CN1188528C - 细胞间粘附分子－3及其配体 - Google Patents

细胞间粘附分子－3及其配体 Download PDF

Info

Publication number
CN1188528C
CN1188528C CNB921051263A CN92105126A CN1188528C CN 1188528 C CN1188528 C CN 1188528C CN B921051263 A CNB921051263 A CN B921051263A CN 92105126 A CN92105126 A CN 92105126A CN 1188528 C CN1188528 C CN 1188528C
Authority
CN
China
Prior art keywords
icam
antibody
cell
fragment
combined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB921051263A
Other languages
English (en)
Chinese (zh)
Other versions
CN1069522A (zh
Inventor
A·R·德伏格罗利斯
T·A·斯普灵格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immune Disease Institute Inc
Original Assignee
Immune Disease Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immune Disease Institute Inc filed Critical Immune Disease Institute Inc
Publication of CN1069522A publication Critical patent/CN1069522A/zh
Application granted granted Critical
Publication of CN1188528C publication Critical patent/CN1188528C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
CNB921051263A 1991-06-11 1992-06-11 细胞间粘附分子－3及其配体 Expired - Fee Related CN1188528C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71287991A 1991-06-11 1991-06-11
US07/712,879 1991-06-11
US712,879 1991-06-11

Publications (2)

Publication Number Publication Date
CN1069522A CN1069522A (zh) 1993-03-03
CN1188528C true CN1188528C (zh) 2005-02-09

Family

ID=24863928

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB921051263A Expired - Fee Related CN1188528C (zh) 1991-06-11 1992-06-11 细胞间粘附分子－3及其配体

Country Status (21)

Country Link
EP (1) EP0590051A4 (pt)
JP (1) JP3288042B2 (pt)
KR (2) KR100333120B1 (pt)
CN (1) CN1188528C (pt)
BG (1) BG61682B1 (pt)
BR (1) BR9206142A (pt)
CA (1) CA2110387A1 (pt)
CZ (1) CZ283478B6 (pt)
FI (1) FI935500A (pt)
HU (1) HU217176B (pt)
IE (1) IE921893A1 (pt)
IL (1) IL102176A (pt)
MX (1) MX9202804A (pt)
NO (1) NO317658B1 (pt)
NZ (1) NZ243114A (pt)
RO (1) RO115415B1 (pt)
RU (1) RU2130782C1 (pt)
SK (1) SK279937B6 (pt)
UA (1) UA27763C2 (pt)
WO (1) WO1992022323A1 (pt)
ZA (1) ZA924276B (pt)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8969021B2 (en) 2001-10-11 2015-03-03 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8986945B2 (en) 2006-07-14 2015-03-24 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629162A (en) * 1991-06-11 1997-05-13 The Center For Blood Research Method of identifying agents which modulate ICAM-3 binding to LFA-1
WO1999018441A1 (en) * 1992-01-27 1999-04-15 Icos Corporation Icam-4 and diagnostic uses thereof
US5525487A (en) * 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
CA2107097A1 (en) * 1992-01-27 1993-07-28 Michael W. Gallatin Icam-related protein
US5811517A (en) * 1992-01-27 1998-09-22 Icos Corporation ICAM-related protein variants
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US6153395A (en) * 1992-01-27 2000-11-28 Icos Corporation ICAM-related protein
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
US6818743B1 (en) 1992-01-27 2004-11-16 Icos Corporation I-CAM related protein
JPH07506007A (ja) * 1993-01-22 1995-07-06 イコス　コーポレイション Ｉｃａｍ−関連タンパク質
DK0726942T3 (da) * 1993-11-02 2002-04-15 Innogenetics Nv Monoklonale antistoffer mod skumceller og deres farmaceutiske og diagnostiske anvendelse
US6884590B1 (en) 1994-02-11 2005-04-26 Cedars-Sinai Medical Center Methods of screening for ulcerative colitis and crohn's disease
US5681699A (en) * 1994-02-11 1997-10-28 Cedars-Sinai Medical Center Methods of diagnosing ulcerative colitis and Crohn's disease
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
JP2001508181A (ja) * 1997-10-02 2001-06-19 アイコス コーポレイション Ｉｃａｍ−４及びその診断用途
EP1741428A3 (en) 1999-08-13 2007-05-09 Biogen Idec MA, Inc. Cell adhesion inhibitors
US7691591B2 (en) * 2002-09-20 2010-04-06 Stichting Katholieke Universiteit Methods of identifying and isolating cells expressing DC-sign
US7196112B2 (en) 2004-07-16 2007-03-27 Biogen Idec Ma Inc. Cell adhesion inhibitors
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
WO2010075579A2 (en) 2008-12-24 2010-07-01 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
GB201016864D0 (en) 2010-10-06 2010-11-17 Univ Aston Therapeutic methods
EP4285988A3 (en) 2013-03-27 2024-03-06 Cedars-Sinai Medical Center Treating fibrosis by inhibiting tl1a
US10316083B2 (en) 2013-07-19 2019-06-11 Cedars-Sinai Medical Center Signature of TL1A (TNFSF15) signaling pathway
KR20220153109A (ko) 2016-03-17 2022-11-17 세다르스-신나이 메디칼 센터 Rnaset2를 통한 염증성 장 질환의 진단 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0387668B1 (en) * 1989-03-09 1996-12-11 Center For Blood Research, Inc. Intercellular adhesion molecule - 2 and its binding ligands

