CN116999521A - 一种早泄功能性药食同源发酵功能制品及制备方法 - Google Patents
一种早泄功能性药食同源发酵功能制品及制备方法 Download PDFInfo
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- CN116999521A CN116999521A CN202310298444.7A CN202310298444A CN116999521A CN 116999521 A CN116999521 A CN 116999521A CN 202310298444 A CN202310298444 A CN 202310298444A CN 116999521 A CN116999521 A CN 116999521A
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明提供了一种早泄功能性药食同源发酵功能制品及制备方法，原料包含黄精、芡实、益智仁、莲子、覆盆子、枸杞子、山茱萸、肉苁蓉、百合、葛根、牡蛎、山栀子、小茴香、甘草。本发明融合传统中医理论与现代生物工程技术优势，围绕中药材主要成分开发靶向复合生物酶解、益生菌发酵转化、新资源食品原料复配等多项关键技术，开发中药材生物酶解、益生菌发酵新技术，实现了中药新产品加工技术的创新突破；采用乳酸菌肠道益生菌菌株混合发酵为核心的发酵工艺，溶出率最高达到80%以上；采用酶解+发酵+沸水浸提复合工艺得到较高的中药配方提取得率，达到33.90%，较单纯发酵工艺提高了46.18%。最终产品有效率高、副作用小、病患接受度高。
Description
技术领域
本发明属于中药生物制剂生产工艺技术领域，涉及一种早泄功能性药食同源发酵功能制品及制备方法。
背景技术
早泄是常见的男性射精功能障碍之一。流行病学结果显示，早泄发病率高达20％-30％，患者的生活质量和心理健康受到严重影响，也是引起家庭不和谐以及夫妻关系紧张的重要因素之一。
早泄传统化学药物治疗存在副作用强等问题，中药药方则存在药理不明，副作用风险高等问题。达泊西汀、帕罗西汀和舍曲林等SSRIs是目前治疗早泄的首选药物。舍曲林起效较快，服用1-2周后即可起效，在国内临床治疗早泄最为普遍。头晕、失眠、疲劳等神经系统症状，口干、恶心、食欲减退、便秘、腹痛或腹泻等消化系统症状，是长期服服用上述药物的不良反应。此外，SSRIs可引起勃起功能障碍、性欲减退、性高潮延迟等并发症。
药食同源方兼具药效和安全性，可以作为日常饮食中的补给品；益生菌通过发酵转化过程，可以将药食同源中药材中的高分子物质分解为更易吸收的小分子成分，提高中药材的吸收率的药效，同时益生菌在发酵过程中自身也合成多种具有生物活性的代谢产物。本专利所涉及的植物乳杆菌Lactobacillus plantarum IAHB-03的胞外发酵产物，对于男性早泄具有良好的改善作用，经动物实验评测，每日摄入5mg/kg体重剂量的发酵物，对于小鼠早泄相关行为学指标，具有明显的改善作用。
发明内容
本发明为根据早泄的发生的生理、心理机制，筛选黄精、芡实、益智仁、莲子、覆盆子等药食同源类材料，以中医君臣佐使理论为指导，围绕固精、养肝柔肝目标，开展药食同源配方设计，形成“早泄功能性药食同源核心组件”。
早泄功能性药食同源发酵功能制品，原料包含如下重量份数的组分：黄精20-35份，芡实20-35份，益智仁10-20份，莲子10-20份，覆盆子10-20份，枸杞子10-20份，山茱萸10-20份，肉苁蓉8-12份，百合8-12份，葛根8-12份，牡蛎25-35份，山栀子5-7份，小茴香5-7份，甘草2-4份。
优选的，包含如下重量份数的组分：黄精30份，芡实30份，益智仁15份，莲子15份，覆盆子15份，枸杞子15份，山茱萸15份，肉苁蓉10份，百合10份，葛根10份，牡蛎30份，山栀子6份，小茴香6份，甘草3份。
其中，方义：方中黄精味甘，平。入肾经，补气养阴，健脾益肾；芡实味甘、涩，平。入肾经，能收敛固涩，益肾固精；二药补肾固精，为方中君药。臣以益智仁、莲子、覆盆子、枸杞子、山茱萸；益智仁暖肾固精；莲子益肾涩精，养心安神；覆盆子、枸杞子、山茱萸养肾柔肝。五药合用，助君药补肾固精，又兼养肝柔肝之效。佐以肉苁蓉、百合、葛根、牡蛎、山栀子、小茴香。肉苁蓉补肾阳，益精血；百合清心安神；葛根通经活络；牡蛎重镇安神兼收涩固精；山栀子清泻心火，除烦安神；小茴香暖肾助阳。六药共助君臣药物补益肝肾，固精止遗之功效，又能清泻心火，敛心安神。甘草调和诸药为使。诸药配伍，共奏补肾柔肝，固精安神之效。
