CN1186061C - Extracted herbal medicine for treating chicken infectious bursa of Fabricius - Google Patents
Extracted herbal medicine for treating chicken infectious bursa of Fabricius Download PDFInfo
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Abstract
The present invention relates to an extracted veterinary medicine for treating chicken infectious Fabricius bursa. The medicine is in the forms of pure traditional Chinese medicine powder and tablets prepared according to a formula of sovereign medicine, minister medicine, envoy medicine and adjuvant medicine that 17 kinds of traditional Chinese medicine comprising honeysuckle flower, weeping forsythia capsule, baical skullcap root, cape jasmine fruit, indigowoad root, common anemarrhena rhizome, red sage root, cyrtomium fortunei, etc., are crushed, decocted, extracted, concentrated and mixed with gypsum powder. The medicine has the advantages of no toxic or side effect and safe use, and a cure rate of the medicine on some viral infectious diseases and bacterial infectious diseases is more than 96%; little relapse occurs, medicine resistance is difficult to generate for bacteria, and residual veterinary medicine and social public nuisance are avoided.
Description
Technical field:
The present invention relates to a kind of herbal medicine, particularly relate to the extraction herbal medicine that a kind of clear pestilence for the treatment of infectious bursal disease is controlled capsule.The field of traditional Chinese veterinary that belongs to treatment fowl bacterial and viral infectious.
Background technology:
Infectious bursal disease is to import China the early 1980s into, and to the very big viral infectious of poultry husbandry harm, primary disease is because intravital immunologic function is lost, and causes multiple secondary infection.Chicken bursa fabricic is a kind of infectious disease of multiple continuous morbidity; Being used for the treatment of this sick Western medicine at present has vaccine and yolk antibody etc., and Chinese medicine has the pipe capsule to loose; Though above-mentioned Chinese medicine and western medicine has certain therapeutic effect, the disadvantage that exists easy recurrence and can not effect a radical cure.And the antibiotic Western medicine of life-time service can produce drug resistance to poultry, and then can cause that the numerical value of the intravital drug residue of poultry exceeds standard, and descendant can transfer to the drug resistance of various bacteria in the human body after having eaten the meat that has the residue of veterinary drug public hazards.The mankind have been caused direct harm.
Summary of the invention:
The object of the present invention is to provide a kind of clear pestilence for the treatment of infectious bursal disease to control the extraction herbal medicine of capsule, be used for the treatment of bacillary and viral infectious disease.Be a kind of extraction medicine of pure Chinese medicine preparation, have no side effect that safe in utilization, cure rate reaches more than 96%; Be difficult for recurrence, antibacterial is difficult to produce drug resistance; Avoided the generation of residue of veterinary drug and social effects of pollution.
Technical scheme of the present invention is: the clear pestilence of treatment infectious bursal disease is controlled the herbal medicine of capsule, it is a kind of pure Chinese medicine extraction medicine, by its prescription of monarch be: Flos Lonicerae 20-60 gram, Fructus Forsythiae 20-60 gram, Radix Scutellariae 20-60 gram, Fructus Gardeniae 20-60 gram, Radix Isatidis 20-60 gram, Rhizoma Anemarrhenae 20-60 gram, Radix Salviae Miltiorrhizae 20-60 gram, Rhizoma Osmundae 15-45 gram, Folium Isatidis 20-60 gram, Radix Paeoniae Rubra 15-45 gram, Gypsum Fibrosum 50-150 gram, Rhizoma Coptidis 10-30 gram, Radix Scrophulariae 20-60 gram, Radix Rehmanniae 20-60 gram, Cortex Phellodendri 20-60 gram, Cortex Moutan 20-60 gram, Radix Glycyrrhizae 15-45 gram.
Concrete processing procedure of the present invention is as follows: (1), Gypsum Fibrosum, Flos Lonicerae, Rhizoma Coptidis, Cortex Phellodendri pulverize separately are become standby behind the coarse powder; (2) surplus medicine is fried in shallow oil altogether, connects to fry in shallow oil each the decoction 1-2 hour three times, after the decoction three decocting liquids is merged, and is concentrated into thick; (3) coarse powder of Flos Lonicerae, Rhizoma Coptidis, Cortex Phellodendri is sneaked into magma and stir; Drying is admixed the Gypsum Fibrosum powder packing after the pulverizing.
