CN117323266A - Anti-saccharification and anti-oxidation composition and application thereof - Google Patents
Anti-saccharification and anti-oxidation composition and application thereof Download PDFInfo
- Publication number
- CN117323266A CN117323266A CN202311546549.6A CN202311546549A CN117323266A CN 117323266 A CN117323266 A CN 117323266A CN 202311546549 A CN202311546549 A CN 202311546549A CN 117323266 A CN117323266 A CN 117323266A
- Authority
- CN
- China
- Prior art keywords
- tricholoma matsutake
- extract
- glycation
- skin
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- 230000003064 anti-oxidating effect Effects 0.000 title claims abstract description 19
- 239000000284 extract Substances 0.000 claims abstract description 53
- 241000121220 Tricholoma matsutake Species 0.000 claims abstract description 48
- 241001673966 Magnolia officinalis Species 0.000 claims abstract description 19
- 230000002087 whitening effect Effects 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 230000002829 reductive effect Effects 0.000 claims description 14
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 230000003078 antioxidant effect Effects 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000003963 antioxidant agent Substances 0.000 claims description 10
- 235000006708 antioxidants Nutrition 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000002893 slag Substances 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000000654 additive Substances 0.000 claims description 4
- 239000012043 crude product Substances 0.000 claims description 4
- 235000013336 milk Nutrition 0.000 claims description 4
- 239000008267 milk Substances 0.000 claims description 4
- 210000004080 milk Anatomy 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 2
- 230000004888 barrier function Effects 0.000 claims description 2
- 239000002738 chelating agent Substances 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 230000001815 facial effect Effects 0.000 claims description 2
- 239000008269 hand cream Substances 0.000 claims description 2
- 230000003020 moisturizing effect Effects 0.000 claims description 2
- 239000000516 sunscreening agent Substances 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 239000002562 thickening agent Substances 0.000 claims description 2
- 239000004909 Moisturizer Substances 0.000 claims 1
- 230000003750 conditioning effect Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 14
- 239000002994 raw material Substances 0.000 abstract description 11
- 239000002537 cosmetic Substances 0.000 abstract description 9
- 241000168517 Haematococcus lacustris Species 0.000 abstract description 6
- 230000037394 skin elasticity Effects 0.000 abstract description 6
- 244000269722 Thea sinensis Species 0.000 abstract description 5
- 235000006468 Thea sinensis Nutrition 0.000 abstract description 5
- 230000001153 anti-wrinkle effect Effects 0.000 abstract description 4
- 235000020279 black tea Nutrition 0.000 abstract description 4
- 230000008021 deposition Effects 0.000 abstract description 3
- 231100000344 non-irritating Toxicity 0.000 abstract description 3
- 239000000419 plant extract Substances 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 22
- 230000000052 comparative effect Effects 0.000 description 21
- 238000012360 testing method Methods 0.000 description 21
- 239000000243 solution Substances 0.000 description 19
- 239000000523 sample Substances 0.000 description 10
- 238000002835 absorbance Methods 0.000 description 9
- 235000019441 ethanol Nutrition 0.000 description 7
- -1 oxygen free radical Chemical class 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 5
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 4
- 102000003425 Tyrosinase Human genes 0.000 description 4
- 108060008724 Tyrosinase Proteins 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 230000002255 enzymatic effect Effects 0.000 description 4
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 230000009759 skin aging Effects 0.000 description 4
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229940098773 bovine serum albumin Drugs 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 3
- 229960004705 kojic acid Drugs 0.000 description 3
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 3
- 238000011056 performance test Methods 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 241000218378 Magnolia Species 0.000 description 2
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 235000013793 astaxanthin Nutrition 0.000 description 2
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 2
- 229940022405 astaxanthin Drugs 0.000 description 2
