CN1198836C - 编码与感觉转导有关的g－蛋白偶联受体的核酸 - Google Patents

编码与感觉转导有关的g－蛋白偶联受体的核酸 Download PDF

Info

Publication number
CN1198836C
CN1198836C CNB998105252A CN99810525A CN1198836C CN 1198836 C CN1198836 C CN 1198836C CN B998105252 A CNB998105252 A CN B998105252A CN 99810525 A CN99810525 A CN 99810525A CN 1198836 C CN1198836 C CN 1198836C
Authority
CN
China
Prior art keywords
seq
nucleic acid
gpcr
receptor
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB998105252A
Other languages
English (en)
Chinese (zh)
Other versions
CN1317010A (zh
Inventor
C·S·朱克
J·E·阿德莱尔
J·林德迈耶
N·里巴
M·胡恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
US Department of Health and Human Services
Original Assignee
University of California San Diego UCSD
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD, US Department of Health and Human Services filed Critical University of California San Diego UCSD
Publication of CN1317010A publication Critical patent/CN1317010A/zh
Application granted granted Critical
Publication of CN1198836C publication Critical patent/CN1198836C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB998105252A 1998-07-28 1999-07-27 编码与感觉转导有关的g－蛋白偶联受体的核酸 Expired - Lifetime CN1198836C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9446598P 1998-07-28 1998-07-28
US60/094,465 1998-07-28

Publications (2)

Publication Number Publication Date
CN1317010A CN1317010A (zh) 2001-10-10
CN1198836C true CN1198836C (zh) 2005-04-27

Family

ID=22245353

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998105252A Expired - Lifetime CN1198836C (zh) 1998-07-28 1999-07-27 编码与感觉转导有关的g－蛋白偶联受体的核酸

Country Status (12)

Country Link
US (3) US20030036630A1 (https=)
EP (1) EP1100810A4 (https=)
JP (2) JP2002521049A (https=)
KR (1) KR100602857B1 (https=)
CN (1) CN1198836C (https=)
AU (1) AU753703B2 (https=)
BR (1) BR9912545A (https=)
CA (2) CA2776054C (https=)
IL (2) IL140979A0 (https=)
NO (1) NO20010363L (https=)
WO (1) WO2000006592A1 (https=)
ZA (1) ZA200100401B (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
WO2000045179A2 (en) * 1999-01-27 2000-08-03 The Regents Of The University Of California Screening for modulators of g-protein subunit beta 3
US6929925B1 (en) 1999-01-27 2005-08-16 The Regents Of The University Of California Assays for sensory modulators using a sensory cell specific G-protein beta subunit
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
WO2001072842A2 (en) * 2000-03-28 2001-10-04 Lexicon Genetics Incorporated Human 7-transmembrane proteins and polynucleotides encoding the same
CA2408140A1 (en) * 2000-05-22 2001-11-29 Incyte Genomics, Inc. G-protein coupled receptors
EP2093293A3 (en) * 2000-06-16 2010-07-07 Incyte Corporation G-Protein coupled receptors
CA2424821A1 (en) * 2000-10-10 2002-04-18 Pe Corporation (Ny) Gene encoding a human g-protein coupled receptor and its use
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7309577B2 (en) 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
EP1572871A4 (en) * 2001-04-20 2007-11-14 Sinai School Medicine T1R3, A NEW TASTE RECEPTOR
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
CN108329393A (zh) * 2001-06-26 2018-07-27 塞诺米克斯公司 T1r异源寡聚的味觉受体和表达所述受体的细胞系及其在鉴定味觉化合物中的用途
EP2293067B1 (en) 2001-06-26 2016-04-20 Senomyx, Inc. T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
AU2002336571A1 (en) * 2001-09-18 2003-04-01 Irm, Llc Sweet taste receptors
US7527944B2 (en) 2003-06-27 2009-05-05 Monell Chemical Senses Center Taste receptors of the T1R family from domestic cat
AR046078A1 (es) 2003-08-06 2005-11-23 Senomyx Inc Nuevos sabores, modificadores de sabores, sustancias gustativas, mejoradores de gusto, sustancias gustativas y/o mejoradoras del gusto umani o dulce y uso de los mismos.
US8796441B2 (en) 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
ES2640453T3 (es) 2006-04-21 2017-11-03 Senomyx, Inc. Procesos para preparar composiciones saborizantes sólidas
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US9128079B2 (en) 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
WO2021150686A1 (en) 2020-01-22 2021-07-29 Firmenich Incorporated High-sensitivity detection of gpcr activity and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146501A (en) * 1975-12-12 1979-03-27 Henkin Robert I Process for isolating and purifying taste bud receptors for screening and evaluating tastants
US5688662A (en) * 1992-04-09 1997-11-18 Linguagen Corporation Gustducin polynucleotides, vectors, host cells and recombinant methods
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US8039233B2 (en) * 2007-01-18 2011-10-18 Givaudan S.A. Nucleic acid sequences and their use in methods to identify umami modulatiors

