JPH11507530A - 疼痛を処置するための鎮痛化合物を産生する細胞株 - Google Patents

疼痛を処置するための鎮痛化合物を産生する細胞株

Info

Publication number
JPH11507530A
JPH11507530A JP9501908A JP50190897A JPH11507530A JP H11507530 A JPH11507530 A JP H11507530A JP 9501908 A JP9501908 A JP 9501908A JP 50190897 A JP50190897 A JP 50190897A JP H11507530 A JPH11507530 A JP H11507530A
Authority
JP
Japan
Prior art keywords
cells
cell
ires
dna encoding
transformed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9501908A
Other languages
English (en)
Japanese (ja)
Inventor
セイドッフ，ジョエル
ウォン，ショウ
Original Assignee
サイトセラピューティクス，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by サイトセラピューティクス，インコーポレイテッド filed Critical サイトセラピューティクス，インコーポレイテッド
Publication of JPH11507530A publication Critical patent/JPH11507530A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP9501908A 1995-06-07 1996-06-07 疼痛を処置するための鎮痛化合物を産生する細胞株 Pending JPH11507530A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48191795A 1995-06-07 1995-06-07
US08/481,917 1995-06-07
PCT/US1996/009629 WO1996040959A1 (en) 1995-06-07 1996-06-07 Cell line producing analgesic compounds for treating pain

Publications (1)

Publication Number Publication Date
JPH11507530A true JPH11507530A (ja) 1999-07-06

Family

ID=23913905

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9501908A Pending JPH11507530A (ja) 1995-06-07 1996-06-07 疼痛を処置するための鎮痛化合物を産生する細胞株

Country Status (20)

Country Link
EP (1) EP0833935A1 (enExample)
JP (1) JPH11507530A (enExample)
KR (1) KR19990022414A (enExample)
CN (1) CN1192246A (enExample)
AR (1) AR004494A1 (enExample)
AU (1) AU6263696A (enExample)
BR (1) BR9608746A (enExample)
CA (1) CA2223246A1 (enExample)
CZ (1) CZ392497A3 (enExample)
EE (1) EE9700326A (enExample)
HU (1) HUP9901191A2 (enExample)
IL (1) IL122415A0 (enExample)
IN (1) IN181898B (enExample)
IS (1) IS4628A (enExample)
NO (1) NO975545L (enExample)
PL (1) PL323867A1 (enExample)
SK (1) SK167997A3 (enExample)
TR (1) TR199701520T1 (enExample)
WO (1) WO1996040959A1 (enExample)
ZA (1) ZA964880B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011510096A (ja) * 2008-04-18 2011-03-31 ウォーソー・オーソペディック・インコーポレーテッド 疼痛および／または炎症の治療のためのαアドレナリン作動性受容体アゴニスト

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525168A (ja) * 1997-11-28 2001-12-11 メディカル リサーチ カウンシル ベクター
AU6151899A (en) * 1998-09-23 2000-04-10 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods of treating chronic pain
US6372489B1 (en) 1998-10-27 2002-04-16 Anticancer, Inc. Method and model for hair pigmentation
WO2000024895A2 (en) * 1998-10-27 2000-05-04 Anticancer, Inc. Method and model for hair pigmentation
US6903244B1 (en) 1999-02-26 2005-06-07 University Of Utah Research Foundation Mice which are +/− or −/− for the elastin gene as models for vascular disease
AU2002952993A0 (en) 2002-11-29 2002-12-12 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Therapeutic and diagnostic agents
CA2551189A1 (en) 2003-12-24 2005-07-07 The Walter And Eliza Hall Institute Of Medical Research Therapeutic agents and uses therefor
NZ551828A (en) 2004-05-12 2009-03-31 Inst Medical W & E Hall A method of cell isolating a homogenous population of mammary stem cells using specific cell surface marker proteins
EP1910535B1 (en) 2005-06-24 2016-08-17 The Walter And Eliza Hall Institute Of Medical Research Therapeutic pro-apoptotic bh3-like molecules and methods for generating and/or selecting the same
JP5558817B2 (ja) 2006-07-18 2014-07-23 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 痛みの処置方法および鎮痛化合物のスクリーニング方法
JP6681826B2 (ja) 2013-05-31 2020-04-15 ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション コノトキシンペプチド、医薬組成物およびそれらの使用
JP6877419B2 (ja) 2015-10-27 2021-05-26 ザ ユニバーシティー オブ クイーンズランド 治療の方法およびそのために有用な剤
CN107964047B (zh) * 2017-12-18 2018-11-02 哈尔滨工业大学 基于内吗啡肽-1和神经降压素(8-13)的嵌合肽及其合成方法和应用
CN112891337A (zh) * 2021-03-26 2021-06-04 河北医科大学 高良姜素及其衍生物在制备预防和治疗神经系统疾病药物中的用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2178654T3 (es) * 1993-08-12 2003-01-01 Neurotech Sa Capsulas biocompatibles inmonoaisladoras que contienen celulas geneticamente alteradas para el suministro de moleculas biologicamente activas.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011510096A (ja) * 2008-04-18 2011-03-31 ウォーソー・オーソペディック・インコーポレーテッド 疼痛および／または炎症の治療のためのαアドレナリン作動性受容体アゴニスト

Also Published As

Publication number Publication date
NO975545D0 (no) 1997-12-02
AU6263696A (en) 1996-12-30
PL323867A1 (en) 1998-04-27
NO975545L (no) 1998-02-04
BR9608746A (pt) 1999-05-11
TR199701520T1 (xx) 1998-04-21
CZ392497A3 (cs) 1998-12-16
IN181898B (enExample) 1998-10-24
SK167997A3 (en) 1998-05-06
IL122415A0 (en) 1998-06-15
HUP9901191A2 (hu) 1999-08-30
AR004494A1 (es) 1998-12-16
ZA964880B (en) 1997-01-07
WO1996040959A1 (en) 1996-12-19
EE9700326A (et) 1998-06-15
CN1192246A (zh) 1998-09-02
CA2223246A1 (en) 1996-12-19
IS4628A (is) 1997-12-04
EP0833935A1 (en) 1998-04-08
KR19990022414A (ko) 1999-03-25

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