- 239000001168 astaxanthin Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 239000007933 dermal patch Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000036564 melanin content Effects 0.000 description 2
- 230000008099 melanin synthesis Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 230000005808 skin problem Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- MBBITBYACKGMSW-UHFFFAOYSA-N 2-(2-hydroxy-5-prop-2-enylphenyl)-4-propylphenol Chemical compound CCCC1=CC=C(O)C(C=2C(=CC=C(CC=C)C=2)O)=C1 MBBITBYACKGMSW-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241001154287 Hucho taimen Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- IPMYMEWFZKHGAX-UHFFFAOYSA-N Isotheaflavin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C(C1=C2)=CC(O)=C(O)C1=C(O)C(=O)C=C2C1C(O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-UHFFFAOYSA-N 0.000 description 1
- 240000004580 Magnolia hypoleuca Species 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- UXRMWRBWCAGDQB-UHFFFAOYSA-N Theaflavin Natural products C1=CC(C2C(CC3=C(O)C=C(O)C=C3O2)O)=C(O)C(=O)C2=C1C(C1OC3=CC(O)=CC(O)=C3CC1O)=CC(O)=C2O UXRMWRBWCAGDQB-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000003172 aldehyde group Chemical group 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 150000001728 carbonyl compounds Chemical class 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 108090000765 processed proteins & peptides Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 235000014620 theaflavin Nutrition 0.000 description 1
- IPMYMEWFZKHGAX-ZKSIBHASSA-N theaflavin Chemical compound C1=C2C([C@H]3OC4=CC(O)=CC(O)=C4C[C@H]3O)=CC(O)=C(O)C2=C(O)C(=O)C=C1[C@@H]1[C@H](O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-ZKSIBHASSA-N 0.000 description 1
- 229940026509 theaflavin Drugs 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an anti-saccharification and anti-oxidation composition and application thereof, belonging to the field of plant extract cosmetic raw materials; the composition comprises the following components: tricholoma matsutake extract, black tea extract, magnolia bark extract, haematococcus pluvialis extract; the raw material components provided by the invention have excellent anti-saccharification and anti-oxidation effects, have the effects of mutual synergy and mutual promotion, are comfortable and non-irritating in use, can improve skin elasticity, reduce melanin deposition, and have certain anti-wrinkle and whitening effects.
Description
Technical Field
The invention belongs to the field of plant extract cosmetic raw materials, and particularly relates to an anti-saccharification and anti-oxidation composition and application thereof.
Background
The living and working pressures lead the skin to accelerate aging, in addition, the cosmetic varieties are various, the skin aging is easy to be caused by improper selection, and the phenomena of fine lines, slackening, dullness, dryness and the like are generated.
Aiming at the skin problems, the common daily chemical products mainly protect external stimulus, solve the skin problems deeply from the inside, and have remarkable effects on the monomer components in partial cosmetics, but have great side effects, are easy to cause allergy for partial skin sensitive people, and have great harm on certain components. For example, the active ingredient kojic acid in cosmetics is synthesized into melanin through complex oxidative polymerization of tyrosine and oxygen free radical under the catalysis of tyrosinase in human skin, and kojic acid can inhibit the synthesis of tyrosinase, so that consistent skin melanin formation is achieved, but kojic acid is in a 3-class carcinogen list and has great harm to human body. For example, cosmetics contain substances such as lead, mercury, benzene, preservative, hormone and the like, and can temporarily make skin in a glossy and tender state, but can make stratum corneum fall off and become thin after long-term use, so that skin is red and swollen, color spots are formed, and the effect is the opposite.
Therefore, there is a need to develop a natural, safe, antioxidant and anti-glycation product which can reduce skin wrinkles from inside and slow down skin aging.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the plant extract composition with anti-saccharification and anti-oxidation functions, the raw materials in the composition are mutually synergistic and mutually promoted, so that the anti-saccharification and anti-oxidation performance of the whole composition is improved, and meanwhile, the composition is comfortable and non-irritating in use, can improve skin elasticity, reduce melanin deposition, and has certain anti-wrinkle and whitening effects.