本发明还提供了一种早泄功能性药食同源发酵功能制品的制备方法，包括以下步骤：
S1：将原料粉碎至80-100目，然后加入原料质量9倍的蒸馏水，添加酸性纤维素酶，质量为原料的0.1-0.5％，用HCl调节pH至4.5-5.5之间，温度40-55℃之间，酶解处理2小时；
S2：将酶解调节PH至6.5-7.0之间，加入5％的葡萄糖，115℃蒸汽灭菌处理20分钟，冷却后接种；
S3：向灭菌后的酶解液中接种5％体积的植物乳杆菌Lactobacillus plantarumIAHB-03，37℃培养3天；
S4：发酵液经陶瓷膜过滤除菌，并向其中加入甜味剂、防腐剂，灌装。
进一步的，所述步骤S3中经过菌株抑菌能力和人工胃肠液耐受能力筛选，得到植物乳杆菌Lactobacillus plantarum SW-1，保藏编号为CCTCC NO:M20221780。
进一步的，步骤S4中陶瓷膜直径为0.45μm。
与现有技术相比，本发明的优点和积极效果在于：
(1)本发明融合传统中医理论与现代生物工程技术优势，围绕中药材主要成分开发靶向复合生物酶解、益生菌发酵转化、新资源食品原料复配等多项关键技术，开发中药材生物酶解、益生菌发酵新技术，实现了中药新产品加工技术的创新突破；
(2)本发明将“药食同源”类原料与“肠道微生态”相关新资源食品有机结合，形成“复合酶解-益生菌发酵”偶联生物转化加工工艺，并针对早泄人群生理、心理发生机制及应用场景开发定制型饮料、冲剂等不同产品剂型，实现了传统中医和现代生命科学理论与技术融合创新；
(3)本发明采用乳酸菌肠道益生菌菌株混合发酵为核心的发酵工艺，溶出率最高达到80％以上；采用酶解+发酵+沸水浸提复合工艺得到较高的中药配方提取得率，达到33.90％，较单纯发酵工艺提高了46.18％。最终产品有效率高、副作用小、病患接受度高。
附图说明
下面结合附图对本发明作进一步的说明。
图1为早泄功能性药食同源发酵功能制品汤剂照片；
图2为本发明阴道内射精潜伏时间(IELT)的比较(x±s)；
图3为本发明早泄诊断量表评分(PEDT)的比较(x±s)。
具体实施方式
为了能够更清楚地理解本发明的上述目的、特征和优点，下面结合具体实施例对本发明做进一步说明。需要说明的是，在不冲突的情况下，本申请的实施例及实施例中的特征可以相互组合。
在下面的描述中阐述了很多具体细节以便于充分理解本发明，但是，本发明还可以采用不同于在此描述的其他方式来实施，因此，本发明并不限于下面公开说明书的具体实施例的限制。
实施例1
益生菌株分离与筛选
本发明采用MRS培养基、YPD培养基，分离、筛选肠道益生菌并对其进行分子生物学及生理生化鉴定，获得了乳酸菌肠道益生菌菌株，并将其保存于中国典型培养物保藏中心，保藏编号为；CCTCC NO:M20221780，保藏日期为2022年11月14日，分类命名为植物乳杆菌SW-1Lactobacillus plantarum SW-1。
具体的，采用液体深层培养方式分析各菌株生长曲线、PH耐受范围，并测定其纤维素酶、淀粉酶、脂肪酶、蛋白酶、果胶酶等酶活，分析各菌株对于大肠杆菌、金黄色葡萄球菌、沙门氏菌等病原菌的拮抗能力，配制了人工肠液/胃液，测定各菌株耐受能力，并通过DPPH等方法测定其代谢产物抗氧化能力，优选适用于本发明发酵的优良菌株。
实施例2
药食同源原料配方为黄精20份，芡实20份，益智仁10份，莲子10份，覆盆子20份，枸杞子20份，山茱萸20份，肉苁蓉8份，百合12份，葛根12份，牡蛎35份，山栀子7份，小茴香7份，甘草4份。
将原料粉碎至100目，然后加入原料质量9倍的蒸馏水，添加酸性纤维素酶，质量为原料的0.5％，用HCl调节pH至4.5-5.5之间，温度40-55℃之间，酶解处理2小时。本步骤将多糖、蛋白、脂肪等大分子水解为小分子，破坏植物细胞壁等成分，提高内容物的释放率和提取率；同时这些大分子降解为小分子后，也更利于人体吸收，从而进一步提高药效。
接着将酶解液用NaOH调节PH至6.5-7.0之间，加入5％的葡萄糖，115℃蒸汽灭菌处理20分钟，冷却后接种；向灭菌后的酶解液中接种5％体积的植物乳杆菌Lactobacillusplantarum SW-1，37℃培养3天,本步骤通过益生菌进一步转化活性物质结构，同时益生菌自身会分泌对人体有益的活性物质，达到相辅相成作用；采用沸水浸提再次处理药材，充分释放前面步骤没有释放的活性物质。
发酵液经0.45μm的陶瓷膜过滤除菌，并向其中加入甜味剂、防腐剂，灌装即可。
表2.早泄诊断量表评分(PEDT)的比较
