CN117860642B - Peptide-containing composition for repairing multiple skin barriers, and preparation method and application thereof - Google Patents
Peptide-containing composition for repairing multiple skin barriers, and preparation method and application thereof Download PDFInfo
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- CN117860642B CN117860642B CN202410278326.4A CN202410278326A CN117860642B CN 117860642 B CN117860642 B CN 117860642B CN 202410278326 A CN202410278326 A CN 202410278326A CN 117860642 B CN117860642 B CN 117860642B
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- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 36
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The application relates to the field of skin care products, in particular to a peptide-containing composition for repairing multiple skin barriers and a preparation method thereof. The peptide-containing composition for repairing multiple skin barriers comprises the following raw materials in parts by mass: 0.002-17 parts of polypeptides, 0.1-15 parts of plant extracts, 0.001-0.5 part of auxiliary agents and 100-250 parts of deionized water; the polypeptides include at least nisin, acetyl tetrapeptide-11, hexapeptide-2, nonapeptide-1, acetyl tetrapeptide-9, dipeptide-1, thymic pentapeptide, acetyl octapeptide-3, and tetrapeptide-3. The peptide-containing composition for repairing multiple skin barriers provided by the application can repair and perfect the skin microecological barriers, solve the problems of dry skin, skin itch, red swelling, inflammation and the like, repair multiple skin barriers, radically solve the skin aging problem, effectively promote skin elasticity, lighten fine lines and ensure skin health and beauty.
Description
Technical Field
The application relates to the field of skin care products, in particular to a peptide-containing composition for repairing multiple skin barriers and a preparation method thereof.
Background
With the rapid development of economy and the improvement of the living standard of people, the demands of consumers for anti-aging products are increasing. Especially skin, which is the largest organ of the human body, tends to give priority to aging symptoms.
The aging symptoms of skin often show symptoms such as thinning of skin, abnormal stratum corneum, increased wrinkles, deepening of wrinkles, loose elasticity, increased dead skin, dryness, lack of water and the like. Among them, the most common is that skin elasticity is reduced, sagging and wrinkles are increased and deepened. This is mainly due to collagen loss by elastase.
Although the prior art has greatly advanced research on the anti-aging effect of skin, the prior art has a plurality of defects for developing anti-aging raw materials and skin care products. At present, anti-aging raw materials and skin care products have one-sided performance, and many of the raw materials and skin care products use a single substance with an anti-oxidation effect or use low-content plant extracts, so that the problem of skin aging cannot be solved from root sources. For solving the skin aging problem, the key point is to repair the skin barrier, so that a perfect skin barrier structure can be established and skin dysfunction phenomenon can be avoided, and further skin aging problems caused by the problems of loose skin, skin itch, skin inflammation, increased fine wrinkles, coarse pores, increased color spots, atrophy, scars, red swelling and the like can be avoided.
Therefore, in order to better solve the problems, the application provides a peptide-containing composition for repairing multiple skin barriers and a preparation method thereof, which can solve the problems of dry skin, skin itch, red swelling, inflammation and the like while repairing and perfecting skin microecological barriers, solve the skin aging problem from the root, and can effectively promote skin elasticity, lighten fine lines and further delay skin aging so as to ensure skin health and beauty.
Disclosure of Invention
In order to solve the above problems, the first aspect of the present application provides a peptide-containing composition for multiple skin barrier repair, comprising, in parts by mass: 0.002-17 parts of polypeptides, 0.1-15 parts of plant extracts, 0.001-0.5 part of auxiliary agents and 100-250 parts of deionized water.
As a preferred embodiment, the polypeptides include nisin, acetyl tetrapeptide-11, hexapeptide-2, nonapeptide-1, acetyl tetrapeptide-9, dipeptide-1, thymic pentapeptide, acetyl octapeptide-3, and tetrapeptide-3.
As a preferred embodiment, the nisin, acetyl tetrapeptide-11, hexapeptide-2, nonapeptide-1, acetyl tetrapeptide-9, dipeptide-1, thymic pentapeptide, acetyl octapeptide-3 and tetrapeptide-3 are in a mass ratio （0.001~2）：（0.0001~0.5）：（0.001~1）：（0.0001~2）：（0.0001~1）：（0.0001~0.3）：（0.0001~5）：（0.0001~5）：（0.00001~1.25）.
The tetrapeptide-3 adopted in the application can rapidly permeate with the help of the components such as acetyl octapeptide-3 in the polypeptide activity compound combination, thereby greatly improving the generation promoting effect of the tetrapeptide-3 on vascular endothelial cells under skin, effectively inhibiting the secretion and the red swelling phenomenon of inflammatory factors caused by the overexpansion of subcutaneous blood vessels, and further providing an excellent skin environment for the effect of the polypeptide composition.
As a preferable scheme, the mass ratio of nisin, acetyl tetrapeptide-11 and nonapeptide-1 is (0.01-0.1): (0.1 to 0.2): (0.3 to 0.5).
As a preferred embodiment, the mass ratio of nisin, acetyl tetrapeptide-11 and nonapeptide-1 is 0.05:0.15:0.3.
The acetyl octapeptide-3 adopted in the application can act synergistically on subcutaneous tissue neuromuscular synapse under the combined action of polypeptide raw materials to inhibit neurotransmitter acetylcholine release, so that the permeation efficiency and speed of active ingredient molecules in the polypeptide composition to skin are improved, the inhibition effect of the polypeptide active molecules on the neurotransmitter release depending on Ca 2+ at neuromuscular junctions is obviously improved, and a more excellent anti-aging effect is achieved.
As a preferable scheme, the mass ratio of the hexapeptide-2, the acetyl tetrapeptide-9, the dipeptide-1 and the thymus pentapeptide is (0.01-0.1): (0.01 to 0.2): (0.1 to 0.15): (0.1 to 0.3).
As a preferred embodiment, the mass ratio of hexapeptide-2, acetyl tetrapeptide-9, dipeptide-1 and thymopentin is 0.05:0.15:0.1:0.2.
In the application, the interaction among the polypeptide components can greatly improve the anti-aging effect of the polypeptide composition when the polypeptide composition is used on skin, and particularly can inhibit itch and inflammation and redness caused by skin aging. Through the polypeptide combination of the formula, the promotion effect of acetyl polypeptide on the expression of skin collagen can be greatly synergistically improved when the acetyl polypeptide acts on the skin, so that the basal lamina glycan generation effect of the skin is improved, the skin can recover the cohesive force and the resistance, and the synthesis of skin active molecules by epidermal cells is promoted. On the other hand, the combined action of the polypeptides can promote the capturing action of the nonapeptide and the dipeptide on inflammatory factors, and effectively increase opioid peptide precursor POMC and inhibit the activation of TRPV1 when acting on the dermis layer, thereby having excellent anti-itch and anti-pain effects.
As a preferred embodiment, the plant extract is at least two of turmeric root extract, withania extract, yellow chrysanthemum extract, centella asiatica extract, aloe vera extract, witch hazel extract, apple extract, saffron extract, paeonia extract, lime extract, horse chestnut extract.
As a preferred embodiment, the plant extract is at least two of turmeric root extract, withania extract, apple extract, saffron extract, peony extract, lime extract, horse chestnut extract.
As a preferred embodiment, the plant extract is paeonia lactiflora extract and lime extract.
As a preferable scheme, the mass ratio of the paeonia lactiflora extract to the lime extract is (0.1-5): (0.1 to 10).
As a preferable scheme, the mass ratio of the paeonia lactiflora extract to the lime extract is (0.5-1): (1-2).
As a preferred scheme, the mass ratio of the paeonia lactiflora extract to the lime extract is 0.6:1.4.
As a preferable scheme, the auxiliary agent is at least one of pH regulator, chelating agent, alcohol, antiseptic, antioxidant, thickener, emollient and humectant.
As a preferred embodiment, the auxiliary agent is a pH adjuster.
As a preferred embodiment, the pH adjuster is hydroxyethylpiperazine ethane sulfonic acid.
As a preferable scheme, the mass ratio of the polypeptide, the plant extract and the auxiliary agent is (1-1.5): (1.8-2.2): (0.1 to 0.3).
As a preferred scheme, the mass ratio of the polypeptide, the plant extract and the auxiliary agent is 1.4:2:0.2.