In order to achieve the aim, the invention discloses an anti-saccharification and anti-oxidation composition which comprises the following components in parts by mass:
preferably, the composition comprises the following components in parts by mass:
more preferably, the preparation method of the tricholoma matsutake extract comprises the following steps: pulverizing Tricholoma matsutake to obtain Tricholoma matsutake residue, extracting the Tricholoma matsutake residue with ethanol water solution to obtain Tricholoma matsutake extractive solution, concentrating and drying to obtain Tricholoma matsutake extract.
Further preferably, the tricholoma matsutake is preferably fresh tricholoma matsutake with a fungus cover diameter of 6-10cm, a fungus handle length of 6-10cm and a diameter of 2-3 cm.
Still more preferably, the tricholoma matsutake is cleaned, crushed into slag and the tricholoma matsutake slag is obtained; adding 75-80wt% ethanol solution, refluxing in water bath for 4-5 times (8-11) for 40-50min each time, filtering under normal pressure, and mixing filtrates to obtain Tricholoma matsutake extractive solution; concentrating the Tricholoma matsutake extractive solution under reduced pressure to recover ethanol, and lyophilizing to obtain Tricholoma matsutake extract with water content less than or equal to 10%.
Preferably, the preparation method of the magnolia bark extract comprises the following steps:
(1) Cleaning and pulverizing Magnolia bark to obtain Magnolia bark residue, adding into 70v/v% ethanol water solution, heating to 55-65deg.C, soaking, filtering, concentrating under reduced pressure to recover ethanol to obtain extract;
(2) Extracting the extract obtained in the step (1) by using chloroform, and recovering the chloroform from the extract under reduced pressure to obtain a crude product;
(3) Concentrating under reduced pressure and rotary distillation at 55-65deg.C until the liquid is no longer distilled, and collecting the rest thick paste to obtain Magnolia bark extract.
The Tricholoma matsutake extract is rich in various natural active ingredients such as Tricholoma matsutake polysaccharide, peptide compounds, steroid compounds, polyphenol compounds, etc., is a natural humectant and antioxidant, and helps to improve skin moisture retention and antioxidant capacity; under the catalytic action of tyrosinase, tyrosine and oxygen free radicals undergo complex oxidative polymerization, and finally melanin is synthesized, and polysaccharide compounds in the tricholoma matsutake extract can effectively inhibit the synthesis of tyrosinase and reduce the synthesis of melanin;
the black tea extract is rich in catechin, theaflavin, theanine and other components, and the components have good antioxidant and anti-wrinkle effects, can enhance skin elasticity, prevent skin aging and improve skin color;
the magnolia bark extract is rich in active ingredients including magnolol, dihydroxyl dihydromagnolol, magnolol and the like, and has the effects of removing fine lines and wrinkles, improving skin elasticity, improving skin firmness and improving color uniformity;
the haematococcus pluvialis extract is rich in astaxanthin, various amino acids, minerals, essential fatty acids and other nutritional components, has strong antioxidant capacity, effectively eliminates free radicals in cells, enhances the regeneration capacity of cells, reduces the accumulation of aging cells, and greatly reduces the skin aging speed;
the raw material components provided by the invention have synergistic interaction and promotion effects, and the antioxidant and anti-saccharification effects can be improved by adding the raw material components into a skin care system according to the preferable proportion.
The invention also discloses application of the anti-saccharification and anti-oxidation composition in preparation of a preparation with barrier repairing, anti-oxidation, anti-saccharification, moisturizing and/or whitening effects.
In a third aspect, the invention discloses a skin resident agent comprising the anti-glycation and anti-oxidation composition and the additive.
Preferably, the additives in the skin resident agent comprise at least one of surfactant, thickener, conditioner, humectant, preservative, chelating agent, essence, and water.
Preferably, the skin resident agent is at least one of essence water, essence milk, body milk, facial cleanser, massage cream, sun cream and hand cream.
The invention has the beneficial effects that:
1. the raw material components provided by the invention have excellent anti-saccharification and anti-oxidation effects, and the raw material components have the effects of mutual synergy and mutual promotion.
