CN117323266B - Anti-saccharification and anti-oxidation composition and application thereof - Google Patents
Anti-saccharification and anti-oxidation composition and application thereof Download PDFInfo
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- CN117323266B CN117323266B CN202311546549.6A CN202311546549A CN117323266B CN 117323266 B CN117323266 B CN 117323266B CN 202311546549 A CN202311546549 A CN 202311546549A CN 117323266 B CN117323266 B CN 117323266B
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- extract
- tricholoma matsutake
- skin
- solution
- magnolia bark
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an anti-saccharification and anti-oxidation composition and application thereof, belonging to the field of plant extract cosmetic raw materials; the composition comprises the following components: tricholoma matsutake extract, black tea extract, magnolia bark extract, haematococcus pluvialis extract; the raw material components provided by the invention have excellent anti-saccharification and anti-oxidation effects, have the effects of mutual synergy and mutual promotion, are comfortable and non-irritating in use, can improve skin elasticity, reduce melanin deposition, and have certain anti-wrinkle and whitening effects.
Description
Technical Field
The invention belongs to the field of plant extract cosmetic raw materials, and particularly relates to an anti-saccharification and anti-oxidation composition and application thereof.
Background
The living and working pressures lead the skin to accelerate aging, in addition, the cosmetic varieties are various, the skin aging is easy to be caused by improper selection, and the phenomena of fine lines, slackening, dullness, dryness and the like are generated.
Aiming at the skin problems, the common daily chemical products mainly protect external stimulus, solve the skin problems deeply from the inside, and have remarkable effects on the monomer components in partial cosmetics, but have great side effects, are easy to cause allergy for partial skin sensitive people, and have great harm on certain components. For example, the active ingredient kojic acid in cosmetics is synthesized into melanin through complex oxidative polymerization of tyrosine and oxygen free radical under the catalysis of tyrosinase in human skin, and kojic acid can inhibit the synthesis of tyrosinase, so that consistent skin melanin formation is achieved, but kojic acid is in a 3-class carcinogen list and has great harm to human body. For example, cosmetics contain substances such as lead, mercury, benzene, preservative, hormone and the like, and can temporarily make skin in a glossy and tender state, but can make stratum corneum fall off and become thin after long-term use, so that skin is red and swollen, color spots are formed, and the effect is the opposite.
Therefore, there is a need to develop a natural, safe, antioxidant and anti-glycation product which can reduce skin wrinkles from inside and slow down skin aging.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the plant extract composition with anti-saccharification and anti-oxidation functions, the raw materials in the composition are mutually synergistic and mutually promoted, so that the anti-saccharification and anti-oxidation performance of the whole composition is improved, and meanwhile, the composition is comfortable and non-irritating in use, can improve skin elasticity, reduce melanin deposition, and has certain anti-wrinkle and whitening effects.
In order to achieve the aim, the invention discloses an anti-saccharification and anti-oxidation composition which comprises the following components in parts by mass:
Preferably, the composition comprises the following components in parts by mass:
more preferably, the preparation method of the tricholoma matsutake extract comprises the following steps: pulverizing Tricholoma matsutake to obtain Tricholoma matsutake residue, extracting the Tricholoma matsutake residue with ethanol water solution to obtain Tricholoma matsutake extractive solution, concentrating and drying to obtain Tricholoma matsutake extract.
Further preferably, the tricholoma matsutake is preferably fresh tricholoma matsutake with a fungus cover diameter of 6-10cm, a fungus handle length of 6-10cm and a diameter of 2-3 cm.
Still more preferably, the tricholoma matsutake is cleaned, crushed into slag and the tricholoma matsutake slag is obtained; adding 75-80wt% ethanol solution, refluxing in water bath for 4-5 times (8-11) for 40-50min each time, filtering under normal pressure, and mixing filtrates to obtain Tricholoma matsutake extractive solution; concentrating the Tricholoma matsutake extractive solution under reduced pressure to recover ethanol, and lyophilizing to obtain Tricholoma matsutake extract with water content less than or equal to 10%.
Preferably, the preparation method of the magnolia bark extract comprises the following steps:
(1) Cleaning and pulverizing Magnolia bark to obtain Magnolia bark residue, adding into 70v/v% ethanol water solution, heating to 55-65deg.C, soaking, filtering, concentrating under reduced pressure to recover ethanol to obtain extract;
(2) Extracting the extract obtained in the step (1) by using chloroform, and recovering the chloroform from the extract under reduced pressure to obtain a crude product;
(3) Concentrating under reduced pressure and rotary distillation at 55-65deg.C until the liquid is no longer distilled, and collecting the rest thick paste to obtain Magnolia bark extract.