The second aspect of the present application provides a method for preparing the above peptide-containing composition for multiple skin barrier repair, comprising the steps of: s1: adding deionized water into a container, then adding the plant extract, mixing and stirring for 30-60 min; s2: and adding the auxiliary agent and the polypeptide into the S1 solution, heating to 40-45 ℃, stirring for 30-40 min, and cooling to room temperature after finishing the treatment to obtain the peptide-containing composition for repairing the multiple skin barrier.
As a preferable scheme, the stirring speed of the mixing stirring in the step S1 is 50-200 r/min.
The second aspect of the application provides an application of the peptide-containing composition for repairing multiple skin barriers, comprising an application of the peptide-containing composition for repairing multiple skin barriers in preparing skin care essence, skin care emulsion, skin care mask liquid and skin care aquatic products.
As a preferred embodiment, the content of the peptide-containing composition for repairing multiple skin barriers in the application product is 0.1-5wt%.
The beneficial effects are that:
1. The application provides a peptide-containing composition for repairing multiple skin barriers, which can repair and perfect the skin microecological barrier, solve the problems of dry skin, skin itching, red swelling, inflammation and the like, solve the problem of skin aging from the root, and can effectively promote skin elasticity, lighten fine lines and further delay skin aging so as to ensure the health and beauty of skin.
2. The application provides a peptide-containing composition for repairing multiple skin barriers, which adopts acetyl octapeptide-3, and can synergistically act on subcutaneous tissue neuromuscular synapses under the combined action of polypeptide raw materials to inhibit the release of neurotransmitter acetylcholine, so that the permeation efficiency and speed of active ingredient molecules in the polypeptide composition to the skin are improved, the inhibition effect of the polypeptide active molecules on the release of neurotransmitter depending on Ca 2+ at neuromuscular junctions is obviously improved, and a more excellent anti-aging effect is achieved; on the other hand, the tetrapeptide-3 adopted can rapidly permeate with the help of the components such as acetyl octapeptide-3 in the polypeptide activity compound combination, so that the generation promoting effect of the tetrapeptide-3 on vascular endothelial cells under skin is greatly improved, the secretion and the red swelling phenomenon of inflammatory factors caused by the overexpansion of subcutaneous blood vessels are effectively inhibited, and an excellent skin environment is provided for the effect of the polypeptide composition.
3. The application provides a peptide-containing composition for repairing multiple skin barriers, which adopts the interaction among the polypeptide components, can greatly improve the anti-aging effect of the polypeptide composition when the polypeptide composition is used on skin, and particularly can inhibit itch and inflammation and redness caused by skin aging; the polypeptide combination of the formula can greatly synergistically improve the promotion effect of acetyl polypeptide on the expression of skin collagen when acting on the skin, so that the basal lamina glycan generation effect of the skin is improved, the skin can recover the cohesive force and the resistance, and the synthesis of skin active molecules by epidermal cells is promoted. On the other hand, the combined action of the polypeptides can promote the capturing action of the nonapeptide and the dipeptide on inflammatory factors, and effectively increase opioid peptide precursor POMC and inhibit the activation of TRPV1 when acting on the dermis.
4. The application provides a peptide-containing composition for repairing multiple skin barriers, which has the advantages of simple preparation method, simple and easily obtained raw materials, simple and easily operated preparation process, effectively ensures lower preparation and labor cost of the composition, and can be widely applied to skin care products such as skin care essence, skin care emulsion, skin care mask liquid and the like due to excellent efficacy.
Detailed Description
The technical solutions in the above summary of the present application will be further described and illustrated in the following detailed description. And the following examples are merely practical examples for illustrating and explaining the technical aspects in the specification, and should not limit the scope of the claims to be protected by the present application. All technical products based on the technical proposal of the application are covered in the scope of the application.
In the examples which follow, the starting materials are commercially available products, unless otherwise specified, or may be prepared by methods well known to those skilled in the art.
Example 1
Example 1a first aspect provides a peptide-containing composition for multiple skin barrier repair, comprising, in parts by mass: 0.05 part of nisin, 0.15 part of acetyl tetrapeptide-11, 0.05 part of hexapeptide-2, 0.3 part of nonapeptide-1, 0.15 part of acetyl tetrapeptide-9, 0.1 part of dipeptide-1, 0.2 part of thymic pentapeptide, 0.3 part of acetyl octapeptide-3, 0.1 part of tetrapeptide-3, 0.2 part of hydroxyethyl piperazine ethane sulfonic acid, 0.6 part of paeonia lactiflora extract, 1.4 parts of lime extract and 150 parts of deionized water.