2. The composition provided by the invention is comfortable and non-irritating in use, can improve skin elasticity, reduce melanin deposition, and has certain anti-wrinkle and whitening effects.
Detailed Description
For a better understanding of the present invention, reference will now be made to the following description of specific examples, which are included in the terminology used to describe specific embodiments of the invention and are not intended to limit the scope of the invention.
In the invention, the following components are added:
the Tricholoma matsutake extract is Tricholoma matsutake (TRICHOLOMA MATSUTAKE) extract, INCI name is TRICHOLOMAMATSUTAKE EXTRACT, and Tricholoma matsutake is available from Yongren Yesen das Limited.
The black tea extract is black tea (CAMELLIA SINENSIS) extract, INCI name is KOU-CHA EKISU, available from Shaanxi Jinkangtai Biotechnology Co.
The MAGNOLIA bark extract is MAGNOLIA (MAGNOLIA OBOVATA) bark extract, the INCI name is MAGNOLIA OBOVATABARK EXTRACT, and the MAGNOLIA bark is purchased from the Qingping traditional Chinese medicine market in the Liwan of Guangzhou city.
The haematococcus pluvialis extract is haematococcus pluvialis (HAEMATOCOCCUS PLUVIALIS) extract, the INCI name is HAEMATOCOCCUS PLUVIALIS EXTRACT, and the astaxanthin specification content is more than or equal to 10% and is purchased from Shanxi hucho taimen biotechnology limited company.
The experimental methods, in which specific conditions are not noted in the following examples, are generally conducted under conventional conditions or under conditions recommended by the manufacturer. Percentages and parts are by weight unless otherwise indicated.
Preparation of Tricholoma matsutake extract
And (1) selecting fresh tricholoma matsutake with the mushroom cap diameter less than or equal to 10cm, the mushroom stem length less than or equal to 10cm and the mushroom stem diameter less than or equal to 3 cm.
Step (2), cleaning the tricholoma matsutake, and crushing the tricholoma matsutake into slag to obtain tricholoma matsutake slag;
adding 75-80v/v% ethanol solution, wherein the mass ratio of the tricholoma matsutake residues to the ethanol solution is 1 (8-11), refluxing in water bath for 4-5 times, each time for 40-50min, filtering at normal pressure, and mixing the filtrates to obtain tricholoma matsutake extract;
and (4) concentrating the tricholoma matsutake extract under reduced pressure to recover ethanol, wherein the concentration pressure is between-0.12 and-0.10 MPa, the temperature is controlled between 30 ℃ and 40 ℃, and the freeze drying is carried out until the water content of the extract is less than or equal to 10%, so as to obtain the tricholoma matsutake extract 1-4, wherein the preparation conditions of each extract are shown in the table 1.
TABLE 1 parameter for producing Tricholoma matsutake extract
Preparation of magnolia bark extract
Step (1), cleaning and crushing magnolia bark to obtain magnolia bark residue, putting the magnolia bark residue into a 70v/v% ethanol water solution, heating to 55-65 ℃ for soaking, filtering, concentrating under reduced pressure to recover ethanol to obtain extract;
step (2), extracting the extract obtained in the step (1) by using chloroform, and recovering the chloroform from the extract under reduced pressure to obtain a crude product;
and (3) concentrating the crude product obtained in the step (2) by reduced pressure rotary distillation at 55-65 ℃ until the liquid is not distilled out, and obtaining magnolia bark extract 1-4 by using thick paste as the rest, wherein the preparation conditions of the extracts are shown in the table 2.
Table 2 parameters for the preparation of magnolia bark extract
Examples and comparative examples
The raw materials in parts by weight of Table 3 were mixed to obtain examples and comparative examples.
TABLE 3 Table 3
Table 3 (subsequent)
Note that: in the table "-indicates that no addition was made.
Performance testing
Human body skin patch test
The 4 examples and the 4 comparative examples prepared above were referred to the human skin patch experiments in 2022 cosmetic safety technical Specification.
