CN117327188A - 结合补体成分c5或血清白蛋白的多肽及其融合蛋白 - Google Patents

结合补体成分c5或血清白蛋白的多肽及其融合蛋白 Download PDF

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Publication number
CN117327188A
CN117327188A CN202311281139.3A CN202311281139A CN117327188A CN 117327188 A CN117327188 A CN 117327188A CN 202311281139 A CN202311281139 A CN 202311281139A CN 117327188 A CN117327188 A CN 117327188A
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Prior art keywords
seq
amino acid
acid sequence
binding
engineered polypeptide
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Pending
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CN202311281139.3A
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English (en)
Chinese (zh)
Inventor
布里奇特·帞菲
朱利安·钱德
尼米斯·基拉
道格拉斯·L·谢里登
赛达斯·金达尔
保罗·P·腾博尼
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Alexion Pharmaceuticals Inc
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Alexion Pharmaceuticals Inc
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Publication of CN117327188A publication Critical patent/CN117327188A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN202311281139.3A 2017-07-11 2018-07-11 结合补体成分c5或血清白蛋白的多肽及其融合蛋白 Pending CN117327188A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762531215P 2017-07-11 2017-07-11
US62/531,215 2017-07-11
PCT/US2018/041661 WO2019014360A1 (en) 2017-07-11 2018-07-11 POLYPEPTIDES BINDING COMPONENT C5 OR SERUM ALBUMIN COMPONENT AND FUSION PROTEINS THEREOF
CN201880046102.3A CN111201246B (zh) 2017-07-11 2018-07-11 结合补体成分c5或血清白蛋白的多肽及其融合蛋白

Related Parent Applications (1)

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CN201880046102.3A Division CN111201246B (zh) 2017-07-11 2018-07-11 结合补体成分c5或血清白蛋白的多肽及其融合蛋白

Publications (1)

Publication Number Publication Date
CN117327188A true CN117327188A (zh) 2024-01-02

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CN201880046102.3A Active CN111201246B (zh) 2017-07-11 2018-07-11 结合补体成分c5或血清白蛋白的多肽及其融合蛋白
CN202311281139.3A Pending CN117327188A (zh) 2017-07-11 2018-07-11 结合补体成分c5或血清白蛋白的多肽及其融合蛋白
CN202311281093.5A Pending CN117327187A (zh) 2017-07-11 2018-07-11 结合补体成分c5或血清白蛋白的多肽及其融合蛋白

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Country Status (12)

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US (3) US11498960B2 (enExample)
EP (1) EP3625265A1 (enExample)
JP (3) JP7684803B2 (enExample)
KR (3) KR20250068795A (enExample)
CN (3) CN111201246B (enExample)
AU (3) AU2018301412B2 (enExample)
BR (1) BR112019028269A2 (enExample)
CA (1) CA3067247A1 (enExample)
CO (1) CO2020000369A2 (enExample)
IL (3) IL271920B2 (enExample)
MX (2) MX2024005945A (enExample)
WO (1) WO2019014360A1 (enExample)

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CN116731149B (zh) * 2023-06-07 2024-02-27 华中农业大学 草鱼补体活化分子碳末端肽C5a-CP及应用
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RU2020102910A (ru) 2021-08-11
CN117327187A (zh) 2024-01-02
US20230235033A1 (en) 2023-07-27
KR20250068795A (ko) 2025-05-16
CN111201246A (zh) 2020-05-26
JP2023120208A (ja) 2023-08-29
AU2018301412B2 (en) 2025-08-07
KR102806328B1 (ko) 2025-05-14
US20250163138A1 (en) 2025-05-22
IL271920A (en) 2020-02-27
US12221473B2 (en) 2025-02-11
EP3625265A1 (en) 2020-03-25
KR20250099285A (ko) 2025-07-01
AU2018301412A1 (en) 2020-01-30
IL324119A (en) 2025-12-01
IL271920B1 (en) 2023-11-01
JP2020532285A (ja) 2020-11-12
IL307197A (en) 2023-11-01
MX2024005946A (es) 2024-06-11
US11498960B2 (en) 2022-11-15
WO2019014360A8 (en) 2019-02-21
JP2025118590A (ja) 2025-08-13
AU2018301412A9 (en) 2025-08-07
CA3067247A1 (en) 2019-01-17
WO2019014360A1 (en) 2019-01-17
CO2020000369A2 (es) 2020-01-31
BR112019028269A2 (pt) 2020-07-14
KR20200026264A (ko) 2020-03-10
AU2025200303A1 (en) 2025-02-13
IL271920B2 (en) 2024-03-01
US20200399351A1 (en) 2020-12-24
MX2024005945A (es) 2024-06-11
AU2025200313A1 (en) 2025-02-13
JP7684803B2 (ja) 2025-05-28
CN111201246B (zh) 2023-10-27
IL307197B1 (en) 2025-11-01
RU2020102910A3 (enExample) 2021-12-02

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