Paeonia lactiflora extract is purchased from Paeonia lactiflora extract products sold by the biological sciences company of Siamica.
The lime extract is purchased from lime extract products sold by the company volley biotechnology, langasite.
In a second aspect, the present embodiment provides a method for preparing the peptide-containing composition for repairing multiple skin barriers, the method comprising the steps of: s1: adding deionized water into a container, then adding the plant extract, and mixing and stirring for 50min at a rotating speed of 100 r/min; s2: adding the auxiliary agent and the polypeptide into the S1 solution, heating to 45 ℃, stirring for 35min, and cooling to room temperature of 25 ℃ after finishing to obtain the peptide-containing composition for repairing the multiple skin barrier.
Example 2
Example 2a first aspect provides a peptide-containing composition for multiple skin barrier repair, comprising, in parts by mass: 0.06 part of nisin, 0.14 part of acetyl tetrapeptide-11, 0.06 part of hexapeptide-2, 0.35 part of nonapeptide-1, 0.14 part of acetyl tetrapeptide-9, 0.15 part of dipeptide-1, 0.15 part of thymic pentapeptide, 0.2 part of acetyl octapeptide-3, 0.2 part of tetrapeptide-3, 0.2 part of hydroxyethyl piperazine ethane sulfonic acid, 0.6 part of paeonia lactiflora extract, 1.4 parts of lime extract and 150 parts of deionized water.
Paeonia lactiflora extract is purchased from Paeonia lactiflora extract products sold by the biological sciences company of Siamica.
The lime extract is purchased from lime extract products sold by the company volley biotechnology, langasite.
In a second aspect, the present embodiment provides a method for preparing the peptide-containing composition for repairing multiple skin barriers, the method comprising the steps of: s1: adding deionized water into a container, then adding the plant extract, and mixing and stirring for 52min at a rotating speed of 100 r/min; s2: adding the auxiliary agent and the polypeptide into the S1 solution, heating to 45 ℃, stirring for 35min, and cooling to room temperature of 25 ℃ after finishing to obtain the peptide-containing composition for repairing the multiple skin barrier.
Example 3
Example 3 a first aspect provides a peptide-containing composition for multiple skin barrier repair, comprising, in parts by mass: 0.05 part of nisin, 0.15 part of acetyl tetrapeptide-11, 0.05 part of hexapeptide-2, 0.3 part of nonapeptide-1, 0.15 part of acetyl tetrapeptide-9, 0.1 part of dipeptide-1, 0.2 part of thymic pentapeptide, 0.3 part of acetyl octapeptide-3, 0.1 part of tetrapeptide-3, 0.2 part of hydroxyethyl piperazine ethane sulfonic acid, 0.8 part of paeonia lactiflora extract, 1.2 parts of lime extract and 150 parts of deionized water.
Paeonia lactiflora extract is purchased from Paeonia lactiflora extract products sold by the biological sciences company of Siamica.
The lime extract is purchased from lime extract products sold by the company volley biotechnology, langasite.
In a second aspect, the present embodiment provides a method for preparing the peptide-containing composition for repairing multiple skin barriers, the method comprising the steps of: s1: adding deionized water into a container, then adding the plant extract, and mixing and stirring for 55min at a rotating speed of 100 r/min; s2: adding the auxiliary agent and the polypeptide into the S1 solution, heating to 45 ℃, stirring for 38min, and cooling to room temperature of 25 ℃ after finishing to obtain the peptide-containing composition for repairing the multiple skin barrier.
Comparative example 1
The specific embodiment of this comparative example is substantially the same as example 1, except that: the peptide-containing composition for repairing multiple skin barriers comprises the following raw materials in parts by mass: 0.05 part of nisin, 0.15 part of acetyl tetrapeptide-11, 0.05 part of hexapeptide-2, 0.3 part of nonapeptide-1, 0.15 part of acetyl tetrapeptide-9, 0.35 part of dipeptide-1, 0.35 part of tetrapeptide-3, 0.2 part of hydroxyethyl piperazine ethane sulfonic acid, 0.6 part of paeonia lactiflora extract, 1.4 parts of lime extract and 150 parts of deionized water.
