CN1196785C - β-淀粉样肽结合蛋白及其编码聚核苷酸 - Google Patents

β-淀粉样肽结合蛋白及其编码聚核苷酸 Download PDF

Info

Publication number
CN1196785C
CN1196785C CNB988043173A CN98804317A CN1196785C CN 1196785 C CN1196785 C CN 1196785C CN B988043173 A CNB988043173 A CN B988043173A CN 98804317 A CN98804317 A CN 98804317A CN 1196785 C CN1196785 C CN 1196785C
Authority
CN
China
Prior art keywords
protein
bbp
sequence
polynucleotide
bap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988043173A
Other languages
English (en)
Chinese (zh)
Other versions
CN1268973A (zh
Inventor
B·A·奥藏伯格
J·A·巴德
E·M·卡科斯基
J·S·雅各布森
S·G·沃克
H·索菲亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of CN1268973A publication Critical patent/CN1268973A/zh
Application granted granted Critical
Publication of CN1196785C publication Critical patent/CN1196785C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB988043173A 1997-04-16 1998-04-14 β-淀粉样肽结合蛋白及其编码聚核苷酸 Expired - Fee Related CN1196785C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6458397P 1997-04-16 1997-04-16
US60/064,583 1997-04-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA200510052975XA Division CN1690203A (zh) 1997-04-16 1998-04-14 β-淀粉样肽结合蛋白及其编码聚核苷酸

Publications (2)

Publication Number Publication Date
CN1268973A CN1268973A (zh) 2000-10-04
CN1196785C true CN1196785C (zh) 2005-04-13

Family

ID=22056941

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA200510052975XA Pending CN1690203A (zh) 1997-04-16 1998-04-14 β-淀粉样肽结合蛋白及其编码聚核苷酸
CNB988043173A Expired - Fee Related CN1196785C (zh) 1997-04-16 1998-04-14 β-淀粉样肽结合蛋白及其编码聚核苷酸

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNA200510052975XA Pending CN1690203A (zh) 1997-04-16 1998-04-14 β-淀粉样肽结合蛋白及其编码聚核苷酸

Country Status (18)

Country Link
EP (1) EP0975753A2 (xx)
JP (3) JP2001523093A (xx)
KR (1) KR20010006393A (xx)
CN (2) CN1690203A (xx)
AU (1) AU740445B2 (xx)
BR (1) BR9808562A (xx)
CA (1) CA2286484A1 (xx)
EA (1) EA004256B1 (xx)
EE (1) EE9900482A (xx)
GE (1) GEP20043386B (xx)
HU (1) HUP0003116A3 (xx)
ID (1) ID24914A (xx)
IL (3) IL132236A0 (xx)
NO (1) NO995062L (xx)
NZ (1) NZ500216A (xx)
SK (1) SK143299A3 (xx)
UA (1) UA72875C2 (xx)
WO (1) WO1998046636A2 (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7005295B1 (en) 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
US6787319B2 (en) 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
JP2002527064A (ja) * 1998-10-13 2002-08-27 アメリカン・ホーム・プロダクツ・コーポレイション 6−蛋白結合受容体様蛋白、それらによりコードされるポリヌクレオチド、ならびにそれらの使用方法
US6455082B1 (en) * 1999-04-26 2002-09-24 Nestec S.A. Shelf-stable calcium fortified milk and dairy products
EP1226241A1 (en) * 1999-10-21 2002-07-31 Panorama Research, Inc. A general method for optimizing the expression of heterologous proteins
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
US7807171B2 (en) 2003-07-25 2010-10-05 Ac Immune Sa Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
WO2012020124A1 (en) 2010-08-12 2012-02-16 Ac Immune S.A. Vaccine engineering
CN103189050B (zh) 2010-10-26 2017-09-29 Ac免疫有限公司 包含通过疏水部分修饰的肽的基于脂质体的构建体
CN102060912B (zh) * 2010-11-22 2012-11-14 清华大学 淀粉样蛋白寡聚体构象型抗原表位多肽及其应用
CN111320678B (zh) * 2020-03-09 2023-06-09 安亭生物有限责任公司 抗菌肽突变体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003951A1 (en) * 1986-11-17 1988-06-02 California Biotechnology, Inc. Recombinant alzheimer's amyloid protein
IL115743A0 (en) * 1994-10-28 1996-01-19 American Nat Red Cross A mammal with cells containing a transgene and its production
US5786180A (en) * 1995-02-14 1998-07-28 Bayer Corporation Monoclonal antibody 369.2B specific for β A4 peptide