The Tricholoma matsutake extract is rich in various natural active ingredients such as Tricholoma matsutake polysaccharide, peptide compounds, steroid compounds, polyphenol compounds, etc., is a natural humectant and antioxidant, and helps to improve skin moisture retention and antioxidant capacity; under the catalytic action of tyrosinase, tyrosine and oxygen free radicals undergo complex oxidative polymerization, and finally melanin is synthesized, and polysaccharide compounds in the tricholoma matsutake extract can effectively inhibit the synthesis of tyrosinase and reduce the synthesis of melanin;
the black tea extract is rich in catechin, theaflavin, theanine and other components, and the components have good antioxidant and anti-wrinkle effects, can enhance skin elasticity, prevent skin aging and improve skin color;
The magnolia bark extract is rich in active ingredients including magnolol, dihydroxyl dihydromagnolol, magnolol and the like, and has the effects of removing fine lines and wrinkles, improving skin elasticity, improving skin firmness and improving color uniformity;
The haematococcus pluvialis extract is rich in astaxanthin, various amino acids, minerals, essential fatty acids and other nutritional components, has strong antioxidant capacity, effectively eliminates free radicals in cells, enhances the regeneration capacity of cells, reduces the accumulation of aging cells, and greatly reduces the skin aging speed;
The raw material components provided by the invention have synergistic interaction and promotion effects, and the antioxidant and anti-saccharification effects can be improved by adding the raw material components into a skin care system according to the preferable proportion.
The invention also discloses application of the anti-saccharification and anti-oxidation composition in preparation of a preparation with barrier repairing, anti-oxidation, anti-saccharification, moisturizing and/or whitening effects.
In a third aspect, the invention discloses a skin resident agent comprising the anti-glycation and anti-oxidation composition and the additive.
Preferably, the additives in the skin resident agent comprise at least one of surfactant, thickener, conditioner, humectant, preservative, chelating agent, essence, and water.
Preferably, the skin resident agent is at least one of essence water, essence milk, body milk, facial cleanser, massage cream, sun cream and hand cream.
The invention has the beneficial effects that:
1. The raw material components provided by the invention have excellent anti-saccharification and anti-oxidation effects, and the raw material components have the effects of mutual synergy and mutual promotion.
2. The composition provided by the invention is comfortable and non-irritating in use, can improve skin elasticity, reduce melanin deposition, and has certain anti-wrinkle and whitening effects.
Detailed Description
For a better understanding of the present invention, reference will now be made to the following description of specific examples, which are included in the terminology used to describe specific embodiments of the invention and are not intended to limit the scope of the invention.
In the invention, the following components are added:
The Tricholoma matsutake extract is Tricholoma matsutake (TRICHOLOMA MATSUTAKE) extract, INCI name TRICHOLOMAMATSUTAKE EXTRACT, and Tricholoma matsutake commercially available from Yongren Yesen das Limited.
The black tea extract is black tea (CAMELLIA SINENSIS) extract, INCI name is KOU-CHA EKISU, available from Shanxi Jinkangtai Biotechnology Co.
The MAGNOLIA bark extract is MAGNOLIA (MAGNOLIA OBOVATA) bark extract, INCI name MAGNOLIA OBOVATABARK EXTRACT, and MAGNOLIA bark is purchased from the Qingping traditional Chinese medicine market in Li Gulf region of Guangzhou city.
The haematococcus pluvialis extract is haematococcus pluvialis (HAEMATOCOCCUS PLUVIALIS) extract, the INCI name is HAEMATOCOCCUS PLUVIALIS EXTRACT, and the astaxanthin specification content is more than or equal to 10% and is purchased from Shanxi hucho taimen biotechnology limited company.
The experimental methods, in which specific conditions are not noted in the following examples, are generally conducted under conventional conditions or under conditions recommended by the manufacturer. Percentages and parts are by weight unless otherwise indicated.
Preparation of Tricholoma matsutake extract
And (1) selecting fresh tricholoma matsutake with the mushroom cap diameter less than or equal to 10cm, the mushroom stem length less than or equal to 10cm and the mushroom stem diameter less than or equal to 3 cm.
