CN119654416A - 4-(氨甲基)环己烷-1-甲酸的制造方法 - Google Patents

4-(氨甲基)环己烷-1-甲酸的制造方法 Download PDF

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Publication number
CN119654416A
CN119654416A CN202380050059.9A CN202380050059A CN119654416A CN 119654416 A CN119654416 A CN 119654416A CN 202380050059 A CN202380050059 A CN 202380050059A CN 119654416 A CN119654416 A CN 119654416A
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CN
China
Prior art keywords
aminomethyl
cyclohexane
amino acid
residue
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380050059.9A
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English (en)
Chinese (zh)
Inventor
合田明日香
山下诚
绞缬健人
青木山本祐梨子
渡边太郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Holdings Co Ltd
Kyowa Hakko Bio Co Ltd
Original Assignee
Kirin Holdings Co Ltd
Kyowa Hakko Bio Co Ltd
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Application filed by Kirin Holdings Co Ltd, Kyowa Hakko Bio Co Ltd filed Critical Kirin Holdings Co Ltd
Publication of CN119654416A publication Critical patent/CN119654416A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01003—Aldehyde dehydrogenase (NAD+) (1.2.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01004—Aldehyde dehydrogenase (NADP+) (1.2.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01005—Aldehyde dehydrogenase [NAD(P)+] (1.2.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01007—Benzaldehyde dehydrogenase (NADP+) (1.2.1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01008—Betaine-aldehyde dehydrogenase (NADH) (1.2.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202380050059.9A 2022-06-30 2023-06-29 4-(氨甲基)环己烷-1-甲酸的制造方法 Pending CN119654416A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022-106294 2022-06-30
JP2022106294 2022-06-30
PCT/JP2023/024236 WO2024005155A1 (ja) 2022-06-30 2023-06-29 ４－（アミノメチル）シクロヘキサン－１－カルボン酸の製造方法

Publications (1)

Publication Number Publication Date
CN119654416A true CN119654416A (zh) 2025-03-18

Family

ID=89382507

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380050059.9A Pending CN119654416A (zh) 2022-06-30 2023-06-29 4-(氨甲基)环己烷-1-甲酸的制造方法

Country Status (5)

Country Link
US (1) US20260002181A1 (https=)
EP (1) EP4541902A1 (https=)
JP (1) JPWO2024005155A1 (https=)
CN (1) CN119654416A (https=)
WO (1) WO2024005155A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4726047A1 (en) * 2023-06-29 2026-04-15 Kirin Holdings Kabushiki Kaisha Method for producing 4-(aminomethyl)cyclohexane-1-carboxylic acid

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5576846A (en) * 1978-12-01 1980-06-10 Takeda Chem Ind Ltd Preparation of 4-aminomethylcyclohexane-1-carboxylic acid
JPS5577894A (en) * 1978-12-05 1980-06-12 Takeda Chem Ind Ltd Preparation of 4-amino methylcyclohexane-1-carboxylic acid
JPS57134500A (en) 1981-02-12 1982-08-19 Kyowa Hakko Kogyo Co Ltd Plasmid pcg1
JPS57183799A (en) 1981-04-17 1982-11-12 Kyowa Hakko Kogyo Co Ltd Novel plasmid
JPS5835197A (ja) 1981-08-26 1983-03-01 Kyowa Hakko Kogyo Co Ltd プラスミドｐｃｇ２
IL67510A (en) 1981-12-17 1988-08-31 Kyowa Hakko Kogyo Kk Recombinant vector plasmids autonomously replicable in microorganisms belonging to the genus corynebacterium or brevibacterium and process for the production thereof
JPS58110600A (ja) 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
JPS63233798A (ja) 1986-10-09 1988-09-29 Kyowa Hakko Kogyo Co Ltd ５′−グアニル酸の製造法
JPS63152991A (ja) * 1986-12-17 1988-06-25 Idemitsu Kosan Co Ltd トランス−４−アミノメチルシクロヘキサン−１−カルボン酸の製造方法
JP2545078B2 (ja) 1987-04-06 1996-10-16 協和醗酵工業株式会社 核酸関連物質の製造法
KR100555161B1 (ko) 1996-09-17 2006-11-30 교와 핫꼬 고교 가부시끼가이샤 당뉴클레오티드류및복합당질의제조법
CN103131649B (zh) * 2012-12-31 2014-11-26 浙江工业大学 荧光假单胞菌及其在制备反式-4-氨甲基-环己烷甲酸中的应用
CN103114122B (zh) * 2012-12-31 2014-06-11 浙江工业大学 利用游动放线菌制备反式-4-氨甲基-环己烷甲酸的方法
WO2018190398A1 (ja) * 2017-04-13 2018-10-18 協和発酵バイオ株式会社 テアニンの製造方法
CN114014768B (zh) 2021-12-03 2024-07-26 南京科瑞健医药科技有限公司 一种无钡盐杂质的氨甲环酸及其制备方法和制剂组合物
CN114231507B (zh) * 2021-12-27 2023-11-14 无锡阿科力科技股份有限公司 一种胆分节杆菌胆碱氧化酶突变体及其应用

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EP4541902A1 (en) 2025-04-23
US20260002181A1 (en) 2026-01-01
JPWO2024005155A1 (https=) 2024-01-04
WO2024005155A1 (ja) 2024-01-04

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