葱重量的25％，将温度降至40℃以下，放出浓缩液；(7)将浓缩液放入喷雾干燥机内，进行喷雾干燥，浸膏的水分含量控制在3-5％以内，收集浸膏备用；(8)将洋葱挥发油与洋葱干浸膏混匀；(9)将浸膏粉碎成200目的细粉。
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| CN101601458B (zh) * | 2008-06-14 | 2013-11-20 | 张斌 | 洋葱干及其制备方法 |
| CN102119993B (zh) * | 2011-03-07 | 2012-05-23 | 天津科技大学 | 洋葱提取物的制备方法 |
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