Step (2), cleaning the tricholoma matsutake, and crushing the tricholoma matsutake into slag to obtain tricholoma matsutake slag;
adding 75-80v/v% ethanol solution, wherein the mass ratio of the tricholoma matsutake residues to the ethanol solution is 1 (8-11), refluxing in water bath for 4-5 times, each time for 40-50min, filtering at normal pressure, and mixing the filtrates to obtain tricholoma matsutake extract;
And (4) concentrating the tricholoma matsutake extract under reduced pressure to recover ethanol, wherein the concentration pressure is between-0.12 and-0.10 MPa, the temperature is controlled between 30 ℃ and 40 ℃, and the freeze drying is carried out until the water content of the extract is less than or equal to 10%, so as to obtain the tricholoma matsutake extract 1-4, wherein the preparation conditions of each extract are shown in the table 1.
TABLE 1 parameter for producing Tricholoma matsutake extract
Preparation of magnolia bark extract
Step (1), cleaning and crushing magnolia bark to obtain magnolia bark residue, putting the magnolia bark residue into a 70v/v% ethanol water solution, heating to 55-65 ℃ for soaking, filtering, concentrating under reduced pressure to recover ethanol to obtain extract;
Step (2), extracting the extract obtained in the step (1) by using chloroform, and recovering the chloroform from the extract under reduced pressure to obtain a crude product;
And (3) concentrating the crude product obtained in the step (2) by reduced pressure rotary distillation at 55-65 ℃ until the liquid is not distilled out, and obtaining magnolia bark extract 1-4 by using thick paste as the rest, wherein the preparation conditions of the extracts are shown in the table 2.
Table 2 parameters for the preparation of magnolia bark extract
Examples and comparative examples
The raw materials in parts by weight of Table 3 were mixed to obtain examples and comparative examples.
TABLE 3 Table 3
Table 3 (subsequent)
Note that: in the table "-indicates that no addition was made.
Performance testing
Human body skin patch test
The 4 examples and the 4 comparative examples prepared above were referred to the human skin patch experiments in 2022 cosmetic safety technical Specification.
Skin reactions were observed as standard at 30min (after the disappearance of the indentations), 24h and 48h, respectively, and the observations were recorded, see table 4.
TABLE 4 human safety test results
| Numbering device | 30min | 24h | 48h |
| Example 1 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 2 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 3 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 4 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 1 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 2 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 3 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 4 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
Measurement of DPPH radical scavenging ability:
Preparing a solution of DPPH with absolute ethyl alcohol of 2X 10 -4 mol/L, taking examples 1-4 and comparative examples 1-4 as a solution to be detected, preparing 2mL of each solution to be detected, 2mL of absolute ethyl alcohol and 2mL of DPPH solution, respectively uniformly mixing, standing at room temperature for 30 minutes, measuring absorbance at a wavelength of 517nm to obtain Ai, measuring each sample in parallel for 3 times, and taking an average value.
Vc is used as a positive control, absolute ethyl alcohol is used for replacing DPPH to measure absorbance value to be used as a control Aj blank, and DPPH solution and absolute ethyl alcohol are mixed to measure absorbance Ac.
The clearance of DPPH radicals from each sample to be tested was calculated according to the following formula (1) and recorded in the following table 5.
Clearance (%) = (1- (Ai-Aj)/Ac) ×100%........... (1)
Wherein: ai is the absorbance of 2mL of the example or comparative example liquid+2 mLDPPH reagent mixture; aj is the absorbance of a mixture of 2mL of sample solution and 2mL of absolute ethanol; ac is the absorbance of a 2mLDPPH solution+2 mL absolute ethanol mixture.
Determination of superoxide radical O 2 -. Scavenging Capacity
Respectively taking the examples 1-4 and the comparative examples 1-4 as the liquid to be detected, precisely sucking 1mL of the liquid to be detected, respectively adding 4.5mL of 50mmol/L Tris-HCl buffer solution with pH=8.2, uniformly mixing, preserving heat for 20 minutes in a constant-temperature water bath at 25 ℃, taking out, immediately adding 0.3mL of 25mmol/L pyrogallol solution, rapidly shaking, reacting in the constant-temperature water bath at 25 ℃ for 5 minutes, adding 8mmol/LHCl 1mL, uniformly mixing, terminating the reaction, measuring absorbance at 325nm, and taking distilled water instead of the sample as a blank. Vc was used as positive control. Each sample was measured 3 times in parallel and averaged.
The clearance was calculated according to formula (2) and recorded in table 5 below.
Clearance (%) = (a 0-A1)/A0 ×100%........... (2)
Wherein: a 0 is the average absorbance of the blank; a 1 is the average absorbance of the liquid to be detected.
