CN1216033C - 亚环己基胺的顺式选择性催化氢化方法 - Google Patents

亚环己基胺的顺式选择性催化氢化方法 Download PDF

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Publication number
CN1216033C
CN1216033C CN998041378A CN99804137A CN1216033C CN 1216033 C CN1216033 C CN 1216033C CN 998041378 A CN998041378 A CN 998041378A CN 99804137 A CN99804137 A CN 99804137A CN 1216033 C CN1216033 C CN 1216033C
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CN
China
Prior art keywords
copper
compound
hydrogenation
cis
catalyst
Prior art date
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Expired - Fee Related
Application number
CN998041378A
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English (en)
Chinese (zh)
Other versions
CN1293653A (zh
Inventor
H·斯坦纳
M·本兹
H·－P·雅勒特
M·托门
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba Spezialitaetenchemie Holding AG
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Publication date
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Publication of CN1293653A publication Critical patent/CN1293653A/zh
Application granted granted Critical
Publication of CN1216033C publication Critical patent/CN1216033C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN998041378A 1998-03-18 1999-03-16 亚环己基胺的顺式选择性催化氢化方法 Expired - Fee Related CN1216033C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH64598 1998-03-18
CH645/1998 1998-03-18

Publications (2)

Publication Number Publication Date
CN1293653A CN1293653A (zh) 2001-05-02
CN1216033C true CN1216033C (zh) 2005-08-24

Family

ID=4191841

Family Applications (1)

Application Number Title Priority Date Filing Date
CN998041378A Expired - Fee Related CN1216033C (zh) 1998-03-18 1999-03-16 亚环己基胺的顺式选择性催化氢化方法

Country Status (16)

Country Link
US (1) US6232501B1 (enExample)
EP (1) EP1064250B1 (enExample)
JP (1) JP2002506844A (enExample)
CN (1) CN1216033C (enExample)
AR (1) AR018164A1 (enExample)
AU (1) AU759530B2 (enExample)
CA (1) CA2323629A1 (enExample)
DE (1) DE69916593T2 (enExample)
ES (1) ES2217748T3 (enExample)
HU (1) HUP0101322A3 (enExample)
IL (2) IL138172A0 (enExample)
PT (1) PT1064250E (enExample)
TR (1) TR200002673T2 (enExample)
TW (1) TWI220427B (enExample)
WO (1) WO1999047486A1 (enExample)
ZA (1) ZA200004624B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500987B1 (en) 1998-11-27 2002-12-31 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride polymorphs
BR0012840A (pt) * 1999-07-29 2002-05-28 Ciba Sc Holding Ag Processo para a hidrogenação catalìtica cis-seletiva de ciclohexilidenaminas
US6495721B1 (en) 1999-08-09 2002-12-17 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride Form II and methods for the preparation thereof
US7442838B2 (en) 1999-10-29 2008-10-28 Ciba Specialty Chemicals Corp. Polymorphic forms of sertraline hydrochloride
TWI260315B (en) 1999-10-29 2006-08-21 Ciba Sc Holding Ag Polymorphic forms of sertraline hydrochloride
WO2001036377A1 (en) * 1999-11-16 2001-05-25 Ciba Specialty Chemicals Holding Inc. Process for the preparation of ketimines
CN1246298C (zh) * 1999-11-16 2006-03-22 西巴特殊化学品控股有限公司 制备酮亚胺的方法
ATE354358T1 (de) 1999-12-21 2007-03-15 Teva Pharma Neue sertralinhydrochlorid polymorphe, verfahren zur herstellung und zur verwendung und diese enthaltende zusammensetzungen
JP2003527359A (ja) 2000-03-14 2003-09-16 テバ ファーマシューティカル インダストリーズ リミティド （＋）−シス−セルトラリンの製造のための新規方法
US6723878B2 (en) 2001-06-15 2004-04-20 Orion Corporation Fermion Method for preparing sertraline
EP1499581A1 (en) 2002-04-29 2005-01-26 Teva Pharmaceutical Industries Ltd. Process for preparation of polymorphic form ii of sertraline hydrochloride, pharmaceutical formulations and methods of administration thereof
ES2242555T1 (es) * 2003-04-14 2005-11-16 Teva Pharmaceutical Industries Limited Hidrogenacion de intermediarios de imina de sertralina con catalizadores.
WO2006129324A2 (en) 2005-06-03 2006-12-07 Hetero Drugs Limited A highly stereoselective synthesis of sertraline
WO2009080511A1 (de) * 2007-12-21 2009-07-02 Basf Se Verfahren zur diastereoselektiven umsetzung von chiralen iminen
KR20100108394A (ko) * 2007-12-21 2010-10-06 바스프 에스이 일단계 환원성 아민화 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US5290806A (en) * 1990-03-06 1994-03-01 Basf Aktiengesellschaft 4-(4-tert-butylphenyl) cyclohexylamines, and fungicides containing same
GB9114948D0 (en) * 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
IL112569A (en) * 1994-02-10 1999-12-22 Wyeth John & Brother Ltd Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation
HU222341B1 (hu) 1996-12-18 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás sertralin előállítására és az eljárásban alkalmazott intermedier
DE19812054A1 (de) * 1998-03-19 1999-09-23 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung 4-substituierter cis-Cyclohexylamine

Also Published As

Publication number Publication date
EP1064250B1 (en) 2004-04-21
AU759530B2 (en) 2003-04-17
ZA200004624B (en) 2001-11-29
EP1064250A1 (en) 2001-01-03
DE69916593T2 (de) 2005-05-25
DE69916593D1 (de) 2004-05-27
WO1999047486A1 (en) 1999-09-23
HUP0101322A3 (en) 2002-06-28
IL138172A0 (en) 2001-10-31
TWI220427B (en) 2004-08-21
US6232501B1 (en) 2001-05-15
IL138172A (en) 2007-09-20
PT1064250E (pt) 2004-09-30
HUP0101322A2 (hu) 2002-05-29
CA2323629A1 (en) 1999-09-23
CN1293653A (zh) 2001-05-02
JP2002506844A (ja) 2002-03-05
ES2217748T3 (es) 2004-11-01
AU3412899A (en) 1999-10-11
TR200002673T2 (tr) 2000-11-21
AR018164A1 (es) 2001-10-31

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050824