CN119731195A - 相对于hras和nras对kras具有选择性抑制作用的环状化合物 - Google Patents

相对于hras和nras对kras具有选择性抑制作用的环状化合物 Download PDF

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Publication number
CN119731195A
CN119731195A CN202380038438.6A CN202380038438A CN119731195A CN 119731195 A CN119731195 A CN 119731195A CN 202380038438 A CN202380038438 A CN 202380038438A CN 119731195 A CN119731195 A CN 119731195A
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China
Prior art keywords
trifluoromethyl
phenyl
ethyl
methylpropyl
spiro
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Pending
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CN202380038438.6A
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English (en)
Chinese (zh)
Inventor
河田发夫
鹰野宏治
小竹智也
阴未来
桥本哲
田宫实
若宫佑真
林龙儿
森田雄也
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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Publication of CN119731195A publication Critical patent/CN119731195A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CN202380038438.6A 2022-05-06 2023-05-02 相对于hras和nras对kras具有选择性抑制作用的环状化合物 Pending CN119731195A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022076449 2022-05-06
JP2022-076449 2022-05-06
PCT/JP2023/017112 WO2023214576A1 (ja) 2022-05-06 2023-05-02 Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物

Publications (1)

Publication Number Publication Date
CN119731195A true CN119731195A (zh) 2025-03-28

Family

ID=88646541

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380038438.6A Pending CN119731195A (zh) 2022-05-06 2023-05-02 相对于hras和nras对kras具有选择性抑制作用的环状化合物

Country Status (15)

Country Link
US (2) US12410212B2 (https=)
EP (1) EP4512818A1 (https=)
JP (1) JP7823181B2 (https=)
KR (1) KR20250008758A (https=)
CN (1) CN119731195A (https=)
AR (1) AR129238A1 (https=)
AU (1) AU2023264918A1 (https=)
CA (1) CA3256645A1 (https=)
CL (1) CL2024003354A1 (https=)
CO (1) CO2024016293A2 (https=)
IL (1) IL316253A (https=)
MX (1) MX2024013352A (https=)
PE (1) PE20251872A1 (https=)
TW (1) TW202406927A (https=)
WO (1) WO2023214576A1 (https=)

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Publication number Publication date
KR20250008758A (ko) 2025-01-15
US20250230193A1 (en) 2025-07-17
WO2023214576A1 (ja) 2023-11-09
US12410212B2 (en) 2025-09-09
AU2023264918A1 (en) 2025-01-09
PE20251872A1 (es) 2025-07-22
TW202406927A (zh) 2024-02-16
CL2024003354A1 (es) 2025-03-21
JPWO2023214576A1 (https=) 2023-11-09
JP7823181B2 (ja) 2026-03-03
CA3256645A1 (en) 2025-04-23
CO2024016293A2 (es) 2025-02-24
US20250051394A1 (en) 2025-02-13
AR129238A1 (es) 2024-07-31
MX2024013352A (es) 2024-12-06
IL316253A (en) 2025-01-01
EP4512818A1 (en) 2025-02-26

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