CN117959401A - Traditional Chinese medicine composition for treating rheumatic bone diseases and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating rheumatic bone diseases and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine compositions and traditional Chinese medicine preparation, and in particular relates to a traditional Chinese medicine composition for treating rheumatism bone diseases and a preparation method thereof. The invention provides a pharmaceutical composition (Jin Yi Bi-pill) for treating rheumatism bone diseases, which comprises black ants, broom roots, deer-horn glue, tortoise shell glue, radix clematidis, rhizoma drynariae, herba epimedii, rhizoma cibotii, mistletoe, radix paeoniae alba, ginseng, fried radish seeds, radix achyranthis bidentatae, scorpion, vinegar-processed rhizoma corydalis, radix salviae miltiorrhizae, fructus amomi, cortex phellodendri, honey-fried licorice roots, caltrop, membrana Follicularis ovi, rhizoma zedoariae, pseudo-ginseng powder, prepared polygonum multiflorum and notopterygium roots, wherein the medicinal materials are compatible according to the principle of monarch, minister, assistant and guide; the pharmaceutical composition can harmonize spleen, regulate conception vessel and governor vessel, balance yin and yang, strengthen tendons and bones, not only can perform immunoregulation, but also can improve joint function and block disease progress, and has small side effect, the compliance of the decoction is increased compared with the decoction, and the total effective rate of treatment is improved from 67.6% to 95.8% compared with the conventional control group.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions and traditional Chinese medicine preparation, and in particular relates to a traditional Chinese medicine composition for treating rheumatism bone diseases and a preparation method thereof.
Background
Rheumatic bone diseases are diseases caused by poor blood circulation due to immune dysfunction and chronic inflammation, such as muscular, ligament, bursa and fascia malnutrition and damage of corresponding bone joint tissues.
At present, the rheumatism bone disease is mainly treated by medicines, such as Western medicine glucocorticoid and nonsteroidal anti-inflammatory medicine; however, the use of western medicines of glucocorticoid and non-steroidal anti-inflammatory drugs can produce serious adverse reactions, and has serious damage to gastrointestinal tracts, livers and kidneys, and particularly the glucocorticoid has the effect of inhibiting immunity, but has serious damage to human bones; the nonsteroidal anti-inflammatory drug has a certain anti-inflammatory and analgesic effect, but cannot control the progress of the disease, cannot prevent the bone and bone joint from being destroyed, and has heavier gastrointestinal tract reaction; the traditional Chinese medicine decoction is inconvenient to take orally, and is not acceptable to patients, and has poor compliance.
Disclosure of Invention
Therefore, the invention aims to provide the pharmaceutical composition for treating the rheumatic bone diseases, and the corresponding prescription is prepared based on the theory of regulating spleen and stomach, regulating conception and governor, so that the five viscera can be conditioned, yin and yang can be balanced, bones and muscles can be strengthened, the immunity can be regulated, the joint function can be improved or recovered, the disease progress can be blocked, the side effect is small, the administration volume is small, the administration is convenient, and the compliance of patients is increased.
In order to achieve the above object, the present invention provides the following technical solutions:
The invention provides a pharmaceutical composition for treating rheumatism bone diseases, which comprises the following components: 100-300 parts of black ants, 290-600 parts of genistein, 12-60 parts of deer-horn glue, 12-60 parts of tortoise-shell glue, 30-100 parts of radix clematidis, 30-60 parts of rhizoma drynariae, 30-60 parts of epimedium, 30-100 parts of rhizoma cibotii, 30-100 parts of herba taxilli, 12-60 parts of white paeony root, 9-30 parts of ginseng, 9-30 parts of fried radish seed, 9-60 parts of radix achyranthis bidentatae, 6-18 parts of scorpion, 12-60 parts of rhizoma corydalis, 12-60 parts of radix salviae miltiorrhizae, 6-12 parts of fructus amomi, 6-18 parts of cortex phellodendri, 6-18 parts of honey-fried licorice root, 12-60 parts of caltrop, 9-30 parts of phoenix-seed, 9-30 parts of rhizoma zedoariae, 9-30 parts of pseudo-ginseng powder and 30-60 parts of prepared polygonum multiflorum and 3-10 parts of notopterygium root.
The invention also provides a preparation method of the pharmaceutical composition according to the scheme, which comprises the following steps:
Mixing Scorpio, colla Cornus Cervi, colla Plastri Testudinis, radix Clematidis, rhizoma Drynariae, herba Epimedii, rhizoma Cibotii, herba Taxilli, radix Paeoniae alba, ginseng radix, parched Raphani semen, achyranthis radix, rhizoma corydalis, saviae Miltiorrhizae radix, fructus Amomi, cortex Phellodendri wine, radix Glycyrrhizae Preparata, fructus Tribuli, membrana Follicularis ovi, curcumae rhizoma, notoginseng radix, radix Polygoni Multiflori Preparata, notopterygii rhizoma and Formica Fusca, and grinding into powder to obtain medicinal powder;
Decocting radix Caraganae Sinicae, and concentrating the decoction to obtain fluid extract;
Mixing the medicinal powder with the fluid extract, making into pill, and drying to obtain the pharmaceutical composition.
Preferably, the grinding into powder further comprises sieving the powder through an 80-mesh sieve.
Preferably, the decocting comprises decocting with 1500mL of water.
Preferably, the mass ratio of the medicinal powder to the fluid extract is 1: (0.35-0.5).
The invention also provides application of the pharmaceutical composition in preparation of a medicament for treating the rheumatic bone diseases.
The invention also provides a pharmaceutical composition for treating the rheumatoid bone diseases, which comprises the following pharmaceutical composition in parts by weight A) or B) and the pharmaceutical composition in the scheme;
a) : 30 parts of radix angelicae pubescentis, 60 parts of wine phellodendron, 15 parts of white mustard seed, 15 parts of arisaema cum bile and 9 parts of asarum;
b) : 10 parts of frankincense, 10 parts of myrrh, 30 parts of vinegar trogopterus dung, 10 parts of radix aconiti kusnezoffii preparata, 15 parts of arisaema cum bile and 15 parts of mint.
Preferably, the preparation method of the pharmaceutical composition of the A) comprises the following steps:
Mixing semen Sinapis Albae and cortex Phellodendri with radix Angelicae Pubescentis, rhizoma arisaematis cum bile and herba asari, and grinding into powder to obtain medicinal powder;
Mixing the powder with water at a ratio of 1: mixing the components according to the mass ratio of (0.35-0.5), making pills and drying to obtain the pharmaceutical composition of the A).
Preferably, the preparation method of the pharmaceutical composition of the B) comprises the following steps:
Mixing vinegar Oletum Trogopterori with Olibanum, myrrha, arisaema cum bile, and radix Aconiti Kusnezoffii Preparata, and grinding to obtain powder;
mixing the medicinal powder with ginger juice according to a ratio of 1: mixing the components according to the mass ratio of (0.35-0.5), pelleting and drying to obtain the pharmaceutical composition of the B).
The beneficial effects are that:
The invention provides a pharmaceutical composition for treating rheumatism bone diseases, which comprises the following components in parts by mass: 100-300 parts of black ants, 290-600 parts of genistein, 12-60 parts of deer-horn glue, 12-60 parts of tortoise-shell glue, 30-100 parts of radix clematidis, 30-60 parts of rhizoma drynariae, 30-60 parts of epimedium, 30-100 parts of rhizoma cibotii, 30-100 parts of herba taxilli, 12-60 parts of white paeony root, 9-30 parts of ginseng, 9-30 parts of fried radish seed, 9-60 parts of radix achyranthis bidentatae, 6-18 parts of scorpion, 12-60 parts of rhizoma corydalis, 12-60 parts of radix salviae miltiorrhizae, 6-12 parts of fructus amomi, 6-18 parts of cortex phellodendri, 6-18 parts of honey-fried licorice root, 12-60 parts of caltrop, 9-30 parts of phoenix-30 parts of zedoary, 9-30 parts of pseudo-ginseng powder and 30-60 parts of prepared fleece-flower root, and 3-10 parts of notopterygium root;
Spleen and stomach are the middle axis of five zang organs, and middle energizer ensures that five zang organs are calm and meridians are smooth, qi and blood are harmonized, and all diseases are not generated. Spleen governs transportation and transformation, spleen strengthening can not promote the generation of damp evils; kidneys are congenital origin, nourish primordial yin and yang, and promote bone marrow production; liver governs tendons, has homology to liver and kidney, has normal liver and kidney functions, and has essence and blood in liver and kidney; the governor vessel runs on the center of the back of the human body, the governor vessel runs on the center of the abdomen of the human body, the governor vessel is the sea of yin vessel, directorate-General the governor vessel is the yin qi of the human body, the governor vessel is the yin and yang, yin and yang are regulated, the bone marrow and tendons are nourished, the bones and tendons are soft, the joints are soft and powerful, so the governor vessel is the key for treating rheumatism bone arthralgia. The traditional Chinese medicine composition for treating the rheumatic bone diseases (rheumatism, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and the like) is based on the theory of regulating the spleen and the conception and governor as a formula principle, so as to regulate the five viscera and the yin and yang of the conception and governor, smooth the channels and collaterals, regulate the ascending and descending of qi movement, restore the qi and blood yin and yang balance of the viscera of a human body, and can heal stubborn arthralgia. So the formula adopts the genius caryophyllus to invigorate the spleen and replenish qi, consolidate the middle energizer, the black ants to invigorate the liver and kidney, dispel wind and remove dampness, and relieve arthralgia and dredge collaterals, wherein two medicines are used for defending the middle warmer and harmonizing the middle warmer, and the two medicines are used as monarch medicines in the formula in the first time, and the first time and the second time are taken as principal medicines in the formula; the genistein has a certain immunosuppression effect, can regulate calcium and phosphorus metabolism, and the black ants have a certain immunobidirectional regulation effect; in addition, the deer horn gelatin and the tortoise shell gelatin tonify liver and kidney, fill essence and promote marrow, and the tortoise-deer two gelatin are gel blocks respectively prepared by decocting the deer horn and the tortoise shell in a concentrated manner, wherein the deer is obtained, the world has the most yang qi and has the life, and the deer has good effect of dredging governor vessel; the turtle can get the most of yin qi to be calm and live, and has good effect of dredging channels, and the two medicines can be combined to regulate the proportion of the two medicines so as to regulate conception vessel and governor vessel and regulate yin and yang, so as to regulate lifting and opening and closing; radix Clematidis can dispel wind and remove dampness, dredge collaterals, coordinate internal and external with tortoise deer to harmonize yin and yang, dredge channels and collaterals, and is also a monarch drug in the recipe; black ants and broom roots are taken as a pair of medicines; the deer horn gum, tortoise-shell gum and clematis root are taken as one corner medicine; the two groups of herbs show compatibility of yin and yang, ascending and descending, dynamic and static, and opening and closing. Optionally radix Polygoni Multiflori Preparata, herba Epimedii, rhizoma Drynariae, herba Taxilli, radix Paeoniae alba, rhizoma Cibotii, and Achyranthis radix for invigorating liver and kidney, nourishing marrow, strengthening bone, nourishing blood and tendons; ginseng and fructus amomi are used for supplementing qi and replenishing primordial qi, regulating qi and harmonizing middle-jiao; rhizoma corydalis, radix salviae miltiorrhizae and radix notoginseng have the effects of promoting blood circulation to remove blood stasis, and activating meridians to stop pain as ministerial drugs; wind-dispelling and collateral-dredging effects of Scorpio; zedoary and membrana Follicularis ovi can promote blood circulation and supplement bones, and can protect stomach and middle warmer; caltrop soothing liver and calming wind; wine Huang Baiqing heat and strengthen yin; radish seed, semen raphani, is an adjuvant drug in the recipe for resolving food stagnation and resolving phlegm; notopterygii rhizoma for dispelling pathogenic wind and removing dampness, and radix Glycyrrhizae Preparata for harmonizing the above materials; the above medicines can be combined to achieve the effects of regulating spleen, regulating conception vessel and governor vessel, strengthening tendons and bones, and regulating immunity.
In addition, the pharmaceutical composition for treating the rheumatic bone diseases can harmonize spleen, regulate conception and governor vessels, balance yin and yang, strengthen tendons and bones, can perform immunoregulation, improve joint functions, block disease progression, has small side effect and increases patient compliance.
In addition, the invention also provides a preparation method of the pharmaceutical composition for treating the rheumatic bone diseases, which has simple process and low cost.
The invention also provides a pharmaceutical composition for treating the rheumatic bone diseases, which comprises the pharmaceutical composition and other two pharmaceutical formulations, and can treat the rheumatic bone diseases with damp-heat symptoms or cold-damp blockage symptoms.
Detailed Description
The invention provides a pharmaceutical composition for treating rheumatic bone diseases, which comprises the following components in parts by mass: 100-300 parts of black ants, 290-600 parts of genistein, 12-60 parts of deer-horn glue, 12-60 parts of tortoise-shell glue, 30-100 parts of radix clematidis, 30-60 parts of rhizoma drynariae, 30-60 parts of epimedium, 30-100 parts of rhizoma cibotii, 30-100 parts of herba taxilli, 12-60 parts of white paeony root, 9-30 parts of ginseng, 9-30 parts of fried radish seed, 9-60 parts of radix achyranthis bidentatae, 6-18 parts of scorpion, 12-60 parts of rhizoma corydalis, 12-60 parts of radix salviae miltiorrhizae, 6-12 parts of fructus amomi, 6-18 parts of cortex phellodendri, 6-18 parts of honey-fried licorice root, 12-60 parts of caltrop, 9-30 parts of phoenix-30 parts of zedoary, 9-30 parts of pseudo-ginseng powder and 30-60 parts of prepared fleece-flower root, and 3-10 parts of notopterygium root.
The pharmaceutical composition provided by the invention comprises 100-300 parts by mass of black ants, preferably 100-150 parts by mass, and more preferably 150 parts by mass.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 290-600 parts of genius peacock roots, more preferably 350-600 parts, and even more preferably 600 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 12-60 parts of deer-horn glue, preferably 36-60 parts of the lower middle warmer of yang deficiency syndrome, more preferably 60 parts of the lower middle warmer of yang deficiency syndrome, preferably 12-36 parts of yin deficiency syndrome, more preferably 30 parts of the lower middle warmer of yang deficiency syndrome, preferably 36 parts of the lower middle warmer of yang deficiency syndrome, and the lower middle warmer of yang deficiency syndrome.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 12-60 parts of tortoise-shell glue, preferably 12-60 parts of excessive middle warmer in yin deficiency syndrome, more preferably 36-60 parts, more preferably 60 parts, preferably 12-60 parts of yang deficiency syndrome, more preferably 30-60 parts, more preferably 30 parts, the symptom of cold and heat is not apparent, or the symptom of damp-heat obstruction is concurrently present, or the symptom of cold-damp obstruction is concurrently preferably 36 parts, and the symptoms and the period of conception and supervision are regulated, and yin and yang are regulated.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 30-100 parts of radix clematidis, more preferably 40-50 parts, and still more preferably 45 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 30-60 parts of drynaria, preferably 30-36 parts, and more preferably 36 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 30-60 parts of epimedium herb, preferably 30-55 parts of epimedium herb, more preferably 45 parts of yang deficiency and cold syndrome, preferably 30 parts of yin deficiency and heat syndrome, the condition of cold and heat is not apparent, the condition of damp-heat obstruction is also treated, or the condition of cold-damp obstruction is also treated, preferably 36 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 30-100 parts of rhizoma cibotii, preferably 30-75 parts of rhizoma cibotii, more preferably 60 parts of yang deficiency and cold arthralgia, and preferably 55 parts of yin deficiency and heat arthralgia, wherein the symptoms of cold and heat are not obvious, or the symptoms of damp-heat arthralgia are combined, or the symptoms of cold-damp arthralgia are combined, and the symptoms of cold-damp arthralgia are preferably 45 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 30-100 parts of mistletoe, preferably 45-55 parts, and more preferably 45 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 12-60 parts of white paeony root, preferably 36-45 parts, and more preferably 36 parts.
The pharmaceutical composition provided by the invention comprises 9-30 parts of ginseng, preferably 12-25 parts, more preferably 16-24 parts, and even more preferably 18 parts by mass of black ants.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 9-30 parts of stir-fried radish seeds, preferably 10-30 parts, more preferably 20-28 parts, and even more preferably 24 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 9-60 parts of radix achyranthis bidentatae, preferably 15-55 parts, more preferably 20-36 parts, and even more preferably 36 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 6-18 parts of scorpion, preferably 6-12 parts, more preferably 9-11 parts, and even more preferably 9 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 12-60 parts of rhizoma corydalis, preferably 20-55 parts, more preferably 30-40 parts, and even more preferably 36 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 12-60 parts of red sage root, preferably 15-55 parts, more preferably 25-40 parts, and even more preferably 36 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 6-12 parts of fructus amomi, preferably 6-11 parts of fructus amomi, more preferably 9-10 parts of fructus amomi, and even more preferably 10 parts of fructus amomi.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 6-18 parts of golden cypress wine, preferably 12-18 parts, more preferably 15-18 parts, more preferably 18 parts, preferably 6 parts of yang deficiency and cold syndrome, and preferably 9 parts of cold and heat syndrome, or damp-heat blockage or cold and damp blockage.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 6-18 parts of honey-fried licorice root, preferably 15-18 parts, more preferably 9-12 parts, and even more preferably 9 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 12-60 parts of caltrops, preferably 45-55 parts of caltrops, more preferably 36-45 parts of caltrops, and even more preferably 36 parts of caltrops.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 9-30 parts of membrana Follicularis ovi, preferably 10-25 parts, more preferably 15-25 parts, and even more preferably 18 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 9-30 parts of curcuma zedoary, preferably 10-25 parts of curcuma zedoary, more preferably 15-25 parts of curcuma zedoary, and even more preferably 18 parts of curcuma zedoary.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 9-30 parts of pseudo-ginseng powder, preferably 15-25 parts, and more preferably 18 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 30-60 parts of prepared fleece-flower root, preferably 36-55 parts, and more preferably 36 parts.
Based on the mass parts of the black ants, the pharmaceutical composition provided by the invention comprises 3-10 parts of notopterygium root, preferably 5-9 parts, more preferably 6-9 parts, and even more preferably 9 parts.
In the invention, the black ants have the effects of tonifying liver and kidney, dispelling wind and removing dampness, eliminating arthralgia and dredging collaterals, the broom root has the effects of strengthening spleen and tonifying qi and strengthening middle energizer, and the black ants and the peacock root are in the middle warmer and in the middle warmer; the deer horn gelatin and the tortoise shell gelatin are gel blocks formed by respectively decocting deer horn and tortoise shell in a concentrated manner, wherein deer is the most abundant and longevity of the yang qi, the governor vessel is good at, tortoise is the most abundant and longevity of the yin qi, the conception vessel is good at, the conception vessel and yin are good at through the mutual adjustment of the two medicines, and the proportion of the two medicines can be adjusted, so that the rising, falling, opening and closing of the deer horn gelatin block can be adjusted, and the deer horn gelatin block has the effects of tonifying liver and kidney and replenishing essence and producing marrow; the radix Clematidis can pass twelve channels, has the effects of dispelling wind and removing dampness, eliminating arthralgia and dredging collaterals, and can be matched with the two-glue of tortoise-deer to harmonize yin and yang and dredge channels and collaterals; the medicines are used as monarch medicines in the medicine composition.
In the invention, the prepared fleece-flower root, epimedium herb, drynaria rhizome, mistletoe, white paeony root, rhizoma cibotii and achyranthes root have the effects of tonifying liver and kidney, nourishing marrow, strengthening bones, nourishing blood and reinforcing tendons; the ginseng and fructus amomi have the effects of tonifying qi, supplementing primordial qi, regulating qi and regulating the middle warmer; the vinegar rhizoma corydalis, the red sage root and the pseudo-ginseng are compatible and have the effects of activating blood circulation to dissipate blood stasis, dredging collaterals and relieving pain; the medicines are used as ministerial medicines in the pharmaceutical composition.
In the invention, the scorpion has the effects of dispelling wind and dredging collaterals; the Curcumae rhizoma and membrana Follicularis ovi have effects of promoting blood circulation, invigorating bone, protecting stomach and protecting middle warmer; the caltrop has the effects of soothing liver and calming wind; the cortex Phellodendri wine has effects of clearing heat and strengthening yin; the radish seed has the effects of promoting digestion and resolving phlegm; the above medicines are used together as adjuvants in pharmaceutical compositions.
In the invention, notopterygium root dissipates wind and removes dampness, and opens the way of resuscitation, and honey-fried licorice root has the function of harmonizing the medicinal materials, and is used as a medicament in the pharmaceutical composition.
The components of the pharmaceutical composition provided by the invention are compatible with monarch, minister, assistant and guide principles, have the effects of regulating spleen and stomach, regulating conception and governor vessels, strengthening bones and muscles and regulating immunity, and embody the principle of combining the traditional Chinese medicine theory with the modern Chinese medicine pharmacology.
The invention also provides a preparation method of the pharmaceutical composition according to the scheme, which comprises the following steps:
Mixing Scorpio, colla Cornus Cervi, colla Plastri Testudinis, radix Clematidis, rhizoma Drynariae, herba Epimedii, rhizoma Cibotii, herba Taxilli, radix Paeoniae alba, ginseng radix, parched Raphani semen, achyranthis radix, vinegar rhizoma corydalis, saviae Miltiorrhizae radix, fructus Amomi, cortex Phellodendri, radix Glycyrrhizae Preparata, fructus Tribuli, membrana Follicularis ovi, curcumae rhizoma, notoginseng radix, radix Polygoni Multiflori Preparata, notopterygii rhizoma and Formica Fusca, and grinding into powder to obtain medicinal powder;
Decocting radix Caraganae Sinicae, and concentrating the decoction to obtain fluid extract;
Mixing the medicinal powder with the fluid extract, making into pill, and drying to obtain the pharmaceutical composition.
The invention mixes scorpion, deer horn glue, tortoise-shell glue, radix clematidis, rhizoma drynariae, epimedium, rhizoma cibotii, mistletoe, white paeony root, ginseng, stir-fried radish seed, radix achyranthis bidentatae, vinegar rhizoma corydalis, radix salviae miltiorrhizae, fructus amomi, wine cortex phellodendri, honey-fried licorice root, caltrop, membrana Follicularis ovi, rhizoma curcumae, pseudo-ginseng, prepared polygonum multiflorum, notopterygium root and black ant, and grinds the mixture into powder to obtain medicinal powder. The black ants according to the present invention are preferably dried black ants, and the drying temperature is preferably 80 to 95 ℃, and more preferably 80 ℃. The method of the present invention is not particularly limited, and a conventional method in the art may be used. After the powder is ground into powder, the powder is preferably sieved by a sieve with 80 meshes, namely the particle size of the powder is preferably less than or equal to 80 meshes, and the 80-mesh powder has the effect of enhancing gastrointestinal tract absorption.
Meanwhile, the invention decocts the sparrow root to obtain the liquid medicine. The invention preferably carries out two times of decoction, each time of decoction is preferably added with 1500mL of water for decoction, and decoction obtained by the two times of decoction is combined to obtain liquid medicine.
After the liquid medicine is obtained, the liquid medicine is concentrated to obtain the clear paste.
After the medicinal powder and the clear paste are obtained, the medicinal powder and the clear paste are preferably mixed, pelleted and dried to obtain the medicinal composition. The medicine powder and the clear paste are preferably prepared by the following steps of 1: (0.35 to 0.5), and more preferably 1:0.4 by mass. The pill preparation method is preferably a pan-prepared pill preparation method. The drying temperature of the present invention is preferably 80℃to100℃and more preferably 95 ℃. The drying apparatus is not particularly limited in the present invention, and conventional drying apparatuses in the art may be used.
The preparation method of the pharmaceutical composition provided by the invention has the advantages of simple process, low cost and mass production, and the prepared pharmaceutical composition can harmonize the spleen, regulate the conception and governor, balance yin and yang, strengthen tendons and bones, not only can perform immunoregulation, but also can improve joint functions, block disease progress and have small side effects.
Based on the advantages, the invention also provides application of the pharmaceutical composition in preparation of the medicine for treating the rheumatoid bone diseases.
The invention also provides a pharmaceutical composition for treating the rheumatoid bone diseases, which comprises the following pharmaceutical composition in parts by weight A) or B) and the pharmaceutical composition in the scheme;
a) : 30 parts of radix angelicae pubescentis, 60 parts of wine phellodendron, 15 parts of white mustard seed, 15 parts of arisaema cum bile and 9 parts of asarum;
b) : 10 parts of frankincense, 10 parts of myrrh, 30 parts of vinegar trogopterus dung, 10 parts of radix aconiti kusnezoffii preparata, 15 parts of arisaema cum bile and 15 parts of mint.
The medicine composition A) disclosed by the invention is prepared by compatibility of radix angelicae pubescentis, cortex phellodendri with wine, semen brassicae, arisaema cum bile and asarum, and can be used for treating rheumatism bone diseases with damp-heat symptoms.
The preparation method of the pharmaceutical composition A) preferably comprises the following steps:
Mixing semen Sinapis Albae and cortex Phellodendri with radix Angelicae Pubescentis, rhizoma arisaematis cum bile and herba asari, and grinding into powder to obtain medicinal powder;
Mixing the powder with water at a ratio of 1: mixing the components according to the mass ratio of (0.35-0.5), making pills and drying to obtain the pharmaceutical composition of the A).
The invention preferably mixes white mustard seed, phellodendron bark, pubescent angelica root, arisaema cum bile and asarum herb, and grinds the mixture into powder to obtain medicinal powder. In the invention, the white mustard seeds are preferably stir-fried by adopting the ginger juice and the bamboo juice, and the stir-fried mixture has the advantages of enhancing the phlegm-resolving effect and protecting the stomach and regulating the middle warmer; the ratio of the mass of the white mustard seeds, the volume of the ginger juice and the volume of the bamboo juice is preferably (10-15) g: (0.4-0.5) mL: (0.4 to 0.5) mL, more preferably 10g:0.5mL:0.5mL. In the invention, the preparation method of the wine phellodendron preferably comprises stir-frying the phellodendron by adopting yellow wine, and the stir-frying has the advantages of alleviating the bitter property of the phellodendron, and improving the functions of clearing heat and resolving dampness by pungent and bitter properties; the ratio of the mass of the phellodendron to the volume of the yellow wine is preferably (10-15) g: (0.8 to 1) mL, more preferably 10g:1mL. The method of the present invention is not particularly limited, and a conventional method in the art may be used. After grinding into powder, the method also preferably comprises the step of sieving the powder through an 80-mesh sieve.
After the powder is obtained, the present invention preferably comprises mixing the powder with water in an amount of 1: mixing, pelleting and drying the mixture according to the mass ratio of (0.35-0.5) to obtain the pharmaceutical composition of the A). The invention preferably comprises the steps of mixing the powder with water according to a ratio of 1: (0.35 to 0.5), more preferably 1:0.4 mass ratio. The pill is preferably prepared by a pan method, and the pill is preferably prepared into mung bean size. The drying temperature of the present invention is preferably 80℃to 100℃and more preferably 95 ℃. The drying apparatus is not particularly limited in the present invention, and conventional drying apparatuses in the art may be used.
The pharmaceutical composition B) disclosed by the invention is prepared from frankincense, myrrh, vinegar trogopterus dung, prepared kusnezoff monkshood root, arisaema cum bile and peppermint, and can be used for treating the rheumatism bone diseases with cold-dampness obstruction symptoms.
The preparation method of the pharmaceutical composition B) preferably comprises the following steps:
Mixing vinegar Oletum Trogopterori with Olibanum, myrrha, arisaema cum bile, and radix Aconiti Kusnezoffii Preparata, and grinding to obtain powder;
Mixing the medicinal powder with ginger juice according to a ratio of 1: mixing (0.35-0.5) by mass ratio, pelleting, and drying to obtain the composition of the B).
The invention preferably mixes the vinegar trogopterus dung with the frankincense, the myrrh, the arisaema cum bile and the prepared kusnezoff monkshood root, and grinds the mixture into powder to obtain medicinal powder. In the invention, the preparation method of the vinegar trogopterus dung preferably comprises the step of stir-frying the trogopterus dung by adopting red vinegar, wherein the ratio of the mass of the trogopterus dung to the volume of the red vinegar is preferably (10-15) g: (1 to 1.5) mL, more preferably 10g:1mL. The method of the present invention is not particularly limited, and a conventional method in the art may be used. After grinding into powder, the method also preferably comprises the step of sieving the powder through an 80-mesh sieve.
After the medicinal powder is obtained, the medicinal powder and ginger juice are preferably mixed according to the invention in a ratio of 1: mixing the components according to the mass ratio of (0.35-0.5), pelleting and drying to obtain the pharmaceutical composition of the B). The invention preferably comprises the following steps of mixing medicinal powder and ginger juice in a ratio of 1: (0.35-0.5), more preferably in a mass ratio of 1:0.4 by mass. The pill is preferably prepared by a pan method, and the pill is preferably prepared into mung bean size. The drying temperature of the present invention is preferably 80℃to 100℃and more preferably 95 ℃.
The pharmaceutical composition provided by the invention can be used for treating the rheumatism bone arthralgia according to the differentiation of the cold, heat, deficiency and excess and the pharmaceutical compositions A) to B) according to the scheme, so as to achieve the effect of relieving the symptoms of damp-heat and cold-damp obstruction.
The medicinal materials related to the invention are all conventional products sold in the field, if not particularly limited.
For further explanation of the present invention, the following examples describe the pharmaceutical compositions for treating rheumatoid bone diseases provided in the present invention in detail, but they should not be construed as limiting the scope of the present invention.
Example 1
A pharmaceutical composition for treating rheumatism bone diseases, with the following formula, comprises the following components:
150g of black ants, 600g of broom cypress roots, 60g of deer-horn glue, 30g of tortoise-shell glue, 45g of radix clematidis, 36g of rhizoma drynariae, 45g of epimedium, 60g of rhizoma cibotii, 45g of herba taxilli, 36g of white paeony roots, 18g of ginseng, 24g of stir-fried radish seeds, 36g of radix achyranthis bidentatae, 9g of scorpion, 36g of rhizoma corydalis, 36g of radix salviae miltiorrhizae, 10g of fructus amomi, 6g of cortex phellodendri, 9g of honey-fried licorice roots, 36g of caltrop fruits, 18g of membrana Folli phoenix, 18g of rhizoma curcumae, 18g of pseudo-ginseng powder, 36g of prepared polygonum multiflorum and 9g of notopterygium roots.
The preparation method of the pharmaceutical composition comprises the following steps:
1) Drying Formica fusca at 80deg.C;
2) Mixing dried black ants in the step 1) with scorpion, deer-horn glue, tortoise-shell glue, radix clematidis, rhizoma drynariae, epimedium, rhizoma cibotii, mistletoe, white peony root, ginseng, fried radish seed, achyranthes root, rhizoma corydalis, radix salviae miltiorrhizae, fructus amomi, wine corktree bark, roasted liquorice, caltrop, membrana Follicularis, rhizoma curcumae, pseudo-ginseng, prepared polygonum multiflorum and notopterygium root, grinding into powder, and sieving with a 80-mesh sieve to obtain medicinal powder;
3) Decocting radix Caraganae Sinicae with water twice, each time with 1500mL water, mixing the decoctions, and concentrating to obtain ointment;
4) Mixing the powder obtained in the step 2) and the fluid extract obtained in the step 3) with 1: mixing at a mass ratio of 0.4, and making into mung bean pill by pan method;
5) And (3) putting the pill obtained in the step (4) into an oven, and drying at 95 ℃ for later use.
Example 2
A pharmaceutical composition for treating rheumatism bone diseases, yin deficiency and internal heat due to deficiency of liver and kidney, excessive movement of middle energizer, comprises the following formula:
150g of black ants, 600g of broom cypress roots, 30g of deer-horn glue, 60g of tortoise-shell glue, 45g of radix clematidis, 36g of drynaria rhizome, 30g of epimedium, 55g of rhizoma cibotii, 45g of Chinese taxillus twig, 36g of white paeony roots, 18g of ginseng, 24g of stir-fried radish seeds, 36g of achyranthes roots, 9g of scorpions, 36g of vinegar-processed rhizoma corydalis, 36g of root of red-rooted salvia, 10g of villous amomum fruits, 18g of golden cypress, 9g of honey-fried liquorice, 36g of caltrop fruits, 18g of phoenix-tail membranes, 18g of curcuma zedoary, 18g of pseudo-ginseng powder, 36g of prepared fleece-flower roots and 9g of notopterygium roots
The preparation method of the pharmaceutical composition comprises the following steps:
1) Drying Formica fusca at 80deg.C;
2) Mixing dried black ants in the step 1) with scorpion, deer-horn glue, tortoise-shell glue, radix clematidis, rhizoma drynariae, epimedium, rhizoma cibotii, mistletoe, white peony root, ginseng, fried radish seed, achyranthes root, rhizoma corydalis, radix salviae miltiorrhizae, fructus amomi, wine corktree bark, roasted liquorice, caltrop, membrana Follicularis, rhizoma curcumae, pseudo-ginseng, prepared polygonum multiflorum and notopterygium root, grinding into powder, and sieving with a 80-mesh sieve to obtain medicinal powder;
3) Decocting radix Caraganae Sinicae with water twice, each time with 1500mL water, mixing the decoctions, and concentrating to obtain ointment;
4) Mixing the powder obtained in the step 2) and the fluid extract obtained in the step 3) with 1: mixing at a mass ratio of 0.4, and making into mung bean pill by pan method;
5) And (3) putting the pill obtained in the step (4) into an oven, and drying at 95 ℃ for later use.
Example 3
A pharmaceutical composition for treating rheumatism bone diseases, with symptoms of deficiency of liver and kidney and no obvious cold and heat, comprises the following formula:
150g of black ants, 600g of broom cypress roots, 36g of deer-horn glue, 36g of tortoise-shell glue, 45g of radix clematidis, 36g of rhizoma drynariae, 36g of epimedium, 45g of rhizoma cibotii, 45g of Chinese taxillus twig, 36g of white paeony roots, 18g of ginseng, 24g of stir-fried radish seeds, 36g of radix achyranthis bidentatae, 9g of scorpion, 36g of rhizoma corydalis, 36g of radix salviae miltiorrhizae, 10g of fructus amomi, 9g of cortex phellodendri, 9g of honey-fried licorice roots, 36g of caltrop fruits, 18g of phoenix-tail membranes, 18g of rhizoma curcumae, 18g of pseudo-ginseng powder, 36g of prepared polygonum multiflorum and 9g of notopterygium roots.
The preparation method of the pharmaceutical composition comprises the following steps:
1) Drying Formica fusca at 80deg.C;
2) Mixing dried black ants in the step 1) with scorpion, deer-horn glue, tortoise-shell glue, radix clematidis, rhizoma drynariae, epimedium, rhizoma cibotii, mistletoe, white peony root, ginseng, fried radish seed, achyranthes root, rhizoma corydalis, radix salviae miltiorrhizae, fructus amomi, wine corktree bark, roasted liquorice, caltrop, membrana Follicularis, rhizoma curcumae, pseudo-ginseng, prepared polygonum multiflorum and notopterygium root, grinding into powder, and sieving with a 80-mesh sieve to obtain medicinal powder;
3) Decocting radix Caraganae Sinicae with water twice, each time with 1500mL water, mixing the decoctions, and concentrating to obtain ointment;
4) Mixing the powder obtained in the step 2) and the fluid extract obtained in the step 3) with 1: mixing at a mass ratio of 0.4, and making into mung bean pill by pan method;
5) And (3) putting the pill obtained in the step (4) into an oven, and drying at 95 ℃ for later use.
Example 4
A pharmaceutical composition for treating rheumatism bone diseases with syndrome of liver and kidney deficiency and syndrome of damp-heat comprises the following components:
A main formula: the pharmaceutical composition obtained in example 3
The auxiliary prescription comprises: a pharmaceutical composition comprises radix Angelicae Pubescentis 30g, cortex Phellodendri 60g, semen Sinapis Albae 15g, arisaema cum bile 15g, and herba asari 9 g.
The preparation method of the pharmaceutical composition of the auxiliary prescription in the pharmaceutical composition comprises the following steps:
1) Squeezing rhizoma Zingiberis recens to obtain rhizoma Zingiberis recens juice;
2) Baking fresh bamboo juice to obtain succus Bambusae;
3) Mixing the ginger juice obtained in the step 1) and the bamboo juice obtained in the step 2) in equal volume by 1:1 to obtain mixed juice;
4) Stirring the mixed juice obtained in the step 3) with stir-fried white mustard to obtain stir-fried white mustard, wherein the mass ratio of the white mustard to the mixed juice is 10g to 1mL;
5) Parching cortex Phellodendri with yellow wine to obtain parched cortex Phellodendri, wherein the volume ratio of cortex Phellodendri to yellow wine is 10 g:1 mL;
6) Mixing the stir-fried white mustard seeds obtained in the step 4) and the stir-fried amur corktree barks obtained in the step 5) with the radix angelicae pubescentis, the arisaema cum bile and the asarum, grinding into powder, and sieving with a 80-mesh sieve to obtain medicinal powder;
7) Mixing the powder obtained in the step 6) with clear water according to a proportion of 1: mixing at a mass ratio of 0.4, bonding to desired degree, and making into mung bean-sized pill by pan-process;
8) And (3) putting the pill obtained in the step 7) into an oven, and drying at 95 ℃ for later use.
Example 5
A pharmaceutical composition for treating rheumatism bone diseases with syndrome of liver and kidney deficiency and cold-dampness obstruction comprises the following components:
A main formula: the pharmaceutical composition obtained in example 3
The auxiliary prescription comprises: the medicine composition consists of 10g of frankincense, 10g of myrrh, 30g of trogopterus dung, 10g of radix aconiti kusnezoffii preparata, 15g of arisaema cum bile and 15g of peppermint.
The preparation method of the pharmaceutical composition of the auxiliary prescription in the pharmaceutical composition comprises the following steps:
1) Decocting rhizoma Zingiberis recens to obtain rhizoma Zingiberis recens juice;
2) Stir-frying trogopterus dung with red vinegar to obtain stir-fried trogopterus dung, wherein the volume ratio of the mass of the trogopterus dung to the red vinegar is 10g:1mL;
3) Mixing the fried trogopterus dung obtained in the step 2) with frankincense, myrrh, arisaema cum bile and prepared kusnezoff monkshood root, grinding into powder, and sieving with a 80-mesh sieve to obtain medicinal powder;
4) Mixing the medicinal powder obtained in the step 4) with the ginger juice obtained in the step 1) in a ratio of 1: mixing at a mass ratio of 0.4, bonding to desired degree, and making into mung bean-sized pill by pan-process;
5) And 5) putting the pill obtained in the step 5) into an oven, and drying at 95 ℃ for standby.
Comparative example 1
A pharmaceutical composition for treating rheumatism bone diseases comprises the following components:
liver and kidney deficiency with kidney qi deficiency cold, and disharmony of middle energizer, the formula is as follows:
60g of deer horn glue, 30g of tortoise-shell glue, 45g of radix clematidis, 36g of rhizoma drynariae, 45g of herba epimedii, 60g of rhizoma cibotii, 45g of herba taxilli, 36g of radix paeoniae alba, 18g of ginseng, 24g of stir-fried radish seed, 36g of radix achyranthis bidentatae, 9g of scorpion, 36g of vinegar-processed rhizoma corydalis, 36g of radix salviae miltiorrhizae, 10g of fructus amomi, 6g of cortex phellodendri, 9g of honey-fried licorice root, 36g of caltrop, 18g of membrana Folli, 18g of rhizoma curcumae, 18g of radix notoginseng powder, 36g of radix polygoni multiflori preparata and 9g of notopterygium root.
The preparation method of the pharmaceutical composition comprises the following steps:
1) Mixing Scorpio, colla cornus cervi, colla Plastri Testudinis, radix Clematidis, rhizoma Drynariae, herba Epimedii, rhizoma Cibotii, herba Taxilli, radix Paeoniae alba, radix Ginseng, parched semen Raphani, radix Achyranthis bidentatae, rhizoma corydalis, radix Salviae Miltiorrhizae, fructus Amomi, cortex Phellodendri preparata, radix Glycyrrhizae Preparata, fructus Tribuli, membrana Follicularis ovi, rhizoma Curcumae, radix Notoginseng, radix Polygoni Multiflori Preparata, and rhizoma Et radix Notopterygii, grinding into powder, and sieving with 80 mesh sieve to obtain medicinal powder;
2) Adding clear water into the medicinal powder obtained in the step 1) to obtain a mixture 1: mixing at a mass ratio of 0.4, and making into mung bean pill by pan method;
3) And (3) putting the pill obtained in the step (3) into an oven, and drying at 95 ℃ for standby.
Comparative example 2
A pharmaceutical composition for treating rheumatism bone diseases, yin deficiency and internal heat due to deficiency of liver and kidney, excessive movement of middle energizer, comprises the following formula:
30g of deer horn gelatin, 60g of tortoise-shell gelatin, 45g of radix clematidis, 36g of rhizoma drynariae, 30g of herba epimedii, 55g of rhizoma cibotii, 45g of herba taxilli, 36g of radix paeoniae alba, 18g of ginseng, 24g of fried radish seed, 36g of radix achyranthis bidentatae, 9g of scorpion, 36g of vinegar-processed rhizoma corydalis, 36g of radix salviae miltiorrhizae, 10g of fructus amomi, 18g of cortex phellodendri, 9g of radix glycyrrhizae preparata, 36g of caltrop, 18g of membrana Follicularis ovi, 18g of rhizoma curcumae, 18g of radix notoginseng powder, 36g of radix polygoni multiflori preparata and 9g of notopterygium root
The preparation method of the pharmaceutical composition comprises the following steps:
1) Mixing Scorpio, colla cornus cervi, colla Plastri Testudinis, radix Clematidis, rhizoma Drynariae, herba Epimedii, rhizoma Cibotii, herba Taxilli, radix Paeoniae alba, radix Ginseng, semen Raphani Preparata, radix Achyranthis bidentatae, rhizoma corydalis, radix Salviae Miltiorrhizae, fructus Amomi, cortex Phellodendri preparata, radix Glycyrrhizae Preparata, fructus Tribuli, membrana Follicularis ovi, rhizoma Curcumae, radix Notoginseng, radix Polygoni Multiflori Preparata, and rhizoma Et radix Notopterygii, grinding into powder, and sieving with 80 mesh sieve to obtain powder;
2) Adding clear water into the medicinal powder obtained in the step 1) to obtain a mixture 1: mixing at a mass ratio of 0.4, and making into mung bean pill by pan method;
3) And (3) putting the pill obtained in the step (4) into an oven, and drying at 95 ℃ for later use.
Comparative example 3
A pharmaceutical composition for treating rheumatism bone diseases, with symptoms of deficiency of liver and kidney and no obvious cold and heat, comprises the following formula:
36g of deer horn glue, 36g of tortoise-shell glue, 45g of radix clematidis, 36g of rhizoma drynariae, 36g of herba epimedii, 45g of rhizoma cibotii, 45g of herba taxilli, 36g of radix paeoniae alba, 18g of ginseng, 24g of fried radish seed, 36g of radix achyranthis bidentatae, 9g of scorpion, 36g of vinegar-processed rhizoma corydalis, 36g of radix salviae miltiorrhizae, 10g of fructus amomi, 9g of cortex phellodendri, 9g of honey-fried licorice root, 36g of caltrop, 18g of membrana Follicularis ovi, 18g of rhizoma curcumae, 18g of radix notoginseng powder, 36g of radix polygoni multiflori preparata and 9g of notopterygium root.
The preparation method of the pharmaceutical composition comprises the following steps:
1) Mixing Scorpio, colla cornus cervi, colla Plastri Testudinis, radix Clematidis, rhizoma Drynariae, herba Epimedii, rhizoma Cibotii, herba Taxilli, radix Paeoniae alba, radix Ginseng, parched semen Raphani, radix Achyranthis bidentatae, rhizoma corydalis, radix Salviae Miltiorrhizae, fructus Amomi, cortex Phellodendri preparata, radix Glycyrrhizae Preparata, fructus Tribuli, membrana Follicularis ovi, rhizoma Curcumae, radix Notoginseng, radix Polygoni Multiflori Preparata, and rhizoma Et radix Notopterygii, grinding into powder, and sieving with 80 mesh sieve to obtain medicinal powder;
2) Adding clear water into the powder obtained in the step 2) to obtain a powder with the weight ratio of 1: mixing at a mass ratio of 0.4, and making into mung bean pill by pan method;
3) And (3) putting the pill obtained in the step (4) into an oven, and drying at 95 ℃ for later use.
Comparative example 4
A pharmaceutical composition for treating rheumatism bone diseases with syndrome of liver and kidney deficiency and syndrome of damp-heat comprises the following components:
a main formula: the pharmaceutical composition obtained in comparative example 3 showed poor transport of middle energizer due to damp-heat obstruction.
The auxiliary prescription comprises: a pharmaceutical composition comprises radix Angelicae Pubescentis 30g, cortex Phellodendri 60g, semen Sinapis Albae 15g, arisaema cum bile 15g, and herba asari 9 g.
The preparation method of the pharmaceutical composition of the auxiliary prescription in the pharmaceutical composition comprises the following steps:
1) Squeezing rhizoma Zingiberis recens to obtain rhizoma Zingiberis recens juice;
2) Baking fresh bamboo juice to obtain succus Bambusae;
3) Mixing the ginger juice obtained in the step 1) with the bamboo juice obtained in the step 2) in equal volume to obtain a mixed juice, wherein the ratio of the ginger juice to the bamboo juice is 1:1;
4) Stirring the mixed juice obtained in the step 3) with stir-fried white mustard to obtain stir-fried white mustard, wherein the mass ratio of the white mustard to the mixed juice is 10g to 1mL;
5) Parching cortex Phellodendri with yellow wine to obtain parched cortex Phellodendri, wherein the volume ratio of cortex Phellodendri to yellow wine is 10 g:1 mL;
6) Mixing the stir-fried white mustard seeds obtained in the step 4) and the stir-fried amur corktree barks obtained in the step 5) with the radix angelicae pubescentis, the arisaema cum bile and the asarum, grinding into powder, and sieving with a 80-mesh sieve to obtain medicinal powder;
7) Mixing the powder obtained in the step 6) with clear water according to a proportion of 1: mixing at a mass ratio of 0.4, bonding to desired degree, and making into mung bean-sized pill by pan-process;
8) And (3) putting the pill obtained in the step 7) into an oven, and drying at 95 ℃ for later use.
Comparative example 5
A pharmaceutical composition for treating rheumatism bone diseases with syndrome of liver and kidney deficiency and cold-dampness obstruction comprises the following components:
A main formula: the pharmaceutical composition obtained in comparative example 3 was inferior in transport of middle energizer due to cold-dampness obstruction.
The auxiliary prescription comprises: the medicine composition consists of 10g of frankincense, 10g of myrrh, 30g of trogopterus dung, 10g of radix aconiti kusnezoffii preparata, 15g of arisaema cum bile and 15g of peppermint.
The preparation method of the pharmaceutical composition of the auxiliary prescription in the pharmaceutical composition comprises the following steps:
1) Decocting rhizoma Zingiberis recens to obtain rhizoma Zingiberis recens juice;
2) Parching Oletum Trogopterori with red vinegar to obtain parched Oletum Trogopterori, wherein the volume ratio of Oletum Trogopterori to red vinegar is 10g:1mL;
3) Mixing the fried trogopterus dung obtained in the step 2) with frankincense, myrrh, arisaema cum bile and prepared kusnezoff monkshood root, grinding into powder, and sieving with a 80-mesh sieve to obtain medicinal powder;
4) Mixing the medicinal powder obtained in the step 4) with the ginger juice obtained in the step 1) in a ratio of 1: mixing at a mass ratio of 0.4, bonding to desired degree, and making into mung bean-sized pill by pan-process;
6) And 5) putting the pill obtained in the step 5) into an oven, and drying at 95 ℃ for standby.
Application example 1
1) Sample acquisition
139 Cases of rheumatism bone disease patients in the doctor clinic of Xincai lunar bay hospital (Xincai orthopedics hospital) in the year 2020, month 06 to 2023 are selected.
The disease information about the rheumatic bone impediment patient is as follows:
diagnostic criteria (diagnostic criteria for rheumatoid arthritis of American society of rheumatology, 1987)
① The morning stiffness is not less than 1 hour and lasts for more than 6 weeks;
② 3 or more than 3 joint swelling lasting for not less than 6 weeks;
③ Swelling of wrist, metacarpophalangeal or proximal finger joint for at least 6 weeks;
④ The symmetrical joint swelling and pain is not less than 6 weeks;
⑤ X-ray performance.
⑥ Subcutaneous nodules;
⑦ Rheumatoid factor positive, titre >1:32.
And 4 or more than 4 of the above standards are met, and the rheumatoid bone disease patients can be diagnosed.
Exclusion criteria
① Severe heart, liver and kidney function abnormalities and hematopoietic function abnormalities; ② Severely deformed joints; ③ Severe gastrointestinal disorders; ④ Patients who have long used glucocorticoids; ⑤ Patients who are not treated according to the course of treatment, discontinue the treatment.
Chinese medicine differentiation and classification standard
Differentiation of types based on patient clinical symptoms and signs treatment groups: the main symptoms of liver and kidney deficiency type rheumatoid arthritis have the symptoms of dizziness and tinnitus, soreness and weakness of waist and knees, lassitude or amnesia, or impotence, premature ejaculation, spermatorrhea, or irregular menstruation of women, etc.; for patients with deficiency of liver and kidney and deficiency of yin, the patients have hectic fever, night sweat, dysphoria with feverish sensation in the heart, red and tender tongue and thready and rapid pulse; aversion to cold, clear and long urine, pale tongue with thin and white coating, and deep, slow and weak pulse due to deficiency of liver and kidney and yang deficiency; for patients with liver and kidney deficiency and damp-heat, patients have symptoms of fever, bitter taste, dry mouth, yellow and greasy tongue coating, slippery and rapid pulse, or soft and slippery pulse; for patients with liver and kidney deficiency and cold accumulation and cold dampness, the joints of the patients are spasm and pain, aversion to cold, clear urine, pale and purple tongue, thin and white coating, or watery and slippery pulse, or wiry pulse.
2) Sample grouping
Group A: 68 patients (28 men and 40 women) with deficiency of liver and kidney, 15 cases with deficiency of kidney-qi and cold, 8 cases with deficiency of liver-kidney, 8 cases with internal heat syndrome, 12 cases with damp-heat obstruction of liver and kidney, 21 cases with cold and heat pattern of liver and kidney deficiency, and the pharmaceutical compositions of comparative example 1, comparative example 2, comparative example 3, comparative example 4 and comparative example 5 were administered; the dosage of the main ingredients of the comparative examples 1,2 and 3 and the comparative examples 4 and 5 is 6 to 8 grams each time, 3 times a day, and the medicine is taken with warm boiled water. 1.5 to 3 grams of the auxiliary formulation of the compositions of comparative examples 4 and 5 are applied respectively; 1.5 to 3g of the Chinese medicinal composition is taken 3 times a day with warm boiled water.
Group B: 71 patients (23 men and 48 women) had deficiency of liver and kidney, 16 cases of deficiency of kidney-qi and cold, 10 cases of deficiency of liver and kidney and internal heat, 15 cases of damp-heat blockage due to deficiency of liver and kidney, 10 cases of cold-dampness blockage due to deficiency of liver and kidney, 20 cases of cold-heat deficiency of liver and kidney, and the pharmaceutical compositions of examples 1, 2,3, 4 and 5 were administered with the pharmaceutical compositions of examples 1, 2 and 3 and 4 and 5 in an amount of 6-8 g each time, 3 times daily with warm boiled water. 1.5 to 3g of the combined auxiliary materials in examples 4 and 5 respectively; 1.5 to 3g of the Chinese medicinal composition is taken 3 times a day with warm boiled water.
The administration of the group A and the group B for 3 months is a course of treatment
Meanwhile, all patients meeting the diagnosis standard of taking decoction at clinic and the Formica Fusca Juanbi pill group (containing B group) are respectively 111 cases and 90 cases, and the compliance of the two groups of patients is observed. Of these 90 patients, group B71 patients meeting diagnostic criteria and meeting exclusion criteria were contemplated.
3) Index observation
After one treatment course, the symptoms and signs were mainly observed. Overall pain intensity: the pain intensity is quantified by a visual simulation scoring method; the physical sign is as follows: the detection indexes and the effective rates of relevant laboratories such as the number of swelling and pain of joints, improvement of blood sedimentation (ESR), C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha) enzyme linked immunosorbent assay and the like.
