CN107050333B - Granules for treating ankylosing spondylitis - Google Patents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a granule for treating ankylosing spondylitis, which comprises the following medicinal materials in parts by weight: 18 parts of parasitic loranthus, 9 parts of notopterygium root, 9 parts of radix angelicae pubescentis, 15 parts of tinospora sinensis, 30 parts of caulis spatholobi, 18 parts of fried eucommia ulmoides, 9 parts of radix achyranthis bidentatae, 12 parts of medlar and 30 parts of rice sprout. The invention mainly utilizes the rattan medicine to dispel wind-damp and dredge channels and collaterals, obviously reduces various indexes of ankylosing spondylitis, simultaneously tonifies liver and kidney, and harmonizes the spleen and stomach, thereby having obvious treatment effect on ankylosing spondylitis.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to granules for treating ankylosing spondylitis.
Background
Ankylosing Spondylitis (AS) is an autoimmune disease with inflammation of the sacroiliac joints and spinal attachment points AS the main symptoms, which can invade multiple systems of the whole body and cause pathological changes of various organs. However, no specific medicine for ankylosing spondylitis exists at present, the clinical medication difference is large, the side effect of western medicines is large, long-term medication is not suitable, the curative effect of the traditional Chinese medicines is different, conventional dialectical treatment is carried out, prescription and composition are more, the cost is high, and the curative effect is often enhanced by combining with western medicines; the worm drugs for treating obstinate arthralgia are difficult in drug source, high in price and large in toxic and side effects, and the drugs need to be standardized under the guidance of doctors, so that the worm drugs are not suitable for long-term administration and popularization.
Disclosure of Invention
The invention aims to provide granules for treating ankylosing spondylitis, which have the effects of dredging channels and collaterals, activating meridians and collaterals and treating the root, can obviously reduce various indexes of ankylosing spondylitis, and simultaneously tonify liver and kidney and harmonize spleen and stomach, thereby having a remarkable treatment effect on ankylosing spondylitis.
In order to achieve the purpose, the invention adopts the following technical scheme:
a granule for treating ankylosing spondylitis is prepared from the following medicinal materials in parts by weight: 18 parts of parasitic loranthus, 9 parts of notopterygium root, 9 parts of radix angelicae pubescentis, 15 parts of tinospora sinensis, 30 parts of caulis spatholobi, 18 parts of fried eucommia ulmoides, 9 parts of radix achyranthis bidentatae, 12 parts of medlar and 30 parts of rice sprout.
The preparation method of the granules comprises the following steps:
1) weighing herba Taxilli, Notopterygii rhizoma, radix Angelicae Pubescentis, caulis tinosporae, caulis Spatholobi, parched Eucommiae cortex, Achyranthis radix, fructus Lycii and fructus oryzae according to the proportion, crushing into powder, adding water 2-3 times the total weight of the medicinal materials, boiling with slow fire, heating for 15 min, cooling to room temperature, and filtering;
2) adding water into the dregs of a decoction, boiling the mixture with soft fire, continuing to heat the mixture for 15 minutes, cooling the liquid medicine to room temperature, and filtering the liquid medicine;
3) mixing the two decoctions, filtering, concentrating the filtrate to relative density of 1.10, cooling to room temperature, adding equal volume of ethanol, and standing; concentrating the supernatant to relative density of 1.20, adding water with the same volume as the supernatant, stirring, standing, and concentrating the supernatant to relative density of 1.40 to obtain fluid extract;
4) adding sucrose powder, dextrin and appropriate amount of ethanol into the obtained fluid extract according to the weight ratio of 1:3:1.25, mixing well, granulating and drying to obtain the product.