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8969021B2 (en) 2001-10-11 2015-03-03 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US9290812B2 (en) 2001-10-11 2016-03-22 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US9556485B2 (en) 2001-10-11 2017-01-31 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986945B2 (en) 2006-07-14 2015-03-24 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample

Also Published As

Publication number Publication date
RO115415B1 (ro) 2000-02-28
IE921893A1 (en) 1992-12-16
UA27763C2 (uk) 2000-10-16
NZ243114A (en) 1995-03-28
BR9206142A (pt) 1994-12-27
KR100333120B1 (ko) 2002-04-18
IL102176A (en) 2001-09-13
NO934491D0 (no) 1993-12-09
CZ270293A3 (en) 1994-08-17
ZA924276B (en) 1993-03-31
CA2110387A1 (en) 1992-12-23
AU2237692A (en) 1993-01-12
BG98287A (bg) 1994-08-30
JP3288042B2 (ja) 2002-06-04
CZ283478B6 (cs) 1998-04-15
AU670243B2 (en) 1996-07-11
CN1069522A (zh) 1993-03-03
FI935500A0 (fi) 1993-12-08
BG61682B1 (bg) 1998-03-31
SK139593A3 (en) 1994-10-05
KR100291844B1 (ko) 2001-09-17
NO934491L (no) 1994-02-11
EP0590051A4 (en) 1994-10-12
WO1992022323A1 (en) 1992-12-23
HUT66617A (en) 1994-12-28
JPH06509706A (ja) 1994-11-02
IL102176A0 (en) 1993-01-14
HU217176B (hu) 1999-12-28
FI935500A (fi) 1994-02-09
MX9202804A (es) 1992-12-01
NO317658B1 (no) 2004-11-29
RU2130782C1 (ru) 1999-05-27
HU9303529D0 (en) 1994-04-28
EP0590051A1 (en) 1994-04-06
SK279937B6 (sk) 1999-06-11

Similar Documents

Publication Publication Date Title
CN1188528C (zh) 细胞间粘附分子－3及其配体
CN1291757C (zh) 炎性肠疾病的治疗剂
CN1863546A (zh) 用可溶性ctla4分子治疗心血管疾病的方法
IE881322L (en) Intercellular adhesion molecules and their binding ligands
CN1685236A (zh) N－11端截短的β－淀粉样蛋白的单克隆抗体、组合物、方法和用途
CN1308676A (zh) 抗cd23抗体、抗cd23抗体衍生物及其治疗性应用
HU214247B (hu) Eljárás sejtközi adhéziós molekula ICAM-2 és kötőligandjai előállítására
US5891841A (en) Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof
CN1315866A (zh) 使用cd2－结合剂调节记忆效应t－细胞的方法和组合物
CN1309419C (zh) Vla－1的单克隆封闭抗体及其应用
CN1703240A (zh) LFA－1α亚基抗体及使用方法
AU629189B2 (en) Intercellular adhesion molecules and their binding ligands
CN1379685A (zh) 用基于MMP－9和β1整联蛋白的拮抗剂抑制血管发生的新方法和组合物
CN1207395A (zh) 抗-fas抗体
CN1826137A (zh) α1β1整联蛋白的可诱导的配体和用途
CN1688601A (zh) 活化t细胞核因子受体
AU670243C (en) Intercellular adhesion molecule-3 and its binding ligands
CN1082609A (zh) 受体衍生物
CN1189484C (zh) 重组抗人CD11a单克隆抗体及其制法和药物组合物
Blanset et al. Selection of Relevant Animal Models/Species
CN1251610A (zh) 新型小鼠cxc趋化因子受体
CN1596269A (zh) 一种新型g蛋白偶联受体:gave10
CN1355299A (zh) 一种新的多肽——人尿嘧啶二里酸葡萄糖焦磷酸化酶100.43和编码这种多肽的多核苷酸
CN1752106A (zh) 制造具有生物受体协同剂、拮抗剂与/或反向协同剂的人类抗体方法
CN1270220A (zh) 一种新的人维生素b12相关蛋白及其编码序列

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee