CN117795074A - 转甲状腺素蛋白（TTR）iRNA组合物和其使用方法 - Google Patents

转甲状腺素蛋白（TTR）iRNA组合物和其使用方法 Download PDF

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Publication number
CN117795074A
CN117795074A CN202280053958.XA CN202280053958A CN117795074A CN 117795074 A CN117795074 A CN 117795074A CN 202280053958 A CN202280053958 A CN 202280053958A CN 117795074 A CN117795074 A CN 117795074A
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nucleotide sequence
ome
antisense strand
dsrna agent
sense strand
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M·K·施莱格尔
A·卡斯托雷诺
J·D·麦金因克
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Alnylam Pharmaceuticals Inc
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CN202280053958.XA 2021-08-03 2022-08-02 转甲状腺素蛋白（TTR）iRNA组合物和其使用方法 Pending CN117795074A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163228830P 2021-08-03 2021-08-03
US63/228,830 2021-08-03
PCT/US2022/039111 WO2023014677A1 (en) 2021-08-03 2022-08-02 Transthyretin (ttr) irna compositions and methods of use thereof

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CN117795074A true CN117795074A (zh) 2024-03-29

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US (2) US11959081B2 (enExample)
EP (1) EP4381067A1 (enExample)
JP (1) JP2024530018A (enExample)
KR (1) KR20240042004A (enExample)
CN (1) CN117795074A (enExample)
AR (1) AR126675A1 (enExample)
AU (1) AU2022323090A1 (enExample)
CA (1) CA3227852A1 (enExample)
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CO (1) CO2024001272A2 (enExample)
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MX (1) MX2024001194A (enExample)
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WO (1) WO2023014677A1 (enExample)
ZA (1) ZA202500487B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2937418B1 (en) 2008-10-20 2017-10-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of transthyretin
LT3329002T (lt) 2015-07-31 2021-01-11 Alnylam Pharmaceuticals, Inc. Transtiretino (ttr) irnr kompozicijos ir jų naudojimo būdai, skirti naudoti su ttr susijusių ligų gydymui arba prevencijai
EP4055165A1 (en) * 2019-11-06 2022-09-14 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
CN121772930A (zh) * 2023-07-31 2026-03-31 基愈治疗股份有限公司 N-乙酰基-半乳糖胺(galnac)和寡核苷酸的缀合物以及其用途
KR20260108581A (ko) 2023-11-06 2026-07-08 아커나 리미티드 트랜스티레틴(TTR) 발현을 억제하는 RNAi 시약, 조성물 및 용도
WO2025113470A1 (en) * 2023-11-27 2025-06-05 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of transthyretin (ttr)
AU2024400950A1 (en) 2023-12-12 2026-06-11 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating transthyretin (ttr)- associated diseases

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