Ankylosing spondylitis is a chronic inflammatory autoimmune disease, which is regarded as a disease of immune hyperactivity through a process of repeated circulation of bone destruction and new bone formation, and the treatment of the disease can be summarized into acute and chronic treatments. The rattan medicine in the medicinal material formula can achieve the effects of dredging the meridian of limbs and eliminating pathogenic wind and dampness, and the two medicines are combined to treat the symptoms; herbs that tonify liver and kidney and herbs that invigorate spleen and stomach are combined for this reason. In the formula, the rattan medicine has the functions of inhibiting autoimmunity and diminishing inflammation and relieving pain, and treats the primary symptoms according to the pathological characteristics; the tinospora sinensis is good at clearing heat, eliminating dampness and relieving pain, is used for red swelling and pain of joints and difficulty in flexion and extension, has better anti-inflammatory and analgesic effects, and can also be used for treatment in the active period; caulis Spatholobi is good at dredging collaterals, relaxing muscles and tendons, promoting blood circulation and replenishing blood, can dredge channels and collaterals, can nourish blood and soften channels, is especially suitable for women and patients with blood deficiency, and is commonly used for patients with arthralgia syndrome at late stage and deficiency of both qi and blood; notopterygii rhizoma and radix Angelicae Pubescentis can dispel wind-damp and remove arthralgia, and the two can be used together to treat arthralgia all over the body to treat the secondary aspect of arthralgia; for patients in the chronic stage, most of the patients have the treatment history of taking immunosuppressive agents such as hormone and methotrexate, the symptoms are mainly shown as deficiency of vital qi and deficiency of essence, the symptoms are marked by excess, the loranthus parasiticus can dispel rheumatism and strengthen muscles and bones, both symptoms and root causes are treated, eucommia ulmoides and medlar are used as adjuvant for tonifying the liver and kidney of the congenital origin, rice sprouts can tonify the spleen and stomach of the congenital origin and strengthening the acquired origin, and achyranthes bidentata draws the medicine to return to the meridian as a messenger medicine, so that the traditional Chinese medicine is suitable for treating various clinically differentiated ankylosing spondylitis, has the effects on acute and chronic stages of the disease, and has the advantages of simple and precise prescription medicine, flexible compatibility, and direct centering on the pathogenesis characteristics of the disease and exact curative effect.
In addition, the medicine has convenient sources and low price, all the medicines in the formula have mild medicine property, liver and kidney functions and abnormal blood picture can not be caused after long-term taking, the medicine is particularly suitable for the patients with ankylosing spondylitis for long-term taking, has better pain relieving effect, can improve the joint movement function of the patients, and is beneficial to the control and treatment of diseases.
Detailed Description
In order to make the present invention more comprehensible, the technical solutions of the present invention are further described below with reference to specific embodiments, but the present invention is not limited thereto.
Example 1
1) 18g of parasitic loranthus, 9g of notopterygium root, 9g of radix angelicae pubescentis, 15g of tinospora sinensis, 30g of caulis spatholobi, 18g of fried eucommia ulmoides, 12g of medlar, 30g of rice sprout and 9g of radix achyranthis bidentatae, the raw materials are smashed into powder, then 300mL of water is added, the mixture is boiled with soft fire and then is heated for 15 minutes, and then the liquid medicine is cooled to room temperature and filtered;
2) adding 300mL of water into the dregs of a decoction, boiling the mixture with soft fire, continuing to heat the mixture for 15 minutes, cooling the liquid medicine to room temperature, and filtering the liquid medicine;
3) mixing the two decoctions, filtering, concentrating the filtrate to relative density of 1.10, cooling to room temperature, adding equal volume of ethanol, and standing; concentrating the supernatant to relative density of 1.20, adding water with the same volume as the supernatant, stirring, standing, and concentrating the supernatant to relative density of 1.40 to obtain fluid extract;
4) adding 30g of sucrose powder, 12.5g of dextrin and a proper amount of ethanol into 10g of the clear paste, mixing uniformly, granulating and drying to obtain the granules for treating ankylosing spondylitis.
Example 2
1) Crushing 18g of parasitic loranthus, 9g of notopterygium root, 9g of radix angelicae pubescentis, 15g of tinospora sinensis, 30g of caulis spatholobi, 18g of fried eucommia ulmoides, 12g of medlar, 30g of rice sprout and 9g of radix achyranthis bidentatae into powder, adding 400mL of water, boiling with soft fire, continuing to heat for 15 minutes, cooling the liquid medicine to room temperature, and filtering;
2) adding 400mL of water into the dregs of a decoction, boiling the mixture with soft fire, continuing to heat the mixture for 15 minutes, cooling the liquid medicine to room temperature, and filtering the liquid medicine;
3) mixing the two decoctions, filtering, concentrating the filtrate to relative density of 1.10, cooling to room temperature, adding equal volume of ethanol, and standing; concentrating the supernatant to relative density of 1.20, adding water with the same volume as the supernatant, stirring, standing, and concentrating the supernatant to relative density of 1.40 to obtain fluid extract;
4) adding 30g of sucrose powder, 12.5g of dextrin and a proper amount of ethanol into 10g of the clear paste, mixing uniformly, granulating and drying to obtain the granules for treating ankylosing spondylitis.