Above-mentioned medicament is powder and tablet.
Indication of the present invention also comprises: infectious laryngotracheitis of chicken, infectious bronchitis, chronic respiratory disease, fowl cholera.Application method: the every day of twice sub-service sooner or later, by the dosed administration of per kilogram of body weight 0.2-0.5 gram, logotype 3-5 days.
Further specify curative effect of the present invention with regard to clinical effectiveness of the present invention below:
One, the present invention is to the therapeutic test of experimental infectious bursal disease:
210 of 19 age in days Luo Si chickling are got in this test, are divided into 7 groups at random,
The 1st group for not infecting the blank group of not administration;
The 2nd group is infected and the positive controls of not administration;
The 3rd group of high dose group;
The 4th group of clinical dosage group;
The 5th group of clinical test group of partly measuring;
The 6th group of Chinese medicine contrasts the diffusing group of quick-acting pipe capsules;
The 7th group is Western medicine contrast fabricius bursa yolk antibody group.
Virus IBDV VC6/85 strain F4, China Veterinary Drugs Supervisory Inst. provides.Test method is that the 2-7 group is all only inoculated IBDV0.1ml/ at 21 ages in days through eye dripping, inoculate back 2 hours 3-6 groups respectively by 0.8,0.4,0.2,0.4 the dosage oral administration of gram/Kg body weight clothes (capsule) the 7th group of intramuscular injection yolk antibody 2ml/ only, administration every day secondary logotype 3 days, each is organized chickling and respectively slaughters 6 respectively at 22,26,28,30,32 ages in days and cut open inspection.Its result: 1, degree of injury is starkly lower than the 2nd group of positive controls behind high, medium and low three the dosage group counteracting toxic substances of the present invention, and fabricius bursa includes the positive-virus granule obviously to be reduced, and viral extinction time shifts to an earlier date relatively.Show that this medicine has the effect of obvious inhibition IBDV; The 5th group is pressed down toxic effect and really is lower than other treatment group, illustrates that its curative effect hangs down relevant with dosage.This medicine and the 6th group and the 7th group of comparative pathology observation, the result shows that this medicine has antiviral effect preferably.2, the immunologically competent cell quantity of three test group of this medicine obviously is lighter than positive controls apparently higher than the histopathology variation of positive controls, fabricius bursa, shows that the present invention has anti-viral, and the protection fabricius bursa is avoided the therapeutical effect of major injury.
Two, the clinical test of invention experiment:
The standard strain of the pasteurella multocida that test strain provides for China Veterinary Drugs Supervisory Inst. is diluted to 3.6 * 10 through increasing after bacterium is cultivated
9/ ml antibacterial was begin treatment in back 2 hours by the pathogenic inoculation of 0.8ml intramuscular injection inoculation.Get 210 of the blue chickens in healthy purebred 35 ages in days sea, be divided into 7 groups at random, 30 every group.
The 1st group of negative matched group: do not inoculate, not administration is observed.
The 2nd group of positive matched group: behind the infection morbidity, not administration is observed.
The 3rd group for high dose group of the present invention, i.e. clinical dosage amount group doubly.
The 4th group is dosage group, i.e. clinical dosage group among the present invention.
The 5th group is low dose group of the present invention, i.e. clinical dosage half amount group.
The 6th group is the Chinese medicine matched group, i.e. the Chinese medicine matched group of specially good effect cholera spirit.
The 7th group is western medicine group, i.e. the ciprofloxacin western medicine group.
Its route of administration is oral, the every day of twice sub-service sooner or later, and high dose group 1 gram/kg body weight/time, middle dosage group 0.5 gram/kg body weight/time, low dose group 0.25 gram/kg body weight/time.Successive administration 4 days, a week is observed in drug withdrawal.
Western medicine group is pressed the same test group of medication number of times 0.1%0.5ml/ time with the water solublity ciprofloxacin that Shandong, Shandong animal pharmaceutical factory produces.
