CN117015545A - Sn-38衍生物、包含该衍生物的纳米粒子、医药及该纳米粒子的制造方法 - Google Patents

Sn-38衍生物、包含该衍生物的纳米粒子、医药及该纳米粒子的制造方法 Download PDF

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Publication number
CN117015545A
CN117015545A CN202280020372.3A CN202280020372A CN117015545A CN 117015545 A CN117015545 A CN 117015545A CN 202280020372 A CN202280020372 A CN 202280020372A CN 117015545 A CN117015545 A CN 117015545A
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CN
China
Prior art keywords
group
compound
mmol
salt
nanoparticles
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Pending
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CN202280020372.3A
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English (en)
Chinese (zh)
Inventor
笠井均
谷田惠太
小关良卓
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National Research And Development Corp Science And Technology Revitalization Organization
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National Research And Development Corp Science And Technology Revitalization Organization
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Publication of CN117015545A publication Critical patent/CN117015545A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
CN202280020372.3A 2021-03-12 2022-01-14 Sn-38衍生物、包含该衍生物的纳米粒子、医药及该纳米粒子的制造方法 Pending CN117015545A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021040799 2021-03-12
JP2021-040799 2021-03-12
PCT/JP2022/001163 WO2022190626A1 (ja) 2021-03-12 2022-01-14 Ｓｎ－３８誘導体、当該誘導体を含むナノ粒子、医薬及び当該ナノ粒子の製造方法

Publications (1)

Publication Number Publication Date
CN117015545A true CN117015545A (zh) 2023-11-07

Family

ID=83226544

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280020372.3A Pending CN117015545A (zh) 2021-03-12 2022-01-14 Sn-38衍生物、包含该衍生物的纳米粒子、医药及该纳米粒子的制造方法

Country Status (6)

Country Link
US (1) US20240300979A1 (https=)
EP (1) EP4306527A4 (https=)
JP (1) JP7626491B2 (https=)
CN (1) CN117015545A (https=)
AU (1) AU2022234045B2 (https=)
WO (1) WO2022190626A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115844891B (zh) * 2022-11-04 2025-02-11 沈阳药科大学 二硫键桥连的sn38二聚体前药及其自组装纳米粒、制备方法与应用
AU2023390747A1 (en) 2022-12-09 2025-06-26 Japan Science And Technology Agency Compound, nanoparticles, medicine and method for producing nanoparticles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103068404A (zh) * 2010-06-11 2013-04-24 独立行政法人科学技术振兴机构 药物多聚物微粒及其制造方法
CN107669626A (zh) * 2017-09-03 2018-02-09 河南师范大学 一种高载药量的还原敏感的药物传递系统的制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015012904A2 (en) 2012-12-13 2015-01-29 Immunomedics, Inc. Antibody-sn-38 immunoconjugates with a cl2a linker
AU2014293670B2 (en) 2013-07-23 2019-08-01 Immunomedics, Inc. Antibody-SN-38 immunoconjugates with a CL2A linker
TWI851577B (zh) 2018-06-07 2024-08-11 美商思進公司 喜樹鹼結合物
JP2021040799A (ja) 2019-09-09 2021-03-18 西川　基守 パチンコ遊技機

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103068404A (zh) * 2010-06-11 2013-04-24 独立行政法人科学技术振兴机构 药物多聚物微粒及其制造方法
CN107669626A (zh) * 2017-09-03 2018-02-09 河南师范大学 一种高载药量的还原敏感的药物传递系统的制备方法及其应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DONGXUAN HE ET AL.: "Self-assembling nanowires of an amphiphilic camptothecin prodrug derived from homologous derivative conjugation", 《CHEM. COMMUN.》, vol. 52, 11 November 2016 (2016-11-11), pages 14145 - 14148, XP055727032, DOI: 10.1039/C6CC07595A *
HUA WANG ET AL.: "Reduction-responsive dithiomaleimide-based nanomedicine with high drug loading and FRET-indicated drug release", 《CHEM. COMMUN.》, vol. 51, 18 February 2015 (2015-02-18), pages 4807 - 4810, XP055966439, DOI: 10.1039/C5CC00148J *

Also Published As

Publication number Publication date
WO2022190626A1 (ja) 2022-09-15
EP4306527A4 (en) 2025-02-19
US20240300979A1 (en) 2024-09-12
JPWO2022190626A1 (https=) 2022-09-15
AU2022234045A1 (en) 2023-08-31
JP7626491B2 (ja) 2025-02-04
EP4306527A1 (en) 2024-01-17
AU2022234045B2 (en) 2025-05-29

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