CN119176871A - 抗金黄色葡萄球菌凝集因子a(clfa)的抗体 - Google Patents

抗金黄色葡萄球菌凝集因子a(clfa)的抗体 Download PDF

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Publication number
CN119176871A
CN119176871A CN202411220211.6A CN202411220211A CN119176871A CN 119176871 A CN119176871 A CN 119176871A CN 202411220211 A CN202411220211 A CN 202411220211A CN 119176871 A CN119176871 A CN 119176871A
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CN
China
Prior art keywords
antibody
antigen
clfa
seq
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202411220211.6A
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English (en)
Chinese (zh)
Inventor
C·特卡奇克
B·塞尔曼
M·博罗奥克三世
D·科尔蒂
A·米诺拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Humabs Biomed SA
MedImmune LLC
Original Assignee
Humabs Biomed SA
MedImmune LLC
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Filing date
Publication date
Application filed by Humabs Biomed SA, MedImmune LLC filed Critical Humabs Biomed SA
Publication of CN119176871A publication Critical patent/CN119176871A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN202411220211.6A 2018-07-24 2019-07-24 抗金黄色葡萄球菌凝集因子a(clfa)的抗体 Pending CN119176871A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862702762P 2018-07-24 2018-07-24
US62/702,762 2018-07-24
CN201980058857.XA CN112672788B (zh) 2018-07-24 2019-07-24 抗金黄色葡萄球菌凝集因子a(clfa)的抗体
PCT/US2019/043254 WO2020023644A2 (en) 2018-07-24 2019-07-24 Antibody directed against s. aureus clumping factor a (clfa)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201980058857.XA Division CN112672788B (zh) 2018-07-24 2019-07-24 抗金黄色葡萄球菌凝集因子a(clfa)的抗体

Publications (1)

Publication Number Publication Date
CN119176871A true CN119176871A (zh) 2024-12-24

Family

ID=67539640

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202411220211.6A Pending CN119176871A (zh) 2018-07-24 2019-07-24 抗金黄色葡萄球菌凝集因子a(clfa)的抗体
CN201980058857.XA Active CN112672788B (zh) 2018-07-24 2019-07-24 抗金黄色葡萄球菌凝集因子a(clfa)的抗体

Family Applications After (1)

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Country Status (10)

Country Link
US (3) US11155606B2 (https=)
EP (1) EP3840838A2 (https=)
JP (2) JP7525471B2 (https=)
CN (2) CN119176871A (https=)
AU (1) AU2019309366B2 (https=)
BR (1) BR112021001214A2 (https=)
CA (1) CA3107463A1 (https=)
MX (1) MX2021000889A (https=)
TW (1) TWI902669B (https=)
WO (1) WO2020023644A2 (https=)

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Also Published As

Publication number Publication date
CN112672788B (zh) 2024-09-17
TWI902669B (zh) 2025-11-01
US20240352098A1 (en) 2024-10-24
EP3840838A2 (en) 2021-06-30
US11155606B2 (en) 2021-10-26
AU2019309366B2 (en) 2025-06-05
US11970527B2 (en) 2024-04-30
US20200048330A1 (en) 2020-02-13
WO2020023644A3 (en) 2020-03-19
JP2021530244A (ja) 2021-11-11
MX2021000889A (es) 2021-04-28
KR20210035846A (ko) 2021-04-01
WO2020023644A2 (en) 2020-01-30
CA3107463A1 (en) 2020-01-30
CN112672788A (zh) 2021-04-16
JP2024105229A (ja) 2024-08-06
JP7525471B2 (ja) 2024-07-30
AU2019309366A1 (en) 2021-02-18
US20220073595A1 (en) 2022-03-10
TW202019956A (zh) 2020-06-01
BR112021001214A2 (pt) 2021-04-27

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