The specially good effect cholera spirit of Chinese medicine matched group, Yucheng, Henan county jade is risen (lot number is 950624) that animal pharmaceutical factory produces, by 1 gram/kg body weight administration, the same test group of administration time and number of times.Efficacy determination between group: 1, cure: body temperature is normal, prothymia, and diet and feces are normal, feather gloss, internal organs are normal substantially after catching and killing, and do not have tangible pathological change.2, produce effects: body temperature is normal, and spirit, diet are desired basic the recovery, and feather is gloss not, loses weight, and cuing open the inspection internal organs has slight pathological change.3, effective: ability is crossed dead closing, fever, and lassitude, appetite is less, and body weight obviously descends, and cuing open the inspection internal organs has obvious pathological change.4, invalid: as, to cross also to have as ability and revisit a shape and heavier septicemia and cut open inspection and change in the death of duration of test endopathy.Drug effect result such as following table are respectively organized in its experiment:
| Group | Type | The inoculation number | The survival number | Death toll | Survival rate | Efficacy determination |
| 1 group | Negative control | 0 | 30 | 0 | 100 | |
| 2 groups | Positive control | 30 | 2 | 28 | 6.6 | |
| 3 groups | High dose | 30 | 27 | 3 | 90 | Produce effects |
| 4 groups | Middle dosage | 30 | 27 | 3 | 90 | Produce effects |
| 5 groups | Low dosage | 30 | 19 | 11 | 63 | Effectively |
| 6 groups | Chinese medicine | 30 | 19 | 11 | 63 | Effectively |
| 7 groups | Western medicine | 30 | 24 | 6 | 80 | Produce effects |
Learning relatively by statistics, the curative effect of two dosage groups of senior middle school of the present invention also is higher than ciprofloxacin group (P＜0.05) apparently higher than Chinese medicine matched group and low dose group (P＜0.01).
Three, the present invention is to the clinical observation of infectious bursal disease:
Infectious bursal disease is a kind of acute contagious disease in 2-15 age in week of being caused by bursal disease virus, with lymphoid tissue generation immunosuppressant or immunodeficiency such as infringement fabricius bursa, and can the multiple infectious disease of secondary, can cause very big economic loss.With the present invention in the Jilin, Jilin Province, suburb, Changchun and Harbin City, Heilongjiang Province city carry out drug test to morbidity chicken group, treats 26099 of disease chickens altogether, cures 25838 altogether, dead 261, cure rate is 99%.The present invention adds up as following table the curative effect of treatment chicken bursal disease:
| Unit | The example number | Cure number | Death toll | Cure rate |
| The family of raising chickens, four estrade villages | 1150 | 1139 | 11 | 99 |
| City meat processing combine chicken house | 4677 | 4630 | 47 | 98.99 |
| City mechanical ﹠ electrical corporation chicken house | 945 | 935 | 10 | 98.9 |
| The grain depot chicken farm | 2267 | 2245 | 22 | 99 |
| Other specialists of raising chickens | 17060 | 16889 | 171 | 98.99 |
| Add up to | 26099 | 25838 | 261 | 99 |
The present invention treats millions of of chicken bursal diseases, all obtains better curative effect, and general treatment can stop death after 2 days, can cure after 3-4 days, does not generally recur after the healing, shows that the present invention has very high curative effect.
Four, the present invention is to the clinical trial of chicken, rabbit Bacillus pasteurii disease:
The chicken Bacillus pasteurii disease is a fowl cholera, is one of main bacteria sexually transmitted disease of the chicken that caused by pasteurella multocida, and primary disease is a feature with the acute hemorrhagic septicemia.Publish 80 of disease chickens and be divided into two treatment groups, use the present invention and olaquindox medicine for treatment respectively.With of the present invention group of dosage is 0.5 gram/kg body weight, gets it filled and packs in the soft gelatin capsule, oral administration clothes, 2 times on the one, logotype 3 days; And olaquindox group dosage is 1 (0.25g)/kg body weight oral administration clothes, 2 times on the one, and logotype 3 days.Its curative effect determinate standard: 1, recovery from illness: clinical symptoms all disappears.It is normal that appetite is recovered, no longer recurrence in the week.2, invalid: clinical symptoms constantly increases weight, and is dead in the week after generation death or the drug withdrawal during treating.Cut open inspection and bacteriology checking and find more pasteurellosis bacillus.Its comparing result such as following table:
| Project | Of the present invention group | The olaquindox group |
| The example number | 40 | 40 |
| Cure number | 38 | 32 |
| Death toll | 2 | 8 |
| Cure rate (%) | 95 | 80 |
Curative effect more of the present invention by statistics is apparently higher than olaquindox group (P＜0.05).
