CN1192246A - 产生治疗疼痛的止痛化合物的细胞系 - Google Patents

产生治疗疼痛的止痛化合物的细胞系 Download PDF

Info

Publication number
CN1192246A
CN1192246A CN96195750A CN96195750A CN1192246A CN 1192246 A CN1192246 A CN 1192246A CN 96195750 A CN96195750 A CN 96195750A CN 96195750 A CN96195750 A CN 96195750A CN 1192246 A CN1192246 A CN 1192246A
Authority
CN
China
Prior art keywords
cell
ires
seq
sequence
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96195750A
Other languages
English (en)
Chinese (zh)
Inventor
J·塞多夫
S·王
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CTI Biopharma Corp
Original Assignee
Cell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Therapeutics Inc filed Critical Cell Therapeutics Inc
Publication of CN1192246A publication Critical patent/CN1192246A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN96195750A 1995-06-07 1996-06-07 产生治疗疼痛的止痛化合物的细胞系 Pending CN1192246A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48191795A 1995-06-07 1995-06-07
US08/481,917 1995-06-07

Publications (1)

Publication Number Publication Date
CN1192246A true CN1192246A (zh) 1998-09-02

Family

ID=23913905

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96195750A Pending CN1192246A (zh) 1995-06-07 1996-06-07 产生治疗疼痛的止痛化合物的细胞系

Country Status (20)

Country Link
EP (1) EP0833935A1 (enExample)
JP (1) JPH11507530A (enExample)
KR (1) KR19990022414A (enExample)
CN (1) CN1192246A (enExample)
AR (1) AR004494A1 (enExample)
AU (1) AU6263696A (enExample)
BR (1) BR9608746A (enExample)
CA (1) CA2223246A1 (enExample)
CZ (1) CZ392497A3 (enExample)
EE (1) EE9700326A (enExample)
HU (1) HUP9901191A2 (enExample)
IL (1) IL122415A0 (enExample)
IN (1) IN181898B (enExample)
IS (1) IS4628A (enExample)
NO (1) NO975545L (enExample)
PL (1) PL323867A1 (enExample)
SK (1) SK167997A3 (enExample)
TR (1) TR199701520T1 (enExample)
WO (1) WO1996040959A1 (enExample)
ZA (1) ZA964880B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107964047A (zh) * 2017-12-18 2018-04-27 哈尔滨工业大学 基于内吗啡肽-1和神经降压素(8-13)的嵌合肽及其合成方法和应用
CN112891337A (zh) * 2021-03-26 2021-06-04 河北医科大学 高良姜素及其衍生物在制备预防和治疗神经系统疾病药物中的用途

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2331752B (en) * 1997-11-28 2001-01-24 Medical Res Council Vectors
AU6151899A (en) * 1998-09-23 2000-04-10 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods of treating chronic pain
DE69928960T2 (de) * 1998-10-27 2006-08-10 Anticancer Inc., San Diego Herstellung eines retrovirus, welches den mel-lokus von streptomyces enthält, sowie dessen expression in säugetierzellen
US6372489B1 (en) 1998-10-27 2002-04-16 Anticancer, Inc. Method and model for hair pigmentation
US6903244B1 (en) 1999-02-26 2005-06-07 University Of Utah Research Foundation Mice which are +/− or −/− for the elastin gene as models for vascular disease
AU2002952993A0 (en) 2002-11-29 2002-12-12 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Therapeutic and diagnostic agents
EP1701736A4 (en) 2003-12-24 2008-05-07 Inst Medical W & E Hall THERAPEUTIC AGENTS AND USES
EP1766389A4 (en) 2004-05-12 2008-08-27 Inst Medical W & E Hall METHOD OF ISOLATING CELLS
AU2006261599B2 (en) 2005-06-24 2011-10-06 The Walter & Eliza Hall Institute Of Medical Research Therapeutic pro-apoptotic BH3-like molecules and methods for generating and/or selecting the same
JP5558817B2 (ja) 2006-07-18 2014-07-23 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 痛みの処置方法および鎮痛化合物のスクリーニング方法
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
MX367858B (es) 2013-05-31 2019-09-09 Univ Utah Res Found Péptidos de conotoxina, composiciones farmacéuticas y usos de los mismos.
AU2016345063B2 (en) 2015-10-27 2021-08-05 The Council Of The Queensland Institute Of Medical Research A method of treatment and agents useful for same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4098355B2 (ja) * 1993-08-12 2008-06-11 ニューロテック ユーエスエー， インコーポレイテッド 遺伝的に改変された細胞を含む生体適合性免疫隔離カプセル

