CN117136232A - 嵌合抗原受体（car）nk细胞及其用途 - Google Patents

嵌合抗原受体（car）nk细胞及其用途 Download PDF

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Publication number
CN117136232A
CN117136232A CN202180075720.2A CN202180075720A CN117136232A CN 117136232 A CN117136232 A CN 117136232A CN 202180075720 A CN202180075720 A CN 202180075720A CN 117136232 A CN117136232 A CN 117136232A
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cells
cell
plasmid
car
aav
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CN202180075720.2A
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Chinese (zh)
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M·N·卡拉鲁迪
D·A·李
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Nationwide Childrens Hospital Inc
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Nationwide Childrens Hospital Inc
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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CN202180075720.2A 2020-10-26 2021-10-26 嵌合抗原受体（car）nk细胞及其用途 Pending CN117136232A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063105722P 2020-10-26 2020-10-26
US63/105,722 2020-10-26
PCT/US2021/056709 WO2022093863A1 (en) 2020-10-26 2021-10-26 Chimeric antigen receptor (car) nk cells and uses thereof

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CN117136232A true CN117136232A (zh) 2023-11-28

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US (1) US20220127644A1 (https=)
EP (1) EP4232560A4 (https=)
JP (1) JP2023552917A (https=)
KR (1) KR20230089570A (https=)
CN (1) CN117136232A (https=)
AR (1) AR123924A1 (https=)
AU (1) AU2021372458A1 (https=)
CA (1) CA3196656A1 (https=)
IL (1) IL302335A (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120118953A (zh) * 2025-05-13 2025-06-10 之江实验室 一种car供体质粒、t细胞及其制备方法和应用

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Publication number Priority date Publication date Assignee Title
EP4630567A2 (en) * 2022-12-09 2025-10-15 Research Institute at Nationwide Children's Hospital Chimeric antigen receptor (car) t cells and uses thereof
EP4633649A1 (en) * 2022-12-15 2025-10-22 The Board of Trustees of the Leland Stanford Junior University Homology-independent targeted dna insertion in human t cells
EP4720130A1 (en) * 2023-06-01 2026-04-08 Research Institute at Nationwide Children's Hospital Cd-33 protein-binding compositions and methods related thereto
WO2025151923A1 (en) * 2024-01-17 2025-07-24 Newsouth Innovations Pty Limited Apparatus for production of engineered cells

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EP3307876B1 (en) * 2015-06-10 2023-09-13 ImmunityBio, Inc. Modified nk-92 cells for treating cancer
CA3025667A1 (en) * 2016-06-08 2017-12-14 Intrexon Corporation Cd33 specific chimeric antigen receptors
CA3030683C (en) * 2016-07-12 2023-11-21 Kite Pharma, Inc. Antigen binding molecules and methods of use thereof
EP4029943A1 (en) * 2017-05-08 2022-07-20 Precision Biosciences, Inc. Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof
WO2019237035A1 (en) * 2018-06-08 2019-12-12 Intellia Therapeutics, Inc. Compositions and methods for immunooncology
JP7520826B2 (ja) * 2018-10-17 2024-07-23 クリスパー・セラピューティクス・アクチェンゲゼルシャフト 導入遺伝子を送達するための組成物および方法
BR112021008041A2 (pt) * 2018-11-07 2021-08-10 Crispr Therapeutics Ag terapia contra o câncer com células imunitárias anti-cd33
SG11202110613SA (en) * 2019-03-27 2021-10-28 Res Inst Nationwide Childrens Hospital Generation of chimeric antigen receptor (car)-primary nk cells for cancer immunotherapy using a combination of cas9/rnp and aav viruses

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120118953A (zh) * 2025-05-13 2025-06-10 之江实验室 一种car供体质粒、t细胞及其制备方法和应用

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EP4232560A4 (en) 2025-05-14
IL302335A (en) 2023-06-01
AR123924A1 (es) 2023-01-25
AU2021372458A1 (en) 2023-06-15
AU2021372458A9 (en) 2024-04-18
CA3196656A1 (en) 2022-05-05
US20220127644A1 (en) 2022-04-28
MX2023004811A (es) 2023-06-29
WO2022093863A1 (en) 2022-05-05
JP2023552917A (ja) 2023-12-19
KR20230089570A (ko) 2023-06-20
EP4232560A1 (en) 2023-08-30

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