Comparative example 2
The specific embodiment of this comparative example is substantially the same as example 1, except that: the peptide-containing composition for repairing multiple skin barriers comprises the following raw materials in parts by mass: 0.05 part of nisin, 0.15 part of acetyl tetrapeptide-11, 0.05 part of hexapeptide-2, 0.3 part of nonapeptide-1, 0.15 part of acetyl tetrapeptide-9, 0.2 part of thymic pentapeptide, 0.4 part of acetyl octapeptide-3, 0.3 part of hydroxyethyl piperazine ethane sulfonic acid, 0.6 part of paeonia lactiflora extract, 1.4 parts of lime extract and 150 parts of deionized water.
Comparative example 3
The specific embodiment of this comparative example is substantially the same as example 1, except that: the peptide-containing composition for repairing multiple skin barriers comprises the following raw materials in parts by mass: 0.05 part of nisin, 0.15 part of acetyl tetrapeptide-11, 0.05 part of hexapeptide-2, 0.3 part of nonapeptide-1, 0.15 part of acetyl tetrapeptide-9, 0.1 part of dipeptide-1, 0.2 part of thymic pentapeptide, 0.3 part of acetyl octapeptide-3, 0.1 part of tetrapeptide-3, 0.2 part of hydroxyethyl piperazine ethane sulfonic acid, 3 parts of lime extract and 150 parts of deionized water.
Comparative example 4
The specific embodiment of this comparative example is substantially the same as example 1, except that: the peptide-containing composition for repairing multiple skin barriers comprises the following raw materials in parts by mass: 0.05 part of nisin, 0.15 part of acetyl tetrapeptide-11, 0.05 part of hexapeptide-2, 0.3 part of nonapeptide-1, 0.15 part of acetyl tetrapeptide-9, 0.1 part of dipeptide-1, 0.2 part of thymic pentapeptide, 0.3 part of acetyl octapeptide-3, 0.1 part of tetrapeptide-3, 0.2 part of hydroxyethyl piperazine ethane sulfonic acid, 0.4 part of turmeric root extract, 2 parts of lime extract and 150 parts of deionized water.
The turmeric root extract is a turmeric root extract product sold by Ying Chuang Industrial group.
Evaluation of Performance
1. Skin itch efficacy test: the skin care compositions obtained in the examples and the comparative examples were subjected to antipruritic test, and the test subjects were Kunming mice, and the weight of the mice was 20 to 25g.
The testing method comprises the following steps: the method comprises the steps of (1) performing subcutaneous injection on mice to influence itching relieving of the mice caused by a histamine phosphate method, wherein a plurality of mice are randomly grouped into groups of 10 mice each; mice were divided into (1): model control group; (2): the sample groups were each of examples and comparative examples, and the amounts of the experimental mice in each of the examples and comparative examples were 10.
Model control group: deionized water, dosage of 0.2 mL/piece; sample administration group: 5wt% of the composition obtained in examples and comparative examples was administered in an amount of 0.2 mL/dose.
After the adaptive feeding, shearing off the hair at the neck and the back of the mouse by scissors one day before the experiment, unhairing by using unhairing paste to expose the skin, wherein the area of a unhairing area is about 2cm x 2cm, and smearing and administering the mice with intact skin; each dose is administered 1 time a day for 2 days continuously; itching: after the last administration for 1 hour, each group of mice was subcutaneously injected with 0.2mL (10 mL/kg) of 0.05% histamine phosphate physiological saline, and the front paws of the mice were observed to scratch the head, the back paws were sowed to scratch the trunk, and the mouth-biting parts of the whole body were used as the itching reaction indexes. And observing and recording the itching times of each group of mice within 30min, judging the itching relieving effect intensity of the test group according to the itching relieving inhibition rate, and representing the effect of the sample administration group by comparing the itching relieving inhibition rate with that of the model group. Wherein, the calculation formula of the antipruritic inhibition rate is as follows:
antipruritic inhibition ratio (%) = (number of scratches of model control group-number of scratches of administration group)/number of scratches of model control group×100%.
2. Anti-inflammatory efficacy test: the skin care compositions obtained in the examples and the comparative examples were subjected to antipruritic test, and the test subjects were Kunming mice, and the weight of the mice was 20 to 25g.