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107964047A (zh) * 2017-12-18 2018-04-27 哈尔滨工业大学 基于内吗啡肽-1和神经降压素(8-13)的嵌合肽及其合成方法和应用
CN107964047B (zh) * 2017-12-18 2018-11-02 哈尔滨工业大学 基于内吗啡肽-1和神经降压素(8-13)的嵌合肽及其合成方法和应用
CN112891337A (zh) * 2021-03-26 2021-06-04 河北医科大学 高良姜素及其衍生物在制备预防和治疗神经系统疾病药物中的用途

Also Published As

Publication number Publication date
AR004494A1 (es) 1998-12-16
AU6263696A (en) 1996-12-30
BR9608746A (pt) 1999-05-11
PL323867A1 (en) 1998-04-27
EP0833935A1 (en) 1998-04-08
KR19990022414A (ko) 1999-03-25
ZA964880B (en) 1997-01-07
JPH11507530A (ja) 1999-07-06
TR199701520T1 (xx) 1998-04-21
WO1996040959A1 (en) 1996-12-19
NO975545D0 (no) 1997-12-02
IN181898B (enExample) 1998-10-24
IS4628A (is) 1997-12-04
CA2223246A1 (en) 1996-12-19
CZ392497A3 (cs) 1998-12-16
IL122415A0 (en) 1998-06-15
HUP9901191A2 (hu) 1999-08-30
NO975545L (no) 1998-02-04
EE9700326A (et) 1998-06-15
SK167997A3 (en) 1998-05-06

Similar Documents

Publication Publication Date Title
CN1192246A (zh) 产生治疗疼痛的止痛化合物的细胞系
CN1217956C (zh) 可溶性单链t细胞受体蛋白
JP3386461B2 (ja) 遺伝子移入法および遺伝子移入療法に用いるシトシンデアミナーゼの負の選択系
CN1197966C (zh) 肿瘤坏死因子受体相关因子的调节剂、及其制备和用途
CN1835971A (zh) 增加的神经胚素分泌
CN1196495C (zh) 突变的人cd80及其制备和应用组合物和方法
CN1044820A (zh) 胰岛素类似物
CN1867350A (zh) 重组润滑素分子及其用途
CN1622995A (zh) 新的受体核酸及多肽
CN1211255A (zh) Ob受体及诊断和治疗体重疾病的方法
CN1308451C (zh) 肿瘤坏死因子相关配基
CN1863815A (zh) 具有脑定位活性的多肽及其用途
CN101060856A (zh) 可溶、稳定的含胰岛素制剂
CN1906211A (zh) 新的肌肉生长调节物
CN1791675A (zh) 表达病毒大包膜蛋白和目的蛋白融合体的病毒载体
CN1823090A (zh) 血小板糖蛋白IB－α变体融合多肽及其用法
CN1733918A (zh) 促胃动素同系物
CN1190437A (zh) 骨刺激因子
CN1257187C (zh) 钙网蛋白－肿瘤坏死因子相关凋亡诱导配体的融合蛋白及其制法和用途
CN1795205A (zh) Spex组合物和使用方法
CN1629285A (zh) 转基因表达细胞趋化因子的自然杀伤细胞
CN100344330C (zh) 用于治疗病毒性乙型肝炎的靶向小干扰rna制剂及制备方法
CN1399680A (zh) 上皮细胞生长抑制剂
CN1155615C (zh) 具有抑制癌细胞生长功能的新的人蛋白及其编码序列
CN1241941C (zh) 一种促进神经分化和抗细胞凋亡的蛋白质及其编码基因

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication