CN1216033C - 亚环己基胺的顺式选择性催化氢化方法 - Google Patents

亚环己基胺的顺式选择性催化氢化方法 Download PDF

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Publication number
CN1216033C
CN1216033C CN998041378A CN99804137A CN1216033C CN 1216033 C CN1216033 C CN 1216033C CN 998041378 A CN998041378 A CN 998041378A CN 99804137 A CN99804137 A CN 99804137A CN 1216033 C CN1216033 C CN 1216033C
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CN
China
Prior art keywords
copper
compound
hydrogenation
cis
catalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN998041378A
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English (en)
Chinese (zh)
Other versions
CN1293653A (zh
Inventor
H·斯坦纳
M·本兹
H·－P·雅勒特
M·托门
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba Spezialitaetenchemie Holding AG
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Publication date
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Publication of CN1293653A publication Critical patent/CN1293653A/zh
Application granted granted Critical
Publication of CN1216033C publication Critical patent/CN1216033C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN998041378A 1998-03-18 1999-03-16 亚环己基胺的顺式选择性催化氢化方法 Expired - Fee Related CN1216033C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH64598 1998-03-18
CH645/1998 1998-03-18

Publications (2)

Publication Number Publication Date
CN1293653A CN1293653A (zh) 2001-05-02
CN1216033C true CN1216033C (zh) 2005-08-24

Family

ID=4191841

Family Applications (1)

Application Number Title Priority Date Filing Date
CN998041378A Expired - Fee Related CN1216033C (zh) 1998-03-18 1999-03-16 亚环己基胺的顺式选择性催化氢化方法

Country Status (16)

Country Link
US (1) US6232501B1 (enExample)
EP (1) EP1064250B1 (enExample)
JP (1) JP2002506844A (enExample)
CN (1) CN1216033C (enExample)
AR (1) AR018164A1 (enExample)
AU (1) AU759530B2 (enExample)
CA (1) CA2323629A1 (enExample)
DE (1) DE69916593T2 (enExample)
ES (1) ES2217748T3 (enExample)
HU (1) HUP0101322A3 (enExample)
IL (2) IL138172A0 (enExample)
PT (1) PT1064250E (enExample)
TR (1) TR200002673T2 (enExample)
TW (1) TWI220427B (enExample)
WO (1) WO1999047486A1 (enExample)
ZA (1) ZA200004624B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500987B1 (en) 1998-11-27 2002-12-31 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride polymorphs
TR200200110T2 (tr) * 1999-07-29 2002-06-21 Ciba Specialty Chemicals Holding Inc. Sikloheksilidenaminlerin cis-selektif katalitik hidrojenasyonu için süreç
US6495721B1 (en) 1999-08-09 2002-12-17 Teva Pharmaceutical Industries Ltd. Sertraline hydrochloride Form II and methods for the preparation thereof
TWI260315B (en) 1999-10-29 2006-08-21 Ciba Sc Holding Ag Polymorphic forms of sertraline hydrochloride
US7442838B2 (en) 1999-10-29 2008-10-28 Ciba Specialty Chemicals Corp. Polymorphic forms of sertraline hydrochloride
ATE299862T1 (de) * 1999-11-16 2005-08-15 Ciba Sc Holding Ag Verfahren zur herstellung von ketiminen
PT1230212E (pt) 1999-11-16 2005-08-31 Ciba Sc Holding Ag Metodo de embalar elementos de construcao de brinquedo
YU47902A (sh) 1999-12-21 2005-11-28 Teva Pharmaceutical Industries Ltd. Novi polimorfi sertralin hidrohlorida, postupci za njihovo dobijanje, preparati koji ih sadrže i postupci za njihovu upotrebu
KR20070002101A (ko) 2000-03-14 2007-01-04 테바 파마슈티컬 인더스트리즈 리미티드 (+)-시스-세르트랄린의 신규한 제조 방법
US6723878B2 (en) 2001-06-15 2004-04-20 Orion Corporation Fermion Method for preparing sertraline
EP1499581A1 (en) 2002-04-29 2005-01-26 Teva Pharmaceutical Industries Ltd. Process for preparation of polymorphic form ii of sertraline hydrochloride, pharmaceutical formulations and methods of administration thereof
WO2004092110A2 (en) * 2003-04-14 2004-10-28 Teva Pharmaceutical Industries Ltd. Hydrogenation of imine intermediates of sertraline with catalysts
WO2006129324A2 (en) 2005-06-03 2006-12-07 Hetero Drugs Limited A highly stereoselective synthesis of sertraline
CA2708315A1 (en) * 2007-12-21 2009-07-02 Basf Se One-stage reductive amination
CN101903329B (zh) * 2007-12-21 2014-11-05 巴斯夫欧洲公司 非对映选择性转化手性亚胺的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US5290806A (en) * 1990-03-06 1994-03-01 Basf Aktiengesellschaft 4-(4-tert-butylphenyl) cyclohexylamines, and fungicides containing same
GB9114948D0 (en) * 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
IL112569A (en) * 1994-02-10 1999-12-22 Wyeth John & Brother Ltd Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation
HU222341B1 (hu) 1996-12-18 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás sertralin előállítására és az eljárásban alkalmazott intermedier
DE19812054A1 (de) * 1998-03-19 1999-09-23 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung 4-substituierter cis-Cyclohexylamine

Also Published As

Publication number Publication date
IL138172A0 (en) 2001-10-31
TR200002673T2 (tr) 2000-11-21
EP1064250B1 (en) 2004-04-21
ES2217748T3 (es) 2004-11-01
EP1064250A1 (en) 2001-01-03
CN1293653A (zh) 2001-05-02
HUP0101322A3 (en) 2002-06-28
AR018164A1 (es) 2001-10-31
WO1999047486A1 (en) 1999-09-23
AU3412899A (en) 1999-10-11
ZA200004624B (en) 2001-11-29
JP2002506844A (ja) 2002-03-05
IL138172A (en) 2007-09-20
DE69916593D1 (de) 2004-05-27
US6232501B1 (en) 2001-05-15
TWI220427B (en) 2004-08-21
DE69916593T2 (de) 2005-05-25
HUP0101322A2 (hu) 2002-05-29
CA2323629A1 (en) 1999-09-23
AU759530B2 (en) 2003-04-17
PT1064250E (pt) 2004-09-30

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050824