CN1169959C - 高肝素结合力的多肽变异体 - Google Patents

高肝素结合力的多肽变异体 Download PDF

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Publication number
CN1169959C
CN1169959C CNB008037183A CN00803718A CN1169959C CN 1169959 C CN1169959 C CN 1169959C CN B008037183 A CNB008037183 A CN B008037183A CN 00803718 A CN00803718 A CN 00803718A CN 1169959 C CN1169959 C CN 1169959C
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China
Prior art keywords
sequence
polypeptide
amino acid
oligopeptide
nucleic acid
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB008037183A
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English (en)
Chinese (zh)
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CN1340102A (zh
Inventor
���ء����߸�
瓦尔特·西巴特
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Pharmaceutical company
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OSTEOGENETICS GmbH
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Publication of CN1340102A publication Critical patent/CN1340102A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CNB008037183A 1999-02-13 2000-01-27 高肝素结合力的多肽变异体 Expired - Fee Related CN1169959C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19906096A DE19906096A1 (de) 1999-02-13 1999-02-13 Protein mit einem Heparin-bindenden Epitop
DE19906096.7 1999-02-13

Publications (2)

Publication Number Publication Date
CN1340102A CN1340102A (zh) 2002-03-13
CN1169959C true CN1169959C (zh) 2004-10-06

Family

ID=7897433

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008037183A Expired - Fee Related CN1169959C (zh) 1999-02-13 2000-01-27 高肝素结合力的多肽变异体

Country Status (11)

Country Link
US (1) US7253254B1 (enExample)
EP (1) EP1151095B1 (enExample)
JP (3) JP4155711B2 (enExample)
CN (1) CN1169959C (enExample)
AT (1) ATE470713T1 (enExample)
AU (1) AU762387B2 (enExample)
BR (1) BR0008785A (enExample)
CA (1) CA2362496C (enExample)
DE (2) DE19906096A1 (enExample)
RU (1) RU2227743C2 (enExample)
WO (1) WO2000047736A1 (enExample)

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WO2005065396A2 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
DE602005023714D1 (de) * 2004-02-20 2010-11-04 Biosurface Eng Tech Inc Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2)
EP1885751B1 (en) * 2005-05-27 2011-11-16 BBS - Bioactive Bone Substitutes Oy Bone morphogenetic protein 6 containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
US9216212B2 (en) * 2005-08-05 2015-12-22 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
US7951384B2 (en) * 2005-08-05 2011-05-31 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
US8992965B2 (en) 2005-11-01 2015-03-31 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
JP2007332106A (ja) * 2006-06-16 2007-12-27 Okayama Univ 骨形成用徐放性医薬組成物
CA2692240C (en) 2006-06-22 2018-03-13 Biosurface Engineering Technologies, Inc. Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis
US20080206299A1 (en) * 2007-02-27 2008-08-28 Shimp Lawrence A Method for Recovering Minerals From Bone and Use of Same
AU2008265850B2 (en) 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2009009688A1 (en) 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
JP2009045142A (ja) * 2007-08-16 2009-03-05 Okayama Univ 生体内にて基材周囲に骨形成を誘導するための基材処理方法
WO2010039224A2 (en) 2008-09-30 2010-04-08 University Of Massachusetts Medical School Respiratory syncytial virus (rsv) sequences for protein expression and vaccines
JP5799409B2 (ja) * 2008-12-19 2015-10-28 国立大学法人 新潟大学 ヘパリン親和性エリスロポエチン
US9101475B2 (en) 2009-02-12 2015-08-11 Warsaw Orthopedic, Inc. Segmented delivery system
GB201601136D0 (en) 2016-01-21 2016-03-09 Mörgelin Matthias And Abdillahi Suado M Novel polypeptides and medical uses thereof
JP6629488B2 (ja) 2016-12-30 2020-01-15 バイオジェンド セラピューティクス カンパニー リミテッド 組換えポリペプチド、核酸分子、それらを含む組成物及びそれらの製造、使用方法

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Also Published As

Publication number Publication date
CA2362496A1 (en) 2000-08-17
AU2110600A (en) 2000-08-29
DE19906096A1 (de) 2000-08-17
JP4155711B2 (ja) 2008-09-24
JP2002536016A (ja) 2002-10-29
JP2009011323A (ja) 2009-01-22
EP1151095B1 (de) 2010-06-09
BR0008785A (pt) 2001-11-06
EP1151095A1 (de) 2001-11-07
JP2008086319A (ja) 2008-04-17
RU2227743C2 (ru) 2004-04-27
CA2362496C (en) 2011-04-19
CN1340102A (zh) 2002-03-13
AU762387B2 (en) 2003-06-26
US7253254B1 (en) 2007-08-07
WO2000047736A1 (de) 2000-08-17
DE50015938D1 (de) 2010-07-22
ATE470713T1 (de) 2010-06-15

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