Skin reactions were observed as standard at 30min (after the disappearance of the indentations), 24h and 48h, respectively, and the observations were recorded, see table 4.
TABLE 4 human safety test results
| Numbering device | 30min | 24h | 48h |
| Example 1 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 2 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 3 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Example 4 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 1 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 2 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 3 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
| Comparative example 4 | Grade 0, 30 | Grade 0, 30 | Grade 0, 30 |
Measurement of DPPH radical scavenging ability:
preparation of DPPH with absolute ethanol into 2×10 -4 The mol/L solution, examples 1-4 and comparative examples 1-4 are used as the liquid to be detected, 2mL of each of the liquid to be detected, absolute ethyl alcohol and DPPH solution are prepared, the liquid to be detected, the absolute ethyl alcohol and the DPPH solution are respectively placed for 30 minutes at room temperature after being uniformly mixed, the absorbance at the wavelength of 517nm is measured to obtain Ai, each sample is measured for 3 times in parallel, and the average value is obtained.
Vc is used as a positive control, absolute ethyl alcohol is used for replacing DPPH to measure absorbance value to be used as a control Aj blank, and DPPH solution and absolute ethyl alcohol are mixed to measure absorbance Ac.
The clearance of DPPH radicals from each sample to be tested was calculated according to the following formula (1) and recorded in the following table 5.
Clearance (%) = (1- (Ai-Aj)/Ac) ×100%........... (1)
Wherein: ai is the absorbance of 2mL of the mixture of example or comparative example liquid+2mLDPPH reagent; aj is the absorbance of a mixture of 2mL of sample solution and 2mL of absolute ethanol; ac is the absorbance of a 2mL mixture of aqueous LDPPH and absolute ethanol.
Superoxide radical O 2 - Determination of the clearance Capacity
Respectively taking the examples 1-4 and the comparative examples 1-4 as the liquid to be detected, precisely sucking 1mL of the liquid to be detected, respectively adding 4.5mL of 50mmol/L Tris-HCl buffer solution with pH=8.2, uniformly mixing, preserving heat for 20 minutes in a constant-temperature water bath at 25 ℃, taking out, immediately adding 0.3mL of 25mmol/L pyrogallol solution, rapidly shaking, reacting in the constant-temperature water bath at 25 ℃ for 5 minutes, adding 8mmol/LHCl 1mL, uniformly mixing, terminating the reaction, measuring absorbance at 325nm, and taking distilled water instead of the sample as a blank. Vc was used as positive control. Each sample was measured 3 times in parallel and averaged.
The clearance was calculated according to formula (2) and recorded in table 5 below.
Clearance (%) = (a) 0 -A 1 )/A 0 ×100％...........(2)
Wherein: a is that 0 Mean absorbance for the blank; a is that 1 Is the average absorbance of the liquid to be detected.
Determination of the ability to scavenge hydroxyl radicals
As the test solutions, 1mL of 0.15 mmol/LFASO was added to each of the sample group test tubes in examples 1 to 4 and comparative examples 1 to 4, respectively 4 0.4mL of 2mmol/L salicylic acid, 0.2mL of liquid to be detected, 1mL of 6mmol/LH 2 O 2 And 0.4mL distilled water; the blank group uses distilled water to replace the liquid to be detected, the control group uses distilled water to replace salicylic acid, and the reaction is carried out for 30 minutes at 37 ℃. Vc was used as positive control. Each sample was measured 3 times in parallel and averaged.
The hydroxyl radical capacity clearance was calculated according to formula (3) and recorded in table 5 below.