Also Published As

Publication number Publication date
NO995062L (no) 1999-12-14
WO1998046636A3 (en) 1999-01-28
KR20010006393A (ko) 2001-01-26
JP2001523093A (ja) 2001-11-20
HUP0003116A2 (hu) 2001-01-29
CN1690203A (zh) 2005-11-02
SK143299A3 (en) 2000-09-12
ID24914A (id) 2000-08-31
EE9900482A (xx) 2000-06-15
JP2008104465A (ja) 2008-05-08
UA72875C2 (uk) 2005-05-16
IL179047A0 (en) 2007-03-08
IL132236A (en) 2007-03-08
BR9808562A (pt) 2000-05-23
JP2008253275A (ja) 2008-10-23
CA2286484A1 (en) 1998-10-22
HUP0003116A3 (en) 2003-03-28
AU7115698A (en) 1998-11-11
AU740445B2 (en) 2001-11-01
GEP20043386B (en) 2004-02-10
NO995062D0 (no) 1999-10-15
WO1998046636A2 (en) 1998-10-22
CN1268973A (zh) 2000-10-04
IL132236A0 (en) 2001-03-19
NZ500216A (en) 2001-06-29
EA004256B1 (ru) 2004-02-26
EP0975753A2 (en) 2000-02-02
EA199900941A1 (ru) 2000-06-26

Similar Documents

Publication Publication Date Title
CN1196785C (zh) β-淀粉样肽结合蛋白及其编码聚核苷酸
CN1404488A (zh) Nogo受体介导的对轴突生长的阻断
CN1253565A (zh) 能调节对细胞因子的细胞反应性的治疗和诊断制剂
WO2002090499A2 (en) ss-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDES ENCODING THE SAME
CN1036987A (zh) 人体C3b/C4b受体(CR1)
CN1310759A (zh) 含治疗和诊断结构域1的β2GP1多肽及其使用方法
CN1258315A (zh) 哺乳动物细胞因子样因子7
CN1159828A (zh) 修饰的胶原诱导血小板凝集抑制剂Pallidipin的制备方法
CN1355845A (zh) PrP样基因
US7005295B1 (en) β-amyloid peptide-binding proteins and polynucleotides encoding the same
CN1422280A (zh) 新型胶原蛋白样蛋白clac、其前体和它们的编码基因
CN1200735C (zh) 肾小球膜细胞增生性肾炎动物模型
CN1137383C (zh) 一种人蛋白和编码序列,及其制法和用途
CN1158896A (zh) 新的应激蛋白
CN1491281A (zh) 神经调节素及其应用
CN1272139A (zh) 编码能与早老素相互作用的蛋白质的核酸
CN1200235A (zh) 从转基因非人动物中纯化高级转录复合物
CN1209369C (zh) 诱导细胞凋亡蛋白、其编码序列及用途
CN1164614C (zh) 记忆清除蛋白及其应用
CN1188508A (zh) 与早老性痴呆病有关的基因序列和蛋白及其用途
CN1414103A (zh) 人丝氨酸/苏氨酸蛋白激酶、其编码序列、制备方法及用途
CN1267730A (zh) 一种新的人钾离子通道调节因子蛋白及其编码序列
CN1570100A (zh) 一种类神经内分泌特异性蛋白,其编码序列,制法和应用
CN1510139A (zh) 人类心房颤动致病基因和编码蛋白及其用途
CZ361299A3 (cs) Proteiny vázající β-amyloidový peptid a polynukleotidy, které je kódují

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050413