The testing method comprises the following steps: the mice are grouped randomly, 10 mice in each group are respectively half male and female; (1): blank control group; (2): model control group; (3): a positive control group; (4): the sample administration groups, i.e., examples and comparative examples, each of the experimental mice amounts of the examples and comparative examples were 10.
Model control group: deionized water, dosage of 0.2 mL/piece; positive control group: the dosage of the compound dexamethasone acetate is 0.2 mL/dose; sample group: 5wt% of the composition obtained in examples and comparative examples was administered in an amount of 0.2 mL/dose.
Each group was dosed continuously for 15 days, and each group, except the blank group, induced delayed allergic inflammation in mice using DNCB, in a specific method: the mice were sensitized once on the abdomen on day 1, day 2, and the backs were challenged with 1% DNCB 0uL on day 6, day 9, day 12, and day 15, respectively, using 5% DNCB 25 uL. After the last administration for 1 day, the mice were sacrificed by cervical removal, the skin thickness and weight were measured by punching the dorsal skin, and the inflammatory cytokines were measured by embedding slice pathology observation, immunohistochemistry. Skin thickness (weight) inhibition ratio (i.e., anti-inflammatory inhibition ratio) (%) = (model control group-sample administration group)/(model control group-blank control group) ×100%.
TABLE 1
From the data in table 1 of examples and comparative examples, it can be seen that examples 1 to 3 adopting the technical scheme specially defined in the present application can obtain excellent skin barrier repairing effect, and at the same time can solve the skin aging problem from the root, further effectively solve the inflammation red swelling and itching problems caused by skin aging, and obtain excellent anti-inflammatory and antipruritic effects. In contrast, the technical effects of the technical solutions adopted in the present application are not obvious and the technical problems can be effectively solved, as compared with the technical effects of the examples 1 to 3, the technical effects of the comparative examples 1 to 4 are obviously inferior to the efficacy performance of the compositions because the technical solutions are not specially limited.
Claims (5)
1. A multiple skin barrier repair peptide-containing composition characterized by: the raw materials of the peptide-containing composition comprise polypeptides, plant extracts, auxiliary agents and deionized water;
the polypeptides are nisin, acetyl tetrapeptide-11, hexapeptide-2, nonapeptide-1, acetyl tetrapeptide-9, dipeptide-1, thymic pentapeptide, acetyl octapeptide-3 and tetrapeptide-3;
The plant extract is radix Paeoniae extract and fructus Citri sinensis extract;
the auxiliary agent is a pH regulator, and the pH regulator is hydroxyethyl piperazine ethane sulfonic acid;
the peptide-containing composition comprises the following components in parts by mass:
0.05 to 0.06 part of nisin, 0.14 to 0.15 part of acetyl tetrapeptide-11, 0.05 to 0.06 part of hexapeptide-2, 0.3 to 0.35 part of nonapeptide-9, 0.14 to 0.15 part of acetyl tetrapeptide-9, 0.1 to 0.15 part of dipeptide-1, 0.15 to 0.2 part of thymic pentapeptide, 0.2 to 0.3 part of acetyl octapeptide-3, 0.1 to 0.2 part of tetrapeptide-3, 0.2 to 0.5 part of hydroxyethyl piperazine ethane sulfonic acid, 0.6 to 0.8 part of paeonia lactiflora extract, 1.2 to 1.4 part of lime extract and 150 parts of deionized water.
2. A method of preparing a multiple skin barrier repair peptide-containing composition according to claim 1, characterized in that: the preparation method comprises the following steps: s1: adding deionized water into a container, then adding the plant extract, mixing and stirring for 30-60 min; s2: and adding the auxiliary agent and the polypeptide into the S1 solution, heating to 40-45 ℃, stirring for 30-40 min, and cooling to room temperature after finishing the treatment to obtain the peptide-containing composition for repairing the multiple skin barrier.
3. Use of a multiple skin barrier repair peptide-containing composition according to claim 1, characterized in that: the use of the peptide-containing composition for multiple skin barrier repair in the preparation of skin care essence or skin care water emulsion products.
4. Use of a multiple skin barrier repair peptide-containing composition according to claim 1, characterized in that: the application of the peptide-containing composition for repairing multiple skin barriers in preparing skin care mask liquid products.
5. Use of a multiple skin barrier repair peptide-containing composition according to claim 1, characterized in that: the application of the peptide-containing composition for repairing multiple skin barriers in preparing skin care aquatic products.
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