Example 3
1) Crushing 18g of parasitic loranthus, 9g of notopterygium root, 9g of radix angelicae pubescentis, 15g of tinospora sinensis, 30g of caulis spatholobi, 18g of fried eucommia ulmoides, 12g of medlar, 30g of rice sprout and 9g of radix achyranthis bidentatae into powder, adding 450mL of water, boiling with soft fire, continuing to heat for 15 minutes, cooling the liquid medicine to room temperature, and filtering;
2) adding 450mL of water into the dregs of a decoction, boiling the mixture with soft fire, continuing to heat the mixture for 15 minutes, cooling the liquid medicine to room temperature, and filtering the liquid medicine;
3) mixing the two decoctions, filtering, concentrating the filtrate to relative density of 1.10, cooling to room temperature, adding equal volume of ethanol, and standing; concentrating the supernatant to relative density of 1.20, adding water with the same volume as the supernatant, stirring, standing, and concentrating the supernatant to relative density of 1.40 to obtain fluid extract;
4) adding 30g of sucrose powder, 12.5g of dextrin and a proper amount of ethanol into 10g of the clear paste, mixing uniformly, granulating and drying to obtain the granules for treating ankylosing spondylitis.
Typical cases are as follows:
the patients are old, male and 27 years old, the patients have a medical consultation with the main complaint of 'repeatedly lower waist pain and half year of limited movement', the pain VAS score is 6 points, and the physical examination is carried out: lumbar vertebra forward bending 45 degrees, back 15 degrees, auxiliary examination: HLA-B27 was positive, blood sedimentation, CRP increased, X-ray: bilateral sacroiliac arthritis (grade III),
the granules obtained in example 1 were divided into two portions, one portion was taken in the morning and one portion was taken in the evening, and two weeks were continued (one treatment course).
After two weeks of reexamination, the pain symptoms of the patients are obviously relieved, the VAS score is 2 points, and the physical examination is as follows: the mobility of the lumbar vertebra is improved earlier, the lumbar vertebra bends forward by 60 degrees, stretches backward by 20 degrees, and the patient can recover.
Examples of the applications
80 clinical outpatients are randomly divided into a test group (traditional Chinese medicine) and a positive control group (western medicine) in 40 cases, and the activity of the lumbar joint and the VAS score are measured as the evaluation index of the curative effect. After two weeks of treatment, the effective rates of the test group and the positive control group are both 100% through statistical analysis, which shows that the two groups have obvious improvement effect on pain symptoms, but the test group has better recovery effect on joint mobility.
The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.
Claims (2)
1. A granule for treating ankylosing spondylitis, which is characterized in that: the medicinal materials are as follows by weight: 18 parts of parasitic loranthus, 9 parts of notopterygium root, 9 parts of radix angelicae pubescentis, 15 parts of tinospora sinensis, 30 parts of caulis spatholobi, 18 parts of fried eucommia ulmoides, 9 parts of radix achyranthis bidentatae, 12 parts of medlar and 30 parts of rice sprout;
the preparation method of the granule for treating ankylosing spondylitis comprises the following steps:
1) weighing herba Taxilli, Notopterygii rhizoma, radix Angelicae Pubescentis, caulis tinosporae, caulis Spatholobi, parched Eucommiae cortex, Achyranthis radix, fructus Lycii and fructus oryzae according to the proportion, crushing into powder, adding water 2-3 times the total weight of the medicinal materials, boiling with slow fire, heating for 15 min, cooling to room temperature, and filtering;
2) adding water into the dregs of a decoction, boiling the mixture with soft fire, continuing to heat the mixture for 15 minutes, cooling the liquid medicine to room temperature, and filtering the liquid medicine;
3) mixing the two decoctions, filtering, concentrating the filtrate to relative density of 1.10, cooling to room temperature, adding equal volume of ethanol, and standing; concentrating the supernatant to relative density of 1.20, adding water with the same volume as the supernatant, stirring, standing, and concentrating the supernatant to relative density of 1.40 to obtain fluid extract;
4) adding sucrose powder, dextrin and ethanol into the obtained fluid extract, mixing, granulating, and drying.
2. The granule for treating ankylosing spondylitis according to claim 1, wherein: the weight ratio of the clear paste to the sucrose powder and the dextrin in the step 4) is 1:3: 1.25.
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Non-Patent Citations (2)
Title |
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二藤通痹合剂结合辨证中药治疗强直性脊柱炎的临床观察;林昌松等;《新中医》;20090131;第41卷(第1期);第34-36页,尤其是第34页摘要、右栏"2.1 中药组"、"2.1.2 肝肾亏虚,邪留督脉"项下,第35页左栏第1段,第36页左栏倒数第2段、右栏倒数第1段 * |
独活寄生汤治疗痹病的临床体会;尚晓良等;《内蒙古中医药》;20081231(第3期);第13-14页 * |
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