Clearance (%) = (a) Blank space -(A Sample of -A Control ))/A Blank space ×100％...........(3)
TABLE 5
Inhibition of non-enzymatic saccharification reaction assay (anti-saccharification)
The amino residues of the sugar containing aldehyde groups and the protein react under non-enzymatic conditions to form Schiff base, early glycosylation products are formed after a period of time, then high-activity carbonyl compounds are formed after a period of time, and saccharification end products AGEs are formed after cyclization, oxidation and other actions. Along with the accumulation of AGEs, the skin is damaged, collagen and elastin in dermal tissues react with non-enzymatic saccharification to form a crosslinked product, so that the skin elasticity is reduced, wrinkles are generated, the tissue permeability is reduced, and the skin color is gradually dark yellow.
(1) Test protocol
The glucose solution and the bovine serum albumin solution were prepared with PBS solution to have final concentrations of 200mmol/L and 40g/L, respectively. Taking the example composition and the comparative example composition, and setting a control group: (1) group A, non-enzymatic saccharification reaction group without composition; (2) group B, bovine serum albumin control; (3) group C, glucose control with composition added; (4) group D, bovine serum albumin control with composition added, each group repeated 3 times.
And (3) testing: the reaction solutions were incubated at 37℃for 30 days in the absence of light, and the fluorescence values F of the reaction solutions of each group were measured by a fluorescence spectrophotometer under excitation at 370nm, emission at 440nm, and slit lnm.
(2) Calculation method
Relative AGEs inhibition calculation:
(3) Test results
TABLE 6AGEs detection results
| Group of | AGEs inhibition Rate (%) |
| Example 1 | 55.25 |
| Example 2 | 56.09 |
| Example 3 | 47.80 |
| Example 4 | 45.29 |
| Comparative example 1 | 28.73 |
| Comparative example 2 | 42.52 |
| Comparative example 3 | 40.67 |
| Comparative example 4 | 31.44 |
Skin whitening and spot lightening test
The 24 volunteers with darker complexion and colored spots on the face are screened, the age is 25-27 years, the average number of the volunteers is divided into 4 groups, the groups are respectively grouped according to examples 1-4, each group is respectively subjected to detection test according to the test method in the cosmetic ultraviolet-induced human skin blackening model freckle removing and whitening efficacy test method by using corresponding samples to be tested.
The test person uses the sample to be tested of the embodiment and the comparative example prepared before cleaning the face in the early and the evening, uses the skin color difference test probe and the multifunctional skin test system and the skin red melanin tester and the test probe continuously for 4 weeks, respectively performs data acquisition on the face of the test person before the test person uses (week 0), after the test person uses the test person 1 and after the test person uses the test person 4 weeks, calculates the change of skin whiteness (brightness)/L and skin melanin content/MI before and after the test person uses the cosmetics, and the L value represents L is white balance, and the larger the value is, the color is more biased to white; the higher the MI measurement value, the higher the melanin content in the skin; the test results were averaged for each panel and the specific results are shown in table 7.
TABLE 7
Analysis of results
From the results of the performance tests of example 1 and comparative examples 1 to 4, it is seen that example 1 significantly decreased the antioxidant and anti-glycation properties of the composition when the component magnolia bark extract was absent, as compared with comparative example 1.
From the results of the performance tests of example 1 and comparative example 2, it was found that the antioxidant properties of the extracts prepared from fresh Tricholoma matsutake were superior to those of the extracts prepared from Tricholoma matsutake or Tricholoma matsutake decoction pieces.
According to the performance test results of the example 1 and the comparative examples 1-4, the raw material components provided by the invention have excellent anti-saccharification and anti-oxidation effects, and the raw material components have mutually synergistic and mutually promoted effects.
According to the results of the whitening and spot-lightening tests in examples 1-4, the composition provided by the invention has the effect of inhibiting melanin synthesis and can play a role in whitening and spot-lightening.
While specific embodiments of the invention have been described above, it will be appreciated by those skilled in the art that this is by way of example only, and the scope of the invention is defined by the appended claims. Various changes and modifications to these embodiments may be made by those skilled in the art without departing from the principles and spirit of the invention, but such changes and modifications fall within the scope of the invention.
