CN1184475A - 具有mdr活性的四氢化萘化合物 - Google Patents
具有mdr活性的四氢化萘化合物 Download PDFInfo
- Publication number
- CN1184475A CN1184475A CN96194028A CN96194028A CN1184475A CN 1184475 A CN1184475 A CN 1184475A CN 96194028 A CN96194028 A CN 96194028A CN 96194028 A CN96194028 A CN 96194028A CN 1184475 A CN1184475 A CN 1184475A
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- group
- hydrogen
- straight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/444,567 US5726184A (en) | 1995-05-19 | 1995-05-19 | Tetralin compounds with improved MDR activity |
US08/444,567 | 1995-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1184475A true CN1184475A (zh) | 1998-06-10 |
Family
ID=23765456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96194028A Pending CN1184475A (zh) | 1995-05-19 | 1996-05-16 | 具有mdr活性的四氢化萘化合物 |
Country Status (22)
Country | Link |
---|---|
US (1) | US5726184A (pt) |
EP (1) | EP0839143B1 (pt) |
JP (1) | JPH11505255A (pt) |
KR (1) | KR19990014848A (pt) |
CN (1) | CN1184475A (pt) |
AT (1) | ATE221881T1 (pt) |
AU (1) | AU705167B2 (pt) |
BR (1) | BR9608789A (pt) |
CA (1) | CA2219752A1 (pt) |
CZ (1) | CZ364197A3 (pt) |
DE (1) | DE69622871T2 (pt) |
DK (1) | DK0839143T3 (pt) |
ES (1) | ES2179945T3 (pt) |
HU (1) | HUP9802679A3 (pt) |
IL (1) | IL118269A0 (pt) |
NO (1) | NO975198L (pt) |
NZ (1) | NZ308789A (pt) |
PL (1) | PL323490A1 (pt) |
PT (1) | PT839143E (pt) |
SK (1) | SK155497A3 (pt) |
WO (1) | WO1996036630A1 (pt) |
ZA (1) | ZA963959B (pt) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103130632A (zh) * | 2011-11-29 | 2013-06-05 | 中国人民解放军第二军医大学 | 1-取代苯亚甲基-2-萘酮类衍生物及制备方法和用途 |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5798355A (en) * | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
US5935989A (en) | 1996-12-31 | 1999-08-10 | Gpi Nil Holdings Inc. | N-linked ureas and carbamates of heterocyclic thioesters |
JP2002515050A (ja) | 1996-12-31 | 2002-05-21 | ジーピーアイ エヌアイエル ホールディングス インコーポレイテッド | ヘテロ環式チオエステルのn−結合尿素およびカルバメート |
US5846979A (en) | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
FR2781218B1 (fr) * | 1998-07-15 | 2001-09-07 | Lafon Labor | Compositions pharmaceutiques comprenant des 2-quinolones |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US6337340B1 (en) | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
AU5606400A (en) | 1999-07-09 | 2001-01-30 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods |
FR2797444B1 (fr) | 1999-08-13 | 2003-02-07 | Lafon Labor | Compositions pharmaceutiques comprenant des 4-quinolones |
BR0114713A (pt) * | 2000-10-16 | 2004-01-13 | Neopharm Inc | Formulação lipossÈmica de mitoxantrona |
US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
JP2005500270A (ja) * | 2001-05-29 | 2005-01-06 | ギルフォード ファーマシュウティカルズ インコーポレイテッド | 手術の結果として発生した神経損傷を治療するための方法 |
JP2005508990A (ja) * | 2001-11-07 | 2005-04-07 | ファルマシア・コーポレーション | 真核細胞におけるポリアミドの取込みおよび核蓄積を促進する方法 |
US7825136B2 (en) | 2003-07-10 | 2010-11-02 | Vertex Pharmaceuticals Incorporated | Potentiators of antibacterial activity |
US20080221163A1 (en) * | 2005-01-18 | 2008-09-11 | Jeffrey Alan Dodge | Selective Estrogen Receptor Modulators |
