CN118903120A - β-内酰胺化合物与丙磺舒的组合及其用途 - Google Patents

β-内酰胺化合物与丙磺舒的组合及其用途 Download PDF

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Publication number
CN118903120A
CN118903120A CN202410957648.1A CN202410957648A CN118903120A CN 118903120 A CN118903120 A CN 118903120A CN 202410957648 A CN202410957648 A CN 202410957648A CN 118903120 A CN118903120 A CN 118903120A
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lactam compound
subject
pharmaceutically acceptable
administration
acceptable salt
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CN202410957648.1A
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Chinese (zh)
Inventor
M·邓尼
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Italen Treatment International Ltd
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Italen Treatment International Ltd
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202410957648.1A 2018-06-07 2019-06-07 β-内酰胺化合物与丙磺舒的组合及其用途 Pending CN118903120A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862682116P 2018-06-07 2018-06-07
US62/682116 2018-06-07
US201962804970P 2019-02-13 2019-02-13
US62/804970 2019-02-13
PCT/EP2019/065016 WO2019234240A1 (en) 2018-06-07 2019-06-07 Combinations of beta-lactam compounds and probenecid and uses thereof
CN201980052188.5A CN112739338A (zh) 2018-06-07 2019-06-07 β-内酰胺化合物与丙磺舒的组合及其用途

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CN118903120A true CN118903120A (zh) 2024-11-08

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CN202410957648.1A Pending CN118903120A (zh) 2018-06-07 2019-06-07 β-内酰胺化合物与丙磺舒的组合及其用途
CN201980052188.5A Pending CN112739338A (zh) 2018-06-07 2019-06-07 β-内酰胺化合物与丙磺舒的组合及其用途

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Country Link
US (3) US11554112B2 (https=)
EP (1) EP3801486A1 (https=)
JP (2) JP2021525787A (https=)
CN (2) CN118903120A (https=)
AU (1) AU2019281018B2 (https=)
BR (1) BR112020024498A2 (https=)
TW (1) TW202005970A (https=)
WO (1) WO2019234240A1 (https=)

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US11554112B2 (en) 2018-06-07 2023-01-17 Herum Therapeutics International Limited Combinations of β-lactam compounds and probenecid and uses thereof
EP3790535A1 (en) 2019-02-13 2021-03-17 Iterum Therapeutics International Limited Combinations of beta-lactam compounds and probenecid and uses thereof
CA3169900A1 (en) * 2020-03-11 2021-09-16 Iterum Therapeutics International Limited Combinations of beta-lactam compounds, probenecid, and valproic acid and uses thereof
EP4132503B1 (en) * 2020-04-10 2026-04-22 University of Georgia Research Foundation, Inc. Probenecid for use in the treatment of sars-co-v2 infections
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CN112076161B (zh) * 2020-08-07 2022-10-18 安徽康正康仁药业有限公司 一种头孢菌素类钠盐与丙磺舒钠组成的复方冻干制剂
CN111840236B (zh) * 2020-08-07 2022-09-02 安徽康正康仁药业有限公司 一种注射用美罗培南丙磺舒钠复方冻干制剂
CN111821462A (zh) * 2020-08-07 2020-10-27 安徽康正康仁药业有限公司 青霉素类钠盐与丙磺舒钠组成的复方冻干制剂

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