TR200102540T2 - Heterosiklik bileşimler, ara ürünleri ve elastaz inhibitörleri. - Google Patents

Heterosiklik bileşimler, ara ürünleri ve elastaz inhibitörleri.

Info

Publication number
TR200102540T2
TR200102540T2 TR2001/02540T TR200102540T TR200102540T2 TR 200102540 T2 TR200102540 T2 TR 200102540T2 TR 2001/02540 T TR2001/02540 T TR 2001/02540T TR 200102540 T TR200102540 T TR 200102540T TR 200102540 T2 TR200102540 T2 TR 200102540T2
Authority
TR
Turkey
Prior art keywords
group
different
same
intermediates
elastase inhibitors
Prior art date
Application number
TR2001/02540T
Other languages
English (en)
Inventor
Sato Fuminori
Inoue Yasunao
Omodani Tomoki
Shiratake Ryotaro
Honda Seiji
Komiya Masanobu
Takemura Tadashi
Original Assignee
Dainippon Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co., Ltd. filed Critical Dainippon Pharmaceutical Co., Ltd.
Publication of TR200102540T2 publication Critical patent/TR200102540T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

Bu bulus, A ve B nin ayni veya farkli olup her birinin tercihe göre bir okso grubuyla ikameli bir alt alkilen grubu oldugu, D'nin tercihe göre bir okso grubuyla ikameli bir heteromono veya heterobi-siklik grup oldugu, R1 ve R2 ayni veya farkli olup her birinin bir alt alkil grubu oldugu, R3 ve R4'ün farkli olup her biri bir hidrojen atomu veya bir hidroksi grubu oldugu veya her ikisinin birleserek bir okso grubu olusturdugu ve R5'in 2-benzoksazolil, trifluorometil, benzilaminokarbonil, vs oldugu bir formül(I-a) heterosiklik bilesim veya esteri veya bir tuzu ile, ve aktif içerik maddesi olarak aynisini içeren bir insan nötrofilik elastaz inhibitörüyle ilgilidir.
TR2001/02540T 1999-03-03 2000-02-23 Heterosiklik bileşimler, ara ürünleri ve elastaz inhibitörleri. TR200102540T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11056052A JP2000256396A (ja) 1999-03-03 1999-03-03 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤

Publications (1)

Publication Number Publication Date
TR200102540T2 true TR200102540T2 (tr) 2002-01-21

Family

ID=13016323

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02540T TR200102540T2 (tr) 1999-03-03 2000-02-23 Heterosiklik bileşimler, ara ürünleri ve elastaz inhibitörleri.

Country Status (23)

Country Link
US (1) US6835714B1 (tr)
EP (1) EP1157998B1 (tr)
JP (1) JP2000256396A (tr)
KR (1) KR100622709B1 (tr)
CN (1) CN1183156C (tr)
AT (1) ATE259376T1 (tr)
AU (1) AU758739B2 (tr)
CA (1) CA2362911A1 (tr)
DE (1) DE60008218T2 (tr)
DK (1) DK1157998T3 (tr)
ES (1) ES2215608T3 (tr)
HK (1) HK1044955B (tr)
HU (1) HUP0200608A3 (tr)
IL (2) IL144813A0 (tr)
MX (1) MXPA01008836A (tr)
NZ (1) NZ513594A (tr)
PL (1) PL199136B1 (tr)
PT (1) PT1157998E (tr)
RU (1) RU2222539C2 (tr)
TR (1) TR200102540T2 (tr)
TW (1) TW534905B (tr)
WO (1) WO2000052032A1 (tr)
ZA (1) ZA200106514B (tr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002546A1 (fr) * 2000-06-30 2002-01-10 Seikagaku Corporation Amides d'acide carboxylique, azides et amino-alcools et procedes de preparation de $g(a)-ceto amides a l'aide de ces derniers
RU2355700C9 (ru) 2000-07-21 2010-03-20 Шеринг Корпорейшн Новые пептиды как ингибиторы ns3-серинпротеазы вируса гепатита с
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
AR029851A1 (es) 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
BR0112666A (pt) 2000-07-21 2003-06-10 Schering Corp Peptìdeos como inibidores de ns3-serina protease de vìrus da hepatite c
GB0021315D0 (en) * 2000-08-30 2000-10-18 Dainippon Pharmaceutical Co Heterocyclic compounds and intermediates thereof
EP1323419A1 (en) * 2000-09-29 2003-07-02 Ono Pharmaceutical Co., Ltd. Airway mucus secretion inhibitors
PL371539A1 (en) 2002-02-05 2005-06-27 Dainippon Pharmaceutical Co, Ltd. Heterocyclic compounds having elastase-inhibiting activity and intermediates thereof
CA2557307A1 (en) * 2004-02-27 2005-09-22 Schering Corporation 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease
JP2009538327A (ja) 2006-05-23 2009-11-05 アイアールエム・リミテッド・ライアビリティ・カンパニー チャネル活性化プロテアーゼ阻害剤である化合物および組成物
DE602007013387D1 (de) * 2006-05-23 2011-05-05 Irm Llc Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer
WO2008032331A1 (en) * 2006-09-12 2008-03-20 Himalaya Global Holdings Ltd. Herbal composition for the prevention of wrinkles and skin disorders, methods of preparing the same and uses thereof
MX2009008518A (es) * 2007-02-09 2009-08-20 Irm Llc Compuestos y composiciones como inhibidores de la proteasa activadora de canal.
US20100239551A1 (en) * 2007-02-09 2010-09-23 Irm Llc Compounds and compositions as channel activating protease inhibitors
WO2012127885A1 (ja) 2011-03-18 2012-09-27 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
CN104031014B (zh) * 2013-03-08 2016-05-11 华中师范大学 香豆素衍生物及其制备方法以及弹性蛋白酶活性检测方法和检测试剂盒
CN104165869B (zh) * 2013-05-17 2016-12-28 华中师范大学 一种检测蛋白水解酶活性的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS231228B1 (en) 1982-10-01 1984-10-15 Evzen Kasafirek Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method
GB8600263D0 (en) 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
GB8809316D0 (en) 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
US5017610A (en) 1988-06-13 1991-05-21 Ono Pharmaceutical Co., Ltd. Derivatives of p-substituted phenyl ester of pivalic acid
US5565568A (en) * 1995-04-06 1996-10-15 Eli Lilly And Company 2-acylaminopropanamides as tachykinin receptor antagonists

Also Published As

Publication number Publication date
DK1157998T3 (da) 2004-06-14
PL199136B1 (pl) 2008-08-29
EP1157998B1 (en) 2004-02-11
ZA200106514B (en) 2002-05-10
KR100622709B1 (ko) 2006-09-13
DE60008218D1 (de) 2004-03-18
KR20020002396A (ko) 2002-01-09
EP1157998A1 (en) 2001-11-28
EP1157998A4 (en) 2003-01-29
RU2222539C2 (ru) 2004-01-27
AU2690200A (en) 2000-09-21
HUP0200608A3 (en) 2002-09-30
HK1044955B (zh) 2005-07-08
PT1157998E (pt) 2004-06-30
IL144813A0 (en) 2002-06-30
CN1349542A (zh) 2002-05-15
AU758739B2 (en) 2003-03-27
JP2000256396A (ja) 2000-09-19
HUP0200608A2 (en) 2002-08-28
CA2362911A1 (en) 2000-09-08
US6835714B1 (en) 2004-12-28
DE60008218T2 (de) 2004-12-09
IL144813A (en) 2006-12-10
ES2215608T3 (es) 2004-10-16
MXPA01008836A (es) 2002-05-14
ATE259376T1 (de) 2004-02-15
HK1044955A1 (en) 2002-11-08
NZ513594A (en) 2003-04-29
TW534905B (en) 2003-06-01
WO2000052032A1 (fr) 2000-09-08
CN1183156C (zh) 2005-01-05

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