JP4125672B2 - アゾール誘導体製造方法における中間体ハロフェニル誘導体およびそれらの使用 - Google Patents

アゾール誘導体製造方法における中間体ハロフェニル誘導体およびそれらの使用 Download PDF

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Publication number
JP4125672B2
JP4125672B2 JP2003508683A JP2003508683A JP4125672B2 JP 4125672 B2 JP4125672 B2 JP 4125672B2 JP 2003508683 A JP2003508683 A JP 2003508683A JP 2003508683 A JP2003508683 A JP 2003508683A JP 4125672 B2 JP4125672 B2 JP 4125672B2
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JP
Japan
Prior art keywords
methyl
phenyl
difluoro
pent
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP2003508683A
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English (en)
Japanese (ja)
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JP2004535444A (ja
JP2004535444A5 (enExample
Inventor
ソークプ，ミラン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basilea Pharmaceutica AG
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Basilea Pharmaceutica AG
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Publication of JP2004535444A5 publication Critical patent/JP2004535444A5/ja
Application granted granted Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2003508683A 2001-06-26 2002-06-17 アゾール誘導体製造方法における中間体ハロフェニル誘導体およびそれらの使用 Expired - Lifetime JP4125672B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01115355 2001-06-26
PCT/EP2002/006644 WO2003002498A1 (en) 2001-06-26 2002-06-17 Intermediate halophenyl derivatives and their use in a process for preparing azole derivatives

Publications (3)

Publication Number Publication Date
JP2004535444A JP2004535444A (ja) 2004-11-25
JP2004535444A5 JP2004535444A5 (enExample) 2005-11-17
JP4125672B2 true JP4125672B2 (ja) 2008-07-30

Family

ID=8177821

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003508683A Expired - Lifetime JP4125672B2 (ja) 2001-06-26 2002-06-17 アゾール誘導体製造方法における中間体ハロフェニル誘導体およびそれらの使用

Country Status (17)

Country Link
US (1) US7115643B2 (enExample)
EP (1) EP1399402B1 (enExample)
JP (1) JP4125672B2 (enExample)
KR (1) KR100898887B1 (enExample)
CN (1) CN1223564C (enExample)
AT (1) ATE482920T1 (enExample)
AU (1) AU2002321068B2 (enExample)
BR (1) BR0210701A (enExample)
CA (1) CA2449800C (enExample)
CY (1) CY1111510T1 (enExample)
DE (1) DE60237817D1 (enExample)
DK (1) DK1399402T3 (enExample)
ES (1) ES2349918T3 (enExample)
MX (1) MXPA03010914A (enExample)
PT (1) PT1399402E (enExample)
WO (1) WO2003002498A1 (enExample)
ZA (1) ZA200309101B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207352B2 (en) * 2009-10-08 2012-06-26 Drug Process Licensing Associates LLC Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole
HUE031679T2 (en) 2012-08-07 2017-07-28 Basilea Pharmaceutica Ag Process for the preparation of isavuconazole or ravuconazole
US20140371179A1 (en) * 2013-06-13 2014-12-18 Professional Compounding Centers Of America Methods and Compositions for Treating Esophageal Diseases
CN105801500B (zh) * 2014-12-31 2018-08-24 四川科伦药物研究院有限公司 拆分艾沙康唑中间化合物消旋体的方法
CN115611822B (zh) * 2022-10-12 2023-09-19 四川澄华生物科技有限公司 艾沙康唑中间体的制备方法
CN116478103B (zh) * 2023-03-24 2025-07-25 四川澄华生物科技有限公司 一种拆分艾沙康唑中间体4的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395942A (en) * 1980-06-02 1995-03-07 Zeneca Limited Heterocyclic compounds
DE3942790A1 (de) * 1989-12-23 1991-06-27 Hoechst Ag Verfahren zur herstellung von 2-(4-chlorphenyl)-3-methylbuttersaeure
GB9107055D0 (en) * 1991-04-04 1991-05-22 Pfizer Ltd Triazole antifungal agents
JP3471831B2 (ja) * 1991-12-09 2003-12-02 富山化学工業株式会社 新規なトリアゾール誘導体およびその塩
ES2062941B1 (es) * 1993-03-15 1995-10-01 Uriach & Cia Sa J Nuevos derivados de azol activos por via oral.
NZ270418A (en) 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions

Also Published As

Publication number Publication date
CN1223564C (zh) 2005-10-19
US7115643B2 (en) 2006-10-03
DK1399402T3 (da) 2010-11-15
KR20040012982A (ko) 2004-02-11
PT1399402E (pt) 2010-11-30
EP1399402A1 (en) 2004-03-24
DE60237817D1 (de) 2010-11-11
ATE482920T1 (de) 2010-10-15
JP2004535444A (ja) 2004-11-25
BR0210701A (pt) 2004-07-20
WO2003002498A1 (en) 2003-01-09
AU2002321068B2 (en) 2007-11-15
KR100898887B1 (ko) 2009-05-21
US20040176432A1 (en) 2004-09-09
CN1520390A (zh) 2004-08-11
EP1399402B1 (en) 2010-09-29
CA2449800C (en) 2009-09-29
ES2349918T3 (es) 2011-01-13
CY1111510T1 (el) 2015-08-05
MXPA03010914A (es) 2004-02-17
CA2449800A1 (en) 2003-01-09
ZA200309101B (en) 2005-03-30

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