CN117412753A - 布鲁顿氏酪氨酸激酶抑制剂及其使用方法 - Google Patents
布鲁顿氏酪氨酸激酶抑制剂及其使用方法 Download PDFInfo
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- CN117412753A CN117412753A CN202280039736.2A CN202280039736A CN117412753A CN 117412753 A CN117412753 A CN 117412753A CN 202280039736 A CN202280039736 A CN 202280039736A CN 117412753 A CN117412753 A CN 117412753A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
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- Immunology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US202163196843P | 2021-06-04 | 2021-06-04 | |
| US63/196,843 | 2021-06-04 | ||
| PCT/IB2022/055154 WO2022254371A1 (en) | 2021-06-04 | 2022-06-02 | Inhibitors of bruton's tyrosine kinase and methods of their use |
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| US20250333398A1 (en) | 2024-04-30 | 2025-10-30 | Boehringer Ingelheim International Gmbh | Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228902A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Heterocyclic acids as sting antagonists and the use thereof as medicament |
| WO2025228899A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Further heterocyclic compounds as sting antagonists and the use thereof as medicament |
| WO2025228900A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Arylamide substituted indazoles and the use thereof as medicament |
| WO2025228895A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament |
| WO2025228889A1 (en) | 2024-04-30 | 2025-11-06 | Boehringer Ingelheim International Gmbh | Monoarylic heterocyclic compounds as sting antagonists and the use thereof as medicament |
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| BR112015008042A2 (pt) | 2012-10-11 | 2017-07-04 | Pharmacyclics Inc | diagnósticos complementares para terapia com inibidor de quinase da família tec |
| MA40596B1 (fr) * | 2014-08-11 | 2021-12-31 | Acerta Pharma Bv | Combinaisons thérapeutiques d'un inhibiteur de btk et d'un inhibiteur de bcl-2 |
| JO3794B1 (ar) * | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون |
| WO2018103060A1 (en) * | 2016-12-09 | 2018-06-14 | Janssen Pharmaceutica Nv | Inhibitors of bruton's tyrosine kinase and methods of their use |
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| EP4346834A1 (en) | 2024-04-10 |
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| CL2023003564A1 (es) | 2024-06-21 |
| TW202317127A (zh) | 2023-05-01 |
| KR20240019214A (ko) | 2024-02-14 |
| WO2022254371A1 (en) | 2022-12-08 |
| US20230013755A1 (en) | 2023-01-19 |
| JOP20230310A1 (ar) | 2023-11-29 |
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| JP2024520630A (ja) | 2024-05-24 |
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