CN1183156C - 杂环化合物、其中间体和弹性蛋白酶抑制剂 - Google Patents

杂环化合物、其中间体和弹性蛋白酶抑制剂 Download PDF

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Publication number
CN1183156C
CN1183156C CNB008070636A CN00807063A CN1183156C CN 1183156 C CN1183156 C CN 1183156C CN B008070636 A CNB008070636 A CN B008070636A CN 00807063 A CN00807063 A CN 00807063A CN 1183156 C CN1183156 C CN 1183156C
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CN
China
Prior art keywords
compound
group
isovaleryl
isopropyl
prolinamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008070636A
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English (en)
Chinese (zh)
Other versions
CN1349542A (zh
Inventor
佐藤文宪
井上泰尚
����ϲ��
面谷智喜
̫
白武亮太郎
本多清二
小宫雅信
武村忠
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Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of CN1349542A publication Critical patent/CN1349542A/zh
Application granted granted Critical
Publication of CN1183156C publication Critical patent/CN1183156C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CNB008070636A 1999-03-03 2000-02-23 杂环化合物、其中间体和弹性蛋白酶抑制剂 Expired - Fee Related CN1183156C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP56052/1999 1999-03-03
JP11056052A JP2000256396A (ja) 1999-03-03 1999-03-03 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
JP56052/99 1999-03-03

Publications (2)

Publication Number Publication Date
CN1349542A CN1349542A (zh) 2002-05-15
CN1183156C true CN1183156C (zh) 2005-01-05

Family

ID=13016323

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008070636A Expired - Fee Related CN1183156C (zh) 1999-03-03 2000-02-23 杂环化合物、其中间体和弹性蛋白酶抑制剂

Country Status (23)

Country Link
US (1) US6835714B1 (enExample)
EP (1) EP1157998B1 (enExample)
JP (1) JP2000256396A (enExample)
KR (1) KR100622709B1 (enExample)
CN (1) CN1183156C (enExample)
AT (1) ATE259376T1 (enExample)
AU (1) AU758739B2 (enExample)
CA (1) CA2362911A1 (enExample)
DE (1) DE60008218T2 (enExample)
DK (1) DK1157998T3 (enExample)
ES (1) ES2215608T3 (enExample)
HK (1) HK1044955B (enExample)
HU (1) HUP0200608A3 (enExample)
IL (2) IL144813A0 (enExample)
MX (1) MXPA01008836A (enExample)
NZ (1) NZ513594A (enExample)
PL (1) PL199136B1 (enExample)
PT (1) PT1157998E (enExample)
RU (1) RU2222539C2 (enExample)
TR (1) TR200102540T2 (enExample)
TW (1) TW534905B (enExample)
WO (1) WO2000052032A1 (enExample)
ZA (1) ZA200106514B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289887A3 (en) 2000-06-30 2011-07-06 Seikagaku Corporation Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them
AR029851A1 (es) 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
SK742003A3 (en) 2000-07-21 2003-06-03 Schering Corp Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
US7012066B2 (en) * 2000-07-21 2006-03-14 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
GB0021315D0 (en) 2000-08-30 2000-10-18 Dainippon Pharmaceutical Co Heterocyclic compounds and intermediates thereof
WO2002026229A1 (en) * 2000-09-29 2002-04-04 Ono Pharmaceutical Co., Ltd. Airway mucus secretion inhibitors
PL371539A1 (en) * 2002-02-05 2005-06-27 Dainippon Pharmaceutical Co, Ltd. Heterocyclic compounds having elastase-inhibiting activity and intermediates thereof
ATE438622T1 (de) * 2004-02-27 2009-08-15 Schering Corp 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
EP2019837B1 (en) * 2006-05-23 2011-03-23 Irm Llc Compounds and compositions as channel activating protease inhibitors
EP2027143A2 (en) * 2006-05-23 2009-02-25 Irm Llc Compounds and compositions as channel activating protease inhibitors
WO2008032331A1 (en) * 2006-09-12 2008-03-20 Himalaya Global Holdings Ltd. Herbal composition for the prevention of wrinkles and skin disorders, methods of preparing the same and uses thereof
CA2677485A1 (en) * 2007-02-09 2008-08-14 Irm Llc Compounds and compositions as channel activating protease inhibitors
CA2677487A1 (en) * 2007-02-09 2008-08-14 Irm Llc Compounds and compositions as channel activating protease inhibitors
US9353113B2 (en) 2011-03-18 2016-05-31 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
CN104031014B (zh) * 2013-03-08 2016-05-11 华中师范大学 香豆素衍生物及其制备方法以及弹性蛋白酶活性检测方法和检测试剂盒
CN104165869B (zh) * 2013-05-17 2016-12-28 华中师范大学 一种检测蛋白水解酶活性的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS231228B1 (en) 1982-10-01 1984-10-15 Evzen Kasafirek Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method
GB8600263D0 (en) 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
GB8809316D0 (en) 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
CA1340191C (en) 1988-06-13 1998-12-15 Katsuhiro Imaki Derivatives of p-substituted phenyl ester of pivalic acid
IT1245712B (it) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
IT1255704B (it) * 1992-09-30 1995-11-10 Boehringer Mannheim Italia Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree
US5565568A (en) * 1995-04-06 1996-10-15 Eli Lilly And Company 2-acylaminopropanamides as tachykinin receptor antagonists

Also Published As

Publication number Publication date
HK1044955B (zh) 2005-07-08
KR100622709B1 (ko) 2006-09-13
RU2222539C2 (ru) 2004-01-27
PT1157998E (pt) 2004-06-30
EP1157998B1 (en) 2004-02-11
AU758739B2 (en) 2003-03-27
EP1157998A4 (en) 2003-01-29
IL144813A (en) 2006-12-10
KR20020002396A (ko) 2002-01-09
JP2000256396A (ja) 2000-09-19
CA2362911A1 (en) 2000-09-08
US6835714B1 (en) 2004-12-28
ES2215608T3 (es) 2004-10-16
HK1044955A1 (en) 2002-11-08
TW534905B (en) 2003-06-01
DE60008218T2 (de) 2004-12-09
TR200102540T2 (tr) 2002-01-21
MXPA01008836A (es) 2002-05-14
NZ513594A (en) 2003-04-29
HUP0200608A3 (en) 2002-09-30
IL144813A0 (en) 2002-06-30
DK1157998T3 (da) 2004-06-14
EP1157998A1 (en) 2001-11-28
ZA200106514B (en) 2002-05-10
HUP0200608A2 (en) 2002-08-28
CN1349542A (zh) 2002-05-15
ATE259376T1 (de) 2004-02-15
AU2690200A (en) 2000-09-21
WO2000052032A1 (en) 2000-09-08
DE60008218D1 (de) 2004-03-18
PL199136B1 (pl) 2008-08-29

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: NIPPO SUMITOMO PHARMACEUTICALS CO., LTD.

Free format text: FORMER NAME OR ADDRESS: DAINIPPON PHARMACEUTICAL CO., LTD.

CP01 Change in the name or title of a patent holder

Address after: Osaka City, Osaka of Japan

Patentee after: Dainippon Sumitomo Pharma Co., Ltd.

Address before: Osaka City, Osaka of Japan

Patentee before: Dainippon Pharmaceutical Co., Ltd.

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050105

Termination date: 20100223