Also Published As

Publication number Publication date
WO2000006592A1 (en) 2000-02-10
CA2335318C (en) 2012-05-01
US20070185312A1 (en) 2007-08-09
NO20010363D0 (no) 2001-01-22
US20030036630A1 (en) 2003-02-20
AU5238199A (en) 2000-02-21
CA2335318A1 (en) 2000-02-10
CA2776054C (en) 2016-08-30
EP1100810A4 (en) 2002-09-18
BR9912545A (pt) 2001-10-30
JP2009261399A (ja) 2009-11-12
CN1317010A (zh) 2001-10-10
US20090148948A1 (en) 2009-06-11
KR100602857B1 (ko) 2006-07-20
IL140979A (en) 2008-07-08
NO20010363L (no) 2001-03-26
CA2776054A1 (en) 2000-02-10
KR20010085306A (ko) 2001-09-07
WO2000006592A9 (en) 2000-11-02
EP1100810A1 (en) 2001-05-23
JP2002521049A (ja) 2002-07-16
AU753703B2 (en) 2002-10-24
ZA200100401B (en) 2001-10-31
IL140979A0 (en) 2002-02-10

Similar Documents

Publication Publication Date Title
CN1178952C (zh) 编码与感觉转导有关的g-蛋白偶联受体的核酸
CN1198836C (zh) 编码与感觉转导有关的g－蛋白偶联受体的核酸
CN1387536A (zh) T2r,一类新味觉受体
CN1310945C (zh) 人g蛋白偶联受体的内源形式和非内源形式
CN1309736C (zh) 人类嗅觉cng亚基多肽、核酸序列及相关的检定法
CN1543474A (zh) T1r味觉受体及其编码基因
CN1525981A (zh) T1r味觉受体及其编码基因
CN1434921A (zh) T2r味觉受体及其编码基因
CN1404488A (zh) Nogo受体介导的对轴突生长的阻断
JPH07503611A (ja) ソマトスタチン受容体
CN101058605A (zh) T2r，一类味觉受体
CN1324405A (zh) 新型g蛋白偶联型受体蛋白、dna及其配体
CN1240834C (zh) Ly6h基因
CN1317044A (zh) 编码与感觉转导有关的蛋白质的核酸
CN1820200A (zh) 鉴定利用促肾上腺皮质激素释放因子受体来调节肌肉质量或功能的化合物的方法
CN1809587A (zh) 涉及g－蛋白偶联受体寡聚体的材料和方法
CN1444599A (zh) 新型化合物
CN1135771A (zh) 编码骨形态形成蛋白受体的脱氧核糖核酸序列
CN1171816A (zh) 编码骨形态形成蛋白ii型受体的互补脱氧核糖核酸
CN1549858A (zh) 内源和非内源型人g蛋白偶联受体
CN1397019A (zh) 筛选方法
CN1321164A (zh) 编码与感觉转导有关的G蛋白γ亚基的核酸
CN1195374A (zh) 整合素调节/信号传递的细胞质调节剂
CN1422281A (zh) 新型g蛋白偶联受体
CN1703625A (zh) 果蝇g蛋白偶联受体,核酸和相关方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term

Granted publication date: 20050427

CX01 Expiry of patent term