CN1223564C - 中间体卤代苯基衍生物及其在制备吡咯衍生物中的应用 - Google Patents
中间体卤代苯基衍生物及其在制备吡咯衍生物中的应用 Download PDFInfo
- Publication number
- CN1223564C CN1223564C CNB028126416A CN02812641A CN1223564C CN 1223564 C CN1223564 C CN 1223564C CN B028126416 A CNB028126416 A CN B028126416A CN 02812641 A CN02812641 A CN 02812641A CN 1223564 C CN1223564 C CN 1223564C
- Authority
- CN
- China
- Prior art keywords
- compound
- converted
- general formula
- reaction
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
- C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
- C07C33/483—Monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01115355.8 | 2001-06-26 | ||
| EP01115355 | 2001-06-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1520390A CN1520390A (zh) | 2004-08-11 |
| CN1223564C true CN1223564C (zh) | 2005-10-19 |
Family
ID=8177821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028126416A Expired - Lifetime CN1223564C (zh) | 2001-06-26 | 2002-06-17 | 中间体卤代苯基衍生物及其在制备吡咯衍生物中的应用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7115643B2 (enExample) |
| EP (1) | EP1399402B1 (enExample) |
| JP (1) | JP4125672B2 (enExample) |
| KR (1) | KR100898887B1 (enExample) |
| CN (1) | CN1223564C (enExample) |
| AT (1) | ATE482920T1 (enExample) |
| AU (1) | AU2002321068B2 (enExample) |
| BR (1) | BR0210701A (enExample) |
| CA (1) | CA2449800C (enExample) |
| CY (1) | CY1111510T1 (enExample) |
| DE (1) | DE60237817D1 (enExample) |
| DK (1) | DK1399402T3 (enExample) |
| ES (1) | ES2349918T3 (enExample) |
| MX (1) | MXPA03010914A (enExample) |
| PT (1) | PT1399402E (enExample) |
| WO (1) | WO2003002498A1 (enExample) |
| ZA (1) | ZA200309101B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8207352B2 (en) * | 2009-10-08 | 2012-06-26 | Drug Process Licensing Associates LLC | Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole |
| HUE031679T2 (en) | 2012-08-07 | 2017-07-28 | Basilea Pharmaceutica Ag | Process for the preparation of isavuconazole or ravuconazole |
| US20140371179A1 (en) * | 2013-06-13 | 2014-12-18 | Professional Compounding Centers Of America | Methods and Compositions for Treating Esophageal Diseases |
| CN105801500B (zh) * | 2014-12-31 | 2018-08-24 | 四川科伦药物研究院有限公司 | 拆分艾沙康唑中间化合物消旋体的方法 |
| CN115611822B (zh) * | 2022-10-12 | 2023-09-19 | 四川澄华生物科技有限公司 | 艾沙康唑中间体的制备方法 |
| CN116478103B (zh) * | 2023-03-24 | 2025-07-25 | 四川澄华生物科技有限公司 | 一种拆分艾沙康唑中间体4的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5395942A (en) * | 1980-06-02 | 1995-03-07 | Zeneca Limited | Heterocyclic compounds |
| DE3942790A1 (de) * | 1989-12-23 | 1991-06-27 | Hoechst Ag | Verfahren zur herstellung von 2-(4-chlorphenyl)-3-methylbuttersaeure |
| GB9107055D0 (en) * | 1991-04-04 | 1991-05-22 | Pfizer Ltd | Triazole antifungal agents |
| JP3471831B2 (ja) * | 1991-12-09 | 2003-12-02 | 富山化学工業株式会社 | 新規なトリアゾール誘導体およびその塩 |
| ES2062941B1 (es) * | 1993-03-15 | 1995-10-01 | Uriach & Cia Sa J | Nuevos derivados de azol activos por via oral. |
| NZ270418A (en) | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
-
2002
- 2002-06-17 AU AU2002321068A patent/AU2002321068B2/en not_active Ceased
- 2002-06-17 EP EP02754691A patent/EP1399402B1/en not_active Expired - Lifetime
- 2002-06-17 CN CNB028126416A patent/CN1223564C/zh not_active Expired - Lifetime
- 2002-06-17 PT PT02754691T patent/PT1399402E/pt unknown