Five, the present invention is to the curative effect of chronic respiratory disease:
Chronic respiratory disease is the chicken that caused by fowl deteriorated blood Mycoplasma and a kind of chronic infectious disease of turkey respiratory tract, and its Clinical symptoms is shaken the head for cough, stream nose liquid, sneeze, and with sinusitis, conjunctivitis and airsacculitis; It is air-breathing that sick chicken often dehisces to stretch neck, and the sound of rumble, rumble is sent in necking down during expiration.This group is selected totally 250 of 1-2 monthly age children chickens.Administrated method is: the treatment of morbidity chicken is dressed up soft gelatin capsule oral administration clothes by the dosage of 0.5 gram/kg body weight, also can mix food and feed logotype 3-4 days 2 times on the one.Fed 2-3 days again after one week, in case recurrence.The chicken that do not fall ill is spread by the dosage mixed feeding of 0.2-0.3 gram/kg body weight and feeds, and 2 times on the one, logotype 2 days.Can mix the clothes of feeding by the dosage of 0.3-0.4 gram when sick chicken and the bad differentiation of strong chicken, 2 logotypes on the one 3 days were fed 2-3 days in case recurrence after the week again.Result such as following table:
| Unit | The example number | Cure number | The produce effects number | More do not count | Total effective rate |
| The Lan Jia village | 110 | 97 | 10 | 3 | 97.27 |
| The Liu Jia village | 65 | 57 | 7 | 1 | 98.48 |
| The Li Jia village | 75 | 66 | 8 | 1 | 98.66 |
| Add up to | 250 | 220 | 25 | 5 | 98 |
Six, the present invention is to the Comparison of therapeutic of viral infectious:
Canine distemper is with the two-phase hyperpyrexia, and cough stream nose liquid is given birth to the eye defect, pneumonia, and thigh portion skin dermexanthesis, the last shank spasm paralysis of dysentery is characteristics.The canine infectious gastroenteritis that Canine Parvovirus causes is common in the 2-3 monthly age.With vomiting, making the blood dysentery is feature, and cold pig and influenza are the infectious disease that influenza virus causes, the hyperpyrexia rapid breathing, and ventral breathing, cough, eye and nose have mucus secretions.The big hepatopathy of chicken causes the chicken liver enlargement by the avian leukosis poison.Above-mentioned disease is with the result such as the following table of herbal medicine of the present invention:
| The sick kind | Canine distemper | Canine Parvovirus enteritis | Cold pig and influenza | The big hepatopathy of chicken | Add up to |
| The example number | 15 | 65 | 28 | 180 | 288 |
| Cure number | 11 | 60 | 26 | 160 | 257 |
| More do not count | 4 | 5 | 2 | 20 | 31 |
| Cure rate % | 73.3 | 92.3 | 92.8 | 88.8 | 89.2 |
Seven, the present invention adds up as following table the curative effect of several bacterial infectious diseases:
| The sick kind | The mink bacterial enteritis | Yellow and white dysentery of piglet | Adenitis equorum | Pig lung plague | Pig erysipelas | Add up to |
| The example number | 80 | 200 | 8 | 10 | 15 | 313 |
| Cure number | 74 | 190 | 8 | 10 | 15 | 297 |
| More do not count | 6 | 10 | 0 | 0 | 0 | 16 |
| Cure rate % | 92.5 | 95 | 8/8 | 10/10 | 15/15 | 94.8 |
The present invention has curative effect preferably to some bacterial infectious disease as seen from the above table, promptly all more than 90%.
Good effect of the present invention is a kind of pure Chinese medicine extraction medicine, is difficult for recurrence, and antibacterial is difficult to produce drug resistance; Have no side effect, safe in utilization, viral and cure rate bacterial infectious disease are reached more than 96%; Avoided the generation of residue of veterinary drug and social effects of pollution.