Claims (10)
1. The anti-saccharification and anti-oxidation composition is characterized by comprising the following components in parts by mass:
2. the anti-saccharification and anti-oxidation composition according to claim 1, comprising the following components in parts by mass:
3. the anti-glycation and anti-oxidation composition of claim 1 or 2, wherein the tricholoma matsutake extract is prepared by the following method: pulverizing Tricholoma matsutake to obtain Tricholoma matsutake residue, extracting the Tricholoma matsutake residue with ethanol water solution to obtain Tricholoma matsutake extractive solution, concentrating and drying to obtain Tricholoma matsutake extract.
4. The anti-glycation and anti-oxidation composition of claim 3, wherein the tricholoma matsutake is fresh tricholoma matsutake with a pileus diameter of 6-10cm, a stipe length of 6-10cm and a diameter of 2-3 cm.
5. The anti-glycation and anti-oxidant composition of claim 4, wherein the tricholoma matsutake is cleaned and crushed into slag to obtain tricholoma matsutake slag; adding 75-80v/v% ethanol water solution, refluxing in water bath for 4-5 times (8-11) for 40-50min each time, filtering, and mixing filtrates to obtain Tricholoma matsutake extractive solution; concentrating the Tricholoma matsutake extractive solution under reduced pressure to recover ethanol, and lyophilizing to obtain Tricholoma matsutake extract with water content less than or equal to 10%.
6. The anti-glycation and anti-oxidant composition of claim 1 or 2, wherein the magnolia bark extract is prepared by the steps of:
(1) Cleaning and pulverizing Magnolia bark to obtain Magnolia bark residue, adding into 70v/v% ethanol water solution, heating to 55-65deg.C, soaking, filtering, concentrating under reduced pressure to remove ethanol to obtain extract;
(2) Extracting the extract obtained in the step (1) by using chloroform, and removing the chloroform from the extract under reduced pressure to obtain a crude product;
(3) Concentrating under reduced pressure at 55-65deg.C until the liquid is no longer distilled, and collecting the rest paste to obtain Magnolia bark extract.
7. Use of the anti-glycation, anti-oxidation composition of any one of claims 1-6 for the preparation of a formulation with barrier repair, anti-oxidation, anti-glycation, moisturizing and/or whitening efficacy.
8. A skin resident comprising the anti-glycation, anti-oxidant composition and additive of any one of claims 1-6.
9. The skin residence agent according to claim 8, wherein said additives comprise at least one of surfactants, thickeners, conditioning agents, moisturizers, preservatives, chelators, fragrances, and water.
10. The skin residence agent according to claim 8, wherein said skin residence agent is at least one of essential water, essential milk, body milk, facial cleanser, massage cream, sun cream, hand cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311546549.6A CN117323266B (en) | 2023-11-20 | 2023-11-20 | Anti-saccharification and anti-oxidation composition and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311546549.6A CN117323266B (en) | 2023-11-20 | 2023-11-20 | Anti-saccharification and anti-oxidation composition and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117323266A true CN117323266A (en) | 2024-01-02 |
| CN117323266B CN117323266B (en) | 2024-05-24 |
Family
ID=89275858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311546549.6A Active CN117323266B (en) | 2023-11-20 | 2023-11-20 | Anti-saccharification and anti-oxidation composition and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117323266B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118178296A (en) * | 2024-03-27 | 2024-06-14 | 植物医生(广东)生物科技有限公司 | Preparation method and application of plant composition for tightening and resisting wrinkles |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109350568A (en) * | 2018-10-25 | 2019-02-19 | 广州市皓雨化妆品有限公司 | It is a kind of with anti-blue light, anti-oxidant, whitening, the composition for effect of releiving and anti-light aging essence and preparation method thereof |