- 2002-06-17 MX MXPA03010914A patent/MXPA03010914A/es active IP Right Grant
- 2002-06-17 WO PCT/EP2002/006644 patent/WO2003002498A1/en not_active Ceased
- 2002-06-17 DE DE60237817T patent/DE60237817D1/de not_active Expired - Lifetime
- 2002-06-17 CA CA002449800A patent/CA2449800C/en not_active Expired - Fee Related
- 2002-06-17 AT AT02754691T patent/ATE482920T1/de active
- 2002-06-17 KR KR1020037016987A patent/KR100898887B1/ko not_active Expired - Fee Related
- 2002-06-17 BR BR0210701-5A patent/BR0210701A/pt not_active IP Right Cessation
- 2002-06-17 ES ES02754691T patent/ES2349918T3/es not_active Expired - Lifetime
- 2002-06-17 DK DK02754691.0T patent/DK1399402T3/da active
- 2002-06-17 US US10/481,654 patent/US7115643B2/en not_active Expired - Lifetime
- 2002-06-17 JP JP2003508683A patent/JP4125672B2/ja not_active Expired - Lifetime
-
2003
- 2003-11-21 ZA ZA2003/09101A patent/ZA200309101B/en unknown
-
2010
- 2010-12-20 CY CY20101101172T patent/CY1111510T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7115643B2 (en) | 2006-10-03 |
| DK1399402T3 (da) | 2010-11-15 |
| KR20040012982A (ko) | 2004-02-11 |
| PT1399402E (pt) | 2010-11-30 |
| EP1399402A1 (en) | 2004-03-24 |
| DE60237817D1 (de) | 2010-11-11 |
| JP4125672B2 (ja) | 2008-07-30 |
| ATE482920T1 (de) | 2010-10-15 |
| JP2004535444A (ja) | 2004-11-25 |
| BR0210701A (pt) | 2004-07-20 |
| WO2003002498A1 (en) | 2003-01-09 |
| AU2002321068B2 (en) | 2007-11-15 |
| KR100898887B1 (ko) | 2009-05-21 |
| US20040176432A1 (en) | 2004-09-09 |
| CN1520390A (zh) | 2004-08-11 |
| EP1399402B1 (en) | 2010-09-29 |
| CA2449800C (en) | 2009-09-29 |
| ES2349918T3 (es) | 2011-01-13 |
| CY1111510T1 (el) | 2015-08-05 |
| MXPA03010914A (es) | 2004-02-17 |
| CA2449800A1 (en) | 2003-01-09 |
| ZA200309101B (en) | 2005-03-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1223564C (zh) | 中间体卤代苯基衍生物及其在制备吡咯衍生物中的应用 | |
| EP4045488A1 (en) | An industrial scale process for the preparation of prothioconazole | |
| WO2004000826A1 (ja) | エポキシトリアゾール誘導体およびその中間体の製造方法 | |
| AU2002321068A1 (en) | Intermediate halophenyl derivatives and their use in a process for preparing azole derivatives | |
| CN103608334B (zh) | 咪唑衍生物的制备方法 | |
| CN103180305B (zh) | 环氧基醇化合物的制造方法 | |
| EP2721014A2 (en) | Hybrid molecules containing pharmacophores of fluconazole as antifungal agents and their preparation | |
| WO2009024214A1 (en) | Process for the production of voriconazole | |
| JP2004535444A5 (enExample) | ||
| CN100349879C (zh) | 制备芳基三唑啉酮的方法及其新中间体 | |
| JP3407088B2 (ja) | トリアゾール誘導体の製造方法およびその中間体 | |
| JP2013518876A (ja) | 新規中間体を使用したボリコナゾールの製造方法 | |
| CN107311946A (zh) | 2‑（1h‑1,2,3‑三氮唑基）‑3‑羟基联苯‑4‑羧酸乙酯类化合物的合成方法 | |
| JP4330898B2 (ja) | 光学活性２−フェニル−２，３−ジヒドロキシプロピルアゾール誘導体の製造法 | |
| CN101500992A (zh) | 制备1-甲基碳青霉烯制备用中间体的方法 | |
| CN100503544C (zh) | 用于制备环氧三唑衍生物的中间体 | |
| JPH04356471A (ja) | トリアゾール化合物およびその用途 | |
| CN114213278B (zh) | 一种苄重氮基苯乙酮类化合物的合成方法及苄重氮基苯乙酮类化合物 | |
| CN101665508A (zh) | 4位-1H-1,2，3-三唑-β-内酰胺衍生物的制备方法 | |
| WO2006059759A1 (ja) | エポキシトリアゾール誘導体の製造方法 | |
| JP4326816B2 (ja) | 光学活性アゾール誘導体およびその製造法 | |
| JP4397579B2 (ja) | １−置換−４−カルバモイル−１，２，４−トリアゾール−５−オン誘導体の製造方法 | |
| JP2004075593A (ja) | 光学活性２，３−エポキシプロパン誘導体の製造法 | |
| JP2006182766A (ja) | エポキシトリアゾール誘導体およびその中間体の製造方法 | |
| JPH08253452A (ja) | 光学活性トリアゾール誘導体の製造法およびその中間体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20051019 |
|
| CX01 | Expiry of patent term |