Result criterion
The effect is shown: the improvement of clinical main symptoms, physical signs and laboratory indexes is more than or equal to 75 percent; the method is effective: the improvement of clinical main symptoms, physical signs and laboratory indexes is more than or equal to 30 percent and less than 75 percent; invalidation: improvement of clinical main symptoms, signs and laboratory indicators is <30%. Patients in the group 2 are ordered to check the liver and kidney functions and blood routine at regular intervals (1 month) so as to know the liver and kidney functions and blood routine of the patients.
The Excel 2010 software is adopted to carry out statistical analysis on the medicine effective rate, the sign index change before and after treatment and the laboratory index change of the patient in the group A and the patient in the group B, all metering data are subjected to t test, the counting data are subjected to χ 2 test, and the difference of P <0.05 is statistically significant. And decoction group compliance with group B. The results are shown in tables 1 to 4.
Table 1 compliance study comparison of decoction patients and Jin Yi bi-dan patients
| Group of | Taste factor (example number) | Adverse reactions (examples number) | Economic factor (example number) |
| Soup medicament group | 111(36) | 111(8) | 111(2) |
| Jin Yi Bi Dan group | 90(2) | 90(3) | 90(1) |
Note that: the number of patients interrupting the treatment is shown in parentheses for comparison.
Table 2A, comparison of Total effective rates of two groups of patients B
| Group of | Number of examples | Obvious effect (example,%) | Effective (example,%) | Invalidation (example,%) | Total effective rate (example,%) |
| Group A | 68 | 25(36.8％) | 21(30.9％) | 22(32.4％) | 46(67.6％) |
| Group B | 71 | 45(63.4％) | 23(32.4％) | 3(4.2％) | 68(95.8％) |
As can be seen from table 2, the total therapeutic efficacy of the patients (group B) administered the pharmaceutical composition of example 1 was 95.8% higher than the total therapeutic efficacy of the patients (group a) administered the pharmaceutical composition of comparative example 1 (67.6%).
Table 3A, B comparison of changes in sign indicators before and after treatment (examples)
Note that 1) P <0.05 compared to prior to treatment in this group; post-treatment group B compared to group A, 2) P <0.05
Table 4A, B comparison of laboratory index changes before and after treatment of two groups of patients (examples)
Note that 1) P <0.05 compared to prior to treatment in this group; group B after treatment compared to group A after treatment, 2) P <0.05
As can be seen from tables 3 and 4, the clinical symptoms, signs and laboratory test results were significantly improved after the treatment of the patients (group B) to which the pharmaceutical composition of example 1 was administered compared with those before the treatment, and the treatment group to which the pharmaceutical compositions of examples 1, 2, 3, 4 and 5 were administered had better improvement effect than those of the pharmaceutical compositions of comparative examples 1, 2, 3, 4 and 5.
The embodiment shows that the pharmaceutical composition for treating the rheumatism bone diseases can harmonize spleen, regulate conception vessel and governor vessel, balance yin and yang, strengthen tendons and bones, can regulate immunity, improve joint function, block disease progression, has small side effect and increases compliance compared with oral decoction patients.
Although the foregoing embodiments have been described in some, but not all, embodiments of the invention, it should be understood that other embodiments may be devised in accordance with this embodiment without the purpose of the invention, and those embodiments fall within the scope of the invention.
Claims (10)
1. The pharmaceutical composition for treating the rheumatic bone diseases is characterized by comprising the following components in parts by weight: 100-300 parts of black ants, 290-600 parts of genistein, 12-60 parts of deer-horn glue, 12-60 parts of tortoise-shell glue, 30-100 parts of radix clematidis, 30-60 parts of rhizoma drynariae, 30-60 parts of epimedium, 30-100 parts of rhizoma cibotii, 30-100 parts of herba taxilli, 12-60 parts of white paeony root, 9-30 parts of ginseng, 9-30 parts of fried radish seed, 9-60 parts of radix achyranthis bidentatae, 6-18 parts of scorpion, 12-60 parts of rhizoma corydalis, 12-60 parts of radix salviae miltiorrhizae, 6-12 parts of fructus amomi, 6-18 parts of cortex phellodendri, 6-18 parts of honey-fried licorice root, 12-60 parts of caltrop, 9-30 parts of phoenix-seed, 9-30 parts of rhizoma zedoariae, 9-30 parts of pseudo-ginseng powder, 30-60 parts of prepared polygonum multiflorum and 3-10 parts of notopterygium root.
2. A process for the preparation of a pharmaceutical composition according to claim 1, characterized in that it comprises the steps of:
Mixing Scorpio, colla Cornus Cervi, colla Plastri Testudinis, radix Clematidis, rhizoma Drynariae, herba Epimedii, rhizoma Cibotii, herba Taxilli, radix Paeoniae alba, ginseng radix, parched Raphani semen, achyranthis radix, vinegar rhizoma corydalis, saviae Miltiorrhizae radix, fructus Amomi, cortex Phellodendri, radix Glycyrrhizae Preparata, fructus Tribuli, membrana Follicularis ovi, curcumae rhizoma, notoginseng radix, radix Polygoni Multiflori Preparata, formica Fusca, and Notopterygii rhizoma, grinding into powder, and obtaining medicinal powder;
Decocting radix Caraganae Sinicae, and concentrating the decoction to obtain fluid extract;
Mixing the medicinal powder with the fluid extract, making into pill, and drying to obtain the pharmaceutical composition.
3. The method of claim 2, wherein grinding to powder further comprises sieving the powder through an 80 mesh sieve.
4. The method of claim 2, wherein the decocting comprises decocting with 1500mL of water.
5. The preparation method according to claim 2, wherein the mass ratio of the powder to the fluid extract is 1: (0.35-0.5).
6. The method according to claim 2, wherein the drying temperature is 80 ℃ to 100 ℃.
7. The use of a pharmaceutical composition according to claim 1 or a pharmaceutical composition according to any one of claims 2 to 6 in the manufacture of a medicament for the treatment of rheumatoid bone diseases.
8. A pharmaceutical composition for treating rheumatoid bone diseases, which is characterized by comprising the following pharmaceutical composition in parts by mass of A) or B), and the pharmaceutical composition of claim 1 or the pharmaceutical composition prepared by the preparation method of any one of claims 2 to 6;
a) : 30 parts of radix angelicae pubescentis, 60 parts of wine phellodendron, 15 parts of white mustard seed, 15 parts of arisaema cum bile and 9 parts of asarum;
b) : 10 parts of frankincense, 10 parts of myrrh, 30 parts of vinegar trogopterus dung, 10 parts of radix aconiti kusnezoffii preparata, 15 parts of arisaema cum bile and 15 parts of mint.
9. The pharmaceutical combination according to claim 8, wherein the method for preparing the pharmaceutical composition of a) comprises the steps of:
Mixing semen Sinapis Albae, cortex Phellodendri, radix Angelicae Pubescentis, rhizoma arisaematis cum bile and herba asari, and grinding into powder to obtain medicinal powder;
Mixing the powder with water at a ratio of 1: mixing the components according to the mass ratio of (0.35-0.5), making pills and drying to obtain the pharmaceutical composition of the A).
10. The pharmaceutical combination according to claim 8, wherein the process for preparing the pharmaceutical composition of B) comprises the steps of:
Mixing vinegar Oletum Trogopterori with Olibanum, myrrha, arisaema cum bile, and radix Aconiti Kusnezoffii Preparata, and grinding to obtain powder;
Mixing the medicinal powder with ginger juice according to a ratio of 1: mixing, pelleting and drying the mixture according to the mass ratio of (0.35-0.5) to obtain the pharmaceutical composition of the B).
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