RU2222539C2 - Гетероциклические соединения, ингибиторы нейтрофильной эластазы и фармацевтические композиции на их основе - Google Patents

Гетероциклические соединения, ингибиторы нейтрофильной эластазы и фармацевтические композиции на их основе Download PDF

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RU2222539C2
RU2222539C2 RU2001126725/04A RU2001126725A RU2222539C2 RU 2222539 C2 RU2222539 C2 RU 2222539C2 RU 2001126725/04 A RU2001126725/04 A RU 2001126725/04A RU 2001126725 A RU2001126725 A RU 2001126725A RU 2222539 C2 RU2222539 C2 RU 2222539C2
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Russia
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group
compound
formula
oxo
valyl
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RU2001126725/04A
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Russian (ru)
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RU2001126725A (ru
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Фуминори САТО (JP)
Фуминори САТО
Ясунао ИНОУЕ (JP)
Ясунао ИНОУЕ
Томоки ОМОДАНИ (JP)
Томоки ОМОДАНИ
Ретаро СИРАТАКЕ (JP)
Ретаро СИРАТАКЕ
Сейдзи ХОНДА (JP)
Сейдзи ХОНДА
Масанобу КОМИЯ (JP)
Масанобу КОМИЯ
Тадаси ТАКЕМУРА (JP)
Тадаси ТАКЕМУРА
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Дайниппон Фармасьютикал Ко., Лтд.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
RU2001126725/04A 1999-03-03 2000-02-23 Гетероциклические соединения, ингибиторы нейтрофильной эластазы и фармацевтические композиции на их основе RU2222539C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11/56052 1999-03-03
JP11056052A JP2000256396A (ja) 1999-03-03 1999-03-03 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤

Publications (2)

Publication Number Publication Date
RU2001126725A RU2001126725A (ru) 2003-06-27
RU2222539C2 true RU2222539C2 (ru) 2004-01-27

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RU2001126725/04A RU2222539C2 (ru) 1999-03-03 2000-02-23 Гетероциклические соединения, ингибиторы нейтрофильной эластазы и фармацевтические композиции на их основе

Country Status (23)

Country Link
US (1) US6835714B1 (enExample)
EP (1) EP1157998B1 (enExample)
JP (1) JP2000256396A (enExample)
KR (1) KR100622709B1 (enExample)
CN (1) CN1183156C (enExample)
AT (1) ATE259376T1 (enExample)
AU (1) AU758739B2 (enExample)
CA (1) CA2362911A1 (enExample)
DE (1) DE60008218T2 (enExample)
DK (1) DK1157998T3 (enExample)
ES (1) ES2215608T3 (enExample)
HK (1) HK1044955B (enExample)
HU (1) HUP0200608A3 (enExample)
IL (2) IL144813A0 (enExample)
MX (1) MXPA01008836A (enExample)
NZ (1) NZ513594A (enExample)
PL (1) PL199136B1 (enExample)
PT (1) PT1157998E (enExample)
RU (1) RU2222539C2 (enExample)
TR (1) TR200102540T2 (enExample)
TW (1) TW534905B (enExample)
WO (1) WO2000052032A1 (enExample)
ZA (1) ZA200106514B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289888A3 (en) * 2000-06-30 2011-07-13 Seikagaku Corporation Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
MXPA03000627A (es) * 2000-07-21 2004-07-30 Schering Corp Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c.
AR029851A1 (es) 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
WO2002008187A1 (en) 2000-07-21 2002-01-31 Schering Corporation Novel peptides as ns3-serine protease inhibitors of hepatitis c virus
GB0021315D0 (en) 2000-08-30 2000-10-18 Dainippon Pharmaceutical Co Heterocyclic compounds and intermediates thereof
CA2423945A1 (en) * 2000-09-29 2003-03-27 Atsushi Nagai Restrainers of airway mucus secretion
KR20040081182A (ko) * 2002-02-05 2004-09-20 다이닛본 세이야꾸 가부시끼가이샤 엘라스타제-저해 활성을 가진 이종고리 화합물 및 그 중간체
ES2328589T3 (es) * 2004-02-27 2009-11-16 Schering Corporation Compuestos de la prolina 3,4(ciclopentil) fusionados como inhibidores de la proteasa serina ns3 del virus de la hepatitis c.
RU2419625C2 (ru) * 2006-05-23 2011-05-27 Айрм Ллк Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы
US7951823B2 (en) * 2006-05-23 2011-05-31 Irm Llc Compounds and compositions as channel activating protease inhibitors
US8142818B2 (en) * 2006-09-12 2012-03-27 Himalaya Global Holdings Limited Herbal composition for the prevention of wrinkles and skin disorders, methods of preparing the same and uses thereof
EP2117541A1 (en) * 2007-02-09 2009-11-18 Irm Llc Compounds and compositions as channel activating protease inhibitors
KR20090108131A (ko) * 2007-02-09 2009-10-14 아이알엠 엘엘씨 채널 활성화 프로테아제 억제제로서의 화합물 및 조성물
WO2012127885A1 (ja) 2011-03-18 2012-09-27 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
CN104031014B (zh) * 2013-03-08 2016-05-11 华中师范大学 香豆素衍生物及其制备方法以及弹性蛋白酶活性检测方法和检测试剂盒
CN104165869B (zh) * 2013-05-17 2016-12-28 华中师范大学 一种检测蛋白水解酶活性的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453423A (en) * 1991-04-09 1995-09-26 Boehringer Mannheim Italia S.P.A. Heterocyclic amines useful in the therapy of asthma and imflammation of the respiratory tract
WO1996031214A1 (en) * 1995-04-06 1996-10-10 Eli Lilly And Company 2-acylaminopropanamides as tachykinin receptor antagonists
RU2119913C1 (ru) * 1992-09-30 1998-10-10 Берингер Маннгейм Италиа С.п.А. 1,4-дизамещенные пиперазины, пригодные при лечении астмы и воспаления дыхательных путей, способ их получения, лекарственные препараты на их основе и способ их получения