Determination of the ability to scavenge hydroxyl radicals
Taking examples 1-4 and comparative examples 1-4 as solutions to be detected respectively, and adding 1mL of 0.15mmol/LFeSO 4, 0.4mL of 2mmol/L salicylic acid, 0.2mL of the solution to be detected, 1mL of 6mmol/LH 2O2 and 0.4mL of distilled water into a sample group test tube respectively; the blank group uses distilled water to replace the liquid to be detected, the control group uses distilled water to replace salicylic acid, and the reaction is carried out for 30 minutes at 37 ℃. Vc was used as positive control. Each sample was measured 3 times in parallel and averaged.
The hydroxyl radical capacity clearance was calculated according to formula (3) and recorded in table 5 below.
Clearance (%) = (a Blank space -(A Sample of -A Control ))/A Blank space ×100%........... (3)
TABLE 5
Inhibition of non-enzymatic saccharification reaction assay (anti-saccharification)
The amino residues of the sugar containing aldehyde groups and the protein react under non-enzymatic conditions to form Schiff base, early glycosylation products are formed after a period of time, then high-activity carbonyl compounds are formed after a period of time, and saccharification end products AGEs are formed after cyclization, oxidation and other actions. Along with the accumulation of AGEs, the skin is damaged, collagen and elastin in dermal tissues react with non-enzymatic saccharification to form a crosslinked product, so that the skin elasticity is reduced, wrinkles are generated, the tissue permeability is reduced, and the skin color is gradually dark yellow.
(1) Test protocol
The glucose solution and the bovine serum albumin solution were prepared with PBS solution to have final concentrations of 200mmol/L and 40g/L, respectively. Taking the example composition and the comparative example composition, and setting a control group: ① Group A, non-enzymatic saccharification reaction group without composition; ② Group B, bovine serum albumin control; ③ Group C, glucose control with composition added; ④ Group D, bovine serum albumin control with composition added, each group repeated 3 times.
And (3) testing: the reaction solution was incubated at 37℃for 30 days in the absence of light, and the fluorescence values F of the reaction solutions of each group were measured by a fluorescence spectrophotometer under the conditions of excitation wavelength of 370nm, emission wavelength of 440nm, and slit lnm.
(2) Calculation method
Relative AGEs inhibition calculation:
(3) Test results
TABLE 6AGEs detection results
| Group of | AGEs inhibition Rate (%) |
| Example 1 | 55.25 |
| Example 2 | 56.09 |
| Example 3 | 47.80 |
| Example 4 | 45.29 |
| Comparative example 1 | 28.73 |
| Comparative example 2 | 42.52 |
| Comparative example 3 | 40.67 |
| Comparative example 4 | 31.44 |
Skin whitening and spot lightening test
The 24 volunteers with darker complexion and colored spots on the face are screened, the age is 25-27 years, the average number of the volunteers is divided into 4 groups, the groups are respectively grouped according to examples 1-4, each group is respectively subjected to detection test according to the test method in the cosmetic ultraviolet-induced human skin blackening model freckle removing and whitening efficacy test method by using corresponding samples to be tested.
The test person uses the sample to be tested of the embodiment and the comparative example prepared before cleaning the face in the early and the evening, uses the skin color difference test probe and the multifunctional skin test system and the skin red melanin tester and the test probe continuously for 4 weeks, respectively performs data acquisition on the face of the test person before the test person uses (week 0), after the test person uses the test person 1 and after the test person uses the test person 4 weeks, calculates the change of skin whiteness (brightness)/L and skin melanin content/MI before and after the test person uses the cosmetics, and the L value represents L is white balance, and the larger the value is, the color is more biased to white; the higher the MI measurement value, the higher the melanin content in the skin; the test results were averaged for each panel and the specific results are shown in table 7.
TABLE 7
Analysis of results
From the results of the performance tests of example 1 and comparative examples 1 to 4, it is seen that example 1 significantly decreased the antioxidant and anti-glycation properties of the composition when the component magnolia bark extract was absent, as compared with comparative example 1.
From the results of the performance tests of example 1 and comparative example 2, it was found that the antioxidant properties of the extracts prepared from fresh Tricholoma matsutake were superior to those of the extracts prepared from Tricholoma matsutake or Tricholoma matsutake decoction pieces.
According to the performance test results of the example 1 and the comparative examples 1-4, the raw material components provided by the invention have excellent anti-saccharification and anti-oxidation effects, and the raw material components have mutually synergistic and mutually promoted effects.
According to the results of the whitening and spot-lightening tests in examples 1-4, the composition provided by the invention has the effect of inhibiting melanin synthesis and can play a role in whitening and spot-lightening.
While specific embodiments of the invention have been described above, it will be appreciated by those skilled in the art that this is by way of example only, and the scope of the invention is defined by the appended claims. Various changes and modifications to these embodiments may be made by those skilled in the art without departing from the principles and spirit of the invention, but such changes and modifications fall within the scope of the invention.
Claims (6)
1. The anti-saccharification and anti-oxidation composition is characterized by comprising the following components in parts by mass:
1.0-1.3 parts of tricholoma matsutake extract;
0.4-0.7 parts of black tea extract;
0.001-0.005 part of magnolia bark extract;
3-4 parts of haematococcus pluvialis extract;
Polysorbate-20.2-0.4 parts;
and water, the said water supplements to 100 shares;
the preparation method of the tricholoma matsutake extract comprises the following steps: washing and crushing fresh tricholoma matsutake into residues to obtain tricholoma matsutake residues, extracting the tricholoma matsutake residues with an ethanol aqueous solution to obtain tricholoma matsutake extracting solution, concentrating and drying the tricholoma matsutake extracting solution to obtain tricholoma matsutake extract;
The extraction by ethanol water solution is as follows: adding 75-80v/v% ethanol water solution, refluxing in water bath for 4-5 times (8-11) for 40-50min each time, filtering, and mixing filtrates to obtain Tricholoma matsutake extractive solution;
the concentrated and dried steps are as follows: concentrating the tricholoma matsutake extract under reduced pressure to recover ethanol, and freeze-drying to obtain tricholoma matsutake extract, wherein the moisture content of the tricholoma matsutake extract is less than or equal to 10%;
the preparation method of the magnolia bark extract comprises the following steps:
(1) Cleaning and pulverizing Magnolia bark to obtain Magnolia bark residue, adding into 70v/v% ethanol water solution, heating to 55-65deg.C, soaking, filtering, concentrating under reduced pressure to remove ethanol to obtain extract;
(2) Extracting the extract obtained in the step (1) by using chloroform, and removing the chloroform from the extract under reduced pressure to obtain a crude product;
(3) Concentrating under reduced pressure at 55-65deg.C until the liquid is no longer distilled, and collecting the rest paste to obtain Magnolia bark extract.
2. The anti-glycation and anti-oxidant composition of claim 1, wherein the fresh tricholoma matsutake is a fresh tricholoma matsutake with a cap diameter of 6-10cm, a handle length of 6-10cm and a diameter of 2-3 cm.
3. Use of the anti-glycation, anti-oxidation composition of claim 1 or 2 for preparing a formulation with anti-oxidation, anti-glycation and/or whitening efficacy.
4. A skin resident comprising the anti-glycation, anti-oxidant composition of claim 1 or 2 and an additive.
5. The skin residence agent according to claim 4, wherein said additives comprise at least one of surfactants, thickeners, conditioning agents, moisturizers, preservatives, chelators, fragrances, and water.
6. The skin residence agent according to claim 5, wherein said skin residence agent is at least one of essential water, essential milk, body milk, massage cream, sun cream, hand cream.
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| CN109350568A (en) * | 2018-10-25 | 2019-02-19 | 广州市皓雨化妆品有限公司 | It is a kind of with anti-blue light, anti-oxidant, whitening, the composition for effect of releiving and anti-light aging essence and preparation method thereof |
| CN109937030A (en) * | 2016-11-07 | 2019-06-25 | 日清纺控股株式会社 | Skin cosmetic |
| CN112656706A (en) * | 2019-10-15 | 2021-04-16 | 康山峰 | Cosmetic repair stock solution and preparation method thereof |
| DE102020206961A1 (en) * | 2020-06-03 | 2021-12-09 | Beiersdorf Aktiengesellschaft | Use of one or more extracts from magnolia bark as an antioxidant or radical scavenger in cosmetic or dermatological preparations, in particular to prevent oxidative stress caused by visible light |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109937030A (en) * | 2016-11-07 | 2019-06-25 | 日清纺控股株式会社 | Skin cosmetic |
| CN109350568A (en) * | 2018-10-25 | 2019-02-19 | 广州市皓雨化妆品有限公司 | It is a kind of with anti-blue light, anti-oxidant, whitening, the composition for effect of releiving and anti-light aging essence and preparation method thereof |
| CN112656706A (en) * | 2019-10-15 | 2021-04-16 | 康山峰 | Cosmetic repair stock solution and preparation method thereof |
| DE102020206961A1 (en) * | 2020-06-03 | 2021-12-09 | Beiersdorf Aktiengesellschaft | Use of one or more extracts from magnolia bark as an antioxidant or radical scavenger in cosmetic or dermatological preparations, in particular to prevent oxidative stress caused by visible light |
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