以上所述，仅是本发明的较佳实施例而已，并非是对本发明作其它形式的限制，任何熟悉本专业的技术人员可能利用上述揭示的技术内容加以变更或改型为等同变化的等效实施例应用于其它领域，但是凡是未脱离本发明技术方案内容，依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与改型，仍属于本发明技术方案的保护范围。
Claims (5)
1.一种早泄功能性药食同源发酵功能制品，其特征在于，原料包含如下重量份数的组分：黄精20-35份，芡实20-35份，益智仁10-20份，莲子10-20份，覆盆子10-20份，枸杞子10-20份，山茱萸10-20份，肉苁蓉8-12份，百合8-12份，葛根8-12份，牡蛎25-35份，山栀子5-7份，小茴香5-7份，甘草2-4份。
2.根据权利要求1所述的一种早泄功能性药食同源发酵功能制品，其特征在于，包含如下重量份数的组分：黄精30份，芡实30份，益智仁15份，莲子15份，覆盆子15份，枸杞子15份，山茱萸15份，肉苁蓉10份，百合10份，葛根10份，牡蛎30份，山栀子6份，小茴香6份，甘草3份。
3.根据权利要求1~2任意一项所述的早泄功能性药食同源发酵功能制品的制备方法，其特征在于，包括以下步骤：
S1：将原料粉碎至80-100目，然后加入原料质量9倍的蒸馏水，添加酸性纤维素酶，质量为原料的0.1-0.5%，用HCl调节pH至4.5-5.5之间，温度40-55℃之间，酶解处理2小时；
S2：将酶解调节PH至6.5-7.0之间，加入5%的葡萄糖，115℃蒸汽灭菌处理20分钟，冷却后接种；
S3：向灭菌后的酶解液中接种5%体积的植物乳杆菌Lactobacillus plantarum IAHB-03，37℃培养3天；
S4：发酵液经陶瓷膜过滤除菌，并向其中加入甜味剂、防腐剂，灌装。
4.根据权利要求3所述的早泄功能性药食同源发酵功能制品的制备方法，其特征在于，所述步骤S3中经过菌株抑菌能力和人工胃肠液耐受能力筛选，得到植物乳杆菌Lactobacillus plantarum SW-1，保藏编号为CCTCC NO:M20221780。
5.根据权利要求3所述的早泄功能性药食同源发酵功能制品的制备方法，其特征在于，步骤S4中陶瓷膜直径为0.45μm。
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491658A (zh) * | 2014-12-30 | 2015-04-08 | 兰州古驰生物科技有限公司 | 一种用于调理男性早泄的中药制剂 |
| CN104789511A (zh) * | 2015-05-08 | 2015-07-22 | 内蒙古农业大学 | 一株具有广谱抑菌特性的植物乳杆菌ab-2及其应用 |
| CN113855769A (zh) * | 2021-11-26 | 2021-12-31 | 济南航晨生物科技有限公司 | 一种适用于缓解早泄的药食同源提取物制备方法 |
| CN115120683A (zh) * | 2021-03-25 | 2022-09-30 | 海德尔(北京)保健食品有限公司 | 原料组合物和中药发酵产品及其制备方法和应用 |
-
2023
- 2023-03-24 CN CN202310298444.7A patent/CN116999521A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491658A (zh) * | 2014-12-30 | 2015-04-08 | 兰州古驰生物科技有限公司 | 一种用于调理男性早泄的中药制剂 |
| CN104789511A (zh) * | 2015-05-08 | 2015-07-22 | 内蒙古农业大学 | 一株具有广谱抑菌特性的植物乳杆菌ab-2及其应用 |
| CN115120683A (zh) * | 2021-03-25 | 2022-09-30 | 海德尔(北京)保健食品有限公司 | 原料组合物和中药发酵产品及其制备方法和应用 |
| CN113855769A (zh) * | 2021-11-26 | 2021-12-31 | 济南航晨生物科技有限公司 | 一种适用于缓解早泄的药食同源提取物制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 刘超;黄晓军;: "少弱精子症中医治疗思路", 山西中医学院学报, vol. 17, no. 02, pages 57 - 59 * |
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