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS231228B1 (en) 1982-10-01 1984-10-15 Evzen Kasafirek Biologically effective tri and tetrapeptide alkylamide derivatives and their processing method
GB8600263D0 (en) 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
GB8809316D0 (en) 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
US5017610A (en) 1988-06-13 1991-05-21 Ono Pharmaceutical Co., Ltd. Derivatives of p-substituted phenyl ester of pivalic acid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453423A (en) * 1991-04-09 1995-09-26 Boehringer Mannheim Italia S.P.A. Heterocyclic amines useful in the therapy of asthma and imflammation of the respiratory tract
RU2119913C1 (ru) * 1992-09-30 1998-10-10 Берингер Маннгейм Италиа С.п.А. 1,4-дизамещенные пиперазины, пригодные при лечении астмы и воспаления дыхательных путей, способ их получения, лекарственные препараты на их основе и способ их получения
WO1996031214A1 (en) * 1995-04-06 1996-10-10 Eli Lilly And Company 2-acylaminopropanamides as tachykinin receptor antagonists

Also Published As

Publication number Publication date
EP1157998A4 (en) 2003-01-29
TR200102540T2 (tr) 2002-01-21
PT1157998E (pt) 2004-06-30
DE60008218T2 (de) 2004-12-09
EP1157998A1 (en) 2001-11-28
IL144813A0 (en) 2002-06-30
EP1157998B1 (en) 2004-02-11
DE60008218D1 (de) 2004-03-18
KR100622709B1 (ko) 2006-09-13
WO2000052032A1 (en) 2000-09-08
KR20020002396A (ko) 2002-01-09
DK1157998T3 (da) 2004-06-14
ES2215608T3 (es) 2004-10-16
MXPA01008836A (es) 2002-05-14
CA2362911A1 (en) 2000-09-08
AU758739B2 (en) 2003-03-27
ZA200106514B (en) 2002-05-10
US6835714B1 (en) 2004-12-28
JP2000256396A (ja) 2000-09-19
PL199136B1 (pl) 2008-08-29
IL144813A (en) 2006-12-10
AU2690200A (en) 2000-09-21
CN1349542A (zh) 2002-05-15
HK1044955B (zh) 2005-07-08
ATE259376T1 (de) 2004-02-15
CN1183156C (zh) 2005-01-05
TW534905B (en) 2003-06-01
NZ513594A (en) 2003-04-29
HK1044955A1 (en) 2002-11-08
HUP0200608A2 (en) 2002-08-28
HUP0200608A3 (en) 2002-09-30

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Effective date: 20100224