The specific embodiment:
The invention will be further described below in conjunction with specific embodiment:
Embodiment 1:(1) with Gypsum Fibrosum 50 gram, it is standby behind the coarse powder that Flos Lonicerae 20 grams, Rhizoma Coptidis 10 grams, Cortex Phellodendri 20 gram pulverize separately become; (2) surplus medicine Fructus Forsythiae 20 grams, Radix Scutellariae 20 grams, Fructus Gardeniae 20 grams, Radix Isatidis 20 grams, the Rhizoma Anemarrhenae 20 grams, Radix Salviae Miltiorrhizae 20 grams, Rhizoma Osmundae 15 grams, Folium Isatidis 20 grams, Radix Paeoniae Rubra 15 grams, Radix Scrophulariae 20 grams, the Radix Rehmanniae 20 grams, Cortex Moutan 20 grams, Radix Glycyrrhizae 15 grams are fried in shallow oil altogether, connect and fry in shallow oil each the decoction 1 hour three times, after the decoction three decocting liquids are merged, be concentrated into thick; (3) coarse powder that Flos Lonicerae 20 grams, Rhizoma Coptidis 10 grams, Cortex Phellodendri 20 are restrained is sneaked into magma and is stirred; Drying, admix after the pulverizing Gypsum Fibrosum 50 powder packing powder or the direct pelletizing press sheet of powder made tablet.
Embodiment 2:(1) with Gypsum Fibrosum 100 gram, it is standby behind the coarse powder that Flos Lonicerae 40 grams, Rhizoma Coptidis 20 grams, Cortex Phellodendri 40 gram pulverize separately become; (2) surplus medicine Fructus Forsythiae 40 grams, Radix Scutellariae 40 grams, Fructus Gardeniae 40 grams, Radix Isatidis 40 grams, the Rhizoma Anemarrhenae 40 grams, Radix Salviae Miltiorrhizae 40 grams, Rhizoma Osmundae 30 grams, Folium Isatidis 40 grams, Radix Paeoniae Rubra 30 grams, Radix Scrophulariae 40 grams, the Radix Rehmanniae 40 grams, Cortex Moutan 40 grams, Radix Glycyrrhizae 30 grams are fried in shallow oil altogether, connect and fry in shallow oil each the decoction 1.5 hours three times, after the decoction three decocting liquids are merged, be concentrated into thick; (3) coarse powder that Flos Lonicerae 40 grams, Rhizoma Coptidis 20 grams, Cortex Phellodendri 40 are restrained is sneaked into magma and is stirred; Drying, admix after the pulverizing Gypsum Fibrosum 100 powder packing powder or the direct pelletizing press sheet of powder made tablet.
Embodiment 3:(1) with Gypsum Fibrosum 150 gram, it is standby behind the coarse powder that Flos Lonicerae 60 grams, Rhizoma Coptidis 30 grams, Cortex Phellodendri 60 gram pulverize separately become; (2) surplus medicine Fructus Forsythiae 60 grams, Radix Scutellariae 60 grams, Fructus Gardeniae 60 grams, Radix Isatidis 60 grams, the Rhizoma Anemarrhenae 60 grams, Radix Salviae Miltiorrhizae 60 grams, Rhizoma Osmundae 45 grams, Folium Isatidis 60 grams, Radix Paeoniae Rubra 45 grams, Radix Scrophulariae 60 grams, the Radix Rehmanniae 60 grams, Cortex Moutan 60 grams, Radix Glycyrrhizae 45 grams are fried in shallow oil altogether, connect and fry in shallow oil each the decoction 2 hours three times, after the decoction three decocting liquids are merged, be concentrated into thick; (3) coarse powder that Flos Lonicerae 60 grams, Rhizoma Coptidis 30 grams, Cortex Phellodendri 60 are restrained is sneaked into magma and is stirred; Drying, admix after the pulverizing Gypsum Fibrosum 150 powder packing powder or make tablet.