CA2772786A1 (en) | 2009-09-11 | 2011-03-17 | Vertex Pharmaceuticals Incorporated | Compositions of n-benzyl-3-(4-chlorophenyl)-2-[methyl-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]amino]-n-[3-(4-pyridyl)-1-[2-(4-pyridyl)ethyl]propyl]propanamide and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
US5387685A (en) * | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
-
1995
- 1995-05-19 US US08/444,567 patent/US5726184A/en not_active Expired - Lifetime
-
1996
- 1996-05-15 IL IL11826996A patent/IL118269A0/xx unknown
- 1996-05-16 NZ NZ308789A patent/NZ308789A/xx not_active IP Right Cessation
- 1996-05-16 HU HU9802679A patent/HUP9802679A3/hu unknown
- 1996-05-16 DK DK96920255T patent/DK0839143T3/da active
- 1996-05-16 EP EP96920255A patent/EP0839143B1/en not_active Expired - Lifetime
- 1996-05-16 CA CA002219752A patent/CA2219752A1/en not_active Abandoned
- 1996-05-16 WO PCT/US1996/007094 patent/WO1996036630A1/en active IP Right Grant
- 1996-05-16 JP JP8535063A patent/JPH11505255A/ja not_active Ceased
- 1996-05-16 KR KR1019970708193A patent/KR19990014848A/ko not_active Application Discontinuation
- 1996-05-16 DE DE69622871T patent/DE69622871T2/de not_active Expired - Fee Related
- 1996-05-16 AT AT96920255T patent/ATE221881T1/de not_active IP Right Cessation
- 1996-05-16 BR BR9608789A patent/BR9608789A/pt not_active Application Discontinuation
- 1996-05-16 PT PT96920255T patent/PT839143E/pt unknown
- 1996-05-16 AU AU58620/96A patent/AU705167B2/en not_active Ceased
- 1996-05-16 CZ CZ973641A patent/CZ364197A3/cs unknown
- 1996-05-16 CN CN96194028A patent/CN1184475A/zh active Pending
- 1996-05-16 SK SK1554-97A patent/SK155497A3/sk unknown
- 1996-05-16 ES ES96920255T patent/ES2179945T3/es not_active Expired - Lifetime
- 1996-05-16 PL PL96323490A patent/PL323490A1/xx unknown
- 1996-05-17 ZA ZA963959A patent/ZA963959B/xx unknown
-
1997
- 1997-11-12 NO NO975198A patent/NO975198L/no not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103130632A (zh) * | 2011-11-29 | 2013-06-05 | 中国人民解放军第二军医大学 | 1-取代苯亚甲基-2-萘酮类衍生物及制备方法和用途 |
CN103130632B (zh) * | 2011-11-29 | 2015-04-15 | 中国人民解放军第二军医大学 | 1-取代苯亚甲基-2-萘酮类衍生物及制备方法和用途 |
Also Published As
Publication number | Publication date |
---|---|
ZA963959B (en) | 1996-11-25 |
WO1996036630A1 (en) | 1996-11-21 |
DE69622871T2 (de) | 2003-04-10 |
JPH11505255A (ja) | 1999-05-18 |
KR19990014848A (ko) | 1999-02-25 |
DE69622871D1 (de) | 2002-09-12 |
NO975198D0 (no) | 1997-11-12 |
IL118269A0 (en) | 1996-09-12 |
AU705167B2 (en) | 1999-05-20 |
AU5862096A (en) | 1996-11-29 |
CZ364197A3 (cs) | 1998-03-18 |
US5726184A (en) | 1998-03-10 |
DK0839143T3 (da) | 2002-11-18 |
EP0839143A1 (en) | 1998-05-06 |
EP0839143B1 (en) | 2002-08-07 |
BR9608789A (pt) | 1999-02-17 |
CA2219752A1 (en) | 1996-11-21 |
PT839143E (pt) | 2002-12-31 |
PL323490A1 (en) | 1998-03-30 |
ATE221881T1 (de) | 2002-08-15 |
HUP9802679A3 (en) | 2000-03-28 |
SK155497A3 (en) | 1998-04-08 |
ES2179945T3 (es) | 2003-02-01 |
NO975198L (no) | 1998-01-19 |
MX9708830A (es) | 1998-03-31 |
NZ308789A (en) | 1999-07-29 |
HUP9802679A2 (hu) | 1999-03-29 |
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