CN1206212C - 新的三－取代的苯基衍生物和类似物 - Google Patents

新的三－取代的苯基衍生物和类似物 Download PDF

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Publication number
CN1206212C
CN1206212C CNB008163812A CN00816381A CN1206212C CN 1206212 C CN1206212 C CN 1206212C CN B008163812 A CNB008163812 A CN B008163812A CN 00816381 A CN00816381 A CN 00816381A CN 1206212 C CN1206212 C CN 1206212C
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CN
China
Prior art keywords
phenyl
oxygen base
methylsulfonyl
benzyl
ethoxy
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Expired - Fee Related
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CNB008163812A
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English (en)
Chinese (zh)
Other versions
CN1402703A (zh
Inventor
M·博杰
J·费格哈格
E·－L·林德斯特德塔斯特马克
B·奥尔森
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AstraZeneca AB
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AstraZeneca AB
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Publication of CN1402703A publication Critical patent/CN1402703A/zh
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Publication of CN1206212C publication Critical patent/CN1206212C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB008163812A 1999-12-03 2000-11-29 新的三－取代的苯基衍生物和类似物 Expired - Fee Related CN1206212C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE99044216 1999-12-03
SE9904421A SE9904421D0 (sv) 1999-12-03 1999-12-03 New compounds
SE9904421-6 1999-12-03

Publications (2)

Publication Number Publication Date
CN1402703A CN1402703A (zh) 2003-03-12
CN1206212C true CN1206212C (zh) 2005-06-15

Family

ID=20417986

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008163812A Expired - Fee Related CN1206212C (zh) 1999-12-03 2000-11-29 新的三－取代的苯基衍生物和类似物

Country Status (23)

Country Link
US (1) US6750252B2 (https=)
EP (1) EP1237856B1 (https=)
JP (1) JP2003515583A (https=)
KR (1) KR100787072B1 (https=)
CN (1) CN1206212C (https=)
AR (1) AR033957A1 (https=)
AT (1) ATE266633T1 (https=)
AU (1) AU766533B2 (https=)
BR (1) BR0016130A (https=)
CA (1) CA2392039A1 (https=)
DE (1) DE60010747T2 (https=)
DK (1) DK1237856T3 (https=)
ES (1) ES2219425T3 (https=)
IL (2) IL149517A0 (https=)
MX (1) MXPA02005223A (https=)
MY (1) MY124727A (https=)
NO (1) NO20022590L (https=)
PT (1) PT1237856E (https=)
SE (1) SE9904421D0 (https=)
TR (1) TR200401716T4 (https=)
TW (1) TWI224590B (https=)
WO (1) WO2001040172A1 (https=)
ZA (1) ZA200203798B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1280574A (zh) 1997-10-27 2001-01-17 雷迪研究基金会 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物
US6369067B1 (en) 1997-10-27 2002-04-09 Dr. Reddy's Research Foundation Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
US6440961B1 (en) 1997-10-27 2002-08-27 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
BR9812770A (pt) 1997-10-27 2000-12-12 Reddy Research Foundation Compostos bicìclicos, processo para seu preparo e composições farmacêuticas contendo os mesmos
MXPA00004036A (es) 1997-10-27 2006-05-24 Reddys Lab Ltd Dr Compuestos triciclicos novedosos y su uso en medicina; proceso para su preparacion y composiciones farmaceuticas que los contienen..
JP2002528535A (ja) 1998-10-29 2002-09-03 ドクター・レディーズ・リサーチ・ファウンデーション 新規抗糖尿病剤製造の改良方法
US6531596B1 (en) 1998-10-29 2003-03-11 Dr. Reddy's Laboratories Ltd. Process for the preparation of new antidiabetic agents
US6897199B2 (en) 2001-02-05 2005-05-24 Dr. Reddy's Laboratories Ltd. Pharmaceutically acceptable salts of phenoxazine and phenothiazine compounds
SE0101386D0 (sv) 2001-04-20 2001-04-20 Astrazeneca Ab New compounds
IL161429A0 (en) * 2001-10-16 2004-09-27 Reddys Lab Ltd Dr Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing the same
UA82835C2 (en) * 2001-12-03 2008-05-26 Reddys Lab Ltd Dr ?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon
SE0104333D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
FR2872159B1 (fr) * 2004-06-28 2007-10-05 Merck Sante Soc Par Actions Si Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete
MX2008014520A (es) * 2006-05-22 2008-11-27 Elan Pharm Inc Preparacion de conjugados polimericos de compuestos terapeuticos, agricolas, y de aditivos para alimentos.
RU2480453C2 (ru) 2007-03-08 2013-04-27 Альбирео Аб Новые соединения
FR2917086B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl acrylique activateurs des recepteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
FR2917084B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
DE102007038251A1 (de) * 2007-08-13 2009-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Herstellverfahren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801992D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl-2-hydroxypropionic acid derivative I
SE9801990D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl propionic acid derivatives and analogs
MA26634A1 (fr) 1998-06-04 2004-12-20 Astra Ab Nouveaux derives de l'acide 3-aryl propionique et analogues

Also Published As

Publication number Publication date
TWI224590B (en) 2004-12-01
AU766533B2 (en) 2003-10-16
AR033957A1 (es) 2004-01-21
KR20020067537A (ko) 2002-08-22
WO2001040172A1 (en) 2001-06-07
PT1237856E (pt) 2004-08-31
DE60010747D1 (de) 2004-06-17
US6750252B2 (en) 2004-06-15
ES2219425T3 (es) 2004-12-01
TR200401716T4 (tr) 2004-09-21
IL149517A0 (en) 2002-11-10
SE9904421D0 (sv) 1999-12-03
NO20022590D0 (no) 2002-05-31
ATE266633T1 (de) 2004-05-15
JP2003515583A (ja) 2003-05-07
EP1237856B1 (en) 2004-05-12
BR0016130A (pt) 2002-08-20
CA2392039A1 (en) 2001-06-07
CN1402703A (zh) 2003-03-12
KR100787072B1 (ko) 2007-12-21
ZA200203798B (en) 2003-10-29
NO20022590L (no) 2002-07-29
DK1237856T3 (da) 2004-08-02
EP1237856A1 (en) 2002-09-11
US20030149104A1 (en) 2003-08-07
MY124727A (en) 2006-06-30
DE60010747T2 (de) 2005-05-19
IL149517A (en) 2007-07-04
MXPA02005223A (es) 2003-09-25
AU2035101A (en) 2001-06-12

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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
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Granted publication date: 20050615

Termination date: 20091229