| CN109937030A (en) * | 2016-11-07 | 2019-06-25 | 日清纺控股株式会社 | Skin cosmetic |
| CN112656706A (en) * | 2019-10-15 | 2021-04-16 | 康山峰 | Cosmetic repair stock solution and preparation method thereof |
| DE102020206961A1 (en) * | 2020-06-03 | 2021-12-09 | Beiersdorf Aktiengesellschaft | Use of one or more extracts from magnolia bark as an antioxidant or radical scavenger in cosmetic or dermatological preparations, in particular to prevent oxidative stress caused by visible light |
-
2023
- 2023-11-20 CN CN202311546549.6A patent/CN117323266B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109937030A (en) * | 2016-11-07 | 2019-06-25 | 日清纺控股株式会社 | Skin cosmetic |
| CN109350568A (en) * | 2018-10-25 | 2019-02-19 | 广州市皓雨化妆品有限公司 | It is a kind of with anti-blue light, anti-oxidant, whitening, the composition for effect of releiving and anti-light aging essence and preparation method thereof |
| CN112656706A (en) * | 2019-10-15 | 2021-04-16 | 康山峰 | Cosmetic repair stock solution and preparation method thereof |
| DE102020206961A1 (en) * | 2020-06-03 | 2021-12-09 | Beiersdorf Aktiengesellschaft | Use of one or more extracts from magnolia bark as an antioxidant or radical scavenger in cosmetic or dermatological preparations, in particular to prevent oxidative stress caused by visible light |
Non-Patent Citations (1)
| Title |
|---|
| 北京植物医生生物科技有限公司: "DR PLANT 高山松茸鲜活玉肌冻干絮精华液", Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakan.html?prodId=1131959480225890304&gb=G> * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118178296A (en) * | 2024-03-27 | 2024-06-14 | 植物医生(广东)生物科技有限公司 | Preparation method and application of plant composition for tightening and resisting wrinkles |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117323266B (en) | 2024-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101746843B1 (en) | Use of a polyphenol-rich plant extract as antioxidant in combination with a hydrating or humectant agent | |
| CN117323266B (en) | Anti-saccharification and anti-oxidation composition and application thereof | |
| CN111643411B (en) | Anti-aging composition and application thereof | |
| CN109091422A (en) | Cosmetics of the extracting solution containing Pleurotus citrinopileatus and preparation method thereof | |
| CN109394640B (en) | Enzyme skin care composition and application thereof | |
| JPH06336430A (en) | Maillard reaction inhibitor | |
| CN111700850B (en) | Freckle-removing mask and preparation method thereof | |
| JP2003201214A (en) | Matrix metalloprotease activity inhibitor | |
| JP2000344655A (en) | Skin cosmetic | |
| CN107669525B (en) | Application of Poria extract with whitening effect and its preparation method | |
| JP5117092B2 (en) | Moisturizer, anti-aging agent, whitening agent, antioxidant, slimming agent, treatment agent, arginase activity promoter and external preparation for skin | |
| KR101491463B1 (en) | Cosmetic composition for skin whitener containing fermented extract of green plum and method thereof | |
| CN115414293A (en) | Anti-aging composition and application thereof | |
| CN113116765B (en) | Essence stock solution, preparation method thereof and collagenase inhibitor | |
| EP4319785A1 (en) | Ligustrum lucidum extract useful for the treatment and/or care of the skin | |
| KR20020035925A (en) | Cosmetics composition comprising extract powder with vitis vinifera l.fermented solution and having whitening and anti-wrinkle effect | |
| KR101648477B1 (en) | Composition for improvement and prevention of dark circle under eyes | |
| CN112618404A (en) | Application of sandalwood polypeptide in preparation of skin care product and composition thereof | |
| KR20050097578A (en) | Cosmetic composition containing the zizyphus jujuba fruit extract and walnut extract for moisturizing effect on the skin | |
| JP3930165B2 (en) | Topical skin preparation | |
| JP2002068952A (en) | Cosmetic | |
| CN116650386B (en) | Composition for whitening human body and preparation method thereof | |
| JP3615001B2 (en) | Skin cosmetics | |
| CN112587457B (en) | Method for preparing anti-aging mask | |
| JPH08133959A (en) | Skin cosmetic |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |