CN1193979A - 大环内酯类化合物 - Google Patents

大环内酯类化合物 Download PDF

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Publication number
CN1193979A
CN1193979A CN96196487A CN96196487A CN1193979A CN 1193979 A CN1193979 A CN 1193979A CN 96196487 A CN96196487 A CN 96196487A CN 96196487 A CN96196487 A CN 96196487A CN 1193979 A CN1193979 A CN 1193979A
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CN
China
Prior art keywords
formula
macrolide
compound
salt
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96196487A
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English (en)
Chinese (zh)
Inventor
T·费尔
L·奥贝雷尔
V·奎斯尼奥克斯－赖费尔
J·J·桑利尔
W·舒勒尔
R·瑟拉尼
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Novartis AG
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Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9513596.8A external-priority patent/GB9513596D0/en
Priority claimed from GBGB9515495.1A external-priority patent/GB9515495D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1193979A publication Critical patent/CN1193979A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • General Engineering & Computer Science (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN96196487A 1995-07-04 1996-07-04 大环内酯类化合物 Pending CN1193979A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9513596.8A GB9513596D0 (en) 1995-07-04 1995-07-04 Organic compounds
GB9513596.8 1995-07-04
GB9515495.1 1995-07-28
GBGB9515495.1A GB9515495D0 (en) 1995-07-28 1995-07-28 Organic compounds

Publications (1)

Publication Number Publication Date
CN1193979A true CN1193979A (zh) 1998-09-23

Family

ID=26307320

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96196487A Pending CN1193979A (zh) 1995-07-04 1996-07-04 大环内酯类化合物

Country Status (17)

Country Link
EP (1) EP0836616A1 (cs)
JP (1) JPH11509092A (cs)
KR (1) KR19990028724A (cs)
CN (1) CN1193979A (cs)
AR (1) AR006514A1 (cs)
AU (1) AU708004B2 (cs)
BR (1) BR9609324A (cs)
CA (1) CA2224715A1 (cs)
CO (1) CO4750713A1 (cs)
CZ (1) CZ424297A3 (cs)
HU (1) HUP9802320A3 (cs)
IL (1) IL122844A0 (cs)
NO (1) NO980016L (cs)
PL (1) PL324346A1 (cs)
SK (1) SK498A3 (cs)
TR (1) TR199800001T1 (cs)
WO (1) WO1997002285A1 (cs)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010034243A1 (en) * 2008-09-24 2010-04-01 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Novel gene cluster
CN101289440B (zh) * 2007-06-29 2010-08-25 中国热带农业科学院热带生物技术研究所 一种多烯大环类化合物及其制备方法与应用
CN102770139A (zh) * 2010-02-09 2012-11-07 百奥帝卡技术有限公司 基于Sanglifehrin的化合物
CN104662033A (zh) * 2012-06-08 2015-05-27 吉利德科学公司 黄病毒科病毒的大环抑制剂
CN104781261A (zh) * 2012-06-08 2015-07-15 吉利德科学公司 黄病毒科病毒的大环抑制剂
CN102770139B (zh) * 2010-02-09 2016-11-30 纽洛维弗制药有限公司 基于Sanglifehrin的化合物
US9512175B2 (en) 2012-06-08 2016-12-06 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124453A (en) * 1995-07-04 2000-09-26 Novartis Ag Macrolides
GB9811854D0 (en) * 1998-06-02 1998-07-29 Ciba Geigy Ag Organic compounds
US7368423B1 (en) * 2001-12-05 2008-05-06 The Scripps Research Institute Composition and method for treating chronic allograft rejection
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CN101242842A (zh) 2005-06-17 2008-08-13 诺瓦提斯公司 Sanglifehrin在hcv中的用途
US8067024B2 (en) 2006-02-10 2011-11-29 Medtronic Vascular, Inc. Medical devices to prevent or inhibit restenosis
WO2011098808A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
WO2011098805A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
GB201008123D0 (en) 2010-05-17 2010-06-30 Biotica Tech Ltd Novel compounds
AR084217A1 (es) 2010-12-10 2013-05-02 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
ES2703433T3 (es) * 2010-12-20 2019-03-08 Neurovive Pharmaceutical Ab Derivados de sangliferina y métodos para su producción
JO3063B1 (ar) 2011-03-29 2017-03-15 Neurovive Pharmaceutical Ab مركب مبتكر وطرق لانتاجه
GB201118334D0 (en) 2011-10-24 2011-12-07 Biotica Tech Ltd Novel dosage form
CN110062626A (zh) 2016-11-18 2019-07-26 纽维制药有限公司 sanglifehrin大环类似物作为抗癌化合物的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9318144D0 (en) * 1993-09-01 1993-10-20 Sandoz Ltd Organic compounds
WO1995015328A1 (en) * 1993-11-30 1995-06-08 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101289440B (zh) * 2007-06-29 2010-08-25 中国热带农业科学院热带生物技术研究所 一种多烯大环类化合物及其制备方法与应用
WO2010034243A1 (en) * 2008-09-24 2010-04-01 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Novel gene cluster
CN102224242B (zh) * 2008-09-24 2014-09-24 中国科学院上海有机化学研究所 新基因簇
US8962329B2 (en) 2008-09-24 2015-02-24 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Gene cluster
CN102770139A (zh) * 2010-02-09 2012-11-07 百奥帝卡技术有限公司 基于Sanglifehrin的化合物
CN102770139B (zh) * 2010-02-09 2016-11-30 纽洛维弗制药有限公司 基于Sanglifehrin的化合物
CN104781261A (zh) * 2012-06-08 2015-07-15 吉利德科学公司 黄病毒科病毒的大环抑制剂
CN104662033A (zh) * 2012-06-08 2015-05-27 吉利德科学公司 黄病毒科病毒的大环抑制剂
US9512175B2 (en) 2012-06-08 2016-12-06 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses
US9642889B2 (en) 2012-06-08 2017-05-09 Gilead Sciences, Inc. Macrocyclic inhibitors of Flaviviridae viruses
US9873716B2 (en) 2012-06-08 2018-01-23 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses
CN104662033B (zh) * 2012-06-08 2018-10-23 吉利德科学公司 黄病毒科病毒的大环抑制剂
USRE47334E1 (en) 2012-06-08 2019-04-02 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses
US10246486B2 (en) 2012-06-08 2019-04-02 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses
US10472392B2 (en) 2012-06-08 2019-11-12 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses

Also Published As

Publication number Publication date
AR006514A1 (es) 1999-09-08
BR9609324A (pt) 1999-05-25
WO1997002285A1 (en) 1997-01-23
AU708004B2 (en) 1999-07-29
IL122844A0 (en) 1998-08-16
AU6519396A (en) 1997-02-05
CZ424297A3 (cs) 1998-04-15
PL324346A1 (en) 1998-05-25
TR199800001T1 (xx) 1998-04-21
HUP9802320A2 (hu) 1999-02-01
SK498A3 (en) 1998-07-08
JPH11509092A (ja) 1999-08-17
MX9800217A (es) 1998-07-31
CA2224715A1 (en) 1997-01-23
HUP9802320A3 (en) 1999-03-29
CO4750713A1 (es) 1999-03-31
NO980016L (no) 1998-03-02
KR19990028724A (ko) 1999-04-15
EP0836616A1 (en) 1998-04-22
NO980016D0 (no) 1998-01-02

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