Claims (3)
1, the extraction herbal medicine of treatment infectious bursal disease is characterized in that it being to be made by following materials of weight proportions: Flos Lonicerae 20-60 gram, Fructus Forsythiae 20-60 gram, Radix Scutellariae 20-60 gram, Fructus Gardeniae 20-60 gram, Radix Isatidis 20-60 gram, Rhizoma Anemarrhenae 20-60 gram, Radix Salviae Miltiorrhizae 20-60 gram, Rhizoma Osmundae 15-45 gram, Folium Isatidis 20-60 gram, Radix Paeoniae Rubra 15-45 gram, Gypsum Fibrosum 50-150 gram, Rhizoma Coptidis 10-30 gram, Radix Scrophulariae 20-60 gram, Radix Rehmanniae 20-60 gram, Cortex Phellodendri 20-60 gram, Cortex Moutan 20-60 gram, Radix Glycyrrhizae 15-45 gram.
2, the method for extraction herbal medicine of preparation treatment infectious bursal disease according to claim 1 is characterized in that carrying out according to the following steps: (1), Gypsum Fibrosum, Flos Lonicerae, Rhizoma Coptidis, Cortex Phellodendri pulverize separately are become standby behind the coarse powder; (2) surplus medicine is fried in shallow oil altogether, connects to fry in shallow oil each the decoction 1-2 hour three times, after the decoction three decocting liquids is merged, and is concentrated into thick; (3) coarse powder of Flos Lonicerae, Rhizoma Coptidis, Cortex Phellodendri is sneaked into magma and stir; Drying is admixed the Gypsum Fibrosum powder packing after the pulverizing.
3, the extraction herbal medicine of treatment infectious bursal disease according to claim 1, the dosage form that it is characterized in that described herbal medicine is powder or tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB02133076XA CN1186061C (en) | 2002-09-27 | 2002-09-27 | Extracted herbal medicine for treating chicken infectious bursa of Fabricius |
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| CNB02133076XA CN1186061C (en) | 2002-09-27 | 2002-09-27 | Extracted herbal medicine for treating chicken infectious bursa of Fabricius |
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| CN1186061C true CN1186061C (en) | 2005-01-26 |
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| CN1927303B (en) * | 2006-08-29 | 2010-11-03 | 天津生机集团有限公司 | Chinese medicine for treating chicken respiratory tract disease |
| CN101032596B (en) * | 2007-02-12 | 2010-05-19 | 西北农林科技大学 | Medicine for treating respiratory tract diseases for chickens and its preparing process |
| CN101194995B (en) * | 2007-10-23 | 2011-05-25 | 杨建春 | Proprietary Chinese medicine for treating animal virus, bacterium and mix infection |
| CN101721602B (en) * | 2008-10-16 | 2012-12-19 | 岳道友 | Animal remedy for treating porcine nameless high-fever syndrome |
| CN102526356B (en) * | 2012-03-14 | 2013-11-27 | 青岛汉河动植物药业有限公司 | Traditional Chinese medicine compound for clearing Ying heat and cooling blood of poultry |
| CN102846825A (en) * | 2012-08-30 | 2013-01-02 | 李承平 | Drug tablets with function of fire-heat pathogenic toxin clearing and relieving |
| CN103202894B (en) * | 2013-04-01 | 2014-08-27 | 陈鹏举 | Chinese herbal medicine feed additive for preventing and curing infectious serositis of duck |
| CN103432343B (en) * | 2013-07-26 | 2014-11-05 | 河南牧翔动物药业有限公司 | Nano traditional Chinese medicine preparation used for preventing and treating upper respiratory infection of poultry and preparation method thereof |
| CN103446373B (en) * | 2013-08-08 | 2014-12-10 | 镇江天和生物技术有限公司 | Chinese herba preparation for treating infectious laryngotracheitis |
| CN103599448B (en) * | 2013-10-23 | 2016-04-06 | 青岛华仁技术孵化器有限公司 | Be used for the treatment of the Chinese medicine composition of infections chicken cloacal bursa |
| CN105232763A (en) * | 2015-10-19 | 2016-01-13 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine combination for treating avian respiratory tract infection and preparation method and application thereof |
| CN107693669A (en) * | 2016-08-08 | 2018-02-16 | 罗剑 | A kind of medicine for treating swine erysipelas |
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2002
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